The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Helgard Claassen - One of the best experts on this subject based on the ideXlab platform.
-
Knee Extensors Muscle Plasticity Over a 5-Years Rehabilitation Process After Open Knee Surgery
Frontiers in physiology, 2018Co-Authors: Martin Flück, Claudio Viecelli, Andreas M. Bapst, Stephanie Kasper, Paola Valdivieso, Martino V. Franchi, Severin Ruoss, Jean-marc Lüthi, Martin Bühler, Helgard ClaassenAbstract:We investigated molecular and cellular parameters which set metabolic and mechanical functioning of knee extensor muscles in the operated and contralateral control leg of 9 patients with a chronically insufficient anterior cruciate ligament (ACL; 26.6 ± 8.3 years, 8 males, 1 female) after open reconstructive surgery (week 0), after ambulant physiotherapy under cast immobilization (week 9), succeeding Rehabilitation training (up to week 26), and subsequent voluntary physical activity (week 260). Clinical indices of knee function in the operated leg were improved at 52 weeks and remained at a comparable level at week 260. CSA of the quadriceps (-18%), MCSA of muscle fibers (-24%), and capillary-to-fiber ratio (-24%) in m. vastus lateralis from the ACL insufficient leg were lower at week 0 than reference values in the contralateral leg at week 260. Slow type fiber percentage (-35%) and mitochondrial volume density (-39%) were reduced in m. vastus lateralis from the operated leg at weeks 9 and 26. Composition alterations in the operated leg exceeded those in the contralateral leg and, with the exception of the volume density of subsarcolemmal mitochondria, returned to the reference levels at week 260. Leg-specific deterioration of metabolic characteristics in the vasti from the operated leg was reflected by the down-regulation of mitochondrial respiration complex I-III markers (-41-57%) at week 9. After Rehabilitation training at week 26, the specific Y397 phosphorylation of focal adhesion kinase (FAK), which is a proxy for mechano-regulation, was elevated by 71% in the operated leg but not in the contralateral leg, which had performed strengthening type exercise during ambulant physiotherapy. Total FAK protein and Y397 phosphorylation levels were lowered in both legs at week 26 resulting in positive correlations with mitochondrial volume densities and mitochondrial protein levels. The findings emphasize that a loss of mechanical and metabolic characteristics in knee extensor muscle remains detectable years after untreated ACL rupture, which may be aggravated in the post-operative phase by the deterioration of slow-oxidative characteristics after reconstruction due to insufficient load-bearing muscle activity. The reestablishment of muscle composition subsequent to years of voluntary physical activity reinforces that slow-to-fast fiber transformation is reversible in humans.
-
Table_1_Knee Extensors Muscle Plasticity Over a 5-Years Rehabilitation Process After Open Knee Surgery.docx
2018Co-Authors: Martin Flück, Claudio Viecelli, Andreas M. Bapst, Stephanie Kasper, Paola Valdivieso, Martino V. Franchi, Severin Ruoss, Jean-marc Lüthi, Martin Bühler, Helgard ClaassenAbstract:We investigated molecular and cellular parameters which set metabolic and mechanical functioning of knee extensor muscles in the operated and contralateral control leg of 9 patients with a chronically insufficient anterior cruciate ligament (ACL; 26.6 ± 8.3 years, 8 males, 1 female) after open reconstructive surgery (week 0), after ambulant physiotherapy under cast immobilization (week 9), succeeding Rehabilitation training (up to week 26), and subsequent voluntary physical activity (week 260). Clinical indices of knee function in the operated leg were improved at 52 weeks and remained at a comparable level at week 260. CSA of the quadriceps (-18%), MCSA of muscle fibers (-24%), and capillary-to-fiber ratio (-24%) in m. vastus lateralis from the ACL insufficient leg were lower at week 0 than reference values in the contralateral leg at week 260. Slow type fiber percentage (-35%) and mitochondrial volume density (-39%) were reduced in m. vastus lateralis from the operated leg at weeks 9 and 26. Composition alterations in the operated leg exceeded those in the contralateral leg and, with the exception of the volume density of subsarcolemmal mitochondria, returned to the reference levels at week 260. Leg-specific deterioration of metabolic characteristics in the vasti from the operated leg was reflected by the down-regulation of mitochondrial respiration complex I-III markers (-41–57%) at week 9. After Rehabilitation training at week 26, the specific Y397 phosphorylation of focal adhesion kinase (FAK), which is a proxy for mechano-regulation, was elevated by 71% in the operated leg but not in the contralateral leg, which had performed strengthening type exercise during ambulant physiotherapy. Total FAK protein and Y397 phosphorylation levels were lowered in both legs at week 26 resulting in positive correlations with mitochondrial volume densities and mitochondrial protein levels. The findings emphasize that a loss of mechanical and metabolic characteristics in knee extensor muscle remains detectable years after untreated ACL rupture, which may be aggravated in the post-operative phase by the deterioration of slow-oxidative characteristics after reconstruction due to insufficient load-bearing muscle activity. The reestablishment of muscle composition subsequent to years of voluntary physical activity reinforces that slow-to-fast fiber transformation is reversible in humans.
