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Daniel S. Berman - One of the best experts on this subject based on the ideXlab platform.

  • influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy
    European Heart Journal, 2013
    Co-Authors: Eric J Velazquez, Gerald M Pohost, Lorenzo Menicanti, Robert O Bonow, Grace Lin, Anne S Hellkamp, Paolo Ferrazzi, Stanislaw Wos, Vivek Rao, Daniel S. Berman
    Abstract:

    Aims The Surgical Treatment for Ischemic Heart Failure (STICH) trial demonstrated no overall benefit when surgical ventricular reconstruction (SVR) was added to coronary artery bypass grafting (CABG) in patients with ischaemic cardiomyopathy. The present analysis was to determine whether, based on baseline left ventricular (LV) function parameters, any subgroups could be identified that benefited from SVR. Methods and results Among the 1000 patients enrolled, Core Lab measures of baseline LV function with adequate quality were obtained in 710 patients using echocardiography, in 352 using cardiovascular magnetic resonance, and in 344 using radionuclide imaging. The relationship between LV end-systolic volume index (ESVI), end-diastolic volume index, ejection fraction (EF), Regional Wall Motion abnormalities, and outcome were first assessed only by echocardiographic measures, and then by 13 algorithms using a different hierarchy of imaging modalities and their quality. The median ESVI and EF were 78.0 (range: 22.8–283.8) mL/m2 and 28.0%, respectively. Hazard ratios comparing the randomized arms by subgroups of LVESVI and LVEF measured by echocardiography found that patients with smaller ventricles (LVESVI 90 mL/m2) and lower LVEF (≤25%) did worse with SVR. Algorithms using all three imaging modalities found a weaker relationship between LV global function and the effects of SVR. The extent of Regional Wall Motion abnormality did not influence the effects of SVR. Conclusions Subgroup analyses of the STICH trial suggest that patients with less dilated LV and better LVEF may benefit from SVR, while those with larger LV and poorer LVEF may do worse. Clinical Trial Registration #: [NCT00023595][1]. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT00023595&atom=%2Fehj%2F34%2F1%2F39.atom

  • influence of angiographic collateral circulation on myocardial perfusion in patients with chronic total occlusion of a single coronary artery and no prior myocardial infarction
    The Journal of Nuclear Medicine, 2004
    Co-Authors: Fatma Aboulenein, Maria G Sciammarella, Aiden Abidov, Neal L. Eigler, Raj Makkar, Sean W Hayes, John D. Friedman, Daniel S. Berman
    Abstract:

    UNLABELLED: The functional role of various angiographic grades for coronary collaterals remains controversial. The aim of this study was to assess the influence of the Rentrop angiographic grading of coronary collaterals on myocardial perfusion in patients with single-vessel chronic total occlusion (CTO) and no prior myocardial infarction (MI). METHODS: The study included 56 patients with single-vessel CTO and no prior MI who underwent rest-stress myocardial perfusion SPECT and coronary angiography within 6 mo. All patients had angiographic evidence of coronary collaterals. Patients were divided according to the Rentrop classification: Group I had grade 1 or 2 (n = 25) and group II had grade 3 collaterals (n = 31). RESULTS: Group I had a higher frequency of resting Regional Wall Motion abnormalities on left ventriculography (52.6% vs. 19.2% [P = 0.019]). The mean perfusion scores of the overall population showed severe and extensive stress perfusion defects (summed stress score of 14.1 +/- 7.1 and summed difference score of 12.9 +/- 6.9) but minimal resting perfusion defects (summed rest score of 1.0 +/- 2.7). No perfusion scores differed between the 2 groups. The perfusion findings suggested that chronic stunning rather than hibernation is the principal cause of Regional Wall Motion abnormalities in these patients. CONCLUSION: In the setting of single-vessel CTO and no prior MI, coronary collaterals appear to protect against resting perfusion defects. Excellent angiographic collaterals may prevent resting Regional Wall Motion abnormalities but do not appear to protect against stress-induced perfusion defects.

John D. Friedman - One of the best experts on this subject based on the ideXlab platform.

