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Ite Lee - One of the best experts on this subject based on the ideXlab platform.
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combined extractives of Red Yeast Rice bitter gourd chlorella soy protein and licoRice improve total cholesterol low density lipoprotein cholesterol and triglyceride in subjects with metabolic syndrome
Nutrition Research, 2012Co-Authors: Ite Lee, Wenjane Lee, Chingmin Tsai, Hsientung Yen, Wayne Hh SheuAbstract:Abstract In this study, we aimed to examine the effects of a plant-extractive compound on lipid profiles in subjects with metabolic syndrome. We hypothesized that extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice have synergistic benefits on cholesterol and metabolic syndrome. In this double-blinded study, adult subjects with metabolic syndrome were randomized to receive a plant-extractive compound or a placebo treatment for 12 weeks. Both total cholesterol (5.4 ± 0.8 to 4.4 ± 0.6 mmol/L, P P P P P = .039). There was also a significantly greater Reduction in the proportion of subjects with hypertensive criteria in the plant-extractive group than in the placebo group ( P = .040). In conclusion, the plant extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice were effective in Reducing total and low-density lipoprotein cholesterol. The plant extractives also showed potential for Reducing triglyceride and normalizing blood pressure.
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combined extractives of Red Yeast Rice bitter gourd chlorella soy protein and licoRice improve total cholesterol low density lipoprotein cholesterol and triglyceride in subjects with metabolic syndrome
Nutrition Research, 2012Co-Authors: Ite Lee, Wenjane Lee, Chingmin Tsai, Hsientung Yen, Wayne Hh SheuAbstract:In this study, we aimed to examine the effects of a plant-extractive compound on lipid profiles in subjects with metabolic syndrome. We hypothesized that extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice have synergistic benefits on cholesterol and metabolic syndrome. In this double-blinded study, adult subjects with metabolic syndrome were randomized to receive a plant-extractive compound or a placebo treatment for 12 weeks. Both total cholesterol (5.4 ± 0.8 to 4.4 ± 0.6 mmol/L, P < .001) and low-density lipoprotein cholesterol (3.4 ± 0.7 to 2.7 ± 0.5 mmol/L, P < .001) were significantly Reduced after treatment with the plant extractives, and the magnitudes of Reduction were significantly greater than in the placebo group (-1.0 ± 0.6 vs 0.0 ± 0.6mmol/L, P < .001; -0.7 ± 0.6 vs 0.0 ± 0.6 mmol/L, P < .001). The Reduction in the fasting triglycerides level was significantly greater in the plant-extractive group than in the placebo group (-0.5 ± 0.8 vs -0.2 ± 1.0 mmol/L, P = .039). There was also a significantly greater Reduction in the proportion of subjects with hypertensive criteria in the plant-extractive group than in the placebo group (P = .040). In conclusion, the plant extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice were effective in Reducing total and low-density lipoprotein cholesterol. The plant extractives also showed potential for Reducing triglyceride and normalizing blood pressure.
Wayne Hh Sheu - One of the best experts on this subject based on the ideXlab platform.
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combined extractives of Red Yeast Rice bitter gourd chlorella soy protein and licoRice improve total cholesterol low density lipoprotein cholesterol and triglyceride in subjects with metabolic syndrome
Nutrition Research, 2012Co-Authors: Ite Lee, Wenjane Lee, Chingmin Tsai, Hsientung Yen, Wayne Hh SheuAbstract:Abstract In this study, we aimed to examine the effects of a plant-extractive compound on lipid profiles in subjects with metabolic syndrome. We hypothesized that extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice have synergistic benefits on cholesterol and metabolic syndrome. In this double-blinded study, adult subjects with metabolic syndrome were randomized to receive a plant-extractive compound or a placebo treatment for 12 weeks. Both total cholesterol (5.4 ± 0.8 to 4.4 ± 0.6 mmol/L, P P P P P = .039). There was also a significantly greater Reduction in the proportion of subjects with hypertensive criteria in the plant-extractive group than in the placebo group ( P = .040). In conclusion, the plant extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice were effective in Reducing total and low-density lipoprotein cholesterol. The plant extractives also showed potential for Reducing triglyceride and normalizing blood pressure.
