The Experts below are selected from a list of 252 Experts worldwide ranked by ideXlab platform
Kim L. Mcbride - One of the best experts on this subject based on the ideXlab platform.
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Renal anomalies in family members of infants with bilateral Renal Agenesis adysplasia
Pediatric Nephrology, 2007Co-Authors: Andrew L. Schwaderer, Carlton M. Bates, Kirk M. Mchugh, Kim L. McbrideAbstract:Renal Agenesis/adysplasia is the leading etiology of end stage Renal disease in children. The etiology for Renal Agenesis/adysplasia has not been identified. The purpose of the present study was to determine if Renal Agenesis/adysplasia occur in a familial pattern. Twenty seven cases of bilateral Renal Agenesis/adysplasia were identified by review of autopsy records, and four were excluded. A male excess of 2.8:1 was noted with a mean gestation of 35 weeks. Prenatal and family histories were obtained on 11/23 families. Potential embryologic stressors were identified in 8/11 pregnancies. Thirty-four 1st and 2nd degree relatives from five families participated in a Renal ultrasound exam. An increased prevalence of congenital Renal anomalies was identified in the relatives of index patients with bilateral Renal Agenesis/adysplasia (14.7%) compared to controls (2.2%), with a recurrence risk of 6.2 for 1st degree relatives. The most frequently identified Renal anomalies in the family members were solitary kidneys and duplicated collecting systems. The increased prevalence of a range of Renal anomalies within affected families raises the possibility that isolated Renal malformations result from unidentified gene-environment interactions.
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Renal anomalies in family members of infants with bilateral Renal Agenesis/adysplasia.
Pediatric nephrology (Berlin Germany), 2006Co-Authors: Andrew L. Schwaderer, Carlton M. Bates, Kirk M. Mchugh, Kim L. McbrideAbstract:Renal Agenesis/adysplasia is the leading etiology of end stage Renal disease in children. The etiology for Renal Agenesis/adysplasia has not been identified. The purpose of the present study was to determine if Renal Agenesis/adysplasia occur in a familial pattern. Twenty seven cases of bilateral Renal Agenesis/adysplasia were identified by review of autopsy records, and four were excluded. A male excess of 2.8:1 was noted with a mean gestation of 35 weeks. Prenatal and family histories were obtained on 11/23 families. Potential embryologic stressors were identified in 8/11 pregnancies. Thirty-four 1st and 2nd degree relatives from five families participated in a Renal ultrasound exam. An increased prevalence of congenital Renal anomalies was identified in the relatives of index patients with bilateral Renal Agenesis/adysplasia (14.7%) compared to controls (2.2%), with a recurrence risk of 6.2 for 1st degree relatives. The most frequently identified Renal anomalies in the family members were solitary kidneys and duplicated collecting systems. The increased prevalence of a range of Renal anomalies within affected families raises the possibility that isolated Renal malformations result from unidentified gene-environment interactions.
Peter H Langlois - One of the best experts on this subject based on the ideXlab platform.
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Maternal diabetes and Renal Agenesis/dysgenesis†‡
Birth Defects Research Part A-clinical and Molecular Teratology, 2010Co-Authors: Erin M. Davis, Robert A. Wild, David M Thompson, Jennifer D. Peck, Peter H LangloisAbstract:BACKGROUND: Renal Agenesis and dysgenesis are potentially lethal congenital malformations affecting 2 to 5 infants per 10,000 live births annually in the United States. The low prevalence of these malformations has complicated understanding of potential risk factors. Maternal diabetes (type 1, type 2, and gestational) has been evaluated extensively as a risk factor for other congenital malformations, but only a limited number of studies have assessed the association between diabetes and Renal Agenesis. METHODS: We conducted a population-based case-control study of deliveries after 20 weeks gestation in Texas Health Service Region 6 (Houston/Galveston area) from January 1, 2000 to December 31, 2002. Cases of Renal Agenesis/dysgenesis (n = 89) were ascertained from the Texas Birth Defects Registry. Cumulative incidence sampling was used to randomly select, from birth and fetal death records, 356 controls frequency matched to cases by delivery year and vital status. Maternal diabetes and other covariates were collected from vital records. RESULTS: The odds of Renal Agenesis/dysgenesis were 3.1 (95% confidence interval [CI], 1.1–9.3) times greater among deliveries of mothers with diabetes compared to deliveries of mothers without diabetes, controlling for matching factors. CONCLUSIONS: Our results are consistent with prior, but limited, research identifying diabetes as a risk factor for Renal Agenesis/dysgenesis. While these data did not differentiate diabetes diagnoses by type, the results suggest that maternal diabetes may be associated with Renal malformations. Further study is warranted. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc.
