The Experts below are selected from a list of 261 Experts worldwide ranked by ideXlab platform
Thomas J. Blacklock - One of the best experts on this subject based on the ideXlab platform.
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Reductive Alkylation of thioureas a highly practical synthesis of unsymmetrical n n disubstituted thioureas
Tetrahedron Letters, 2004Co-Authors: Lech Ciszewski, Olijan Repič, Thomas J. BlacklockAbstract:A highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas by the Reductive Alkylation of N-monosubstituted thioureas with aldehydes is described. N-Monosubstituted thioureas can in turn be synthesized by the Reductive amination of thiourea with an appropriate aldehyde. This Reductive Alkylation methodology was also extended to carbamates.
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Reductive Alkylation of thioureas: a highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas
Tetrahedron Letters, 2004Co-Authors: Lech Ciszewski, Olijan Repič, Thomas J. BlacklockAbstract:A highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas by the Reductive Alkylation of N-monosubstituted thioureas with aldehydes is described. N-Monosubstituted thioureas can in turn be synthesized by the Reductive amination of thiourea with an appropriate aldehyde. This Reductive Alkylation methodology was also extended to carbamates.
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Reductive Alkylation of urea: A practical route to substituted ureas
Tetrahedron Letters, 1998Co-Authors: Lech Ciszewski, Olijan Repič, Thomas J. BlacklockAbstract:Abstract Conditions are disclosed for the formation of either mono- or di-substituted ureas by Reductive Alkylation, which are readily adaptable to large scale preparations. Dehydrating agents such as acetyl chloride or trimethylsilyl chloride effectively promote the condensation of ureas and aldehydes. Reduction of the adducts affords the mono- or di-substituted ureas in high yields.
Ian S. Blagbrough - One of the best experts on this subject based on the ideXlab platform.
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A novel solid-phase Reductive Alkylation route to acridine and dansyl polyamine conjugates
Chemical Communications, 1999Co-Authors: Simon Carrington, Ian S. Blagbrough, Jacques Renault, Sophie Tomasi, Jean-charles Corbel, Philippe UriacAbstract:Solid-phase organic synthesis (SPOS) routes to target unsymmetrical polyamines and their acridinyl and dansyl conjugates have been developed based upon borane–pyridine complex (BAP) mediated Reductive Alkylation, azide reduction with triphenylphosphine, and the use of pent-4-enoyl (Pnt) as an orthogonal amine protecting group.
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Total synthesis of polyamine amide spider toxin argiotoxin-636 by a practical Reductive Alkylation strategy
Tetrahedron Letters, 1995Co-Authors: Ian S. Blagbrough, Eduardo MoyaAbstract:Abstract Reductive Alkylation is a practical strategy for a total synthesis of spider toxin argiotoxin 636, a polyamine amide which is a selective glutamate receptor antagonist and may have potential as a neuroprotective agent. Central to this synthesis are a Swern oxidation and a Reductive Alkylation.
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Total synthesis of modified jstx toxins: Reductive Alkylation is a practical route to hexahydropyrimidine polyamine amides
Tetrahedron Letters, 1995Co-Authors: Mark R. Ashton, Eduardo Moya, Ian S. BlagbroughAbstract:Abstract Reductive Alkylation is a practical route for a total synthesis of regioisomers of spider toxin JSTX-3, a polyamine amide which is a selective glutamate receptor antagonist and may have potential as a neuroprotective agent. The strategy is based upon a Reductive Alkylation step which enables one free araine to be generated regiospecifically in the new polyamine, or the regiospecific incorporation of a hexahydropyrimidine moiety which conformationally restricts the polyamine amide backbone.
Lech Ciszewski - One of the best experts on this subject based on the ideXlab platform.
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Reductive Alkylation of thioureas a highly practical synthesis of unsymmetrical n n disubstituted thioureas
Tetrahedron Letters, 2004Co-Authors: Lech Ciszewski, Olijan Repič, Thomas J. BlacklockAbstract:A highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas by the Reductive Alkylation of N-monosubstituted thioureas with aldehydes is described. N-Monosubstituted thioureas can in turn be synthesized by the Reductive amination of thiourea with an appropriate aldehyde. This Reductive Alkylation methodology was also extended to carbamates.
