The Experts below are selected from a list of 98997 Experts worldwide ranked by ideXlab platform
Iwona Auergrzesiak - One of the best experts on this subject based on the ideXlab platform.
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immune Reconstitution after anti thymocyte globulin conditioned hematopoietic cell transplantation
Cytotherapy, 2012Co-Authors: Mark Bosch, Manveer Dhadda, Mette Hoeghpetersen, Laura M Hagel, Peter Podgorny, Alejandra Ugartetorres, Joanne Luider, Iwona Auergrzesiak, Faisal Khan, Adnan MansoorAbstract:Background aims. Anti-thymocyte globulin (ATG) is being used increasingly to prevent graft-versus-host disease (GvHD); however, its impact on immune Reconstitution is relatively unknown. We (i) studied immune Reconstitution after ATG-conditioned hematopoietic cell transplantation (HCT), (ii) determined the factors influencing the Reconstitution, and (iii) compared it with non-ATG-conditioned HCT. Methods. Immune cell subset counts were determined at 1–24 months post-transplant in 125 HCT recipients who received ATG during conditioning. Subset counts were also determined in 46 non-ATG-conditioned patients (similarly treated). Results. (i) Reconstitution after ATG-conditioned HCT was fast for innate immune cells, intermediate for B cells and CD8 T cells, and very slow for CD4 T cells and invariant natural killer T (iNKT) (iNKT) cells. (ii) Faster Reconstitution after ATG-conditioned HCT was associated with a higher number of cells of the same subset transferred with the graft in the case of memory B cells, ...
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immune Reconstitution after anti thymocyte globulin conditioned hematopoietic cell transplantation
Cytotherapy, 2012Co-Authors: Mark Bosch, Manveer Dhadda, Mette Hoeghpetersen, Laura M Hagel, Peter Podgorny, Alejandra Ugartetorres, Joanne Luider, Faisal Khan, Yiping Liu, Iwona AuergrzesiakAbstract:Abstract Background aims Anti-thymocyte globulin (ATG) is being used increasingly to prevent graft-versus-host disease (GvHD); however, its impact on immune Reconstitution is relatively unknown. We (i) studied immune Reconstitution after ATG-conditioned hematopoietic cell transplantation (HCT), (ii) determined the factors influencing the Reconstitution, and (iii) compared it with non-ATG-conditioned HCT. Methods Immune cell subset counts were determined at 1–24 months post-transplant in 125 HCT recipients who received ATG during conditioning. Subset counts were also determined in 46 non-ATG-conditioned patients (similarly treated). Results (i) Reconstitution after ATG-conditioned HCT was fast for innate immune cells, intermediate for B cells and CD8 T cells, and very slow for CD4 T cells and invariant natural killer T (iNKT) (iNKT) cells. (ii) Faster Reconstitution after ATG-conditioned HCT was associated with a higher number of cells of the same subset transferred with the graft in the case of memory B cells, naive CD4 T cells, naive CD8 T cells, iNKT cells and myeloid dendritic cells; lower recipient age in the case of naive CD4 T cells and naive CD8 T cells; cytomegalovirus recipient seropositivity in the case of memory/effector T cells; an absence of GvHD in the case of naive B cells; lower ATG serum levels in the case of most T-cell subsets, including iNKT cells; and higher ATG levels in the case of NK cells and B cells. (iii) Compared with non-ATG-conditioned HCT, Reconstitution after ATG-conditioned HCT was slower for CD4 T cells, and faster for NK cells and B cells. Conclusions ATG worsens the Reconstitution of CD4 T cells but improves the Reconstitution of NK and B cells.
Mark Bosch - One of the best experts on this subject based on the ideXlab platform.