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combined extractives of Red Yeast Rice bitter gourd chlorella soy protein and licoRice improve total cholesterol low density lipoprotein cholesterol and triglyceride in subjects with metabolic syndrome
Nutrition Research, 2012Co-Authors: Ite Lee, Wenjane Lee, Chingmin Tsai, Hsientung Yen, Wayne Hh SheuAbstract:In this study, we aimed to examine the effects of a plant-extractive compound on lipid profiles in subjects with metabolic syndrome. We hypothesized that extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice have synergistic benefits on cholesterol and metabolic syndrome. In this double-blinded study, adult subjects with metabolic syndrome were randomized to receive a plant-extractive compound or a placebo treatment for 12 weeks. Both total cholesterol (5.4 ± 0.8 to 4.4 ± 0.6 mmol/L, P < .001) and low-density lipoprotein cholesterol (3.4 ± 0.7 to 2.7 ± 0.5 mmol/L, P < .001) were significantly Reduced after treatment with the plant extractives, and the magnitudes of Reduction were significantly greater than in the placebo group (-1.0 ± 0.6 vs 0.0 ± 0.6mmol/L, P < .001; -0.7 ± 0.6 vs 0.0 ± 0.6 mmol/L, P < .001). The Reduction in the fasting triglycerides level was significantly greater in the plant-extractive group than in the placebo group (-0.5 ± 0.8 vs -0.2 ± 1.0 mmol/L, P = .039). There was also a significantly greater Reduction in the proportion of subjects with hypertensive criteria in the plant-extractive group than in the placebo group (P = .040). In conclusion, the plant extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice were effective in Reducing total and low-density lipoprotein cholesterol. The plant extractives also showed potential for Reducing triglyceride and normalizing blood pressure.
David J. Becker - One of the best experts on this subject based on the ideXlab platform.
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phytosterols Red Yeast Rice and lifestyle changes instead of statins a randomized double blinded placebo controlled trial
American Heart Journal, 2013Co-Authors: David J. Becker, Benjamin French, Patti B Morris, Erin SilventAbstract:Background Many patients who refuse or cannot tolerate statin drugs choose alternative therapies for lipid lowering. Objectives This study aimed to determine the lipid-lowering effects of phytosterol tablets and lifestyle change (LC) on top of Red Yeast Rice (RYR) therapy in patients with a history of statin refusal or statin-associated myalgias. Design A total of 187 participants (mean low-density lipoprotein cholesterol [LDL-C], 154 mg/dL) took RYR 1800 mg twice daily and were randomized to phytosterol tablets 900 mg twice daily or placebo. Participants were also randomized to a 12-week LC program or usual care (UC). Primary end point was change in LDL-C at 12, 24, and 52 weeks. Secondary end points were effect on other lipoproteins, high-sensitivity C-reactive protein, weight, and development of myalgia. Results Phytosterols did not significantly improve LDL-C at weeks 12 ( P = .54), 24 ( P = .67), or 52 ( P = .76) compaRed with placebo. CompaRed with the UC group, the LC group had greater Reductions in LDL-C at weeks 12 (−51 vs −42 mg/dL, P = .006) and 24 (−48 vs −40 mg/dL, P = .034) and was 2.3 times more likely to achieve an LDL-C P = .004). The LC group lost more weight for 1 year (−2.3 vs −0.3 kg, P P Conclusions The addition of phytosterol tablets to RYR did not result in further lowering of LDL-C levels. Participants in an LC program lost significantly more weight and were more likely to achieve an LDL-C
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the role of Red Yeast Rice for the physician
Current Atherosclerosis Reports, 2011Co-Authors: Ram Y Gordon, David J. BeckerAbstract:Red Yeast Rice is an ancient Chinese dietary staple and medication used by millions of patients as an alternative therapy for hypercholesterolemia. In recent years, the use of Red Yeast Rice has grown exponentially due to increased public interest in complementary and alternative medications and the publication of several randomized, controlled trials demonstrating its efficacy and safety in different populations. The most promising role for Red Yeast Rice is as an alternative lipid-lowering therapy for patients who refuse to take statins because of philosophical reasons or patients who are unable to tolerate statin therapy due to statin-associated myalgias. However, there is limited government oversight of Red Yeast Rice products, wide variability of active ingRedients in available formulations, and the potential of toxic byproducts. Therefore, until Red Yeast Rice products are regulated and standardized, physicians and patients should be cautious in recommending this promising alternative therapy for hyperlipidemia.
