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Lutz Roewer - One of the best experts on this subject based on the ideXlab platform.
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the new y chromosome haplotype Reference Database
Forensic Science International-genetics, 2015Co-Authors: Sascha Willuweit, Lutz RoewerAbstract:Abstract After opening the first version of an internet-accessible worldwide Reference Database of Y chromosome profiles 14 years ago and six years after the last major relaunch the new YHRD 4.0 repository and website has been rolled-out. By November 2014 about 136k 9-locus haplotypes, among these 84k 17-locus haplotypes, 25k 23-locus haplotypes and 15k Y SNP profiles from 917 sampling locations in 128 countries have been submitted by more than 250 institutes and laboratories. In geographic terms, about 39% of the YHRD samples are from Europe, 32% from Asia, 16% from South America, 6% from North America, 4% from Africa and 2% from Oceania/Australia. Worldwide collaboration is the driving force for the rapid growth of the Database and this, in turn, allows the evaluation and implementation of enhanced interpretation tools (variable frequency estimators, LR-based mixture and kinship analysis, Y-SNP-based ancestry assessment).
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y chromosome haplotype Reference Database yhrd update
Forensic Science International-genetics, 2007Co-Authors: Sascha Willuweit, Lutz RoewerAbstract:The freely accessible YHRD (Y Chromosome Haplotype Reference Database, www.yhrd.org) is designed to store Y chromosome haplotypes from global populations and had replaced three earlier Database versions collecting European, Asian and US American Y chromosomes separately. The focus is to disseminate haplotype frequency data to forensic analysts, researchers, and to everyone who is interested in historical and family genetics. YHRD considers reduction of the available number of polymorphisms on the Y chromosome to a uniform data string of 11 highly variable Y-STR loci as an efficient way to rapidly screen many world populations and to make their Y chromosome profiles comparable. Typing of the YHRD 11-locus core set is facilitated by commercial products, namely diagnostic PCR kits, and endorsed by scientific and forensic analyst's societies as ISFG or SWGDAM. YHRD is structured by the assignment of each submitted population sample to a set of populations sharing a common linguistic, demographic, genetic or geographic background (metapopulations). This principle facilitates the statistical evaluation of haplotype matches due to a significant enlargement of sample sizes. With the rapid growth of the Database the definition of homogeneous metapopulations is now also feasible solely on the basis of the genetic data as exemplified for the whole dataset of YHRD, release 19 (August 2006). Large sample numbers within genetically defined metapopulations also allows the development of biostatistical methods to estimate the frequency of unobserved or rare haplotypes ("haplotype frequency surveying method"). Essential for the YHRD project is its collaborative character relying on the engagement of individual laboratories to make their data accessible via YHRD and to share the YHRD standards regarding data quality.
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y chromosome haplotype Reference Database yhrd update
Forensic Science International-genetics, 2007Co-Authors: Sascha Willuweit, Lutz RoewerAbstract:ThefreelyaccessibleYHRD(YChromosomeHaplotypeReferenceDatabase,www.yhrd.org)isdesignedtostoreYchromosomehaplotypesfrom global populations and had replaced three earlier Database versions collecting European, Asian and US American Y chromosomes separately. The focus is to disseminate haplotype frequency data to forensicanalysts, researchers, and to everyonewhois interested in historical and family genetics. YHRDconsidersreductionoftheavailablenumberofpolymorphismsontheYchromosometoauniformdatastringof11highlyvariableY-STRloci asanefficientwaytorapidlyscreenmanyworldpopulationsandtomaketheirYchromosomeprofilescomparable.TypingoftheYHRD11-locuscore set is facilitated by commercial products, namely diagnostic PCR kits, and endorsed by scientific and forensic analyst’s societies as ISFG or SWGDAM. YHRD is structured by the assignment of each submitted population sample to a set of populations sharing a common linguistic, demographic, genetic or geographic background (metapopulations). This principle facilitates the statistical evaluation of haplotype matches du et o a significant enlargement of sample sizes. With the rapid growth of the Database the definition of homogeneous metapopulations is now also feasible solely on the basis of the genetic data as exemplified for the whole dataset of YHRD, release 19 (August 2006). Large sample numbers within geneticallydefinedmetapopulationsalsoallowsthedevelopmentofbiostatisticalmethodstoestimatethefrequencyofunobservedorrarehaplotypes (‘‘haplotype frequency surveying method’’). Essential for the YHRD project is its collaborative character relying on the engagement of individual laboratories to make their data accessible via YHRD and to share the YHRD standards regarding data quality. # 2007 Elsevier Ireland Ltd. All rights reserved.
