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Philipp Wiggermann - One of the best experts on this subject based on the ideXlab platform.
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gd eob dtpa enhanced t1 Relaxometry for assessment of liver function determined by real time 13c methacetin breath test
European Radiology, 2018Co-Authors: M Haimerl, N Verloh, Claudia Fellner, Christian Stroszczynski, Irene Fuhrmann, S Poelsterl, Marcel Dominik Nickel, K Weigand, Marc H Dahlke, Philipp WiggermannAbstract:To determine whether liver function as determined by intravenous administration of 13C-methacetin and continuous real-time breath analysis can be estimated quantitatively from gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) Relaxometry. Sixty-six patients underwent a 13C-methacetin breath test (13C-MBT) for evaluation of liver function and Gd-EOB-DTPA-enhanced T1-Relaxometry at 3 T. A transverse 3D VIBE sequence with an inline T1 calculation based on variable flip angles was acquired prior to (T1 pre) and 20 min post-Gd-EOB-DTPA (T1 post) administration. The reduction rate of T1 relaxation time (rrT1) and T1 relaxation velocity index (∆R1) between pre- and post-contrast images was evaluated. 13C-MBT values were correlated with T1post, ∆R1 and rrT1, providing an MRI-based estimated 13C-MBT value. The interobserver reliability was assessed by determining the intraclass correlation coefficient (ICC). Stratified by three different categories of 13C-MBT readouts, there was a constant increase of T1 post with increasing progression of diminished liver function (p ≤ 0.030) and a constant significant decrease of ∆R1 (p ≤ 0.025) and rrT1 (p 0.88). A simple regression model showed a log-linear correlation of 13C-MBT values with T1post (r = 0.57; p < 0.001), ∆R1 (r = 0.59; p < 0.001) and rrT1 (r = 0.70; p < 0.001). Liver function as determined using real-time 13C-methacetin breath analysis can be estimated quantitatively from Gd-EOB-DTPA-enhanced MR Relaxometry. • Gd-EOB-DTPA-enhanced T1 Relaxometry quantifies liver function • Gd-EOB-DTPA-enhanced MR Relaxometry may provide parameters for assessing liver function before surgery • Gd-EOB-DTPA-enhanced MR Relaxometry may be useful for monitoring liver disease progression • Gd-EOB-DTPA-enhanced MR Relaxometry has the potential to become a novel liver function index
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volume assisted estimation of liver function based on gd eob dtpa enhanced mr Relaxometry
European Radiology, 2016Co-Authors: M Haimerl, Mona Schlabeck, N Verloh, Florian Zeman, Claudia Fellner, Dominik Nickel, Ana Paula Barreiros, Martin Loss, Christian Stroszczynski, Philipp WiggermannAbstract:To determine whether liver function as determined by indocyanine green (ICG) clearance can be estimated quantitatively from hepatic magnetic resonance (MR) Relaxometry with gadoxetic acid (Gd-EOB-DTPA). One hundred and seven patients underwent an ICG clearance test and Gd-EOB-DTPA–enhanced MRI, including MR Relaxometry at 3 Tesla. A transverse 3D VIBE sequence with an inline T1 calculation was acquired prior to and 20 minutes post-Gd-EOB-DTPA administration. The reduction rate of T1 relaxation time (rrT1) between pre- and post-contrast images and the liver volume-assisted index of T1 reduction rate (LVrrT1) were evaluated. The plasma disappearance rate of ICG (ICG-PDR) was correlated with the liver volume (LV), rrT1 and LVrrT1, providing an MRI-based estimated ICG-PDR value (ICG-PDRest). Simple linear regression model showed a significant correlation of ICG-PDR with LV (r = 0.32; p = 0.001), T1post (r = 0.65; p < 0.001) and rrT1 (r = 0.86; p < 0.001). Assessment of LV and consecutive evaluation of multiple linear regression model revealed a stronger correlation of ICG-PDR with LVrrT1 (r = 0.92; p < 0.001), allowing for the calculation of ICG-PDRest. Liver function as determined using ICG-PDR can be estimated quantitatively from Gd-EOB-DTPA–enhanced MR Relaxometry. Volume-assisted MR Relaxometry has a stronger correlation with liver function than does MR Relaxometry. • Measurement of T1 relaxation times in Gd-EOB-DTPA–enhanced MR imaging quantifies liver function. • Volume-assisted Gd-EOB-DTPA–enhanced MR Relaxometry has stronger correlation with ICG-PDR than does Gd-EOB-DTPA–enhanced MR Relaxometry. • Gd-EOB-DTPA–enhanced MR Relaxometry may provide robust parameters for detecting and characterizing liver disease. • Gd-EOB-DTPA–enhanced MR Relaxometry may be useful for monitoring liver disease progression. • Gd-EOB-DTPA–enhanced MR Relaxometry has the potential to become a novel liver function index.