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maternal diabetes and Renal Agenesis dysgenesis
Birth Defects Research Part A-clinical and Molecular Teratology, 2010Co-Authors: Erin M. Davis, Robert A. Wild, David M Thompson, Jennifer D. Peck, Peter H LangloisAbstract:BACKGROUND: Renal Agenesis and dysgenesis are potentially lethal congenital malformations affecting 2 to 5 infants per 10,000 live births annually in the United States. The low prevalence of these malformations has complicated understanding of potential risk factors. Maternal diabetes (type 1, type 2, and gestational) has been evaluated extensively as a risk factor for other congenital malformations, but only a limited number of studies have assessed the association between diabetes and Renal Agenesis. METHODS: We conducted a population-based case-control study of deliveries after 20 weeks gestation in Texas Health Service Region 6 (Houston/Galveston area) from January 1, 2000 to December 31, 2002. Cases of Renal Agenesis/dysgenesis (n = 89) were ascertained from the Texas Birth Defects Registry. Cumulative incidence sampling was used to randomly select, from birth and fetal death records, 356 controls frequency matched to cases by delivery year and vital status. Maternal diabetes and other covariates were collected from vital records. RESULTS: The odds of Renal Agenesis/dysgenesis were 3.1 (95% confidence interval [CI], 1.1–9.3) times greater among deliveries of mothers with diabetes compared to deliveries of mothers without diabetes, controlling for matching factors. CONCLUSIONS: Our results are consistent with prior, but limited, research identifying diabetes as a risk factor for Renal Agenesis/dysgenesis. While these data did not differentiate diabetes diagnoses by type, the results suggest that maternal diabetes may be associated with Renal malformations. Further study is warranted. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc.
Erin M. Davis - One of the best experts on this subject based on the ideXlab platform.
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Maternal diabetes and Renal Agenesis/dysgenesis†‡
Birth Defects Research Part A-clinical and Molecular Teratology, 2010Co-Authors: Erin M. Davis, Robert A. Wild, David M Thompson, Jennifer D. Peck, Peter H LangloisAbstract:BACKGROUND: Renal Agenesis and dysgenesis are potentially lethal congenital malformations affecting 2 to 5 infants per 10,000 live births annually in the United States. The low prevalence of these malformations has complicated understanding of potential risk factors. Maternal diabetes (type 1, type 2, and gestational) has been evaluated extensively as a risk factor for other congenital malformations, but only a limited number of studies have assessed the association between diabetes and Renal Agenesis. METHODS: We conducted a population-based case-control study of deliveries after 20 weeks gestation in Texas Health Service Region 6 (Houston/Galveston area) from January 1, 2000 to December 31, 2002. Cases of Renal Agenesis/dysgenesis (n = 89) were ascertained from the Texas Birth Defects Registry. Cumulative incidence sampling was used to randomly select, from birth and fetal death records, 356 controls frequency matched to cases by delivery year and vital status. Maternal diabetes and other covariates were collected from vital records. RESULTS: The odds of Renal Agenesis/dysgenesis were 3.1 (95% confidence interval [CI], 1.1–9.3) times greater among deliveries of mothers with diabetes compared to deliveries of mothers without diabetes, controlling for matching factors. CONCLUSIONS: Our results are consistent with prior, but limited, research identifying diabetes as a risk factor for Renal Agenesis/dysgenesis. While these data did not differentiate diabetes diagnoses by type, the results suggest that maternal diabetes may be associated with Renal malformations. Further study is warranted. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc.
