The Experts below are selected from a list of 2133 Experts worldwide ranked by ideXlab platform
Heshmatollah Alinezhad - One of the best experts on this subject based on the ideXlab platform.
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Safe and Efficient Reductive Methylation of Primary and Secondary Amines Using N-Methylpyrrolidine Zinc Borohydride.
ChemInform, 2010Co-Authors: Heshmatollah Alinezhad, Mahmood Tajbakhsh, Fatemeh Salehian, Kazem FazliAbstract:A new and efficient method for the Reductive Methylation of amines is developed, which can be a good substitute for NaBH3CN- or zinc-modified cyanoborohydride-mediated Reductive Methylation reactions.
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Safe and Efficient Reductive Methylation of Primary and Secondary Amines Using N-Methylpyrrolidine Zinc Borohydride
Synthetic Communications, 2010Co-Authors: Heshmatollah Alinezhad, Mahmood Tajbakhsh, Fatemeh Salehian, Kazem FazliAbstract:An efficient, general procedure for Reductive Methylation of primary and secondary amines with 37% formaldehyde using N-methylpyrrolidine zinc borohydride (ZBHNMP) as a reducing agent gave the corresponding tertiary amines in excellent yields. The reaction was carried out in tetrahydrofuran under neutral conditions at 0–10 °C.
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efficient and mild procedure for Reductive Methylation of amines using n methylpiperidine zinc borohydride
Synthetic Communications, 2006Co-Authors: Heshmatollah Alinezhad, Mahmood Tajbakhsh, Reza ZamaniAbstract:Abstract A simple and efficient procedure for Reductive Methylation of primary and secondary amines using N‐methylpiperidine zinc borohydride (ZBNMPP), giving tertiary amines, is described. The reaction is carried out in methanol at room temperature under neutral conditions.
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Efficient and Mild Procedure for Reductive Methylation of Amines Using N‐Methylpiperidine Zinc Borohydride
Synthetic Communications, 2006Co-Authors: Heshmatollah Alinezhad, Mahmood Tajbakhsh, Reza ZamaniAbstract:Abstract A simple and efficient procedure for Reductive Methylation of primary and secondary amines using N‐methylpiperidine zinc borohydride (ZBNMPP), giving tertiary amines, is described. The reaction is carried out in methanol at room temperature under neutral conditions.
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Dichlorobis(1,4-diazabicyclo[2.2.2]octane)(tetrahydroborato)zirconium(IV), [Zr(BH4)2Cl2(dabco)2](ZrBDC), as a New, Stable, and Versatile Bench Top Reducing Agent: Reduction of Imines and Enamines, Reductive Amination of Aldehydes and Ketones and Redu
Bulletin of the Chemical Society of Japan, 2003Co-Authors: Habib Firouzabadi, Nasser Iranpoor, Heshmatollah AlinezhadAbstract:The reducing agent is easily prepared in an almost quantitative yield from commercially available starting materials. This compound is stable under mild aqueous acidic conditions (pH 4–6) and survives in H2O for several days without losing its reducing abilities. ZrBDC has been successfully used for the reduction of imines and enamines, Reductive amination of aldehydes and ketones, and Reductive Methylation of amines.
Antonio Cavazzuti - One of the best experts on this subject based on the ideXlab platform.
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Antibacterial agent discovery using thymidylate synthase biolibrary screening.
Journal of medicinal chemistry, 2006Co-Authors: M. Paola Costi, Arianna Gelain, Daniela Barlocco, Stefano Ghelli, Fabrizia Soragni, Fabiano Reniero, Tiziana Rossi, A.i. Ruberto, Claude Guillou, Antonio CavazzutiAbstract:Thymidylate synthase (TS, ThyA) catalyzes the Reductive Methylation of 2‘-deoxyuridine 5‘-monophosphate to 2‘-deoxythymidine 5‘-monophosphate, an essential precursor for DNA synthesis. A specific i...
Xi Liu - One of the best experts on this subject based on the ideXlab platform.
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Copper(II)-Catalyzed Selective Reductive Methylation of Amines with Formic Acid: An Option for Indirect Utilization of CO2.
Organic letters, 2017Co-Authors: Chang Qiao, Xiao-fang Liu, Xi LiuAbstract:A copper-catalyzed protocol for Reductive Methylation of amines and imine with formic acid as a C1 source and phenylsilane as a reductant is reported for the first time, affording the corresponding methylamines in good to excellent yields under mild conditions. This protocol offers an alternative method for indirect utilization of CO2, as formic acid can be readily obtained from hydrogenation of CO2.
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Copper(II)-Catalyzed Selective Reductive Methylation of Amines with Formic Acid: An Option for Indirect Utilization of CO2
2017Co-Authors: Chang Qiao, Xiao-fang Liu, Xi LiuAbstract:A copper-catalyzed protocol for Reductive Methylation of amines and imine with formic acid as a C1 source and phenylsilane as a reductant is reported for the first time, affording the corresponding methylamines in good to excellent yields under mild conditions. This protocol offers an alternative method for indirect utilization of CO2, as formic acid can be readily obtained from hydrogenation of CO2
Walter Leitner - One of the best experts on this subject based on the ideXlab platform.
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Ruthenium‐Catalyzed Reductive Methylation of Imines Using Carbon Dioxide and Molecular Hydrogen
Angewandte Chemie International Edition, 2014Co-Authors: Kassem Beydoun, Ghazi Ghattas, Katharina Thenert, Jürgen Klankermayer, Walter LeitnerAbstract:The use of the well-defined [Ru(triphos)(tmm)] catalyst, CO2 as C1 source, and H2 as reducing agent enabled the Reductive Methylation of isolated imines, as well as the direct coupling of amines with aldehydes and the subsequent Reductive Methylation of the in situ formed imines. The method, which afforded the corresponding N-methyl amines in very good to excellent yields, was also used for the preparation of the antifungal agent butenafine in one step with no apparent waste, thus increasing the atom efficiency of its synthesis.
Megan A. Macnaughtan - One of the best experts on this subject based on the ideXlab platform.
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Review of methods to assign the nuclear magnetic resonance peaks of Reductively methylated proteins.
Analytical biochemistry, 2014Co-Authors: Kevin J. Roberson, Megan A. MacnaughtanAbstract:Abstract Reductive Methylation of lysyl side-chain amines has been a successful tool in the advancement of high-resolution structural biology. The utility of this method has continuously gained ground as a protein chemical modification, first as a tool to aid protein crystallization and later as a probe in protein nuclear magnetic resonance (NMR) spectroscopy. As an isotope-labeling strategy for NMR studies, Reductive Methylation has contributed to the study of protein–protein interactions and global conformational changes. Although more detailed structural studies using this labeling strategy are possible, the hurdle of assigning the NMR peaks to the corresponding Reductively methylated amine hinders its use. In this review, we discuss and compare strategies used to assign the NMR peaks of Reductively methylated protein amines.