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mri based estimation of liver function gd eob dtpa enhanced t1 Relaxometry of 3t vs the meld score
Scientific Reports, 2015Co-Authors: M Haimerl, N Verloh, Florian Zeman, Claudia Fellner, Christian Stroszczynski, Andreas Teufel, Stefan Fichtnerfeigl, Andreas G Schreyer, Philipp WiggermannAbstract:Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 Relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI Relaxometry was performed before and 20 min after Gd-EOB-DTPA administration. A strong correlation between changes in the T1 Relaxometry and the extent of liver disease, expressed by the MELD score, was documented. Reduced liver function correlates with decreased Gd-EOB-DTPA accumulation in the hepatocytes during the hepatobiliary phase. MRI-based T1 Relaxometry with Gd-EOB-DTPA may be a useful method for assessing overall and segmental liver function.
M Haimerl - One of the best experts on this subject based on the ideXlab platform.
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gd eob dtpa enhanced t1 Relaxometry for assessment of liver function determined by real time 13c methacetin breath test
European Radiology, 2018Co-Authors: M Haimerl, N Verloh, Claudia Fellner, Christian Stroszczynski, Irene Fuhrmann, S Poelsterl, Marcel Dominik Nickel, K Weigand, Marc H Dahlke, Philipp WiggermannAbstract:To determine whether liver function as determined by intravenous administration of 13C-methacetin and continuous real-time breath analysis can be estimated quantitatively from gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) Relaxometry. Sixty-six patients underwent a 13C-methacetin breath test (13C-MBT) for evaluation of liver function and Gd-EOB-DTPA-enhanced T1-Relaxometry at 3 T. A transverse 3D VIBE sequence with an inline T1 calculation based on variable flip angles was acquired prior to (T1 pre) and 20 min post-Gd-EOB-DTPA (T1 post) administration. The reduction rate of T1 relaxation time (rrT1) and T1 relaxation velocity index (∆R1) between pre- and post-contrast images was evaluated. 13C-MBT values were correlated with T1post, ∆R1 and rrT1, providing an MRI-based estimated 13C-MBT value. The interobserver reliability was assessed by determining the intraclass correlation coefficient (ICC). Stratified by three different categories of 13C-MBT readouts, there was a constant increase of T1 post with increasing progression of diminished liver function (p ≤ 0.030) and a constant significant decrease of ∆R1 (p ≤ 0.025) and rrT1 (p 0.88). A simple regression model showed a log-linear correlation of 13C-MBT values with T1post (r = 0.57; p < 0.001), ∆R1 (r = 0.59; p < 0.001) and rrT1 (r = 0.70; p < 0.001). Liver function as determined using real-time 13C-methacetin breath analysis can be estimated quantitatively from Gd-EOB-DTPA-enhanced MR Relaxometry. • Gd-EOB-DTPA-enhanced T1 Relaxometry quantifies liver function • Gd-EOB-DTPA-enhanced MR Relaxometry may provide parameters for assessing liver function before surgery • Gd-EOB-DTPA-enhanced MR Relaxometry may be useful for monitoring liver disease progression • Gd-EOB-DTPA-enhanced MR Relaxometry has the potential to become a novel liver function index