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online y chromosomal short tandem repeat haplotype Reference Database yhrd for u s populations
Journal of Forensic Sciences, 2002Co-Authors: Manfred Kayser, Sascha Willuweit, Lutz Roewer, Silke Brauer, Hiltrud Schadlich, Mark A Batzer, Jennifer Zawacki, Mechthild Prinz, Mark StonekingAbstract:We describe here an online Y-chromosomal short tandem repeat haplotype Reference Database (YHRD) for U.S. populations, which represents 9-locus Y-STR haplotypes for 1705 African-Americans, European-Americans and Hispanics as of October 2001. This Database is available online (http://www.ystr. org/usa/), free to access and was generated in order to supply the U.S. forensic DNA community with a valuable resource for frequencies of complete or incomplete 9-locus Y-STR haplotypes, as well as information about typing protocols and population genetic analyses. Pairwise R(ST)-statistics derived from the Y-STR haplotypes indicate no significant substructure among African-American populations from different regions of the U.S., nor (usually) among European-American and Hispanic populations. Thus, pooling of Y-STR haplotype data from regional populations within these three major groups is appropriate in order to obtain larger sample sizes. However, pooling of different major populations is generally not recommended due to statistically significant differences between African-American populations and all European-American/Hispanic populations, as well as between some European-American and Hispanic populations.
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online Reference Database of european y chromosomal short tandem repeat str haplotypes
Forensic Science International, 2001Co-Authors: Lutz Roewer, Sascha Willuweit, Michael Krawczak, M Nagy, Cintia Alves, A Amorim, K Anslinger, Christa Augustin, A Betz, Elena BoschAbstract:The Reference Database of highly informative Y-chromosomal short tandem repeat (STR) haplotypes (YHRD), available online at http://ystr.charite.de, represents the largest collection of male-specific genetic profiles currently available for European populations. By September 2000, YHRD contained 4688 9-locus (so-called "minimal") haplotypes, 40% of which have been extended further to include two additional loci. Establishment of YHRD has been facilitated by the joint efforts of 31 forensic and anthropological institutions. All contributing laboratories have agreed to standardize their Y-STR haplotyping protocols and to participate in a quality assurance exercise prior to the inclusion of any data. In view of its collaborative character, and in order to put YHRD to its intended use, viz. the support of forensic caseworkers in their routine decision-making process, the Database has been made publicly available via the Internet in February 2000. Online searches for complete or partial Y-STR haplotypes from evidentiary or non-probative material can be performed on a non-commercial basis, and yield observed haplotype counts as well as extrapolated population frequency estimates. In addition, the YHRD website provides information about the quality control test, genotyping protocols, haplotype formats and informativity, population genetic analysis, literature References, and a list of contact addresses of the contributing laboratories.
Sascha Willuweit - One of the best experts on this subject based on the ideXlab platform.
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the new y chromosome haplotype Reference Database
Forensic Science International-genetics, 2015Co-Authors: Sascha Willuweit, Lutz RoewerAbstract:Abstract After opening the first version of an internet-accessible worldwide Reference Database of Y chromosome profiles 14 years ago and six years after the last major relaunch the new YHRD 4.0 repository and website has been rolled-out. By November 2014 about 136k 9-locus haplotypes, among these 84k 17-locus haplotypes, 25k 23-locus haplotypes and 15k Y SNP profiles from 917 sampling locations in 128 countries have been submitted by more than 250 institutes and laboratories. In geographic terms, about 39% of the YHRD samples are from Europe, 32% from Asia, 16% from South America, 6% from North America, 4% from Africa and 2% from Oceania/Australia. Worldwide collaboration is the driving force for the rapid growth of the Database and this, in turn, allows the evaluation and implementation of enhanced interpretation tools (variable frequency estimators, LR-based mixture and kinship analysis, Y-SNP-based ancestry assessment).
