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J Y Kim - One of the best experts on this subject based on the ideXlab platform.
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clinical features treatment and outcomes of colon and Rectum Mucosa associated lymphoid tissue malt lymphoma literature reviews published in english between 1993 and 2017
Annals of Oncology, 2019Co-Authors: J Y KimAbstract:Abstract Background Colorectal Mucosa associated lymphoid tissue (MALT) lymphoma (CML) is rare and comprises only 2.5% of the MALT lymphomas. Its etiology and treatment are not well established. The aim of this systematic literature review is trying to characterize CML and analyzing treatment failure cases treated with various therapeutic strategies. Methods We reviewed cases reports on colorectal lymphoma from 1993 to 2017. A PubMed search of the English medical literature was conducted using the search words "colon," "Rectum," and "Maltoma" or “MALT lymphoma” as filters. Through the review, 65 case reports were found, of which 15 case reports were excluded, due to literature written in languages other than English, poorly documented cases and combined colonic disease such as adenocarcinoma or inflammatory bowel disease. After all, 67 patients reported in 50 studies were included from PubMed search. And we added 6 patients treated for CML in our multicenter institutes. Risk factor analysis was done for treatment failure, defined as remission failure and recurrence. Results Of 73 patients diagnosed as CML, tumors were located in Rectum in 54 patients (74.0%), 10 patients (13.6%) in right colon, 3 patients (4.1%) in the transverse colon and 6 patients (8.2%) in the sigmoid colon. The patients were achieved complete response (CR) with surgery (18/19cases), local resection (18/19 cases), chemotherapy (12/13 cases), radiation therapy (4/5cases), or antibiotics therapy including Helicobacter pylori (H. pylori) eradication (12/15 cases) in the first-line treatment. Eight cases (10.9%) needed second-line treatment for remission failure, CR was achieved in 5. The tumor recurrence occurred in 5 patients in remission patients (6.8%). The multivariable analysis showed that male, multiple tumor, first-line treatment failure was significantly related with treatment failure (p = 0.03, p = 0.05, p = 0.03, respectively). Conclusions Complete regression of primary CML was achieved using various therapeutic strategies. The first-line treatment failure, multiple tumors were associated with treatment failure, although the numbers of failure cases are too small to draw definitive conclusions. Legal entity responsible for the study The author. Funding Has not received any funding. Disclosure The author has declared no conflicts of interest.
Zabrods`ka O. S. - One of the best experts on this subject based on the ideXlab platform.
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Pathophysiological bases about Hirsсhsprung`S disease (Morbus Hirsсhsprung)
Українська медична стоматологічна академія, 2018Co-Authors: Процак, Тетяна Василівна, Забродська, Ольга Сергіївна, Процак, Татьяна Васильевна, Забродская, Ольга Сергеевна, Protsak T., Zabrods`ka O. S.Abstract:На сьогоднішній день захворювання Гіршспрунга (ЗГ) у новонароджених та грудних дітей – це важка та складна проблема у розвитку сучасної дитячої хірургії. Це пов’язано із широким спектром клінічних проявів, складності діагностики та вибору методики лікування. Зауважуємо, що неадекватна тактика хірургічного втручання в ранньому віці є основною причиною смертності пацієнта. В статті подано інформацію про перші згадки захворювання Гіршспрунга (ЗГ). Представлено декілька яскравих випадків лікування аномалії, а також класифікацію хвороби, котрою користуються лікарі протягом багатьох років. Автори докладно пояснюють сутність проблеми ЗГ, складність в діагностиці та лікуванні, а також причини можливого ускладнення; На сегодняшний день заболевание Гиршспрунга (ЗГ) у новорожденных и грудных детей – это тяжелая и сложная проблема в развитии современной детской хирургии. Это связано с широким спектром клинических проявлений, сложности диагностики и выбора методики лечения. Замечаем, что неадекватная тактика хирургического вмешательства в раннем возрасте является основной причиной смертности пациента. В статье представлена информация о первых упоминаниях o ЗГ. Представлено несколько ярких случаев лечения аномалии, а также классификацию болезни, которой пользуются врачи на протяжении многих лет. Авторы подробно объясняют сущность проблемы ЗГ, сложность в диагностике и лечении, а также возможного осложнения; Today, Hirschsprung`s disease (HD) in newborns and infants is a difficult and complicate problem for development of modern pediatric surgery. This is due to a wide range of clinical symptoms, the complexity of diagnosis and choice of treatment methods. Its need to replaced, that inadequate tactics of surgical intervention at an early age is the main cause of death of the patient. Aganglionic megacolon or Hirschsprung’s disease is an anomaly of the colon development, which is represented by a violation of the innervation of a specific area of the body. The anomaly is particularly characteristic of the sigmoid colon and Rectum and is more common in boys than in girls. Characteristic symptoms of agangliosis are persistent constipation, which