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immune Reconstitution after anti thymocyte globulin conditioned hematopoietic cell transplantation
Cytotherapy, 2012Co-Authors: Mark Bosch, Manveer Dhadda, Mette Hoeghpetersen, Laura M Hagel, Peter Podgorny, Alejandra Ugartetorres, Joanne Luider, Iwona Auergrzesiak, Faisal Khan, Adnan MansoorAbstract:Background aims. Anti-thymocyte globulin (ATG) is being used increasingly to prevent graft-versus-host disease (GvHD); however, its impact on immune Reconstitution is relatively unknown. We (i) studied immune Reconstitution after ATG-conditioned hematopoietic cell transplantation (HCT), (ii) determined the factors influencing the Reconstitution, and (iii) compared it with non-ATG-conditioned HCT. Methods. Immune cell subset counts were determined at 1–24 months post-transplant in 125 HCT recipients who received ATG during conditioning. Subset counts were also determined in 46 non-ATG-conditioned patients (similarly treated). Results. (i) Reconstitution after ATG-conditioned HCT was fast for innate immune cells, intermediate for B cells and CD8 T cells, and very slow for CD4 T cells and invariant natural killer T (iNKT) (iNKT) cells. (ii) Faster Reconstitution after ATG-conditioned HCT was associated with a higher number of cells of the same subset transferred with the graft in the case of memory B cells, ...
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immune Reconstitution after anti thymocyte globulin conditioned hematopoietic cell transplantation
Cytotherapy, 2012Co-Authors: Mark Bosch, Manveer Dhadda, Mette Hoeghpetersen, Laura M Hagel, Peter Podgorny, Alejandra Ugartetorres, Joanne Luider, Faisal Khan, Yiping Liu, Iwona AuergrzesiakAbstract:Abstract Background aims Anti-thymocyte globulin (ATG) is being used increasingly to prevent graft-versus-host disease (GvHD); however, its impact on immune Reconstitution is relatively unknown. We (i) studied immune Reconstitution after ATG-conditioned hematopoietic cell transplantation (HCT), (ii) determined the factors influencing the Reconstitution, and (iii) compared it with non-ATG-conditioned HCT. Methods Immune cell subset counts were determined at 1–24 months post-transplant in 125 HCT recipients who received ATG during conditioning. Subset counts were also determined in 46 non-ATG-conditioned patients (similarly treated). Results (i) Reconstitution after ATG-conditioned HCT was fast for innate immune cells, intermediate for B cells and CD8 T cells, and very slow for CD4 T cells and invariant natural killer T (iNKT) (iNKT) cells. (ii) Faster Reconstitution after ATG-conditioned HCT was associated with a higher number of cells of the same subset transferred with the graft in the case of memory B cells, naive CD4 T cells, naive CD8 T cells, iNKT cells and myeloid dendritic cells; lower recipient age in the case of naive CD4 T cells and naive CD8 T cells; cytomegalovirus recipient seropositivity in the case of memory/effector T cells; an absence of GvHD in the case of naive B cells; lower ATG serum levels in the case of most T-cell subsets, including iNKT cells; and higher ATG levels in the case of NK cells and B cells. (iii) Compared with non-ATG-conditioned HCT, Reconstitution after ATG-conditioned HCT was slower for CD4 T cells, and faster for NK cells and B cells. Conclusions ATG worsens the Reconstitution of CD4 T cells but improves the Reconstitution of NK and B cells.
Adnan Mansoor - One of the best experts on this subject based on the ideXlab platform.