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y chromosome haplotype Reference Database yhrd update
Forensic Science International-genetics, 2007Co-Authors: Sascha Willuweit, Lutz RoewerAbstract:The freely accessible YHRD (Y Chromosome Haplotype Reference Database, www.yhrd.org) is designed to store Y chromosome haplotypes from global populations and had replaced three earlier Database versions collecting European, Asian and US American Y chromosomes separately. The focus is to disseminate haplotype frequency data to forensic analysts, researchers, and to everyone who is interested in historical and family genetics. YHRD considers reduction of the available number of polymorphisms on the Y chromosome to a uniform data string of 11 highly variable Y-STR loci as an efficient way to rapidly screen many world populations and to make their Y chromosome profiles comparable. Typing of the YHRD 11-locus core set is facilitated by commercial products, namely diagnostic PCR kits, and endorsed by scientific and forensic analyst's societies as ISFG or SWGDAM. YHRD is structured by the assignment of each submitted population sample to a set of populations sharing a common linguistic, demographic, genetic or geographic background (metapopulations). This principle facilitates the statistical evaluation of haplotype matches due to a significant enlargement of sample sizes. With the rapid growth of the Database the definition of homogeneous metapopulations is now also feasible solely on the basis of the genetic data as exemplified for the whole dataset of YHRD, release 19 (August 2006). Large sample numbers within genetically defined metapopulations also allows the development of biostatistical methods to estimate the frequency of unobserved or rare haplotypes ("haplotype frequency surveying method"). Essential for the YHRD project is its collaborative character relying on the engagement of individual laboratories to make their data accessible via YHRD and to share the YHRD standards regarding data quality.
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y chromosome haplotype Reference Database yhrd update
Forensic Science International-genetics, 2007Co-Authors: Sascha Willuweit, Lutz RoewerAbstract:ThefreelyaccessibleYHRD(YChromosomeHaplotypeReferenceDatabase,www.yhrd.org)isdesignedtostoreYchromosomehaplotypesfrom global populations and had replaced three earlier Database versions collecting European, Asian and US American Y chromosomes separately. The focus is to disseminate haplotype frequency data to forensicanalysts, researchers, and to everyonewhois interested in historical and family genetics. YHRDconsidersreductionoftheavailablenumberofpolymorphismsontheYchromosometoauniformdatastringof11highlyvariableY-STRloci asanefficientwaytorapidlyscreenmanyworldpopulationsandtomaketheirYchromosomeprofilescomparable.TypingoftheYHRD11-locuscore set is facilitated by commercial products, namely diagnostic PCR kits, and endorsed by scientific and forensic analyst’s societies as ISFG or SWGDAM. YHRD is structured by the assignment of each submitted population sample to a set of populations sharing a common linguistic, demographic, genetic or geographic background (metapopulations). This principle facilitates the statistical evaluation of haplotype matches du et o a significant enlargement of sample sizes. With the rapid growth of the Database the definition of homogeneous metapopulations is now also feasible solely on the basis of the genetic data as exemplified for the whole dataset of YHRD, release 19 (August 2006). Large sample numbers within geneticallydefinedmetapopulationsalsoallowsthedevelopmentofbiostatisticalmethodstoestimatethefrequencyofunobservedorrarehaplotypes (‘‘haplotype frequency surveying method’’). Essential for the YHRD project is its collaborative character relying on the engagement of individual laboratories to make their data accessible via YHRD and to share the YHRD standards regarding data quality. # 2007 Elsevier Ireland Ltd. All rights reserved.
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Asian online Y-STR Haplotype Reference Database.
Legal medicine (Tokyo Japan), 2003Co-Authors: Ruediger Lessig, Sascha Willuweit, Michael Krawczak, Wook Kim, Lotte Henke, Juergen Henke, Jasmin Miranda, Monika HiddingAbstract:For several years Y-chromosomal microsatellites (short tandem repeats, STRs) have been well established in forensic practice. In this context, the genetic characteristics of the Y chromosome (i.e. its paternal inheritance and lack of recombination) render STRs particularly powerful. However, genetic differences between male populations appear to be larger for Y-STRs than for autosomal STRs, a fact that is most likely due to the higher sensitivity of Y-chromosomal lineages to genetic drift (Forensic Sci Int 118 (2001) 153). The assessment of probabilities for matches between haplotyped male persons or traces/persons requires the typing of a large number of haplotypes in the appropriate Reference populations. The haplotype data of a large number of European as well as South and North American populations have been collected and are continuously published online (Y-STR Haplotype Reference Database--YHRD; http://www.ystr.org). The most recent multicentric effort has led to the establishment of an Asian YHRD (http://www.ystr.org/asia) which has been available since January 2002. All Databases are maintained and curated at the Institute of Legal Medicine, Humboldt-University, Berlin and will soon be fused to a global repository including populations from all continents.