-
Image_2_Knee Extensors Muscle Plasticity Over a 5-Years Rehabilitation Process After Open Knee Surgery.pdf
2018Co-Authors: Martin Flück, Claudio Viecelli, Andreas M. Bapst, Stephanie Kasper, Paola Valdivieso, Martino V. Franchi, Severin Ruoss, Jean-marc Lüthi, Martin Bühler, Helgard ClaassenAbstract:We investigated molecular and cellular parameters which set metabolic and mechanical functioning of knee extensor muscles in the operated and contralateral control leg of 9 patients with a chronically insufficient anterior cruciate ligament (ACL; 26.6 ± 8.3 years, 8 males, 1 female) after open reconstructive surgery (week 0), after ambulant physiotherapy under cast immobilization (week 9), succeeding Rehabilitation training (up to week 26), and subsequent voluntary physical activity (week 260). Clinical indices of knee function in the operated leg were improved at 52 weeks and remained at a comparable level at week 260. CSA of the quadriceps (-18%), MCSA of muscle fibers (-24%), and capillary-to-fiber ratio (-24%) in m. vastus lateralis from the ACL insufficient leg were lower at week 0 than reference values in the contralateral leg at week 260. Slow type fiber percentage (-35%) and mitochondrial volume density (-39%) were reduced in m. vastus lateralis from the operated leg at weeks 9 and 26. Composition alterations in the operated leg exceeded those in the contralateral leg and, with the exception of the volume density of subsarcolemmal mitochondria, returned to the reference levels at week 260. Leg-specific deterioration of metabolic characteristics in the vasti from the operated leg was reflected by the down-regulation of mitochondrial respiration complex I-III markers (-41–57%) at week 9. After Rehabilitation training at week 26, the specific Y397 phosphorylation of focal adhesion kinase (FAK), which is a proxy for mechano-regulation, was elevated by 71% in the operated leg but not in the contralateral leg, which had performed strengthening type exercise during ambulant physiotherapy. Total FAK protein and Y397 phosphorylation levels were lowered in both legs at week 26 resulting in positive correlations with mitochondrial volume densities and mitochondrial protein levels. The findings emphasize that a loss of mechanical and metabolic characteristics in knee extensor muscle remains detectable years after untreated ACL rupture, which may be aggravated in the post-operative phase by the deterioration of slow-oxidative characteristics after reconstruction due to insufficient load-bearing muscle activity. The reestablishment of muscle composition subsequent to years of voluntary physical activity reinforces that slow-to-fast fiber transformation is reversible in humans.
Martin Flück - One of the best experts on this subject based on the ideXlab platform.
