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Guy Perrière - One of the best experts on this subject based on the ideXlab platform.

  • RTKdb: database of Receptor Tyrosine Kinase.
    Nucleic Acids Research, 2003
    Co-Authors: Julien Grassot, Guy Mouchiroud, Guy Perrière
    Abstract:

    Receptor Tyrosine Kinases (RTK) are transmembrane Receptors specifically found in metazoans. They represent an excellent model for studying evolution of cellular processes in metazoans because they encompass large families of modular proteins and belong to a major family of contingency generating molecules in eukaryotic cells: the protein Kinases. Because Tyrosine Kinases have been under close scrutiny for many years in various species, they are associated with a wealth of information, mainly in mammals. Presently, most categories of RTK were identified in mammals, but in a near future other model species will be sequenced, and will bring us RTKs from other metazoan clades. Thus, collecting RTK sequences would provide a good starting point as a new model for comparative and evolutionary studies applying to multigene families. In this context, we are developing the Receptor Tyrosine Kinase database (RTKdb), which is the only database on Tyrosine Kinase Receptors presently available. In this database, protein sequences from eight model metazoan species are organized under the format previously used for the HOVERGEN, HOBACGEN and NUREBASE systems. RTKdb can be accessed through the PBIL (P?Bioinformatique Lyonnais) World Wide Web server at http://pbil.univ-lyon1.fr/RTKdb/, or through the FamFetch graphical user interface available at the same address.

  • RTKdb: database of Receptor Tyrosine Kinase.
    Nucleic acids research, 2003
    Co-Authors: Julien Grassot, Guy Mouchiroud, Guy Perrière
    Abstract:

    Receptor Tyrosine Kinases (RTK) are transmembrane Receptors specifically found in metazoans. They represent an excellent model for studying evolution of cellular processes in metazoans because they encompass large families of modular proteins and belong to a major family of contingency generating molecules in eukaryotic cells: the protein Kinases. Because Tyrosine Kinases have been under close scrutiny for many years in various species, they are associated with a wealth of information, mainly in mammals. Presently, most categories of RTK were identified in mammals, but in a near future other model species will be sequenced, and will bring us RTKs from other metazoan clades. Thus, collecting RTK sequences would provide a good starting point as a new model for comparative and evolutionary studies applying to multigene families. In this context, we are developing the Receptor Tyrosine Kinase database (RTKdb), which is the only database on Tyrosine Kinase Receptors presently available. In this database, protein sequences from eight model metazoan species are organized under the format previously used for the HOVERGEN, HOBACGEN and NUREBASE systems. RTKdb can be accessed through the PBIL (Pole Bioinformatique Lyonnais) World Wide Web server at http://pbil.univ-lyon1.fr/RTKdb/, or through the FamFetch graphical user interface available at the same address.

Michel C Nussenzweig - One of the best experts on this subject based on the ideXlab platform.

Julien Grassot - One of the best experts on this subject based on the ideXlab platform.

  • RTKdb: database of Receptor Tyrosine Kinase.
    Nucleic Acids Research, 2003
    Co-Authors: Julien Grassot, Guy Mouchiroud, Guy Perrière
    Abstract:

    Receptor Tyrosine Kinases (RTK) are transmembrane Receptors specifically found in metazoans. They represent an excellent model for studying evolution of cellular processes in metazoans because they encompass large families of modular proteins and belong to a major family of contingency generating molecules in eukaryotic cells: the protein Kinases. Because Tyrosine Kinases have been under close scrutiny for many years in various species, they are associated with a wealth of information, mainly in mammals. Presently, most categories of RTK were identified in mammals, but in a near future other model species will be sequenced, and will bring us RTKs from other metazoan clades. Thus, collecting RTK sequences would provide a good starting point as a new model for comparative and evolutionary studies applying to multigene families. In this context, we are developing the Receptor Tyrosine Kinase database (RTKdb), which is the only database on Tyrosine Kinase Receptors presently available. In this database, protein sequences from eight model metazoan species are organized under the format previously used for the HOVERGEN, HOBACGEN and NUREBASE systems. RTKdb can be accessed through the PBIL (P?Bioinformatique Lyonnais) World Wide Web server at http://pbil.univ-lyon1.fr/RTKdb/, or through the FamFetch graphical user interface available at the same address.

  • RTKdb: database of Receptor Tyrosine Kinase.
    Nucleic acids research, 2003
    Co-Authors: Julien Grassot, Guy Mouchiroud, Guy Perrière
    Abstract:

    Receptor Tyrosine Kinases (RTK) are transmembrane Receptors specifically found in metazoans. They represent an excellent model for studying evolution of cellular processes in metazoans because they encompass large families of modular proteins and belong to a major family of contingency generating molecules in eukaryotic cells: the protein Kinases. Because Tyrosine Kinases have been under close scrutiny for many years in various species, they are associated with a wealth of information, mainly in mammals. Presently, most categories of RTK were identified in mammals, but in a near future other model species will be sequenced, and will bring us RTKs from other metazoan clades. Thus, collecting RTK sequences would provide a good starting point as a new model for comparative and evolutionary studies applying to multigene families. In this context, we are developing the Receptor Tyrosine Kinase database (RTKdb), which is the only database on Tyrosine Kinase Receptors presently available. In this database, protein sequences from eight model metazoan species are organized under the format previously used for the HOVERGEN, HOBACGEN and NUREBASE systems. RTKdb can be accessed through the PBIL (Pole Bioinformatique Lyonnais) World Wide Web server at http://pbil.univ-lyon1.fr/RTKdb/, or through the FamFetch graphical user interface available at the same address.

J M Bishop - One of the best experts on this subject based on the ideXlab platform.

  • torso a Receptor Tyrosine Kinase required for embryonic pattern formation shares substrates with the sevenless and egf r pathways in drosophila
    Genes & Development, 1993
    Co-Authors: H J Doyle, J M Bishop
    Abstract:

    : The maternally expressed Drosophila gene torso (tor) is a Receptor Tyrosine Kinase that, when activated, initiates a signal transduction cascade that is responsible for the proper differentiation of the terminal, nonsegmented regions of the embryo. l(1)pole hole, the Drosophila raf-1 serine-threonine Kinase homolog, and corkscrew, a Tyrosine phosphatase, have been shown previously to function in this signal transduction pathway. We have identified other products in this pathway by carrying out a mutagenesis screen for dominant suppressors of a tor gain-of-function allele. More than 40 mutations, some of which fall into seven complementation groups, have been characterized genetically. Two of these correspond to mutations in ras-1 and Son of sevenless (Sos), which also function in the sevenless and EGF Receptor (Der) Tyrosine Kinase pathways. The phenotypes of several other Su(tor) mutations suggest that they also function in other Receptor Tyrosine Kinase-activated pathways at different times during Drosophila development.

  • torso a Receptor Tyrosine Kinase required for embryonic pattern formation shares substrates with the sevenless and egf r pathways in drosophila
    Genes & Development, 1993
    Co-Authors: H J Doyle, J M Bishop
    Abstract:

    : The maternally expressed Drosophila gene torso (tor) is a Receptor Tyrosine Kinase that, when activated, initiates a signal transduction cascade that is responsible for the proper differentiation of the terminal, nonsegmented regions of the embryo. l(1)pole hole, the Drosophila raf-1 serine-threonine Kinase homolog, and corkscrew, a Tyrosine phosphatase, have been shown previously to function in this signal transduction pathway. We have identified other products in this pathway by carrying out a mutagenesis screen for dominant suppressors of a tor gain-of-function allele. More than 40 mutations, some of which fall into seven complementation groups, have been characterized genetically. Two of these correspond to mutations in ras-1 and Son of sevenless (Sos), which also function in the sevenless and EGF Receptor (Der) Tyrosine Kinase pathways. The phenotypes of several other Su(tor) mutations suggest that they also function in other Receptor Tyrosine Kinase-activated pathways at different times during Drosophila development.

Chen Jun - One of the best experts on this subject based on the ideXlab platform.

  • Advances in VEGF Receptor Tyrosine Kinase Inhibitors
    Progress in Pharmaceutical Sciences, 2002
    Co-Authors: Chen Jun
    Abstract:

    Angiogenesis is a fundamental process of tumor growth and metastasis, and thus inhibition of angiogenesis induced by tumors has become an important trend in research and development of novel antineoplastic drugs. The vascular endothelial growth factor (VEGF), known as the most potent and specific angiogenetic factor, represents an key target for the discovery of anti angiogenesis inhibitors. Receptor Tyrosine Kinase (RTK) inhibitors targeting VEGF Receptor is one of the most promising agents. Recent developments of these inhibitors were reviewed, and their structure activity relationship was discussed.