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maternal diabetes and Renal Agenesis dysgenesis
Birth Defects Research Part A-clinical and Molecular Teratology, 2010Co-Authors: Erin M. Davis, Robert A. Wild, David M Thompson, Jennifer D. Peck, Peter H LangloisAbstract:BACKGROUND: Renal Agenesis and dysgenesis are potentially lethal congenital malformations affecting 2 to 5 infants per 10,000 live births annually in the United States. The low prevalence of these malformations has complicated understanding of potential risk factors. Maternal diabetes (type 1, type 2, and gestational) has been evaluated extensively as a risk factor for other congenital malformations, but only a limited number of studies have assessed the association between diabetes and Renal Agenesis. METHODS: We conducted a population-based case-control study of deliveries after 20 weeks gestation in Texas Health Service Region 6 (Houston/Galveston area) from January 1, 2000 to December 31, 2002. Cases of Renal Agenesis/dysgenesis (n = 89) were ascertained from the Texas Birth Defects Registry. Cumulative incidence sampling was used to randomly select, from birth and fetal death records, 356 controls frequency matched to cases by delivery year and vital status. Maternal diabetes and other covariates were collected from vital records. RESULTS: The odds of Renal Agenesis/dysgenesis were 3.1 (95% confidence interval [CI], 1.1–9.3) times greater among deliveries of mothers with diabetes compared to deliveries of mothers without diabetes, controlling for matching factors. CONCLUSIONS: Our results are consistent with prior, but limited, research identifying diabetes as a risk factor for Renal Agenesis/dysgenesis. While these data did not differentiate diabetes diagnoses by type, the results suggest that maternal diabetes may be associated with Renal malformations. Further study is warranted. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc.
Robert A. Wild - One of the best experts on this subject based on the ideXlab platform.
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Maternal diabetes and Renal Agenesis/dysgenesis†‡
Birth Defects Research Part A-clinical and Molecular Teratology, 2010Co-Authors: Erin M. Davis, Robert A. Wild, David M Thompson, Jennifer D. Peck, Peter H LangloisAbstract:BACKGROUND: Renal Agenesis and dysgenesis are potentially lethal congenital malformations affecting 2 to 5 infants per 10,000 live births annually in the United States. The low prevalence of these malformations has complicated understanding of potential risk factors. Maternal diabetes (type 1, type 2, and gestational) has been evaluated extensively as a risk factor for other congenital malformations, but only a limited number of studies have assessed the association between diabetes and Renal Agenesis. METHODS: We conducted a population-based case-control study of deliveries after 20 weeks gestation in Texas Health Service Region 6 (Houston/Galveston area) from January 1, 2000 to December 31, 2002. Cases of Renal Agenesis/dysgenesis (n = 89) were ascertained from the Texas Birth Defects Registry. Cumulative incidence sampling was used to randomly select, from birth and fetal death records, 356 controls frequency matched to cases by delivery year and vital status. Maternal diabetes and other covariates were collected from vital records. RESULTS: The odds of Renal Agenesis/dysgenesis were 3.1 (95% confidence interval [CI], 1.1–9.3) times greater among deliveries of mothers with diabetes compared to deliveries of mothers without diabetes, controlling for matching factors. CONCLUSIONS: Our results are consistent with prior, but limited, research identifying diabetes as a risk factor for Renal Agenesis/dysgenesis. While these data did not differentiate diabetes diagnoses by type, the results suggest that maternal diabetes may be associated with Renal malformations. Further study is warranted. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc.