-
Knee Extensors Muscle Plasticity Over a 5-Years Rehabilitation Process After Open Knee Surgery
Frontiers in physiology, 2018Co-Authors: Martin Flück, Claudio Viecelli, Andreas M. Bapst, Stephanie Kasper, Paola Valdivieso, Martino V. Franchi, Severin Ruoss, Jean-marc Lüthi, Martin Bühler, Helgard ClaassenAbstract:We investigated molecular and cellular parameters which set metabolic and mechanical functioning of knee extensor muscles in the operated and contralateral control leg of 9 patients with a chronically insufficient anterior cruciate ligament (ACL; 26.6 ± 8.3 years, 8 males, 1 female) after open reconstructive surgery (week 0), after ambulant physiotherapy under cast immobilization (week 9), succeeding Rehabilitation training (up to week 26), and subsequent voluntary physical activity (week 260). Clinical indices of knee function in the operated leg were improved at 52 weeks and remained at a comparable level at week 260. CSA of the quadriceps (-18%), MCSA of muscle fibers (-24%), and capillary-to-fiber ratio (-24%) in m. vastus lateralis from the ACL insufficient leg were lower at week 0 than reference values in the contralateral leg at week 260. Slow type fiber percentage (-35%) and mitochondrial volume density (-39%) were reduced in m. vastus lateralis from the operated leg at weeks 9 and 26. Composition alterations in the operated leg exceeded those in the contralateral leg and, with the exception of the volume density of subsarcolemmal mitochondria, returned to the reference levels at week 260. Leg-specific deterioration of metabolic characteristics in the vasti from the operated leg was reflected by the down-regulation of mitochondrial respiration complex I-III markers (-41-57%) at week 9. After Rehabilitation training at week 26, the specific Y397 phosphorylation of focal adhesion kinase (FAK), which is a proxy for mechano-regulation, was elevated by 71% in the operated leg but not in the contralateral leg, which had performed strengthening type exercise during ambulant physiotherapy. Total FAK protein and Y397 phosphorylation levels were lowered in both legs at week 26 resulting in positive correlations with mitochondrial volume densities and mitochondrial protein levels. The findings emphasize that a loss of mechanical and metabolic characteristics in knee extensor muscle remains detectable years after untreated ACL rupture, which may be aggravated in the post-operative phase by the deterioration of slow-oxidative characteristics after reconstruction due to insufficient load-bearing muscle activity. The reestablishment of muscle composition subsequent to years of voluntary physical activity reinforces that slow-to-fast fiber transformation is reversible in humans.
-
Table_1_Knee Extensors Muscle Plasticity Over a 5-Years Rehabilitation Process After Open Knee Surgery.docx
2018Co-Authors: Martin Flück, Claudio Viecelli, Andreas M. Bapst, Stephanie Kasper, Paola Valdivieso, Martino V. Franchi, Severin Ruoss, Jean-marc Lüthi, Martin Bühler, Helgard ClaassenAbstract:We investigated molecular and cellular parameters which set metabolic and mechanical functioning of knee extensor muscles in the operated and contralateral control leg of 9 patients with a chronically insufficient anterior cruciate ligament (ACL; 26.6 ± 8.3 years, 8 males, 1 female) after open reconstructive surgery (week 0), after ambulant physiotherapy under cast immobilization (week 9), succeeding Rehabilitation training (up to week 26), and subsequent voluntary physical activity (week 260). Clinical indices of knee function in the operated leg were improved at 52 weeks and remained at a comparable level at week 260. CSA of the quadriceps (-18%), MCSA of muscle fibers (-24%), and capillary-to-fiber ratio (-24%) in m. vastus lateralis from the ACL insufficient leg were lower at week 0 than reference values in the contralateral leg at week 260. Slow type fiber percentage (-35%) and mitochondrial volume density (-39%) were reduced in m. vastus lateralis from the operated leg at weeks 9 and 26. Composition alterations in the operated leg exceeded those in the contralateral leg and, with the exception of the volume density of subsarcolemmal mitochondria, returned to the reference levels at week 260. Leg-specific deterioration of metabolic characteristics in the vasti from the operated leg was reflected by the down-regulation of mitochondrial respiration complex I-III markers (-41–57%) at week 9. After Rehabilitation training at week 26, the specific Y397 phosphorylation of focal adhesion kinase (FAK), which is a proxy for mechano-regulation, was elevated by 71% in the operated leg but not in the contralateral leg, which had performed strengthening type exercise during ambulant physiotherapy. Total FAK protein and Y397 phosphorylation levels were lowered in both legs at week 26 resulting in positive correlations with mitochondrial volume densities and mitochondrial protein levels. The findings emphasize that a loss of mechanical and metabolic characteristics in knee extensor muscle remains detectable years after untreated ACL rupture, which may be aggravated in the post-operative phase by the deterioration of slow-oxidative characteristics after reconstruction due to insufficient load-bearing muscle activity. The reestablishment of muscle composition subsequent to years of voluntary physical activity reinforces that slow-to-fast fiber transformation is reversible in humans.