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marked variability of monacolin levels in commercial Red Yeast Rice products buyer beware
JAMA Internal Medicine, 2010Co-Authors: Ram Y Gordon, Tod Cooperman, William Obermeyer, David J. BeckerAbstract:BACKGROUND: Red Yeast Rice (RYR) is a widely available dietary supplement used by millions of patients as an alternative therapy for hyperlipidemia. It contains 14 active compounds called monacolins that inhibit hepatic cholesterol synthesis. Although studies have suggested that some formulations of RYR may be effective and safe for lipid lowering, monacolin levels are not standardized among marketed products and are generally not published on labels. We evaluated monacolin levels in 12 commercial RYR formulations and tested for citrinin, a mycotoxin that is nephrotoxic in animals. METHODS: Each formulation of RYR was labeled "600 mg/capsule" of active product. Analyses for monacolins and citrinin were performed between August 2006 and June 2008 using high-performance liquid chromatography with mass spectroscopy-mass spectroscopy detection. Laboratory analyses of RYR products were conducted by ConsumerLab.com, White Plains, New York. RESULTS: There was marked variability in the 12 RYR products in total monacolins (0.31-11.15 mg/capsule), monacolin K (lovastatin) (0.10-10.09 mg/capsule), and monacolin KA (0.00-2.30 mg/capsule). Four products had elevated levels of citrinin. CONCLUSIONS: We found striking variability in monacolin content in 12 proprietary RYR products and the presence of citrinin in one-third of the formulations tested. Although RYR may have potential as an alternative lipid-lowering agent, our findings suggest the need for improved standardization of RYR products and product labeling. Until this occurs, physicians should be cautious in recommending RYR to their patients for the treatment of hyperlipidemia and primary and secondary prevention of cardiovascular disease.
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tolerability of Red Yeast Rice 2 400 mg twice daily versus pravastatin 20 mg twice daily in patients with previous statin intolerance
American Journal of Cardiology, 2010Co-Authors: Steven C Halbert, Ram Y Gordon, Benjamin French, Patti B Morris, Daniel J Rader, Paul D Thompson, John T Farrar, Kathryn H Schmitz, David J. BeckerAbstract:Currently, no consensus has been reached regarding the management of hyperlipidemia in patients who develop statin-associated myalgia (SAM). Many statin-intolerant patients use alternative lipid-lowering therapies, including Red Yeast Rice. The present trial evaluated the tolerability of Red Yeast Rice versus pravastatin in patients unable to tolerate other statins because of myalgia. The study was conducted in a community-based setting in Philadelphia, Pennsylvania. A total of 43 adults with dyslipidemia and a history of statin discontinuation because of myalgia were randomly assigned to Red Yeast Rice 2,400 mg twice daily or pravastatin 20 mg twice daily for 12 weeks. All subjects were concomitantly enrolled in a 12-week therapeutic lifestyle change program. The primary outcomes included the incidence of treatment discontinuation because of myalgia and a daily pain severity score. The secondary outcomes were muscle strength and plasma lipids. The incidence of withdrawal from medication owing to myalgia was 5% (1 of 21) in the Red Yeast Rice group and 9% (2 of 22) in the pravastatin group (p = 0.99). The mean pain severity did not differ significantly between the 2 groups. No difference was found in muscle strength between the 2 groups at week 4 (p = 0.61), week 8 (p = 0.81), or week 12 (p = 0.82). The low-density lipoprotein cholesterol level decreased 30% in the Red Yeast Rice group and 27% in the pravastatin group. In conclusion, Red Yeast Rice was tolerated as well as pravastatin and achieved a comparable Reduction of low-density lipoprotein cholesterol in a population previously intolerant to statins.
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marked variability of monacolin levels in commercial Red Yeast Rice products
2010Co-Authors: Ram Y Gordon, Tod Cooperman, William Obermeyer, David J. BeckerAbstract:Background: Red Yeast Rice (RYR) is a widely available dietary supplement used by millions of patients as an alternative therapy for hyperlipidemia. It contains 14 active compounds called monacolins that inhibit hepatic cholesterol synthesis. Although studies have suggested that some formulations of RYR may be effective and safe for lipid lowering, monacolin levels are not standardized among marketed products and are generally not published on labels. We evaluated monacolin levels in 12 commercial RYR formulations and tested for citrinin, a mycotoxin that is nephrotoxic in animals.
Wenjane Lee - One of the best experts on this subject based on the ideXlab platform.
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combined extractives of Red Yeast Rice bitter gourd chlorella soy protein and licoRice improve total cholesterol low density lipoprotein cholesterol and triglyceride in subjects with metabolic syndrome
Nutrition Research, 2012Co-Authors: Ite Lee, Wenjane Lee, Chingmin Tsai, Hsientung Yen, Wayne Hh SheuAbstract:Abstract In this study, we aimed to examine the effects of a plant-extractive compound on lipid profiles in subjects with metabolic syndrome. We hypothesized that extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice have synergistic benefits on cholesterol and metabolic syndrome. In this double-blinded study, adult subjects with metabolic syndrome were randomized to receive a plant-extractive compound or a placebo treatment for 12 weeks. Both total cholesterol (5.4 ± 0.8 to 4.4 ± 0.6 mmol/L, P P P P P = .039). There was also a significantly greater Reduction in the proportion of subjects with hypertensive criteria in the plant-extractive group than in the placebo group ( P = .040). In conclusion, the plant extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice were effective in Reducing total and low-density lipoprotein cholesterol. The plant extractives also showed potential for Reducing triglyceride and normalizing blood pressure.