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online y chromosomal short tandem repeat haplotype Reference Database yhrd for u s populations
Journal of Forensic Sciences, 2002Co-Authors: Manfred Kayser, Sascha Willuweit, Lutz Roewer, Silke Brauer, Hiltrud Schadlich, Mark A Batzer, Jennifer Zawacki, Mechthild Prinz, Mark StonekingAbstract:We describe here an online Y-chromosomal short tandem repeat haplotype Reference Database (YHRD) for U.S. populations, which represents 9-locus Y-STR haplotypes for 1705 African-Americans, European-Americans and Hispanics as of October 2001. This Database is available online (http://www.ystr. org/usa/), free to access and was generated in order to supply the U.S. forensic DNA community with a valuable resource for frequencies of complete or incomplete 9-locus Y-STR haplotypes, as well as information about typing protocols and population genetic analyses. Pairwise R(ST)-statistics derived from the Y-STR haplotypes indicate no significant substructure among African-American populations from different regions of the U.S., nor (usually) among European-American and Hispanic populations. Thus, pooling of Y-STR haplotype data from regional populations within these three major groups is appropriate in order to obtain larger sample sizes. However, pooling of different major populations is generally not recommended due to statistically significant differences between African-American populations and all European-American/Hispanic populations, as well as between some European-American and Hispanic populations.
Sinan Akkar - One of the best experts on this subject based on the ideXlab platform.
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RESORCE (Reference Database for seismic ground motion in Europe)
2014Co-Authors: Paola Traversa, Sinan Akkar, Gabriele Ameri, Fabrice Cotton, John Douglas, Laurent Frobert, Stéphanie Godey, Bruno Hernandez, Lucia Luzi, M. Abdullah SandikkayaAbstract:With the aim of improving seismic ground-motion models in Europe and reducing associated uncertainties, the compilation of a high-quality Database of seismic-motion recordings and associated metadata is of primary importance. SIGMA research and development project, devoted to the improvement of seismic hazard estimates, methods and data for France and nearby regions, has been funding the implementation of RESORCE (Reference Database fOR seismiC ground-motion in Europe, Akkar et al., 2014).
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Reference Database for seismic ground-motion in Europe (RESORCE)
Bulletin of Earthquake Engineering, 2014Co-Authors: Sinan Akkar, Paola Traversa, Fabrice Cotton, John Douglas, Bruno Hernandez, Lucia Luzi, M. Abdullah Sandikkaya, M. Senyurt, A. Azari Sisi, Stéphanie GodeyAbstract:This paper presents 1 the overall procedure followed in order to assemble the most recent pan-European strong-motion databank: Reference Database for Seismic Ground-Motion in Europe (RESORCE). RESORCE is one of the by-products of the SeIsmic Ground Motion Assessment (SIGMA; projet-sigma.com) project. RESORCE is intended to be a single integrated accelerometric databank for broader Europe to understand the regional differences in seismic hazard for improving risk studies in Europe and surrounding countries. RESORCE principally updates and extends the previous pan-European strong-motion data-bank (Ambraseys in Bollettino di Geofisica Teorica ed Applicata 45:113-129, 2004a) from recently compiled Greek, Italian, Swiss and Turkish accelerometric archives. The updates also include the earthquake-specific literature studies published in recent years. The current content of RESORCE includes 5,882 multi-component and uniformly processed accelerograms from 1,814 events and 1,540 strong-motion stations. The moment magnitude range covered by RESORCE is 2.8 Mw 7.8. The source-to-site distance interval extends to 587 km and distance information is given by the common point- and extended-source distance measures. The paper presents the current features of RESORCE through simple statistics that also quantify the differences in metadata and strong-motion processing with respect to the previous version of the pan-European strong-motion databank.
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Reference Database for seismic ground-motion in Europe (RESORCE)
Bulletin of Earthquake Engineering, 2013Co-Authors: Sinan Akkar, Paola Traversa, Fabrice Cotton, John Douglas, Lucia Luzi, M. Senyurt, M. A. Sandıkkaya, A. Azari Sisi, B. HernandezAbstract:This paper presents the overall procedure followed in order to assemble the most recent pan-European strong-motion databank: Reference Database for Seismic Ground-Motion in Europe (RESORCE). RESORCE is one of the products of the SeIsmic Ground Motion Assessment (SIGMA; projet-sigma.com) project. RESORCE is intended to be a single integrated accelerometric databank for Europe and surrounding areas for use in the development and testing of ground-motion models and for other engineering seismology and earthquake engineering applications. RESORCE aims to contribute to the improvement of earthquake risk studies in Europe and surrounding areas. RESORCE principally updates and extends the previous pan-European strong-motion databank (Ambraseys et al. in Bollettino di Geofisica Teorica ed Applicata 45:113–129, 2004a) with recently compiled Greek, Italian, Swiss and Turkish accelerometric archives. The updates also include earthquake-specific studies published in recent years. The current content of RESORCE includes 5,882 multi-component and uniformly processed accelerograms from 1,814 events and 1,540 strong-motion stations. The moment magnitude range covered by RESORCE is \(2.8 \le \hbox {M}_{\mathrm{w}} \le 7.8\). The source-to-site distance interval extends to 587 km and distance information is given by the common point- and extended-source distance measures. The paper presents the current features of RESORCE through simple statistics that also quantify the differences in metadata and strong-motion processing with respect to the previous version of the pan-European strong-motion databank.