  • influence of angiographic collateral circulation on myocardial perfusion in patients with chronic total occlusion of a single coronary artery and no prior myocardial infarction
    The Journal of Nuclear Medicine, 2004
    Co-Authors: Fatma Aboulenein, Maria G Sciammarella, Aiden Abidov, Neal L. Eigler, Raj Makkar, Sean W Hayes, John D. Friedman, Daniel S. Berman
    Abstract:

    UNLABELLED: The functional role of various angiographic grades for coronary collaterals remains controversial. The aim of this study was to assess the influence of the Rentrop angiographic grading of coronary collaterals on myocardial perfusion in patients with single-vessel chronic total occlusion (CTO) and no prior myocardial infarction (MI). METHODS: The study included 56 patients with single-vessel CTO and no prior MI who underwent rest-stress myocardial perfusion SPECT and coronary angiography within 6 mo. All patients had angiographic evidence of coronary collaterals. Patients were divided according to the Rentrop classification: Group I had grade 1 or 2 (n = 25) and group II had grade 3 collaterals (n = 31). RESULTS: Group I had a higher frequency of resting Regional Wall Motion abnormalities on left ventriculography (52.6% vs. 19.2% [P = 0.019]). The mean perfusion scores of the overall population showed severe and extensive stress perfusion defects (summed stress score of 14.1 +/- 7.1 and summed difference score of 12.9 +/- 6.9) but minimal resting perfusion defects (summed rest score of 1.0 +/- 2.7). No perfusion scores differed between the 2 groups. The perfusion findings suggested that chronic stunning rather than hibernation is the principal cause of Regional Wall Motion abnormalities in these patients. CONCLUSION: In the setting of single-vessel CTO and no prior MI, coronary collaterals appear to protect against resting perfusion defects. Excellent angiographic collaterals may prevent resting Regional Wall Motion abnormalities but do not appear to protect against stress-induced perfusion defects.

  • influence of angiographic collateral circulation on myocardial perfusion in patients with chronic total occlusion of a single coronary artery and no prior myocardial infarction
    The Journal of Nuclear Medicine, 2004
    Co-Authors: Fatma Aboulenein, Maria G Sciammarella, Aiden Abidov, Raj Makkar, Sean W Hayes, John D. Friedman, Saibal Kar, Neal L. Eigler
    Abstract:

    The functional role of various angiographic grades for coronary collaterals remains controversial. The aim of this study was to assess the influence of the Rentrop angiographic grading of coronary collaterals on myocardial perfusion in patients with single-vessel chronic total occlusion (CTO) and no prior myocardial infarction (MI). Methods: The study included 56 patients with single-vessel CTO and no prior MI who underwent rest–stress myocardial perfusion SPECT and coronary angiography within 6 mo. All patients had angiographic evidence of coronary collaterals. Patients were divided according to the Rentrop classification: Group I had grade 1 or 2 (n = 25) and group II had grade 3 collaterals (n = 31). Results: Group I had a higher frequency of resting Regional Wall Motion abnormalities on left ventriculography (52.6% vs. 19.2% [P = 0.019]). The mean perfusion scores of the overall population showed severe and extensive stress perfusion defects (summed stress score of 14.1 ± 7.1 and summed difference score of 12.9 ± 6.9) but minimal resting perfusion defects (summed rest score of 1.0 ± 2.7). No perfusion scores differed between the 2 groups. The perfusion findings suggested that chronic stunning rather than hibernation is the principal cause of Regional Wall Motion abnormalities in these patients. Conclusion: In the setting of single-vessel CTO and no prior MI, coronary collaterals appear to protect against resting perfusion defects. Excellent angiographic collaterals may prevent resting Regional Wall Motion abnormalities but do not appear to protect against stress-induced perfusion defects.

Neal L. Eigler - One of the best experts on this subject based on the ideXlab platform.

  • influence of angiographic collateral circulation on myocardial perfusion in patients with chronic total occlusion of a single coronary artery and no prior myocardial infarction
    The Journal of Nuclear Medicine, 2004
    Co-Authors: Fatma Aboulenein, Maria G Sciammarella, Aiden Abidov, Neal L. Eigler, Raj Makkar, Sean W Hayes, John D. Friedman, Daniel S. Berman
    Abstract:

    UNLABELLED: The functional role of various angiographic grades for coronary collaterals remains controversial. The aim of this study was to assess the influence of the Rentrop angiographic grading of coronary collaterals on myocardial perfusion in patients with single-vessel chronic total occlusion (CTO) and no prior myocardial infarction (MI). METHODS: The study included 56 patients with single-vessel CTO and no prior MI who underwent rest-stress myocardial perfusion SPECT and coronary angiography within 6 mo. All patients had angiographic evidence of coronary collaterals. Patients were divided according to the Rentrop classification: Group I had grade 1 or 2 (n = 25) and group II had grade 3 collaterals (n = 31). RESULTS: Group I had a higher frequency of resting Regional Wall Motion abnormalities on left ventriculography (52.6% vs. 19.2% [P = 0.019]). The mean perfusion scores of the overall population showed severe and extensive stress perfusion defects (summed stress score of 14.1 +/- 7.1 and summed difference score of 12.9 +/- 6.9) but minimal resting perfusion defects (summed rest score of 1.0 +/- 2.7). No perfusion scores differed between the 2 groups. The perfusion findings suggested that chronic stunning rather than hibernation is the principal cause of Regional Wall Motion abnormalities in these patients. CONCLUSION: In the setting of single-vessel CTO and no prior MI, coronary collaterals appear to protect against resting perfusion defects. Excellent angiographic collaterals may prevent resting Regional Wall Motion abnormalities but do not appear to protect against stress-induced perfusion defects.