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combined extractives of Red Yeast Rice bitter gourd chlorella soy protein and licoRice improve total cholesterol low density lipoprotein cholesterol and triglyceride in subjects with metabolic syndrome
Nutrition Research, 2012Co-Authors: Ite Lee, Wenjane Lee, Chingmin Tsai, Hsientung Yen, Wayne Hh SheuAbstract:In this study, we aimed to examine the effects of a plant-extractive compound on lipid profiles in subjects with metabolic syndrome. We hypothesized that extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice have synergistic benefits on cholesterol and metabolic syndrome. In this double-blinded study, adult subjects with metabolic syndrome were randomized to receive a plant-extractive compound or a placebo treatment for 12 weeks. Both total cholesterol (5.4 ± 0.8 to 4.4 ± 0.6 mmol/L, P < .001) and low-density lipoprotein cholesterol (3.4 ± 0.7 to 2.7 ± 0.5 mmol/L, P < .001) were significantly Reduced after treatment with the plant extractives, and the magnitudes of Reduction were significantly greater than in the placebo group (-1.0 ± 0.6 vs 0.0 ± 0.6mmol/L, P < .001; -0.7 ± 0.6 vs 0.0 ± 0.6 mmol/L, P < .001). The Reduction in the fasting triglycerides level was significantly greater in the plant-extractive group than in the placebo group (-0.5 ± 0.8 vs -0.2 ± 1.0 mmol/L, P = .039). There was also a significantly greater Reduction in the proportion of subjects with hypertensive criteria in the plant-extractive group than in the placebo group (P = .040). In conclusion, the plant extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice were effective in Reducing total and low-density lipoprotein cholesterol. The plant extractives also showed potential for Reducing triglyceride and normalizing blood pressure.
Hsientung Yen - One of the best experts on this subject based on the ideXlab platform.
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combined extractives of Red Yeast Rice bitter gourd chlorella soy protein and licoRice improve total cholesterol low density lipoprotein cholesterol and triglyceride in subjects with metabolic syndrome
Nutrition Research, 2012Co-Authors: Ite Lee, Wenjane Lee, Chingmin Tsai, Hsientung Yen, Wayne Hh SheuAbstract:Abstract In this study, we aimed to examine the effects of a plant-extractive compound on lipid profiles in subjects with metabolic syndrome. We hypothesized that extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice have synergistic benefits on cholesterol and metabolic syndrome. In this double-blinded study, adult subjects with metabolic syndrome were randomized to receive a plant-extractive compound or a placebo treatment for 12 weeks. Both total cholesterol (5.4 ± 0.8 to 4.4 ± 0.6 mmol/L, P P P P P = .039). There was also a significantly greater Reduction in the proportion of subjects with hypertensive criteria in the plant-extractive group than in the placebo group ( P = .040). In conclusion, the plant extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice were effective in Reducing total and low-density lipoprotein cholesterol. The plant extractives also showed potential for Reducing triglyceride and normalizing blood pressure.
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combined extractives of Red Yeast Rice bitter gourd chlorella soy protein and licoRice improve total cholesterol low density lipoprotein cholesterol and triglyceride in subjects with metabolic syndrome
Nutrition Research, 2012Co-Authors: Ite Lee, Wenjane Lee, Chingmin Tsai, Hsientung Yen, Wayne Hh SheuAbstract:In this study, we aimed to examine the effects of a plant-extractive compound on lipid profiles in subjects with metabolic syndrome. We hypothesized that extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice have synergistic benefits on cholesterol and metabolic syndrome. In this double-blinded study, adult subjects with metabolic syndrome were randomized to receive a plant-extractive compound or a placebo treatment for 12 weeks. Both total cholesterol (5.4 ± 0.8 to 4.4 ± 0.6 mmol/L, P < .001) and low-density lipoprotein cholesterol (3.4 ± 0.7 to 2.7 ± 0.5 mmol/L, P < .001) were significantly Reduced after treatment with the plant extractives, and the magnitudes of Reduction were significantly greater than in the placebo group (-1.0 ± 0.6 vs 0.0 ± 0.6mmol/L, P < .001; -0.7 ± 0.6 vs 0.0 ± 0.6 mmol/L, P < .001). The Reduction in the fasting triglycerides level was significantly greater in the plant-extractive group than in the placebo group (-0.5 ± 0.8 vs -0.2 ± 1.0 mmol/L, P = .039). There was also a significantly greater Reduction in the proportion of subjects with hypertensive criteria in the plant-extractive group than in the placebo group (P = .040). In conclusion, the plant extractives from Red Yeast Rice, bitter gourd, chlorella, soy protein, and licoRice were effective in Reducing total and low-density lipoprotein cholesterol. The plant extractives also showed potential for Reducing triglyceride and normalizing blood pressure.