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A. Della Rossa - One of the best experts on this subject based on the ideXlab platform.

Lauren M. Osborne - One of the best experts on this subject based on the ideXlab platform.

  • Neuroactive Steroids and Perinatal Depression: a Review of Recent Literature
    Current psychiatry reports, 2018
    Co-Authors: Katherine Mcevoy, Jennifer L. Payne, Lauren M. Osborne
    Abstract:

    The purpose of this review is to provide a theoretical explanation and a review of the Recent Literature concerning the role of neuroactive steroids in perinatal depression, and to use this information to suggest future directions of research. The bulk of the evidence on neuroactive steroids in perinatal depression concerns allopregnanolone. Recent studies have been mixed, with some studies finding a direct correlation between lower levels of allopregnanolone and increased depressive symptoms but other studies finding no relationship. Evidence concerning other neuroactive steroids and perinatal depression is sparse. Additional research is needed with larger sample sizes and better characterization across the perinatal period (rather than cross-sectionally). Because some studies point to a lag between neuroactive steroid dysregulation and subsequent symptoms, future research should consider interactions with other aspects of neuroactive steroid physiology, such as synthetic enzymes or receptor plasticity.

  • Neuroactive Steroids and Perinatal Depression: a Review of Recent Literature
    Current Psychiatry Reports, 2018
    Co-Authors: Katherine Mcevoy, Jennifer L. Payne, Lauren M. Osborne
    Abstract:

    Purpose of Review The purpose of this review is to provide a theoretical explanation and a review of the Recent Literature concerning the role of neuroactive steroids in perinatal depression, and to use this information to suggest future directions of research. Recent Findings The bulk of the evidence on neuroactive steroids in perinatal depression concerns allopregnanolone. Recent studies have been mixed, with some studies finding a direct correlation between lower levels of allopregnanolone and increased depressive symptoms but other studies finding no relationship. Evidence concerning other neuroactive steroids and perinatal depression is sparse. Summary Additional research is needed with larger sample sizes and better characterization across the perinatal period (rather than cross-sectionally). Because some studies point to a lag between neuroactive steroid dysregulation and subsequent symptoms, future research should consider interactions with other aspects of neuroactive steroid physiology, such as synthetic enzymes or receptor plasticity.

Rolando Leal - One of the best experts on this subject based on the ideXlab platform.

Rosaria Talarico - One of the best experts on this subject based on the ideXlab platform.

Katherine Mcevoy - One of the best experts on this subject based on the ideXlab platform.

  • Neuroactive Steroids and Perinatal Depression: a Review of Recent Literature
    Current psychiatry reports, 2018
    Co-Authors: Katherine Mcevoy, Jennifer L. Payne, Lauren M. Osborne
    Abstract:

    The purpose of this review is to provide a theoretical explanation and a review of the Recent Literature concerning the role of neuroactive steroids in perinatal depression, and to use this information to suggest future directions of research. The bulk of the evidence on neuroactive steroids in perinatal depression concerns allopregnanolone. Recent studies have been mixed, with some studies finding a direct correlation between lower levels of allopregnanolone and increased depressive symptoms but other studies finding no relationship. Evidence concerning other neuroactive steroids and perinatal depression is sparse. Additional research is needed with larger sample sizes and better characterization across the perinatal period (rather than cross-sectionally). Because some studies point to a lag between neuroactive steroid dysregulation and subsequent symptoms, future research should consider interactions with other aspects of neuroactive steroid physiology, such as synthetic enzymes or receptor plasticity.

  • Neuroactive Steroids and Perinatal Depression: a Review of Recent Literature
    Current Psychiatry Reports, 2018
    Co-Authors: Katherine Mcevoy, Jennifer L. Payne, Lauren M. Osborne
    Abstract:

    Purpose of Review The purpose of this review is to provide a theoretical explanation and a review of the Recent Literature concerning the role of neuroactive steroids in perinatal depression, and to use this information to suggest future directions of research. Recent Findings The bulk of the evidence on neuroactive steroids in perinatal depression concerns allopregnanolone. Recent studies have been mixed, with some studies finding a direct correlation between lower levels of allopregnanolone and increased depressive symptoms but other studies finding no relationship. Evidence concerning other neuroactive steroids and perinatal depression is sparse. Summary Additional research is needed with larger sample sizes and better characterization across the perinatal period (rather than cross-sectionally). Because some studies point to a lag between neuroactive steroid dysregulation and subsequent symptoms, future research should consider interactions with other aspects of neuroactive steroid physiology, such as synthetic enzymes or receptor plasticity.