are accompanied by acute intestinal obstruction. There are early and late symptoms of disease, the first of which is the delay or failure of defecation and flatulence, which arise from the moment of birth. The symptoms are aggravated by the introduction of solid food. Physical methods of research make it possible to successfully differentiate the flaw among others. The late symptoms are anemia, fecal intoxication and asymmetry of the chest and abdomen. The Scientists point out the existence of several anatomical forms of the disease – rectal (25%), rectosigmoidal in proportion, which accounts for 70%, segmental (1.5%), subtotal (3%) and total, accounting for 0.5% of cases. Also, there are known phases of HD – compensatory, subcompensatory and decompensatory stages. The main methods of HD investigation are irrigoscopy, anorectal manometry, and biopsy of the Rectum Mucosa for histochemical and immunological examination. In particular, when conducting a complete X-ray, it is possible to detect pneumotization and a sharp increase in intestinal loops, especially in the region of the sigmoid colon. It is proved, that with complication of HD enterocolitis, there is a toxic organ distribution. A characteristical symptoms of agangliosis in irrigoscopy is the narrowing of the distal intestinal tract, as well as the appearance of acute enterocolitis. The sense of the aganglionical megacolon is in the absence or reduction in the muscle fiber of the Auerbach plexus and the sympathetic nerve component of the Meisner plexus. Therefore, the large intestine is constantly in tone, that is spasm, which is not desirable for the digestive system. So, it explains the problem of the complexity of passing feces by a natural way. This disease is observed in different age groups, ranging from newborns to elderly people. Despite on it such number, the disease is manifested by several characteristical symptoms, that helps to differentiate the anomaly. Thus, the task of pediatricians and neonatologists is to monitor the fetus of a pregnant woman and identify pathology in the early stages of development, and for surgeons, its the creation of conditions for the failure of possible complications. The problem requires a further detailed investigation, since this anomaly can take place both in mild form and in severe, even leading to mortality. If the etiology of HD has already been studied, but there is no specific solution to this situation; it remains only to use operational methods that partly help the patient. The article provides information about first mentions of the Hirschsprung`s disease (HD). There are presented several bright cases of abnormalities treatment, a classification of the disease, that doctors have been using for many years. The authors detaily explain the origin of the HD problem, the complication of diagnosis and treatment
Процак, Тетяна Василівна - One of the best experts on this subject based on the ideXlab platform.
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Pathophysiological bases about Hirsсhsprung`S disease (Morbus Hirsсhsprung)
Українська медична стоматологічна академія, 2018Co-Authors: Процак, Тетяна Василівна, Забродська, Ольга Сергіївна, Процак, Татьяна Васильевна, Забродская, Ольга Сергеевна, Protsak T., Zabrods`ka O. S.Abstract:На сьогоднішній день захворювання Гіршспрунга (ЗГ) у новонароджених та грудних дітей – це важка та складна проблема у розвитку сучасної дитячої хірургії. Це пов’язано із широким спектром клінічних проявів, складності діагностики та вибору методики лікування. Зауважуємо, що неадекватна тактика хірургічного втручання в ранньому віці є основною причиною смертності пацієнта. В статті подано інформацію про перші згадки захворювання Гіршспрунга (ЗГ). Представлено декілька яскравих випадків лікування аномалії, а також класифікацію хвороби, котрою користуються лікарі протягом багатьох років. Автори докладно пояснюють сутність проблеми ЗГ, складність в діагностиці та лікуванні, а також причини можливого ускладнення; На сегодняшний день заболевание Гиршспрунга (ЗГ) у новорожденных и грудных детей – это тяжелая и сложная проблема в развитии современной детской хирургии. Это связано с широким спектром клинических проявлений, сложности диагностики и выбора методики лечения. Замечаем, что неадекватная тактика хирургического вмешательства в раннем возрасте является основной причиной смертности пациента. В статье представлена информация о первых упоминаниях o ЗГ. Представлено несколько ярких случаев лечения аномалии, а также классификацию болезни, которой пользуются врачи на протяжении многих лет. Авторы подробно объясняют сущность проблемы ЗГ, сложность в диагностике и лечении, а также возможного осложнения; Today, Hirschsprung`s disease (HD) in newborns and infants is a difficult and complicate problem for development of modern pediatric surgery. This is due to a wide range of clinical symptoms, the complexity of diagnosis and choice of treatment methods. Its need to replaced, that inadequate tactics of surgical intervention at an early age is the main cause of death of the patient. Aganglionic megacolon or Hirschsprung’s disease is an anomaly of the colon development, which is represented by a violation of the innervation of a specific area of the body. The anomaly is particularly characteristic of the sigmoid colon and Rectum and is