The Experts below are selected from a list of 97554 Experts worldwide ranked by ideXlab platform
Stéphane Blanc - One of the best experts on this subject based on the ideXlab platform.
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the [1-13]acetate Recovery Factor to correct tracer-derived dietary fat oxidation is lower in overweight insulin-resistant subjects
e-SPEN the European e-Journal of Clinical Nutrition and Metabolism, 2010Co-Authors: Edwina Antoun, Audrey Bergouignan, Dale A. Schoeller, Stéphane Blanc, Iman Momken, Clément Villars, Carine Platat, Chantal SimonAbstract:Background&aims: An acetate Recovery Factor (ARF) is utilized to correct tracer-derived fat oxidation when 13C is used. We showed that when 13C labelled fatty acid are given orally, dietary fat oxidation can be accurately corrected by using an averaged dietary ARF (dARF) derived from 56 lean healthy subjects, instead of individual dARF. The extent to which this Factor is valid in overweight insulin resistant subjects is unknown. Methods: [1-13C]dARF and [1-13C]fatty acid recoveries were assessed before and after physical activity/ inactivity interventions in overweight insulin-resistant (n ¼ 11) and lean subjects (n ¼ 70) in five studies herein compiled. Results: Overweight dARF was lower compared to lean subjects (45.3 1.5% vs. 50.6 0.6%; P ¼ 0.002). Physical activity intervention did not impact dARF. dARF correlated negatively with %body fat (r2 ¼ 0.10; P ¼ 0.005) and fasting insulin to glucose ratio (r2 ¼ 0.08; P ¼ 0.02). Applying the lean average [1-13C] dARF induced an 11.5% (P ¼ 0.006) average error in fatty acid oxidation rate. Conclusions: Overweight insulin resistant subjects have lower dARF than lean individuals. An average dARF derived from lean subjects cannot be applied in overweight subjects to calculate dietary fat oxidation. We recommend that individual dARF are measured in subjects with metabolic disorders
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The acetate Recovery Factor to correct tracer-derived dietary fat oxidation in humans
American Journal of Physiology-Endocrinology and Metabolism, 2008Co-Authors: Audrey Bergouignan, Dale A. Schoeller, Susanne B. Votruba, Chantal Simon, Stéphane BlancAbstract:When using 13C tracer to measure plasma fat oxidation, an acetate Recovery Factor should be determined in every subject to correct for label sequestration. Less is known regarding the acetate recov...
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The acetate Recovery Factor to correct tracer-derived dietary fat oxidation in humans.
AJP - Endocrinology and Metabolism, 2008Co-Authors: Audrey Bergouignan, Dale A. Schoeller, Susanne B. Votruba, Chantal Simon, Stéphane BlancAbstract:When using (13)C tracer to measure plasma fat oxidation, an acetate Recovery Factor should be determined in every subject to correct for label sequestration. Less is known regarding the acetate Recovery Factor for dietary fatty acid oxidation. We compiled data from six studies to investigate the determinants of the dietary acetate Recovery Factor (dARF) at rest and after physical activity interventions and compared the effects of different methods of dARF calculation on both the fat oxidation and its variability. In healthy lean subjects, dARF was 50.6 +/- 5.4% dose (n = 56) with an interindividual coefficient of variation of 10.6% at rest and 9.2% after physical activity modifications. The physical activity interventions did not impact dARF, and the intraindividual coefficient of variation was 4.6%. No major anthropological or physiological determinants were detected except for resting metabolic rate, which explains 7.4% of the dARF variability. Applying an individual or an average group dARF did not affect the mean and the variability of the derived dietary lipid oxidation at rest or after physical activity interventions. Using a mean dARF for a group leads to over- or underestimation of fat oxidation of less than 10% in individual subjects. Moreover, the use of a group or individual correction did not affect the significant relationship found between fasting respiratory exchange ratio and dietary fat oxidation. These data indicate that an average dARF can be applied for longitudinal and cross-sectional studies investigating dietary lipid metabolism.
Audrey Bergouignan - One of the best experts on this subject based on the ideXlab platform.