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volume assisted estimation of liver function based on gd eob dtpa enhanced mr Relaxometry
European Radiology, 2016Co-Authors: M Haimerl, Mona Schlabeck, N Verloh, Florian Zeman, Claudia Fellner, Dominik Nickel, Ana Paula Barreiros, Martin Loss, Christian Stroszczynski, Philipp WiggermannAbstract:To determine whether liver function as determined by indocyanine green (ICG) clearance can be estimated quantitatively from hepatic magnetic resonance (MR) Relaxometry with gadoxetic acid (Gd-EOB-DTPA). One hundred and seven patients underwent an ICG clearance test and Gd-EOB-DTPA–enhanced MRI, including MR Relaxometry at 3 Tesla. A transverse 3D VIBE sequence with an inline T1 calculation was acquired prior to and 20 minutes post-Gd-EOB-DTPA administration. The reduction rate of T1 relaxation time (rrT1) between pre- and post-contrast images and the liver volume-assisted index of T1 reduction rate (LVrrT1) were evaluated. The plasma disappearance rate of ICG (ICG-PDR) was correlated with the liver volume (LV), rrT1 and LVrrT1, providing an MRI-based estimated ICG-PDR value (ICG-PDRest). Simple linear regression model showed a significant correlation of ICG-PDR with LV (r = 0.32; p = 0.001), T1post (r = 0.65; p < 0.001) and rrT1 (r = 0.86; p < 0.001). Assessment of LV and consecutive evaluation of multiple linear regression model revealed a stronger correlation of ICG-PDR with LVrrT1 (r = 0.92; p < 0.001), allowing for the calculation of ICG-PDRest. Liver function as determined using ICG-PDR can be estimated quantitatively from Gd-EOB-DTPA–enhanced MR Relaxometry. Volume-assisted MR Relaxometry has a stronger correlation with liver function than does MR Relaxometry. • Measurement of T1 relaxation times in Gd-EOB-DTPA–enhanced MR imaging quantifies liver function. • Volume-assisted Gd-EOB-DTPA–enhanced MR Relaxometry has stronger correlation with ICG-PDR than does Gd-EOB-DTPA–enhanced MR Relaxometry. • Gd-EOB-DTPA–enhanced MR Relaxometry may provide robust parameters for detecting and characterizing liver disease. • Gd-EOB-DTPA–enhanced MR Relaxometry may be useful for monitoring liver disease progression. • Gd-EOB-DTPA–enhanced MR Relaxometry has the potential to become a novel liver function index.
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mri based estimation of liver function gd eob dtpa enhanced t1 Relaxometry of 3t vs the meld score
Scientific Reports, 2015Co-Authors: M Haimerl, N Verloh, Florian Zeman, Claudia Fellner, Christian Stroszczynski, Andreas Teufel, Stefan Fichtnerfeigl, Andreas G Schreyer, Philipp WiggermannAbstract:Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 Relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI Relaxometry was performed before and 20 min after Gd-EOB-DTPA administration. A strong correlation between changes in the T1 Relaxometry and the extent of liver disease, expressed by the MELD score, was documented. Reduced liver function correlates with decreased Gd-EOB-DTPA accumulation in the hepatocytes during the hepatobiliary phase. MRI-based T1 Relaxometry with Gd-EOB-DTPA may be a useful method for assessing overall and segmental liver function.
Christian Stroszczynski - One of the best experts on this subject based on the ideXlab platform.