-
Image_2_Knee Extensors Muscle Plasticity Over a 5-Years Rehabilitation Process After Open Knee Surgery.pdf
2018Co-Authors: Martin Flück, Claudio Viecelli, Andreas M. Bapst, Stephanie Kasper, Paola Valdivieso, Martino V. Franchi, Severin Ruoss, Jean-marc Lüthi, Martin Bühler, Helgard ClaassenAbstract:We investigated molecular and cellular parameters which set metabolic and mechanical functioning of knee extensor muscles in the operated and contralateral control leg of 9 patients with a chronically insufficient anterior cruciate ligament (ACL; 26.6 ± 8.3 years, 8 males, 1 female) after open reconstructive surgery (week 0), after ambulant physiotherapy under cast immobilization (week 9), succeeding Rehabilitation training (up to week 26), and subsequent voluntary physical activity (week 260). Clinical indices of knee function in the operated leg were improved at 52 weeks and remained at a comparable level at week 260. CSA of the quadriceps (-18%), MCSA of muscle fibers (-24%), and capillary-to-fiber ratio (-24%) in m. vastus lateralis from the ACL insufficient leg were lower at week 0 than reference values in the contralateral leg at week 260. Slow type fiber percentage (-35%) and mitochondrial volume density (-39%) were reduced in m. vastus lateralis from the operated leg at weeks 9 and 26. Composition alterations in the operated leg exceeded those in the contralateral leg and, with the exception of the volume density of subsarcolemmal mitochondria, returned to the reference levels at week 260. Leg-specific deterioration of metabolic characteristics in the vasti from the operated leg was reflected by the down-regulation of mitochondrial respiration complex I-III markers (-41–57%) at week 9. After Rehabilitation training at week 26, the specific Y397 phosphorylation of focal adhesion kinase (FAK), which is a proxy for mechano-regulation, was elevated by 71% in the operated leg but not in the contralateral leg, which had performed strengthening type exercise during ambulant physiotherapy. Total FAK protein and Y397 phosphorylation levels were lowered in both legs at week 26 resulting in positive correlations with mitochondrial volume densities and mitochondrial protein levels. The findings emphasize that a loss of mechanical and metabolic characteristics in knee extensor muscle remains detectable years after untreated ACL rupture, which may be aggravated in the post-operative phase by the deterioration of slow-oxidative characteristics after reconstruction due to insufficient load-bearing muscle activity. The reestablishment of muscle composition subsequent to years of voluntary physical activity reinforces that slow-to-fast fiber transformation is reversible in humans.
A Mohd M Ali - One of the best experts on this subject based on the ideXlab platform.
-
artificial hand gripper controller via smart glove for Rehabilitation Process
International Conference on Biomedical Engineering, 2012Co-Authors: A Mohd M Ali, M Abdul M Jamil, Radzi Ambar, A Mohd J Wahi, Sana SalimAbstract:Most parts in this research are dedicated to control of multi finger grippers with emphasis on the finger tips or finger joints. By controlling a multi finger gripper, we enable the gripper to handle an object; in another words, controlling a multi finger gripper can be viewed in terms of controlling an object's pose and the forces between the object and its environment. Hence, an object pose controller with feedback from an object pose sensor suits multi finger gripper control. Also due to the non-linear dynamic system behavior in the joints of most multi finger grippers, an effective, easily-adaptable joint controller is employed. The paper discusses the object pose controller with great detail in a new joint controller. Since the joint controller is based on microcontroller thus, we do not use an exact analytical model for this case.