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the [1-13]acetate Recovery Factor to correct tracer-derived dietary fat oxidation is lower in overweight insulin-resistant subjects
e-SPEN the European e-Journal of Clinical Nutrition and Metabolism, 2010Co-Authors: Edwina Antoun, Audrey Bergouignan, Dale A. Schoeller, Stéphane Blanc, Iman Momken, Clément Villars, Carine Platat, Chantal SimonAbstract:Background&aims: An acetate Recovery Factor (ARF) is utilized to correct tracer-derived fat oxidation when 13C is used. We showed that when 13C labelled fatty acid are given orally, dietary fat oxidation can be accurately corrected by using an averaged dietary ARF (dARF) derived from 56 lean healthy subjects, instead of individual dARF. The extent to which this Factor is valid in overweight insulin resistant subjects is unknown. Methods: [1-13C]dARF and [1-13C]fatty acid recoveries were assessed before and after physical activity/ inactivity interventions in overweight insulin-resistant (n ¼ 11) and lean subjects (n ¼ 70) in five studies herein compiled. Results: Overweight dARF was lower compared to lean subjects (45.3 1.5% vs. 50.6 0.6%; P ¼ 0.002). Physical activity intervention did not impact dARF. dARF correlated negatively with %body fat (r2 ¼ 0.10; P ¼ 0.005) and fasting insulin to glucose ratio (r2 ¼ 0.08; P ¼ 0.02). Applying the lean average [1-13C] dARF induced an 11.5% (P ¼ 0.006) average error in fatty acid oxidation rate. Conclusions: Overweight insulin resistant subjects have lower dARF than lean individuals. An average dARF derived from lean subjects cannot be applied in overweight subjects to calculate dietary fat oxidation. We recommend that individual dARF are measured in subjects with metabolic disorders
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The acetate Recovery Factor to correct tracer-derived dietary fat oxidation in humans
American Journal of Physiology-Endocrinology and Metabolism, 2008Co-Authors: Audrey Bergouignan, Dale A. Schoeller, Susanne B. Votruba, Chantal Simon, Stéphane BlancAbstract:When using 13C tracer to measure plasma fat oxidation, an acetate Recovery Factor should be determined in every subject to correct for label sequestration. Less is known regarding the acetate recov...
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The acetate Recovery Factor to correct tracer-derived dietary fat oxidation in humans.
AJP - Endocrinology and Metabolism, 2008Co-Authors: Audrey Bergouignan, Dale A. Schoeller, Susanne B. Votruba, Chantal Simon, Stéphane BlancAbstract:When using (13)C tracer to measure plasma fat oxidation, an acetate Recovery Factor should be determined in every subject to correct for label sequestration. Less is known regarding the acetate Recovery Factor for dietary fatty acid oxidation. We compiled data from six studies to investigate the determinants of the dietary acetate Recovery Factor (dARF) at rest and after physical activity interventions and compared the effects of different methods of dARF calculation on both the fat oxidation and its variability. In healthy lean subjects, dARF was 50.6 +/- 5.4% dose (n = 56) with an interindividual coefficient of variation of 10.6% at rest and 9.2% after physical activity modifications. The physical activity interventions did not impact dARF, and the intraindividual coefficient of variation was 4.6%. No major anthropological or physiological determinants were detected except for resting metabolic rate, which explains 7.4% of the dARF variability. Applying an individual or an average group dARF did not affect the mean and the variability of the derived dietary lipid oxidation at rest or after physical activity interventions. Using a mean dARF for a group leads to over- or underestimation of fat oxidation of less than 10% in individual subjects. Moreover, the use of a group or individual correction did not affect the significant relationship found between fasting respiratory exchange ratio and dietary fat oxidation. These data indicate that an average dARF can be applied for longitudinal and cross-sectional studies investigating dietary lipid metabolism.
Chantal Simon - One of the best experts on this subject based on the ideXlab platform.