  • influence of angiographic collateral circulation on myocardial perfusion in patients with chronic total occlusion of a single coronary artery and no prior myocardial infarction
    The Journal of Nuclear Medicine, 2004
    Co-Authors: Fatma Aboulenein, Maria G Sciammarella, Aiden Abidov, Raj Makkar, Sean W Hayes, John D. Friedman, Saibal Kar, Neal L. Eigler
    Abstract:

    The functional role of various angiographic grades for coronary collaterals remains controversial. The aim of this study was to assess the influence of the Rentrop angiographic grading of coronary collaterals on myocardial perfusion in patients with single-vessel chronic total occlusion (CTO) and no prior myocardial infarction (MI). Methods: The study included 56 patients with single-vessel CTO and no prior MI who underwent rest–stress myocardial perfusion SPECT and coronary angiography within 6 mo. All patients had angiographic evidence of coronary collaterals. Patients were divided according to the Rentrop classification: Group I had grade 1 or 2 (n = 25) and group II had grade 3 collaterals (n = 31). Results: Group I had a higher frequency of resting Regional Wall Motion abnormalities on left ventriculography (52.6% vs. 19.2% [P = 0.019]). The mean perfusion scores of the overall population showed severe and extensive stress perfusion defects (summed stress score of 14.1 ± 7.1 and summed difference score of 12.9 ± 6.9) but minimal resting perfusion defects (summed rest score of 1.0 ± 2.7). No perfusion scores differed between the 2 groups. The perfusion findings suggested that chronic stunning rather than hibernation is the principal cause of Regional Wall Motion abnormalities in these patients. Conclusion: In the setting of single-vessel CTO and no prior MI, coronary collaterals appear to protect against resting perfusion defects. Excellent angiographic collaterals may prevent resting Regional Wall Motion abnormalities but do not appear to protect against stress-induced perfusion defects.

Thomas H Marwick - One of the best experts on this subject based on the ideXlab platform.

  • reply characteristic lv Regional Wall Motion abnormality sign of cardiotoxicity
    Journal of the American College of Cardiology, 2015
    Co-Authors: Paaladinesh Thavendiranathan, Thomas H Marwick
    Abstract:

    We thank Dr. Drinkovic for the interest in our State-of-the-Art Paper [(1)][1]. Studies based on histology [(2)][2], echocardiography, and/or nuclear imaging [(3)][3] all recognize the possibility of Regional involvement from cardiotoxicity. Abnormal Regional myocardial strain assessment—which is

  • anatomical m mode a novel technique for the quantitative evaluation of Regional Wall Motion analysis during dobutamine echocardiography
    International Journal of Cardiac Imaging, 2000
    Co-Authors: Jonathan Chan, S Wahi, P A Cain, Thomas H Marwick
    Abstract:

    Recognition of abnormal Wall Motion during dobutamine echocardiography requires an expert observer. Anatomical M-mode echocardiography may offer a novel quantitative approach to interpretation, amenable to less expert readers. We studied the application of this new modality to 124 patients (80 with known coronary anatomy and 44 patients at low probability of coronary disease) who underwent dobutamine echocardiography, using a standard protocol. Wall Motion was interpreted by an experienced reader, using digitally stored 2-dimensional echocardiographic images at rest and peak stress. Percentage of systolic thickening was measured offline using anatomical M-mode echocardiography in the basal and mid segments at rest and peak dose, and compared with Wall Motion scores and coronary angiography. Of 729 segments, Wall Motion was identified as normal in 449, ischemic or viable in 171 and showed resting WM abnormalities only in 109 segments. After exclusion of the apex, anatomical M-mode measurements were feasible in 729 of 960 possible basal- and mid-zone segments (76%). Measurement of systolic thickening at peak dose was reproducible within (r2 = 0.83) and between observers (r2 = 0.93). Systolic thickening was significantly greater in segments with normal Wall Motion (37 ± 2%) compared with ischemic or viable segments (30 ± 2%, p 70% diameter) was present in 59 patients. Systolic thickening showed significant variation between segments interpreted by Wall Motion scoring and angiography as true and false positive and true and false negative (p < 0.05). Measurement of systolic thickening using anatomical M-mode echocardiography offers an objective method to quantify systolic thickening at dobutamine echocardiography but has limited clinical feasibility.

