The Experts below are selected from a list of 19692 Experts worldwide ranked by ideXlab platform
Francesco Dellaccio - One of the best experts on this subject based on the ideXlab platform.
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mesenchymal stem cells in rheumatology a Regenerative Approach to joint repair
Clinical Science, 2007Co-Authors: Cosimo De Bari, Francesco DellaccioAbstract:The advent of biologics in rheumatology has considerably changed the evolution and prognosis of chronic inflammatory arthritis. The success of these new treatments has contributed to steering more attention to research focussed on repair and remodelling of joint tissues. Indeed, when the tissue damage is established, treatment options are very limited and the risk of progression towards joint destruction and failure remains high. Increasing evidence indicates that mesenchymal stem cells persist postnatally within joint tissues. It is postulated that they would function to safeguard joint homoeostasis and guarantee tissue remodelling and repair throughout life. Alterations in mesenchymal stem cell biology in arthritis have indeed been reported but a causal relationship has not been demonstrated, mainly because our current knowledge of mesenchymal stem cell niches and functions within the joint in health and disease is very limited. Nonetheless, mesenchymal stem cell technologies have attracted the attention of the biomedical research community as very promising tools to achieve the repair of joint tissues such as articular cartilage, subchondral bone, menisci and tendons. This review will outline stem-cell-mediated strategies for the repair of joint tissues, spanning from the use of expanded mesenchymal stem cell populations to therapeutic targeting of endogenous stem cells, resident in their native tissues, and related reparative signals in traumatic, degenerative and inflammatory joint disorders.
Marc H Hedrick - One of the best experts on this subject based on the ideXlab platform.
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multipotential differentiation of adipose tissue derived stem cells
The Keio Journal of Medicine, 2005Co-Authors: Brian M Strem, Kevin C Hicok, Min Zhu, Isabella Wulur, Zeni Alfonso, Ronda Elizabeth Schreiber, John K Fraser, Marc H HedrickAbstract:Tissue engineering offers considerable promise in the repair or replacement of diseased and/or damaged tissues. The cellular component of this Regenerative Approach will play a key role in bringing these tissue engineered constructs from the laboratory bench to the clinical bedside. However, the ideal source of cells still remains unclear and may differ depending upon the application. Current research for many applications is focused on the use of adult stem cells. The properties of adult stem cells that make them well-suited for Regenerative medicine are (1) ease of harvest for autologous transplantation, (2) high proliferation rates for ex vivo expansion and (3) multilineage differentiation capacity. This review will highlight the use of adipose tissue as a reservoir of adult stem cells and draw conclusions based upon comparisons with bone marrow stromal cells. (Keio JM ed 54 (3): 132-141, September 2005)
Brian M Strem - One of the best experts on this subject based on the ideXlab platform.
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multipotential differentiation of adipose tissue derived stem cells
The Keio Journal of Medicine, 2005Co-Authors: Brian M Strem, Kevin C Hicok, Min Zhu, Isabella Wulur, Zeni Alfonso, Ronda Elizabeth Schreiber, John K Fraser, Marc H HedrickAbstract:Tissue engineering offers considerable promise in the repair or replacement of diseased and/or damaged tissues. The cellular component of this Regenerative Approach will play a key role in bringing these tissue engineered constructs from the laboratory bench to the clinical bedside. However, the ideal source of cells still remains unclear and may differ depending upon the application. Current research for many applications is focused on the use of adult stem cells. The properties of adult stem cells that make them well-suited for Regenerative medicine are (1) ease of harvest for autologous transplantation, (2) high proliferation rates for ex vivo expansion and (3) multilineage differentiation capacity. This review will highlight the use of adipose tissue as a reservoir of adult stem cells and draw conclusions based upon comparisons with bone marrow stromal cells. (Keio JM ed 54 (3): 132-141, September 2005)
Hao Qian - One of the best experts on this subject based on the ideXlab platform.
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design of high efficiency bidirectional dc dc converter and high precision efficiency measurement
IEEE Transactions on Power Electronics, 2010Co-Authors: Wensong Yu, Hao QianAbstract:This paper first introduces the design of an ultrahigh efficiency 50-kW bidirectional dc-dc converter at zero-voltage-switching operation, and then, a high-precision efficiency measurement method using a Regenerative Approach. The ultrahigh efficiency bidirectional dc-dc converter is achieved with 1) the use of CoolMOS as the main switch under zero-voltage soft switching condition; 2) multiple-phase legs for current sharing to reduce the conduction loss; and 3) coupling inductors between each two-phase legs to reduce the core loss. Two identical hardware prototypes were designed, fabricated, and tested for performance evaluation. In order to precisely measure the converter efficiency, the two identical bidirectional dc-dc converters are tested with one as the device under test and the other as the Regenerative unit. With the use of ± 0.5% current shunt and Regenerative measurement, the relative efficiency error stays below ±0.025%. Measured efficiency with load from 20% to 100% consistently shows above 97.50%. At the 50 kW full-load condition, the efficiency is 99.05% with ±0.01% efficiency relative error.
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design of high efficiency bidirectional dc dc converter and high precision efficiency measurement
Conference of the Industrial Electronics Society, 2008Co-Authors: Wensong Yu, Hao QianAbstract:This paper first introduces the design of an ultra high-efficiency 50 kW bidirectional DC-DC converter at ZVS operation and then a high-precision efficiency measurement method using Regenerative Approach. The ultra high-efficiency bidirectional DC-DC converter is achieved with (1) the use of CoolMOS as the main switch under zero-voltage soft switching condition (2) multiple phase legs for current sharing to reduce the conduction loss, and (3) coupling inductors between each two phase legs to reduce the core loss. Two identical hardware prototypes were designed, fabricated and tested for performance evaluation. In order to precisely measure the converter efficiency, the two identical bidirectional DC-DC converters are tested with one as the device under test (DUT) and the other as the Regenerative unit. With the use of plusmn0.5% current shunt and Regenerative measurement, the relative efficiency error stays below plusmn0.025%. Measured efficiency from 20% to 100% load consistently show above 97.50% and peaks at 99.05%.
Cosimo De Bari - One of the best experts on this subject based on the ideXlab platform.
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mesenchymal stem cells in rheumatology a Regenerative Approach to joint repair
Clinical Science, 2007Co-Authors: Cosimo De Bari, Francesco DellaccioAbstract:The advent of biologics in rheumatology has considerably changed the evolution and prognosis of chronic inflammatory arthritis. The success of these new treatments has contributed to steering more attention to research focussed on repair and remodelling of joint tissues. Indeed, when the tissue damage is established, treatment options are very limited and the risk of progression towards joint destruction and failure remains high. Increasing evidence indicates that mesenchymal stem cells persist postnatally within joint tissues. It is postulated that they would function to safeguard joint homoeostasis and guarantee tissue remodelling and repair throughout life. Alterations in mesenchymal stem cell biology in arthritis have indeed been reported but a causal relationship has not been demonstrated, mainly because our current knowledge of mesenchymal stem cell niches and functions within the joint in health and disease is very limited. Nonetheless, mesenchymal stem cell technologies have attracted the attention of the biomedical research community as very promising tools to achieve the repair of joint tissues such as articular cartilage, subchondral bone, menisci and tendons. This review will outline stem-cell-mediated strategies for the repair of joint tissues, spanning from the use of expanded mesenchymal stem cell populations to therapeutic targeting of endogenous stem cells, resident in their native tissues, and related reparative signals in traumatic, degenerative and inflammatory joint disorders.