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the [1-13]acetate Recovery Factor to correct tracer-derived dietary fat oxidation is lower in overweight insulin-resistant subjects
e-SPEN the European e-Journal of Clinical Nutrition and Metabolism, 2010Co-Authors: Edwina Antoun, Audrey Bergouignan, Dale A. Schoeller, Stéphane Blanc, Iman Momken, Clément Villars, Carine Platat, Chantal SimonAbstract:Background&aims: An acetate Recovery Factor (ARF) is utilized to correct tracer-derived fat oxidation when 13C is used. We showed that when 13C labelled fatty acid are given orally, dietary fat oxidation can be accurately corrected by using an averaged dietary ARF (dARF) derived from 56 lean healthy subjects, instead of individual dARF. The extent to which this Factor is valid in overweight insulin resistant subjects is unknown. Methods: [1-13C]dARF and [1-13C]fatty acid recoveries were assessed before and after physical activity/ inactivity interventions in overweight insulin-resistant (n ¼ 11) and lean subjects (n ¼ 70) in five studies herein compiled. Results: Overweight dARF was lower compared to lean subjects (45.3 1.5% vs. 50.6 0.6%; P ¼ 0.002). Physical activity intervention did not impact dARF. dARF correlated negatively with %body fat (r2 ¼ 0.10; P ¼ 0.005) and fasting insulin to glucose ratio (r2 ¼ 0.08; P ¼ 0.02). Applying the lean average [1-13C] dARF induced an 11.5% (P ¼ 0.006) average error in fatty acid oxidation rate. Conclusions: Overweight insulin resistant subjects have lower dARF than lean individuals. An average dARF derived from lean subjects cannot be applied in overweight subjects to calculate dietary fat oxidation. We recommend that individual dARF are measured in subjects with metabolic disorders
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The acetate Recovery Factor to correct tracer-derived dietary fat oxidation in humans
American Journal of Physiology-Endocrinology and Metabolism, 2008Co-Authors: Audrey Bergouignan, Dale A. Schoeller, Susanne B. Votruba, Chantal Simon, Stéphane BlancAbstract:When using 13C tracer to measure plasma fat oxidation, an acetate Recovery Factor should be determined in every subject to correct for label sequestration. Less is known regarding the acetate recov...
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The acetate Recovery Factor to correct tracer-derived dietary fat oxidation in humans.
AJP - Endocrinology and Metabolism, 2008Co-Authors: Audrey Bergouignan, Dale A. Schoeller, Susanne B. Votruba, Chantal Simon, Stéphane BlancAbstract:When using (13)C tracer to measure plasma fat oxidation, an acetate Recovery Factor should be determined in every subject to correct for label sequestration. Less is known regarding the acetate Recovery Factor for dietary fatty acid oxidation. We compiled data from six studies to investigate the determinants of the dietary acetate Recovery Factor (dARF) at rest and after physical activity interventions and compared the effects of different methods of dARF calculation on both the fat oxidation and its variability. In healthy lean subjects, dARF was 50.6 +/- 5.4% dose (n = 56) with an interindividual coefficient of variation of 10.6% at rest and 9.2% after physical activity modifications. The physical activity interventions did not impact dARF, and the intraindividual coefficient of variation was 4.6%. No major anthropological or physiological determinants were detected except for resting metabolic rate, which explains 7.4% of the dARF variability. Applying an individual or an average group dARF did not affect the mean and the variability of the derived dietary lipid oxidation at rest or after physical activity interventions. Using a mean dARF for a group leads to over- or underestimation of fat oxidation of less than 10% in individual subjects. Moreover, the use of a group or individual correction did not affect the significant relationship found between fasting respiratory exchange ratio and dietary fat oxidation. These data indicate that an average dARF can be applied for longitudinal and cross-sectional studies investigating dietary lipid metabolism.
Dale A. Schoeller - One of the best experts on this subject based on the ideXlab platform.
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the [1-13]acetate Recovery Factor to correct tracer-derived dietary fat oxidation is lower in overweight insulin-resistant subjects
e-SPEN the European e-Journal of Clinical Nutrition and Metabolism, 2010Co-Authors: Edwina Antoun, Audrey Bergouignan, Dale A. Schoeller, Stéphane Blanc, Iman Momken, Clément Villars, Carine Platat, Chantal SimonAbstract:Background&aims: An acetate Recovery Factor (ARF) is utilized to correct tracer-derived fat oxidation when 13C is used. We showed that when 13C labelled fatty acid are given orally, dietary fat oxidation can be accurately corrected by using an averaged dietary ARF (dARF) derived from 56 lean healthy subjects, instead of individual dARF. The extent to which this Factor is valid in overweight insulin resistant subjects is unknown. Methods: [1-13C]dARF and [1-13C]fatty acid recoveries were assessed before and after physical activity/ inactivity interventions in overweight insulin-resistant (n ¼ 11) and lean subjects (n ¼ 70) in five studies herein compiled. Results: Overweight dARF was lower compared to lean subjects (45.3 1.5% vs. 50.6 0.6%; P ¼ 0.002). Physical activity intervention did not impact dARF. dARF correlated negatively with %body fat (r2 ¼ 0.10; P ¼ 0.005) and fasting insulin to glucose ratio (r2 ¼ 0.08; P ¼ 0.02). Applying the lean average [1-13C] dARF induced an 11.5% (P ¼ 0.006) average error in fatty acid oxidation rate. Conclusions: Overweight insulin resistant subjects have lower dARF than lean individuals. An average dARF derived from lean subjects cannot be applied in overweight subjects to calculate dietary fat oxidation. We recommend that individual dARF are measured in subjects with metabolic disorders
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The acetate Recovery Factor to correct tracer-derived dietary fat oxidation in humans
American Journal of Physiology-Endocrinology and Metabolism, 2008Co-Authors: Audrey Bergouignan, Dale A. Schoeller, Susanne B. Votruba, Chantal Simon, Stéphane BlancAbstract:When using 13C tracer to measure plasma fat oxidation, an acetate Recovery Factor should be determined in every subject to correct for label sequestration. Less is known regarding the acetate recov...