  • myocardial doppler velocity imaging a quantitative technique for interpretation of dobutamine echocardiography
    American Journal of Cardiology, 1998
    Co-Authors: Elina Yamada, Mario J Garcia, James D Thomas, Thomas H Marwick
    Abstract:

    Myocardial Doppler velocity (MDV) imaging was evaluated as a quantitative method for interpretation of dobutamine echocardiography by comparison with Regional Wall Motion abnormalities in 70 patients with known or suspected coronary artery disease. Ischemic segments had the lowest increment of systolic MDV from rest to peak dose, and using a peak MDV of <12 cm/s to define an abnormal response, the sensitivity and specificity of MDV for ischemia was 86% and 96% for basal segments, and 81% and 89% for mid segments.

Fatma Aboulenein - One of the best experts on this subject based on the ideXlab platform.

  • influence of angiographic collateral circulation on myocardial perfusion in patients with chronic total occlusion of a single coronary artery and no prior myocardial infarction
    The Journal of Nuclear Medicine, 2004
    Co-Authors: Fatma Aboulenein, Maria G Sciammarella, Aiden Abidov, Neal L. Eigler, Raj Makkar, Sean W Hayes, John D. Friedman, Daniel S. Berman
    Abstract:

    UNLABELLED: The functional role of various angiographic grades for coronary collaterals remains controversial. The aim of this study was to assess the influence of the Rentrop angiographic grading of coronary collaterals on myocardial perfusion in patients with single-vessel chronic total occlusion (CTO) and no prior myocardial infarction (MI). METHODS: The study included 56 patients with single-vessel CTO and no prior MI who underwent rest-stress myocardial perfusion SPECT and coronary angiography within 6 mo. All patients had angiographic evidence of coronary collaterals. Patients were divided according to the Rentrop classification: Group I had grade 1 or 2 (n = 25) and group II had grade 3 collaterals (n = 31). RESULTS: Group I had a higher frequency of resting Regional Wall Motion abnormalities on left ventriculography (52.6% vs. 19.2% [P = 0.019]). The mean perfusion scores of the overall population showed severe and extensive stress perfusion defects (summed stress score of 14.1 +/- 7.1 and summed difference score of 12.9 +/- 6.9) but minimal resting perfusion defects (summed rest score of 1.0 +/- 2.7). No perfusion scores differed between the 2 groups. The perfusion findings suggested that chronic stunning rather than hibernation is the principal cause of Regional Wall Motion abnormalities in these patients. CONCLUSION: In the setting of single-vessel CTO and no prior MI, coronary collaterals appear to protect against resting perfusion defects. Excellent angiographic collaterals may prevent resting Regional Wall Motion abnormalities but do not appear to protect against stress-induced perfusion defects.

  • influence of angiographic collateral circulation on myocardial perfusion in patients with chronic total occlusion of a single coronary artery and no prior myocardial infarction
    The Journal of Nuclear Medicine, 2004
    Co-Authors: Fatma Aboulenein, Maria G Sciammarella, Aiden Abidov, Raj Makkar, Sean W Hayes, John D. Friedman, Saibal Kar, Neal L. Eigler
    Abstract:

    The functional role of various angiographic grades for coronary collaterals remains controversial. The aim of this study was to assess the influence of the Rentrop angiographic grading of coronary collaterals on myocardial perfusion in patients with single-vessel chronic total occlusion (CTO) and no prior myocardial infarction (MI). Methods: The study included 56 patients with single-vessel CTO and no prior MI who underwent rest–stress myocardial perfusion SPECT and coronary angiography within 6 mo. All patients had angiographic evidence of coronary collaterals. Patients were divided according to the Rentrop classification: Group I had grade 1 or 2 (n = 25) and group II had grade 3 collaterals (n = 31). Results: Group I had a higher frequency of resting Regional Wall Motion abnormalities on left ventriculography (52.6% vs. 19.2% [P = 0.019]). The mean perfusion scores of the overall population showed severe and extensive stress perfusion defects (summed stress score of 14.1 ± 7.1 and summed difference score of 12.9 ± 6.9) but minimal resting perfusion defects (summed rest score of 1.0 ± 2.7). No perfusion scores differed between the 2 groups. The perfusion findings suggested that chronic stunning rather than hibernation is the principal cause of Regional Wall Motion abnormalities in these patients. Conclusion: In the setting of single-vessel CTO and no prior MI, coronary collaterals appear to protect against resting perfusion defects. Excellent angiographic collaterals may prevent resting Regional Wall Motion abnormalities but do not appear to protect against stress-induced perfusion defects.