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immune Reconstitution after anti thymocyte globulin conditioned hematopoietic cell transplantation
Cytotherapy, 2012Co-Authors: Mark Bosch, Manveer Dhadda, Mette Hoeghpetersen, Laura M Hagel, Peter Podgorny, Alejandra Ugartetorres, Joanne Luider, Iwona Auergrzesiak, Faisal Khan, Adnan MansoorAbstract:Background aims. Anti-thymocyte globulin (ATG) is being used increasingly to prevent graft-versus-host disease (GvHD); however, its impact on immune Reconstitution is relatively unknown. We (i) studied immune Reconstitution after ATG-conditioned hematopoietic cell transplantation (HCT), (ii) determined the factors influencing the Reconstitution, and (iii) compared it with non-ATG-conditioned HCT. Methods. Immune cell subset counts were determined at 1–24 months post-transplant in 125 HCT recipients who received ATG during conditioning. Subset counts were also determined in 46 non-ATG-conditioned patients (similarly treated). Results. (i) Reconstitution after ATG-conditioned HCT was fast for innate immune cells, intermediate for B cells and CD8 T cells, and very slow for CD4 T cells and invariant natural killer T (iNKT) (iNKT) cells. (ii) Faster Reconstitution after ATG-conditioned HCT was associated with a higher number of cells of the same subset transferred with the graft in the case of memory B cells, ...
Alejandra Ugartetorres - One of the best experts on this subject based on the ideXlab platform.
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immune Reconstitution after anti thymocyte globulin conditioned hematopoietic cell transplantation
Cytotherapy, 2012Co-Authors: Mark Bosch, Manveer Dhadda, Mette Hoeghpetersen, Laura M Hagel, Peter Podgorny, Alejandra Ugartetorres, Joanne Luider, Iwona Auergrzesiak, Faisal Khan, Adnan MansoorAbstract:Background aims. Anti-thymocyte globulin (ATG) is being used increasingly to prevent graft-versus-host disease (GvHD); however, its impact on immune Reconstitution is relatively unknown. We (i) studied immune Reconstitution after ATG-conditioned hematopoietic cell transplantation (HCT), (ii) determined the factors influencing the Reconstitution, and (iii) compared it with non-ATG-conditioned HCT. Methods. Immune cell subset counts were determined at 1–24 months post-transplant in 125 HCT recipients who received ATG during conditioning. Subset counts were also determined in 46 non-ATG-conditioned patients (similarly treated). Results. (i) Reconstitution after ATG-conditioned HCT was fast for innate immune cells, intermediate for B cells and CD8 T cells, and very slow for CD4 T cells and invariant natural killer T (iNKT) (iNKT) cells. (ii) Faster Reconstitution after ATG-conditioned HCT was associated with a higher number of cells of the same subset transferred with the graft in the case of memory B cells, ...
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immune Reconstitution after anti thymocyte globulin conditioned hematopoietic cell transplantation
Cytotherapy, 2012Co-Authors: Mark Bosch, Manveer Dhadda, Mette Hoeghpetersen, Laura M Hagel, Peter Podgorny, Alejandra Ugartetorres, Joanne Luider, Faisal Khan, Yiping Liu, Iwona AuergrzesiakAbstract:Abstract Background aims Anti-thymocyte globulin (ATG) is being used increasingly to prevent graft-versus-host disease (GvHD); however, its impact on immune Reconstitution is relatively unknown. We (i) studied immune Reconstitution after ATG-conditioned hematopoietic cell transplantation (HCT), (ii) determined the factors influencing the Reconstitution, and (iii) compared it with non-ATG-conditioned HCT. Methods Immune cell subset counts were determined at 1–24 months post-transplant in 125 HCT recipients who received ATG during conditioning. Subset counts were also determined in 46 non-ATG-conditioned patients (similarly treated). Results (i) Reconstitution after ATG-conditioned HCT was fast for innate immune cells, intermediate for B cells and CD8 T cells, and very slow for CD4 T cells and invariant natural killer T (iNKT) (iNKT) cells. (ii) Faster Reconstitution after ATG-conditioned HCT was associated with a higher number of cells of the same subset transferred with the graft in the case of memory B cells, naive CD4 T cells, naive CD8 T cells, iNKT cells and myeloid dendritic cells; lower recipient age in the case of naive CD4 T cells and naive CD8 T cells; cytomegalovirus recipient seropositivity in the case of memory/effector T cells; an absence of GvHD in the case of naive B cells; lower ATG serum levels in the case of most T-cell subsets, including iNKT cells; and higher ATG levels in the case of NK cells and B cells. (iii) Compared with non-ATG-conditioned HCT, Reconstitution after ATG-conditioned HCT was slower for CD4 T cells, and faster for NK cells and B cells. Conclusions ATG worsens the Reconstitution of CD4 T cells but improves the Reconstitution of NK and B cells.