-
development of artificial hand gripper for Rehabilitation Process
2011Co-Authors: A Mohd M Ali, M Y Ismail, M Abdul M JamilAbstract:This paper focuses on the development of a robotic hand that imitates the movement of a human hand. The basic movement of the surgeon hand was limited from a wrist, elbow and shoulder degree of freedom during an operation. The artificial hand gripper system requires sensors for a smooth and accurate movement. This allows large movement from the surgeon hand to be corrected on a small scale with a perfect incision and without any vibration. Although such a system available in the market, the utilization of robotic hand particularly in Malaysia for medical application are still very minimum due to its expensive cost. Therefore, in this research we plan to develop a reasonably cheaper home built robotic hand which can perform the task of a hand gripper as a beginning step. The initial objective of this research is to analyze and develop artificial arm with a strength limit proportional to the weight. Next, followed by the attachment of a wireless system on the prosthetic gripper via Radio Frequency (RF) transceiver. The system development involves a Programming Interfacing Circuit (PIC) 16F877 as a core Processing for the instrumentation, communication and controlling applications. A series of flex force sensors are fitted in a leather glove to get reading from the movement of human fingers. Microcontroller will further use this information to control multiple servo that act as a mechanical hand inside the prosthetic gripper.
Sana Salim - One of the best experts on this subject based on the ideXlab platform.
-
artificial hand gripper controller via smart glove for Rehabilitation Process
International Conference on Biomedical Engineering, 2012Co-Authors: A Mohd M Ali, M Abdul M Jamil, Radzi Ambar, A Mohd J Wahi, Sana SalimAbstract:Most parts in this research are dedicated to control of multi finger grippers with emphasis on the finger tips or finger joints. By controlling a multi finger gripper, we enable the gripper to handle an object; in another words, controlling a multi finger gripper can be viewed in terms of controlling an object's pose and the forces between the object and its environment. Hence, an object pose controller with feedback from an object pose sensor suits multi finger gripper control. Also due to the non-linear dynamic system behavior in the joints of most multi finger grippers, an effective, easily-adaptable joint controller is employed. The paper discusses the object pose controller with great detail in a new joint controller. Since the joint controller is based on microcontroller thus, we do not use an exact analytical model for this case.
M Abdul M Jamil - One of the best experts on this subject based on the ideXlab platform.
-
artificial hand gripper controller via smart glove for Rehabilitation Process
International Conference on Biomedical Engineering, 2012Co-Authors: A Mohd M Ali, M Abdul M Jamil, Radzi Ambar, A Mohd J Wahi, Sana SalimAbstract:Most parts in this research are dedicated to control of multi finger grippers with emphasis on the finger tips or finger joints. By controlling a multi finger gripper, we enable the gripper to handle an object; in another words, controlling a multi finger gripper can be viewed in terms of controlling an object's pose and the forces between the object and its environment. Hence, an object pose controller with feedback from an object pose sensor suits multi finger gripper control. Also due to the non-linear dynamic system behavior in the joints of most multi finger grippers, an effective, easily-adaptable joint controller is employed. The paper discusses the object pose controller with great detail in a new joint controller. Since the joint controller is based on microcontroller thus, we do not use an exact analytical model for this case.
-
development of artificial hand gripper for Rehabilitation Process
2011Co-Authors: A Mohd M Ali, M Y Ismail, M Abdul M JamilAbstract:This paper focuses on the development of a robotic hand that imitates the movement of a human hand. The basic movement of the surgeon hand was limited from a wrist, elbow and shoulder degree of freedom during an operation. The artificial hand gripper system requires sensors for a smooth and accurate movement. This allows large movement from the surgeon hand to be corrected on a small scale with a perfect incision and without any vibration. Although such a system available in the market, the utilization of robotic hand particularly in Malaysia for medical application are still very minimum due to its expensive cost. Therefore, in this research we plan to develop a reasonably cheaper home built robotic hand which can perform the task of a hand gripper as a beginning step. The initial objective of this research is to analyze and develop artificial arm with a strength limit proportional to the weight. Next, followed by the attachment of a wireless system on the prosthetic gripper via Radio Frequency (RF) transceiver. The system development involves a Programming Interfacing Circuit (PIC) 16F877 as a core Processing for the instrumentation, communication and controlling applications. A series of flex force sensors are fitted in a leather glove to get reading from the movement of human fingers. Microcontroller will further use this information to control multiple servo that act as a mechanical hand inside the prosthetic gripper.