Elena Bosch - One of the best experts on this subject based on the ideXlab platform.
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online Reference Database of european y chromosomal short tandem repeat str haplotypes
Forensic Science International, 2001Co-Authors: Lutz Roewer, Sascha Willuweit, Michael Krawczak, M Nagy, Cintia Alves, A Amorim, K Anslinger, Christa Augustin, A Betz, Elena BoschAbstract:The Reference Database of highly informative Y-chromosomal short tandem repeat (STR) haplotypes (YHRD), available online at http://ystr.charite.de, represents the largest collection of male-specific genetic profiles currently available for European populations. By September 2000, YHRD contained 4688 9-locus (so-called "minimal") haplotypes, 40% of which have been extended further to include two additional loci. Establishment of YHRD has been facilitated by the joint efforts of 31 forensic and anthropological institutions. All contributing laboratories have agreed to standardize their Y-STR haplotyping protocols and to participate in a quality assurance exercise prior to the inclusion of any data. In view of its collaborative character, and in order to put YHRD to its intended use, viz. the support of forensic caseworkers in their routine decision-making process, the Database has been made publicly available via the Internet in February 2000. Online searches for complete or partial Y-STR haplotypes from evidentiary or non-probative material can be performed on a non-commercial basis, and yield observed haplotype counts as well as extrapolated population frequency estimates. In addition, the YHRD website provides information about the quality control test, genotyping protocols, haplotype formats and informativity, population genetic analysis, literature References, and a list of contact addresses of the contributing laboratories.
Chun Gon Kim - One of the best experts on this subject based on the ideXlab platform.
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impact localization on composite wing using 1d array fbg sensor and rms correlation based Reference Database algorithm
Composite Structures, 2015Co-Authors: Pratik Shrestha, Yurim Park, Jin-hyuk Kim, Chun Gon KimAbstract:Abstract In this paper 1-dimensional (1D) array fiber Bragg grating (FBG) sensor configuration is proposed for impact localization of random impact points on composite wing. Firstly, 2D and 1D array FBG sensor localization results are compared and then 1D array FBG sensor configuration is implemented on a full scale composite wing of Jabiru UL-D aircraft. A high speed FBG interrogator is used to sample the impact signals at 100 kHz and Reference Database impact localization algorithm is used to estimate the impact location. The sensor configuration and impact localization techniques presented in this paper demonstrates an excellent means of decreasing the number of required sensor for localizing impact points. Moreover, through a parametric study it is demonstrated that using 1D array sensor configuration and Reference Database algorithm, two FBG sensors covering 4.2 m × 0.6 m wing area can approximate the impact location with maximum localization error limited to about 35.0 mm, which is as effective as using 1D array configuration with six FBG sensors.
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Impact localization on composite wing using 1D array FBG sensor and RMS/correlation based Reference Database algorithm
Composite Structures, 2015Co-Authors: Pratik Shrestha, Yurim Park, Jin-hyuk Kim, Chun Gon KimAbstract:In this paper 1-dimensional (1D) array fiber Bragg grating (FBG) sensor configuration is proposed for impact localization of random impact points on composite wing. Firstly, 2D and 1D array FBG sensor localization results are compared and then 1D array FBG sensor configuration is implemented on a full scale composite wing of Jabiru UL-D aircraft. A high speed FBG interrogator is used to sample the impact signals at 100. kHz and Reference Database impact localization algorithm is used to estimate the impact location. The sensor configuration and impact localization techniques presented in this paper demonstrates an excellent means of decreasing the number of required sensor for localizing impact points. Moreover, through a parametric study it is demonstrated that using 1D array sensor configuration and Reference Database algorithm, two FBG sensors covering 4.2. m. ×. 0.6. m wing area can approximate the impact location with maximum localization error limited to about 35.0. mm, which is as effective as using 1D array configuration with six FBG sensors.