Peter Podgorny - One of the best experts on this subject based on the ideXlab platform.
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immune Reconstitution after anti thymocyte globulin conditioned hematopoietic cell transplantation
Cytotherapy, 2012Co-Authors: Mark Bosch, Manveer Dhadda, Mette Hoeghpetersen, Laura M Hagel, Peter Podgorny, Alejandra Ugartetorres, Joanne Luider, Iwona Auergrzesiak, Faisal Khan, Adnan MansoorAbstract:Background aims. Anti-thymocyte globulin (ATG) is being used increasingly to prevent graft-versus-host disease (GvHD); however, its impact on immune Reconstitution is relatively unknown. We (i) studied immune Reconstitution after ATG-conditioned hematopoietic cell transplantation (HCT), (ii) determined the factors influencing the Reconstitution, and (iii) compared it with non-ATG-conditioned HCT. Methods. Immune cell subset counts were determined at 1–24 months post-transplant in 125 HCT recipients who received ATG during conditioning. Subset counts were also determined in 46 non-ATG-conditioned patients (similarly treated). Results. (i) Reconstitution after ATG-conditioned HCT was fast for innate immune cells, intermediate for B cells and CD8 T cells, and very slow for CD4 T cells and invariant natural killer T (iNKT) (iNKT) cells. (ii) Faster Reconstitution after ATG-conditioned HCT was associated with a higher number of cells of the same subset transferred with the graft in the case of memory B cells, ...
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immune Reconstitution after anti thymocyte globulin conditioned hematopoietic cell transplantation
Cytotherapy, 2012Co-Authors: Mark Bosch, Manveer Dhadda, Mette Hoeghpetersen, Laura M Hagel, Peter Podgorny, Alejandra Ugartetorres, Joanne Luider, Faisal Khan, Yiping Liu, Iwona AuergrzesiakAbstract:Abstract Background aims Anti-thymocyte globulin (ATG) is being used increasingly to prevent graft-versus-host disease (GvHD); however, its impact on immune Reconstitution is relatively unknown. We (i) studied immune Reconstitution after ATG-conditioned hematopoietic cell transplantation (HCT), (ii) determined the factors influencing the Reconstitution, and (iii) compared it with non-ATG-conditioned HCT. Methods Immune cell subset counts were determined at 1–24 months post-transplant in 125 HCT recipients who received ATG during conditioning. Subset counts were also determined in 46 non-ATG-conditioned patients (similarly treated). Results (i) Reconstitution after ATG-conditioned HCT was fast for innate immune cells, intermediate for B cells and CD8 T cells, and very slow for CD4 T cells and invariant natural killer T (iNKT) (iNKT) cells. (ii) Faster Reconstitution after ATG-conditioned HCT was associated with a higher number of cells of the same subset transferred with the graft in the case of memory B cells, naive CD4 T cells, naive CD8 T cells, iNKT cells and myeloid dendritic cells; lower recipient age in the case of naive CD4 T cells and naive CD8 T cells; cytomegalovirus recipient seropositivity in the case of memory/effector T cells; an absence of GvHD in the case of naive B cells; lower ATG serum levels in the case of most T-cell subsets, including iNKT cells; and higher ATG levels in the case of NK cells and B cells. (iii) Compared with non-ATG-conditioned HCT, Reconstitution after ATG-conditioned HCT was slower for CD4 T cells, and faster for NK cells and B cells. Conclusions ATG worsens the Reconstitution of CD4 T cells but improves the Reconstitution of NK and B cells.