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Reductive Alkylation of thioureas: a highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas
Tetrahedron Letters, 2004Co-Authors: Lech Ciszewski, Olijan Repič, Thomas J. BlacklockAbstract:A highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas by the Reductive Alkylation of N-monosubstituted thioureas with aldehydes is described. N-Monosubstituted thioureas can in turn be synthesized by the Reductive amination of thiourea with an appropriate aldehyde. This Reductive Alkylation methodology was also extended to carbamates.
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Reductive Alkylation of urea: A practical route to substituted ureas
Tetrahedron Letters, 1998Co-Authors: Lech Ciszewski, Olijan Repič, Thomas J. BlacklockAbstract:Abstract Conditions are disclosed for the formation of either mono- or di-substituted ureas by Reductive Alkylation, which are readily adaptable to large scale preparations. Dehydrating agents such as acetyl chloride or trimethylsilyl chloride effectively promote the condensation of ureas and aldehydes. Reduction of the adducts affords the mono- or di-substituted ureas in high yields.
Olijan Repič - One of the best experts on this subject based on the ideXlab platform.
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Reductive Alkylation of thioureas a highly practical synthesis of unsymmetrical n n disubstituted thioureas
Tetrahedron Letters, 2004Co-Authors: Lech Ciszewski, Olijan Repič, Thomas J. BlacklockAbstract:A highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas by the Reductive Alkylation of N-monosubstituted thioureas with aldehydes is described. N-Monosubstituted thioureas can in turn be synthesized by the Reductive amination of thiourea with an appropriate aldehyde. This Reductive Alkylation methodology was also extended to carbamates.
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Reductive Alkylation of thioureas: a highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas
Tetrahedron Letters, 2004Co-Authors: Lech Ciszewski, Olijan Repič, Thomas J. BlacklockAbstract:A highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas by the Reductive Alkylation of N-monosubstituted thioureas with aldehydes is described. N-Monosubstituted thioureas can in turn be synthesized by the Reductive amination of thiourea with an appropriate aldehyde. This Reductive Alkylation methodology was also extended to carbamates.
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Reductive Alkylation of urea: A practical route to substituted ureas
Tetrahedron Letters, 1998Co-Authors: Lech Ciszewski, Olijan Repič, Thomas J. BlacklockAbstract:Abstract Conditions are disclosed for the formation of either mono- or di-substituted ureas by Reductive Alkylation, which are readily adaptable to large scale preparations. Dehydrating agents such as acetyl chloride or trimethylsilyl chloride effectively promote the condensation of ureas and aldehydes. Reduction of the adducts affords the mono- or di-substituted ureas in high yields.
Eduardo Moya - One of the best experts on this subject based on the ideXlab platform.
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Total synthesis of polyamine amide spider toxin argiotoxin-636 by a practical Reductive Alkylation strategy
Tetrahedron Letters, 1995Co-Authors: Ian S. Blagbrough, Eduardo MoyaAbstract:Abstract Reductive Alkylation is a practical strategy for a total synthesis of spider toxin argiotoxin 636, a polyamine amide which is a selective glutamate receptor antagonist and may have potential as a neuroprotective agent. Central to this synthesis are a Swern oxidation and a Reductive Alkylation.
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Total synthesis of modified jstx toxins: Reductive Alkylation is a practical route to hexahydropyrimidine polyamine amides
Tetrahedron Letters, 1995Co-Authors: Mark R. Ashton, Eduardo Moya, Ian S. BlagbroughAbstract:Abstract Reductive Alkylation is a practical route for a total synthesis of regioisomers of spider toxin JSTX-3, a polyamine amide which is a selective glutamate receptor antagonist and may have potential as a neuroprotective agent. The strategy is based upon a Reductive Alkylation step which enables one free araine to be generated regiospecifically in the new polyamine, or the regiospecific incorporation of a hexahydropyrimidine moiety which conformationally restricts the polyamine amide backbone.