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gd eob dtpa enhanced t1 Relaxometry for assessment of liver function determined by real time 13c methacetin breath test
European Radiology, 2018Co-Authors: M Haimerl, N Verloh, Claudia Fellner, Christian Stroszczynski, Irene Fuhrmann, S Poelsterl, Marcel Dominik Nickel, K Weigand, Marc H Dahlke, Philipp WiggermannAbstract:To determine whether liver function as determined by intravenous administration of 13C-methacetin and continuous real-time breath analysis can be estimated quantitatively from gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) Relaxometry. Sixty-six patients underwent a 13C-methacetin breath test (13C-MBT) for evaluation of liver function and Gd-EOB-DTPA-enhanced T1-Relaxometry at 3 T. A transverse 3D VIBE sequence with an inline T1 calculation based on variable flip angles was acquired prior to (T1 pre) and 20 min post-Gd-EOB-DTPA (T1 post) administration. The reduction rate of T1 relaxation time (rrT1) and T1 relaxation velocity index (∆R1) between pre- and post-contrast images was evaluated. 13C-MBT values were correlated with T1post, ∆R1 and rrT1, providing an MRI-based estimated 13C-MBT value. The interobserver reliability was assessed by determining the intraclass correlation coefficient (ICC). Stratified by three different categories of 13C-MBT readouts, there was a constant increase of T1 post with increasing progression of diminished liver function (p ≤ 0.030) and a constant significant decrease of ∆R1 (p ≤ 0.025) and rrT1 (p 0.88). A simple regression model showed a log-linear correlation of 13C-MBT values with T1post (r = 0.57; p < 0.001), ∆R1 (r = 0.59; p < 0.001) and rrT1 (r = 0.70; p < 0.001). Liver function as determined using real-time 13C-methacetin breath analysis can be estimated quantitatively from Gd-EOB-DTPA-enhanced MR Relaxometry. • Gd-EOB-DTPA-enhanced T1 Relaxometry quantifies liver function • Gd-EOB-DTPA-enhanced MR Relaxometry may provide parameters for assessing liver function before surgery • Gd-EOB-DTPA-enhanced MR Relaxometry may be useful for monitoring liver disease progression • Gd-EOB-DTPA-enhanced MR Relaxometry has the potential to become a novel liver function index
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volume assisted estimation of liver function based on gd eob dtpa enhanced mr Relaxometry
European Radiology, 2016Co-Authors: M Haimerl, Mona Schlabeck, N Verloh, Florian Zeman, Claudia Fellner, Dominik Nickel, Ana Paula Barreiros, Martin Loss, Christian Stroszczynski, Philipp WiggermannAbstract:To determine whether liver function as determined by indocyanine green (ICG) clearance can be estimated quantitatively from hepatic magnetic resonance (MR) Relaxometry with gadoxetic acid (Gd-EOB-DTPA). One hundred and seven patients underwent an ICG clearance test and Gd-EOB-DTPA–enhanced MRI, including MR Relaxometry at 3 Tesla. A transverse 3D VIBE sequence with an inline T1 calculation was acquired prior to and 20 minutes post-Gd-EOB-DTPA administration. The reduction rate of T1 relaxation time (rrT1) between pre- and post-contrast images and the liver volume-assisted index of T1 reduction rate (LVrrT1) were evaluated. The plasma disappearance rate of ICG (ICG-PDR) was correlated with the liver volume (LV), rrT1 and LVrrT1, providing an MRI-based estimated ICG-PDR value (ICG-PDRest). Simple linear regression model showed a significant correlation of ICG-PDR with LV (r = 0.32; p = 0.001), T1post (r = 0.65; p < 0.001) and rrT1 (r = 0.86; p < 0.001). Assessment of LV and consecutive evaluation of multiple linear regression model revealed a stronger correlation of ICG-PDR with LVrrT1 (r = 0.92; p < 0.001), allowing for the calculation of ICG-PDRest. Liver function as determined using ICG-PDR can be estimated quantitatively from Gd-EOB-DTPA–enhanced MR Relaxometry. Volume-assisted MR Relaxometry has a stronger correlation with liver function than does MR Relaxometry. • Measurement of T1 relaxation times in Gd-EOB-DTPA–enhanced MR imaging quantifies liver function. • Volume-assisted Gd-EOB-DTPA–enhanced MR Relaxometry has stronger correlation with ICG-PDR than does Gd-EOB-DTPA–enhanced MR Relaxometry. • Gd-EOB-DTPA–enhanced MR Relaxometry may provide robust parameters for detecting and characterizing liver disease. • Gd-EOB-DTPA–enhanced MR Relaxometry may be useful for monitoring liver disease progression. • Gd-EOB-DTPA–enhanced MR Relaxometry has the potential to become a novel liver function index.
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mri based estimation of liver function gd eob dtpa enhanced t1 Relaxometry of 3t vs the meld score
Scientific Reports, 2015Co-Authors: M Haimerl, N Verloh, Florian Zeman, Claudia Fellner, Christian Stroszczynski, Andreas Teufel, Stefan Fichtnerfeigl, Andreas G Schreyer, Philipp WiggermannAbstract:Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 Relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI Relaxometry was performed before and 20 min after Gd-EOB-DTPA administration. A strong correlation between changes in the T1 Relaxometry and the extent of liver disease, expressed by the MELD score, was documented. Reduced liver function correlates with decreased Gd-EOB-DTPA accumulation in the hepatocytes during the hepatobiliary phase. MRI-based T1 Relaxometry with Gd-EOB-DTPA may be a useful method for assessing overall and segmental liver function.
Claudia Fellner - One of the best experts on this subject based on the ideXlab platform.
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gd eob dtpa enhanced t1 Relaxometry for assessment of liver function determined by real time 13c methacetin breath test
European Radiology, 2018Co-Authors: M Haimerl, N Verloh, Claudia Fellner, Christian Stroszczynski, Irene Fuhrmann, S Poelsterl, Marcel Dominik Nickel, K Weigand, Marc H Dahlke, Philipp WiggermannAbstract:To determine whether liver function as determined by intravenous administration of 13C-methacetin and continuous real-time breath analysis can be estimated quantitatively from gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) Relaxometry. Sixty-six patients underwent a 13C-methacetin breath test (13C-MBT) for evaluation of liver function and Gd-EOB-DTPA-enhanced T1-Relaxometry at 3 T. A transverse 3D VIBE sequence with an inline T1 calculation based on variable flip angles was acquired prior to (T1 pre) and 20 min post-Gd-EOB-DTPA (T1 post) administration. The reduction rate of T1 relaxation time (rrT1) and T1 relaxation velocity index (∆R1) between pre- and post-contrast images was evaluated. 13C-MBT values were correlated with T1post, ∆R1 and rrT1, providing an MRI-based estimated 13C-MBT value. The interobserver reliability was assessed by determining the intraclass correlation coefficient (ICC). Stratified by three different categories of 13C-MBT readouts, there was a constant increase of T1 post with increasing progression of diminished liver function (p ≤ 0.030) and a constant significant decrease of ∆R1 (p ≤ 0.025) and rrT1 (p 0.88). A simple regression model showed a log-linear correlation of 13C-MBT values with T1post (r = 0.57; p < 0.001), ∆R1 (r = 0.59; p < 0.001) and rrT1 (r = 0.70; p < 0.001). Liver function as determined using real-time 13C-methacetin breath analysis can be estimated quantitatively from Gd-EOB-DTPA-enhanced MR Relaxometry. • Gd-EOB-DTPA-enhanced T1 Relaxometry quantifies liver function • Gd-EOB-DTPA-enhanced MR Relaxometry may provide parameters for assessing liver function before surgery • Gd-EOB-DTPA-enhanced MR Relaxometry may be useful for monitoring liver disease progression • Gd-EOB-DTPA-enhanced MR Relaxometry has the potential to become a novel liver function index
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volume assisted estimation of liver function based on gd eob dtpa enhanced mr Relaxometry
European Radiology, 2016Co-Authors: M Haimerl, Mona Schlabeck, N Verloh, Florian Zeman, Claudia Fellner, Dominik Nickel, Ana Paula Barreiros, Martin Loss, Christian Stroszczynski, Philipp WiggermannAbstract:To determine whether liver function as determined by indocyanine green (ICG) clearance can be estimated quantitatively from hepatic magnetic resonance (MR) Relaxometry with gadoxetic acid (Gd-EOB-DTPA). One hundred and seven patients underwent an ICG clearance test and Gd-EOB-DTPA–enhanced MRI, including MR Relaxometry at 3 Tesla. A transverse 3D VIBE sequence with an inline T1 calculation was acquired prior to and 20 minutes post-Gd-EOB-DTPA administration. The reduction rate of T1 relaxation time (rrT1) between pre- and post-contrast images and the liver volume-assisted index of T1 reduction rate (LVrrT1) were evaluated. The plasma disappearance rate of ICG (ICG-PDR) was correlated with the liver volume (LV), rrT1 and LVrrT1, providing an MRI-based estimated ICG-PDR value (ICG-PDRest). Simple linear regression model showed a significant correlation of ICG-PDR with LV (r = 0.32; p = 0.001), T1post (r = 0.65; p < 0.001) and rrT1 (r = 0.86; p < 0.001). Assessment of LV and consecutive evaluation of multiple linear regression model revealed a stronger correlation of ICG-PDR with LVrrT1 (r = 0.92; p < 0.001), allowing for the calculation of ICG-PDRest. Liver function as determined using ICG-PDR can be estimated quantitatively from Gd-EOB-DTPA–enhanced MR Relaxometry. Volume-assisted MR Relaxometry has a stronger correlation with liver function than does MR Relaxometry. • Measurement of T1 relaxation times in Gd-EOB-DTPA–enhanced MR imaging quantifies liver function. • Volume-assisted Gd-EOB-DTPA–enhanced MR Relaxometry has stronger correlation with ICG-PDR than does Gd-EOB-DTPA–enhanced MR Relaxometry. • Gd-EOB-DTPA–enhanced MR Relaxometry may provide robust parameters for detecting and characterizing liver disease. • Gd-EOB-DTPA–enhanced MR Relaxometry may be useful for monitoring liver disease progression. • Gd-EOB-DTPA–enhanced MR Relaxometry has the potential to become a novel liver function index.
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mri based estimation of liver function gd eob dtpa enhanced t1 Relaxometry of 3t vs the meld score
Scientific Reports, 2015Co-Authors: M Haimerl, N Verloh, Florian Zeman, Claudia Fellner, Christian Stroszczynski, Andreas Teufel, Stefan Fichtnerfeigl, Andreas G Schreyer, Philipp WiggermannAbstract:Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 Relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI Relaxometry was performed before and 20 min after Gd-EOB-DTPA administration. A strong correlation between changes in the T1 Relaxometry and the extent of liver disease, expressed by the MELD score, was documented. Reduced liver function correlates with decreased Gd-EOB-DTPA accumulation in the hepatocytes during the hepatobiliary phase. MRI-based T1 Relaxometry with Gd-EOB-DTPA may be a useful method for assessing overall and segmental liver function.
N Verloh - One of the best experts on this subject based on the ideXlab platform.
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gd eob dtpa enhanced t1 Relaxometry for assessment of liver function determined by real time 13c methacetin breath test
European Radiology, 2018Co-Authors: M Haimerl, N Verloh, Claudia Fellner, Christian Stroszczynski, Irene Fuhrmann, S Poelsterl, Marcel Dominik Nickel, K Weigand, Marc H Dahlke, Philipp WiggermannAbstract:To determine whether liver function as determined by intravenous administration of 13C-methacetin and continuous real-time breath analysis can be estimated quantitatively from gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) Relaxometry. Sixty-six patients underwent a 13C-methacetin breath test (13C-MBT) for evaluation of liver function and Gd-EOB-DTPA-enhanced T1-Relaxometry at 3 T. A transverse 3D VIBE sequence with an inline T1 calculation based on variable flip angles was acquired prior to (T1 pre) and 20 min post-Gd-EOB-DTPA (T1 post) administration. The reduction rate of T1 relaxation time (rrT1) and T1 relaxation velocity index (∆R1) between pre- and post-contrast images was evaluated. 13C-MBT values were correlated with T1post, ∆R1 and rrT1, providing an MRI-based estimated 13C-MBT value. The interobserver reliability was assessed by determining the intraclass correlation coefficient (ICC). Stratified by three different categories of 13C-MBT readouts, there was a constant increase of T1 post with increasing progression of diminished liver function (p ≤ 0.030) and a constant significant decrease of ∆R1 (p ≤ 0.025) and rrT1 (p 0.88). A simple regression model showed a log-linear correlation of 13C-MBT values with T1post (r = 0.57; p < 0.001), ∆R1 (r = 0.59; p < 0.001) and rrT1 (r = 0.70; p < 0.001). Liver function as determined using real-time 13C-methacetin breath analysis can be estimated quantitatively from Gd-EOB-DTPA-enhanced MR Relaxometry. • Gd-EOB-DTPA-enhanced T1 Relaxometry quantifies liver function • Gd-EOB-DTPA-enhanced MR Relaxometry may provide parameters for assessing liver function before surgery • Gd-EOB-DTPA-enhanced MR Relaxometry may be useful for monitoring liver disease progression • Gd-EOB-DTPA-enhanced MR Relaxometry has the potential to become a novel liver function index
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volume assisted estimation of liver function based on gd eob dtpa enhanced mr Relaxometry
European Radiology, 2016Co-Authors: M Haimerl, Mona Schlabeck, N Verloh, Florian Zeman, Claudia Fellner, Dominik Nickel, Ana Paula Barreiros, Martin Loss, Christian Stroszczynski, Philipp WiggermannAbstract:To determine whether liver function as determined by indocyanine green (ICG) clearance can be estimated quantitatively from hepatic magnetic resonance (MR) Relaxometry with gadoxetic acid (Gd-EOB-DTPA). One hundred and seven patients underwent an ICG clearance test and Gd-EOB-DTPA–enhanced MRI, including MR Relaxometry at 3 Tesla. A transverse 3D VIBE sequence with an inline T1 calculation was acquired prior to and 20 minutes post-Gd-EOB-DTPA administration. The reduction rate of T1 relaxation time (rrT1) between pre- and post-contrast images and the liver volume-assisted index of T1 reduction rate (LVrrT1) were evaluated. The plasma disappearance rate of ICG (ICG-PDR) was correlated with the liver volume (LV), rrT1 and LVrrT1, providing an MRI-based estimated ICG-PDR value (ICG-PDRest). Simple linear regression model showed a significant correlation of ICG-PDR with LV (r = 0.32; p = 0.001), T1post (r = 0.65; p < 0.001) and rrT1 (r = 0.86; p < 0.001). Assessment of LV and consecutive evaluation of multiple linear regression model revealed a stronger correlation of ICG-PDR with LVrrT1 (r = 0.92; p < 0.001), allowing for the calculation of ICG-PDRest. Liver function as determined using ICG-PDR can be estimated quantitatively from Gd-EOB-DTPA–enhanced MR Relaxometry. Volume-assisted MR Relaxometry has a stronger correlation with liver function than does MR Relaxometry. • Measurement of T1 relaxation times in Gd-EOB-DTPA–enhanced MR imaging quantifies liver function. • Volume-assisted Gd-EOB-DTPA–enhanced MR Relaxometry has stronger correlation with ICG-PDR than does Gd-EOB-DTPA–enhanced MR Relaxometry. • Gd-EOB-DTPA–enhanced MR Relaxometry may provide robust parameters for detecting and characterizing liver disease. • Gd-EOB-DTPA–enhanced MR Relaxometry may be useful for monitoring liver disease progression. • Gd-EOB-DTPA–enhanced MR Relaxometry has the potential to become a novel liver function index.
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mri based estimation of liver function gd eob dtpa enhanced t1 Relaxometry of 3t vs the meld score
Scientific Reports, 2015Co-Authors: M Haimerl, N Verloh, Florian Zeman, Claudia Fellner, Christian Stroszczynski, Andreas Teufel, Stefan Fichtnerfeigl, Andreas G Schreyer, Philipp WiggermannAbstract:Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 Relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI Relaxometry was performed before and 20 min after Gd-EOB-DTPA administration. A strong correlation between changes in the T1 Relaxometry and the extent of liver disease, expressed by the MELD score, was documented. Reduced liver function correlates with decreased Gd-EOB-DTPA accumulation in the hepatocytes during the hepatobiliary phase. MRI-based T1 Relaxometry with Gd-EOB-DTPA may be a useful method for assessing overall and segmental liver function.