more common in boys than in girls. Characteristic symptoms of agangliosis are persistent constipation, which are accompanied by acute intestinal obstruction. There are early and late symptoms of disease, the first of which is the delay or failure of defecation and flatulence, which arise from the moment of birth. The symptoms are aggravated by the introduction of solid food. Physical methods of research make it possible to successfully differentiate the flaw among others. The late symptoms are anemia, fecal intoxication and asymmetry of the chest and abdomen. The Scientists point out the existence of several anatomical forms of the disease – rectal (25%), rectosigmoidal in proportion, which accounts for 70%, segmental (1.5%), subtotal (3%) and total, accounting for 0.5% of cases. Also, there are known phases of HD – compensatory, subcompensatory and decompensatory stages. The main methods of HD investigation are irrigoscopy, anorectal manometry, and biopsy of the Rectum Mucosa for histochemical and immunological examination. In particular, when conducting a complete X-ray, it is possible to detect pneumotization and a sharp increase in intestinal loops, especially in the region of the sigmoid colon. It is proved, that with complication of HD enterocolitis, there is a toxic organ distribution. A characteristical symptoms of agangliosis in irrigoscopy is the narrowing of the distal intestinal tract, as well as the appearance of acute enterocolitis. The sense of the aganglionical megacolon is in the absence or reduction in the muscle fiber of the Auerbach plexus and the sympathetic nerve component of the Meisner plexus. Therefore, the large intestine is constantly in tone, that is spasm, which is not desirable for the digestive system. So, it explains the problem of the complexity of passing feces by a natural way. This disease is observed in different age groups, ranging from newborns to elderly people. Despite on it such number, the disease is manifested by several characteristical symptoms, that helps to differentiate the anomaly. Thus, the task of pediatricians and neonatologists is to monitor the fetus of a pregnant woman and identify pathology in the early stages of development, and for surgeons, its the creation of conditions for the failure of possible complications. The problem requires a further detailed investigation, since this anomaly can take place both in mild form and in severe, even leading to mortality. If the etiology of HD has already been studied, but there is no specific solution to this situation; it remains only to use operational methods that partly help the patient. The article provides information about first mentions of the Hirschsprung`s disease (HD). There are presented several bright cases of abnormalities treatment, a classification of the disease, that doctors have been using for many years. The authors detaily explain the origin of the HD problem, the complication of diagnosis and treatment
Marlowe J Schneidkraut - One of the best experts on this subject based on the ideXlab platform.
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tissue distribution and elimination of isavuconazole following single and repeat oral dose administration of isavuconazonium sulfate to rats
Antimicrobial Agents and Chemotherapy, 2017Co-Authors: Annehortense Schmitthoffmann, Kota Kato, Robert Townsend, Michael J Potchoiba, William W Hope, David R Andes, Jochen Spickermann, Marlowe J SchneidkrautAbstract:Quantitative whole-body autoradiography was used to assess the distribution and tissue penetration of isavuconazole in rats following single and repeated oral-dose administration of radiolabeled isavuconazonium sulfate, the prodrug of isavuconazole. Following a single-dose administration of radiolabeled isavuconazonium sulfate (labeled on the active moiety), radioactivity was detectable within 1 h postdose in 56 of 65 tissue/fluid specimens. The highest maximum concentrations (Cmax) were observed in bile and liver (66.6 and 24.7 μg eq/g, respectively). The lowest Cmax values were in bone and eye lens (0.070 and 0.077 μg eq/g, respectively). By 144 h postdose, radioactivity was undetectable in all tissues/fluids except liver (undetectable at 336 h) and adrenal gland tissues (undetectable at 672 h). Following daily administration for up to 21 days, 1-h-postdose Cmax values were the highest on or before day 14 in all except seven tissues/fluids, of which only Rectum Mucosa and small intestine Mucosa had Cmax values >25% higher than all other 1-h-postdose values. For 24-h-postdose Cmax values, only large intestine, large intestine Mucosa, and urine had the highest Cmax values at day 21. The penetration of single oral doses of unlabeled isavuconazole (25 mg/kg of body weight isavuconazonium sulfate) and voriconazole (50 mg/kg) into rat brain (assessed using liquid chromatography-tandem mass spectrometry) was also compared. Brain concentration/plasma concentration ratios reached approximately 1.8:1 and 2:1, respectively. These data suggest that isavuconazole penetrates most tissues rapidly, reaches a steady state in most or all tissues/fluids within 14 days, does not accumulate in tissues/fluids over time, and achieves potentially efficacious concentrations in the brain.
Protsak T. - One of the best experts on this subject based on the ideXlab platform.
