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Bernard Pirotte - One of the best experts on this subject based on the ideXlab platform.
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3 bromophenyl 6 acetoxymethyl 2 oxo 2h 1 benzopyran 3 carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo
British Journal of Cancer, 2003Co-Authors: I Kempen, D Papapostolou, N Thierry, Lionel Pochet, Stephane Counerotte, Bernard Masereel, Jeanmichel Foidart, M Reboudravaux, Agnes Noel, Bernard PirotteAbstract:In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important activity: 3-chlorophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate and 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate. Both drugs were able to inhibit cell invasion markedly in a Boyden chamber assay, the bromo derivative being more potent than the Reference Matrix metalloprotease (MMP) inhibitor GI 129471. In vivo, tumour growth was reduced when nude mice grafted with HT1080 or MDA-MB231 cells were treated i.p. 3 days week(-1) with the bromo coumarin derivative. These effects were not associated with the inhibition of urokinase, plasmin, MMP-2 or MMP-9. The mechanism of action of the drugs remains to be elucidated. However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents.
I Kempen - One of the best experts on this subject based on the ideXlab platform.
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3 bromophenyl 6 acetoxymethyl 2 oxo 2h 1 benzopyran 3 carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo
British Journal of Cancer, 2003Co-Authors: I Kempen, D Papapostolou, N Thierry, Lionel Pochet, Stephane Counerotte, Bernard Masereel, Jeanmichel Foidart, M Reboudravaux, Agnes Noel, Bernard PirotteAbstract:In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important activity: 3-chlorophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate and 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate. Both drugs were able to inhibit cell invasion markedly in a Boyden chamber assay, the bromo derivative being more potent than the Reference Matrix metalloprotease (MMP) inhibitor GI 129471. In vivo, tumour growth was reduced when nude mice grafted with HT1080 or MDA-MB231 cells were treated i.p. 3 days week(-1) with the bromo coumarin derivative. These effects were not associated with the inhibition of urokinase, plasmin, MMP-2 or MMP-9. The mechanism of action of the drugs remains to be elucidated. However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents.
Bernard Masereel - One of the best experts on this subject based on the ideXlab platform.
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3 bromophenyl 6 acetoxymethyl 2 oxo 2h 1 benzopyran 3 carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo
British Journal of Cancer, 2003Co-Authors: I Kempen, D Papapostolou, N Thierry, Lionel Pochet, Stephane Counerotte, Bernard Masereel, Jeanmichel Foidart, M Reboudravaux, Agnes Noel, Bernard PirotteAbstract:In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important activity: 3-chlorophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate and 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate. Both drugs were able to inhibit cell invasion markedly in a Boyden chamber assay, the bromo derivative being more potent than the Reference Matrix metalloprotease (MMP) inhibitor GI 129471. In vivo, tumour growth was reduced when nude mice grafted with HT1080 or MDA-MB231 cells were treated i.p. 3 days week(-1) with the bromo coumarin derivative. These effects were not associated with the inhibition of urokinase, plasmin, MMP-2 or MMP-9. The mechanism of action of the drugs remains to be elucidated. However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents.
D Papapostolou - One of the best experts on this subject based on the ideXlab platform.
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3 bromophenyl 6 acetoxymethyl 2 oxo 2h 1 benzopyran 3 carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo
British Journal of Cancer, 2003Co-Authors: I Kempen, D Papapostolou, N Thierry, Lionel Pochet, Stephane Counerotte, Bernard Masereel, Jeanmichel Foidart, M Reboudravaux, Agnes Noel, Bernard PirotteAbstract:In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important activity: 3-chlorophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate and 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate. Both drugs were able to inhibit cell invasion markedly in a Boyden chamber assay, the bromo derivative being more potent than the Reference Matrix metalloprotease (MMP) inhibitor GI 129471. In vivo, tumour growth was reduced when nude mice grafted with HT1080 or MDA-MB231 cells were treated i.p. 3 days week(-1) with the bromo coumarin derivative. These effects were not associated with the inhibition of urokinase, plasmin, MMP-2 or MMP-9. The mechanism of action of the drugs remains to be elucidated. However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents.
N Thierry - One of the best experts on this subject based on the ideXlab platform.
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3 bromophenyl 6 acetoxymethyl 2 oxo 2h 1 benzopyran 3 carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo
British Journal of Cancer, 2003Co-Authors: I Kempen, D Papapostolou, N Thierry, Lionel Pochet, Stephane Counerotte, Bernard Masereel, Jeanmichel Foidart, M Reboudravaux, Agnes Noel, Bernard PirotteAbstract:In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important activity: 3-chlorophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate and 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate. Both drugs were able to inhibit cell invasion markedly in a Boyden chamber assay, the bromo derivative being more potent than the Reference Matrix metalloprotease (MMP) inhibitor GI 129471. In vivo, tumour growth was reduced when nude mice grafted with HT1080 or MDA-MB231 cells were treated i.p. 3 days week(-1) with the bromo coumarin derivative. These effects were not associated with the inhibition of urokinase, plasmin, MMP-2 or MMP-9. The mechanism of action of the drugs remains to be elucidated. However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents.