The Experts below are selected from a list of 216 Experts worldwide ranked by ideXlab platform
Donald G. Stein - One of the best experts on this subject based on the ideXlab platform.
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Estrogen and progesterone as neuroprotective agents in the treatment of acute brain injuries
Pediatric Rehabilitation, 2003Co-Authors: Donald G. Stein, Stuart W. HoffmanAbstract:Estrogen and progesterone are often thought of as steroid hormones that strongly influence reproductive and maternal behaviours. However, the steroids are now showing considerable promise as neuroprotective and neuroregenerative agents in stroke and traumatic brain injuries. Collectively, these two hormones have been reported to reduce the consequences of the injury cascade by enhancing anti-oxidant mechanisms, reducing excitotoxicity: altering glutamate receptor activity, reducing immune inflammation, providing neurotrophic support, stimulating axonal Remyelinization and enhancing synaptogenesis and dendritic arborization. Estrogen has often been tried as a prophylactic treatment in females for ischemic brain injury, while progesterone has, thus far, been given as a post-injury treatment for both male and female subjects with acute, ischemic and traumatic injuries of the brain and spinal cord. This review compares and evaluates estrogen and progesterone as neuroactive agents in the acute treatment of brain damage caused by stroke and trauma.
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Brain damage, sex hormones and recovery: a new role for progesterone and estrogen?
Trends in neurosciences, 2001Co-Authors: Donald G. SteinAbstract:Estrogen and progesterone, long considered for their roles as primary hormones in reproductive and maternal behavior, are now being studied as neuroprotective and neuroregenerative agents in stroke and traumatic brain injuries. Collectively, the hormones reduce the consequences of the injury cascade by enhancing anti-oxidant mechanisms, reducing excitotoxicity (altering glutamate receptor activity, reducing immune inflammation, providing neurotrophic support, stimulating axonal Remyelinization), and enhancing synaptogenesis and dendritic arborization. Estrogen seems more effective as a prophylactic treatment in females at risk for cardiac and ischemic brain injury, whereas progesterone appears to be more helpful in the post-injury treatment of both male and female subjects with acute traumatic brain damage. However, a recent clinical trial with estradiol replacement therapy in elderly women that have a history of cerebrovascular disease, showed that this hormone was unable to protect against reoccurrence of ischemia or to reduce the incidence of mortality compared to a placebo.
Eva Syková - One of the best experts on this subject based on the ideXlab platform.
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Current developments in cell- and biomaterial-based approaches for stroke repair.
Expert Opinion on Biological Therapy, 2015Co-Authors: Pavla Jendelova, Slaven Erceg, Axel Sandvig, Sarka Kubinova, Ioanna Sandvig, Eva SykováAbstract:Introduction: Stroke is one of the most devastating diseases and a leading cause of mortality worldwide. So far, clinical management of stroke involves surgical clot retrieval or thrombolytic treatment inducing reperfusion of the occluded vessels in the cerebral infarcted area, which is dependent on early intervention following insult. New treatment strategies involve the promotion of angiogenesis and neuroplasticity, stimulation of endogenous neurogenesis, Remyelinization, and immunomodulation by means of cell transplantation and sustained drug delivery.Areas covered: This review describes different types of stem cells (endogenous and exogenous neural progenitors, pluripotent stem cell derivatives, mesenchymal stem cells [MSCs], olfactory ensheathing cells) and biomaterials, their routes of administration, means of noninvasive imaging, and the prerequisites and hurdles for the successful translation of the cell therapies to the clinic.Expert opinion: Neural precursors (NPs) derived from pluripotent stem ...
Darina Kluchová - One of the best experts on this subject based on the ideXlab platform.
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Chemokines as Possible Targets in Modulation of the Secondary Damage After Acute Spinal Cord Injury: A Review
Cellular and Molecular Neurobiology, 2009Co-Authors: Peter Gál, Petra Kravčuková, Michal Mokrý, Darina KluchováAbstract:In spite of many promising experimental studies, an effective treatment dramatically eliminating the secondary damage after spinal cord injury (SCI) is still missing. Since clinical data on the therapeutical effect after methylprednisolone treatment are not conclusive, new therapeutical modalities targeting specific components of secondary spinal cord damage needs to be developed. It is known that immune cells are recruited to injury sites by chemokines, which are small, structurally similar proteins released locally at the site of inflammation. Hence, this review was aimed to summarize possible roles of chemokines in the inflammation following SCI as well as to identify possible new therapeutical targets which can potentially be effective in ameliorating individual components of this inflammatory response. Data concerning inflammation reduction together with techniques improving axonal growth, cell replacement and Remyelinization, may be crucial to move a small step forward in an attempt to make paraplegic and quadriplegic patients to walk.
Stuart W. Hoffman - One of the best experts on this subject based on the ideXlab platform.
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Estrogen and progesterone as neuroprotective agents in the treatment of acute brain injuries
Pediatric Rehabilitation, 2003Co-Authors: Donald G. Stein, Stuart W. HoffmanAbstract:Estrogen and progesterone are often thought of as steroid hormones that strongly influence reproductive and maternal behaviours. However, the steroids are now showing considerable promise as neuroprotective and neuroregenerative agents in stroke and traumatic brain injuries. Collectively, these two hormones have been reported to reduce the consequences of the injury cascade by enhancing anti-oxidant mechanisms, reducing excitotoxicity: altering glutamate receptor activity, reducing immune inflammation, providing neurotrophic support, stimulating axonal Remyelinization and enhancing synaptogenesis and dendritic arborization. Estrogen has often been tried as a prophylactic treatment in females for ischemic brain injury, while progesterone has, thus far, been given as a post-injury treatment for both male and female subjects with acute, ischemic and traumatic injuries of the brain and spinal cord. This review compares and evaluates estrogen and progesterone as neuroactive agents in the acute treatment of brain damage caused by stroke and trauma.
Pavla Jendelova - One of the best experts on this subject based on the ideXlab platform.
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Current developments in cell- and biomaterial-based approaches for stroke repair.
Expert Opinion on Biological Therapy, 2015Co-Authors: Pavla Jendelova, Slaven Erceg, Axel Sandvig, Sarka Kubinova, Ioanna Sandvig, Eva SykováAbstract:Introduction: Stroke is one of the most devastating diseases and a leading cause of mortality worldwide. So far, clinical management of stroke involves surgical clot retrieval or thrombolytic treatment inducing reperfusion of the occluded vessels in the cerebral infarcted area, which is dependent on early intervention following insult. New treatment strategies involve the promotion of angiogenesis and neuroplasticity, stimulation of endogenous neurogenesis, Remyelinization, and immunomodulation by means of cell transplantation and sustained drug delivery.Areas covered: This review describes different types of stem cells (endogenous and exogenous neural progenitors, pluripotent stem cell derivatives, mesenchymal stem cells [MSCs], olfactory ensheathing cells) and biomaterials, their routes of administration, means of noninvasive imaging, and the prerequisites and hurdles for the successful translation of the cell therapies to the clinic.Expert opinion: Neural precursors (NPs) derived from pluripotent stem ...