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Pathophysiological bases about Hirsсhsprung`S disease (Morbus Hirsсhsprung)
Українська медична стоматологічна академія, 2018Co-Authors: Процак, Тетяна Василівна, Забродська, Ольга Сергіївна, Процак, Татьяна Васильевна, Забродская, Ольга Сергеевна, Protsak T., Zabrods`ka O. S.Abstract:На сьогоднішній день захворювання Гіршспрунга (ЗГ) у новонароджених та грудних дітей – це важка та складна проблема у розвитку сучасної дитячої хірургії. Це пов’язано із широким спектром клінічних проявів, складності діагностики та вибору методики лікування. Зауважуємо, що неадекватна тактика хірургічного втручання в ранньому віці є основною причиною смертності пацієнта. В статті подано інформацію про перші згадки захворювання Гіршспрунга (ЗГ). Представлено декілька яскравих випадків лікування аномалії, а також класифікацію хвороби, котрою користуються лікарі протягом багатьох років. Автори докладно пояснюють сутність проблеми ЗГ, складність в діагностиці та лікуванні, а також причини можливого ускладнення; На сегодняшний день заболевание Гиршспрунга (ЗГ) у новорожденных и грудных детей – это тяжелая и сложная проблема в развитии современной детской хирургии. Это связано с широким спектром клинических проявлений, сложности диагностики и выбора методики лечения. Замечаем, что неадекватная тактика хирургического вмешательства в раннем возрасте является основной причиной смертности пациента. В статье представлена информация о первых упоминаниях o ЗГ. Представлено несколько ярких случаев лечения аномалии, а также классификацию болезни, которой пользуются врачи на протяжении многих лет. Авторы подробно объясняют сущность проблемы ЗГ, сложность в диагностике и лечении, а также возможного осложнения; Today, Hirschsprung`s disease (HD) in newborns and infants is a difficult and complicate problem for development of modern pediatric surgery. This is due to a wide range of clinical symptoms, the complexity of diagnosis and choice of treatment methods. Its need to replaced, that inadequate tactics of surgical intervention at an early age is the main cause of death of the patient. Aganglionic megacolon or Hirschsprung’s disease is an anomaly of the colon development, which is represented by a violation of the innervation of a specific area of the body. The anomaly is particularly characteristic of the sigmoid colon and Rectum and is more common in boys than in girls. Characteristic symptoms of agangliosis are persistent constipation, which are accompanied by acute intestinal obstruction. There are early and late symptoms of disease, the first of which is the delay or failure of defecation and flatulence, which arise from the moment of birth. The symptoms are aggravated by the introduction of solid food. Physical methods of research make it possible to successfully differentiate the flaw among others. The late symptoms are anemia, fecal intoxication and asymmetry of the chest and abdomen. The Scientists point out the existence of several anatomical forms of the disease – rectal (25%), rectosigmoidal in proportion, which accounts for 70%, segmental (1.5%), subtotal (3%) and total, accounting for 0.5% of cases. Also, there are known phases of HD – compensatory, subcompensatory and decompensatory stages. The main methods of HD investigation are irrigoscopy, anorectal manometry, and biopsy of the Rectum Mucosa for histochemical and immunological examination. In particular, when conducting a complete X-ray, it is possible to detect pneumotization and a sharp increase in intestinal loops, especially in the region of the sigmoid colon. It is proved, that with complication of HD enterocolitis, there is a toxic organ distribution. A characteristical symptoms of agangliosis in irrigoscopy is the narrowing of the distal intestinal tract, as well as the appearance of acute enterocolitis. The sense of the aganglionical megacolon is in the absence or reduction in the muscle fiber of the Auerbach plexus and the sympathetic nerve component of the Meisner plexus. Therefore, the large intestine is constantly in tone, that is spasm, which is not desirable for the digestive system. So, it explains the problem of the complexity of passing feces by a natural way. This disease is observed in different age groups, ranging from newborns to elderly people. Despite on it such number, the disease is manifested by several characteristical symptoms, that helps to differentiate the anomaly. Thus, the task of pediatricians and neonatologists is to monitor the fetus of a pregnant woman and identify pathology in the early stages of development, and for surgeons, its the creation of conditions for the failure of possible complications. The problem requires a further detailed investigation, since this anomaly can take place both in mild form and in severe, even leading to mortality. If the etiology of HD has already been studied, but there is no specific solution to this situation; it remains only to use operational methods that partly help the patient. The article provides information about first mentions of the Hirschsprung`s disease (HD). There are presented several bright cases of abnormalities treatment, a classification of the disease, that doctors have been using for many years. The authors detaily explain the origin of the HD problem, the complication of diagnosis and treatment