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The acetate Recovery Factor to correct tracer-derived dietary fat oxidation in humans.
AJP - Endocrinology and Metabolism, 2008Co-Authors: Audrey Bergouignan, Dale A. Schoeller, Susanne B. Votruba, Chantal Simon, Stéphane BlancAbstract:When using (13)C tracer to measure plasma fat oxidation, an acetate Recovery Factor should be determined in every subject to correct for label sequestration. Less is known regarding the acetate Recovery Factor for dietary fatty acid oxidation. We compiled data from six studies to investigate the determinants of the dietary acetate Recovery Factor (dARF) at rest and after physical activity interventions and compared the effects of different methods of dARF calculation on both the fat oxidation and its variability. In healthy lean subjects, dARF was 50.6 +/- 5.4% dose (n = 56) with an interindividual coefficient of variation of 10.6% at rest and 9.2% after physical activity modifications. The physical activity interventions did not impact dARF, and the intraindividual coefficient of variation was 4.6%. No major anthropological or physiological determinants were detected except for resting metabolic rate, which explains 7.4% of the dARF variability. Applying an individual or an average group dARF did not affect the mean and the variability of the derived dietary lipid oxidation at rest or after physical activity interventions. Using a mean dARF for a group leads to over- or underestimation of fat oxidation of less than 10% in individual subjects. Moreover, the use of a group or individual correction did not affect the significant relationship found between fasting respiratory exchange ratio and dietary fat oxidation. These data indicate that an average dARF can be applied for longitudinal and cross-sectional studies investigating dietary lipid metabolism.
Susanne B. Votruba - One of the best experts on this subject based on the ideXlab platform.
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The acetate Recovery Factor to correct tracer-derived dietary fat oxidation in humans
American Journal of Physiology-Endocrinology and Metabolism, 2008Co-Authors: Audrey Bergouignan, Dale A. Schoeller, Susanne B. Votruba, Chantal Simon, Stéphane BlancAbstract:When using 13C tracer to measure plasma fat oxidation, an acetate Recovery Factor should be determined in every subject to correct for label sequestration. Less is known regarding the acetate recov...
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The acetate Recovery Factor to correct tracer-derived dietary fat oxidation in humans.
AJP - Endocrinology and Metabolism, 2008Co-Authors: Audrey Bergouignan, Dale A. Schoeller, Susanne B. Votruba, Chantal Simon, Stéphane BlancAbstract:When using (13)C tracer to measure plasma fat oxidation, an acetate Recovery Factor should be determined in every subject to correct for label sequestration. Less is known regarding the acetate Recovery Factor for dietary fatty acid oxidation. We compiled data from six studies to investigate the determinants of the dietary acetate Recovery Factor (dARF) at rest and after physical activity interventions and compared the effects of different methods of dARF calculation on both the fat oxidation and its variability. In healthy lean subjects, dARF was 50.6 +/- 5.4% dose (n = 56) with an interindividual coefficient of variation of 10.6% at rest and 9.2% after physical activity modifications. The physical activity interventions did not impact dARF, and the intraindividual coefficient of variation was 4.6%. No major anthropological or physiological determinants were detected except for resting metabolic rate, which explains 7.4% of the dARF variability. Applying an individual or an average group dARF did not affect the mean and the variability of the derived dietary lipid oxidation at rest or after physical activity interventions. Using a mean dARF for a group leads to over- or underestimation of fat oxidation of less than 10% in individual subjects. Moreover, the use of a group or individual correction did not affect the significant relationship found between fasting respiratory exchange ratio and dietary fat oxidation. These data indicate that an average dARF can be applied for longitudinal and cross-sectional studies investigating dietary lipid metabolism.