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maternal diabetes and Renal Agenesis dysgenesis
Birth Defects Research Part A-clinical and Molecular Teratology, 2010Co-Authors: Erin M. Davis, Robert A. Wild, David M Thompson, Jennifer D. Peck, Peter H LangloisAbstract:BACKGROUND: Renal Agenesis and dysgenesis are potentially lethal congenital malformations affecting 2 to 5 infants per 10,000 live births annually in the United States. The low prevalence of these malformations has complicated understanding of potential risk factors. Maternal diabetes (type 1, type 2, and gestational) has been evaluated extensively as a risk factor for other congenital malformations, but only a limited number of studies have assessed the association between diabetes and Renal Agenesis. METHODS: We conducted a population-based case-control study of deliveries after 20 weeks gestation in Texas Health Service Region 6 (Houston/Galveston area) from January 1, 2000 to December 31, 2002. Cases of Renal Agenesis/dysgenesis (n = 89) were ascertained from the Texas Birth Defects Registry. Cumulative incidence sampling was used to randomly select, from birth and fetal death records, 356 controls frequency matched to cases by delivery year and vital status. Maternal diabetes and other covariates were collected from vital records. RESULTS: The odds of Renal Agenesis/dysgenesis were 3.1 (95% confidence interval [CI], 1.1–9.3) times greater among deliveries of mothers with diabetes compared to deliveries of mothers without diabetes, controlling for matching factors. CONCLUSIONS: Our results are consistent with prior, but limited, research identifying diabetes as a risk factor for Renal Agenesis/dysgenesis. While these data did not differentiate diabetes diagnoses by type, the results suggest that maternal diabetes may be associated with Renal malformations. Further study is warranted. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc.
Jennifer D. Peck - One of the best experts on this subject based on the ideXlab platform.
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Maternal diabetes and Renal Agenesis/dysgenesis†‡
Birth Defects Research Part A-clinical and Molecular Teratology, 2010Co-Authors: Erin M. Davis, Robert A. Wild, David M Thompson, Jennifer D. Peck, Peter H LangloisAbstract:BACKGROUND: Renal Agenesis and dysgenesis are potentially lethal congenital malformations affecting 2 to 5 infants per 10,000 live births annually in the United States. The low prevalence of these malformations has complicated understanding of potential risk factors. Maternal diabetes (type 1, type 2, and gestational) has been evaluated extensively as a risk factor for other congenital malformations, but only a limited number of studies have assessed the association between diabetes and Renal Agenesis. METHODS: We conducted a population-based case-control study of deliveries after 20 weeks gestation in Texas Health Service Region 6 (Houston/Galveston area) from January 1, 2000 to December 31, 2002. Cases of Renal Agenesis/dysgenesis (n = 89) were ascertained from the Texas Birth Defects Registry. Cumulative incidence sampling was used to randomly select, from birth and fetal death records, 356 controls frequency matched to cases by delivery year and vital status. Maternal diabetes and other covariates were collected from vital records. RESULTS: The odds of Renal Agenesis/dysgenesis were 3.1 (95% confidence interval [CI], 1.1–9.3) times greater among deliveries of mothers with diabetes compared to deliveries of mothers without diabetes, controlling for matching factors. CONCLUSIONS: Our results are consistent with prior, but limited, research identifying diabetes as a risk factor for Renal Agenesis/dysgenesis. While these data did not differentiate diabetes diagnoses by type, the results suggest that maternal diabetes may be associated with Renal malformations. Further study is warranted. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc.
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maternal diabetes and Renal Agenesis dysgenesis
Birth Defects Research Part A-clinical and Molecular Teratology, 2010Co-Authors: Erin M. Davis, Robert A. Wild, David M Thompson, Jennifer D. Peck, Peter H LangloisAbstract:BACKGROUND: Renal Agenesis and dysgenesis are potentially lethal congenital malformations affecting 2 to 5 infants per 10,000 live births annually in the United States. The low prevalence of these malformations has complicated understanding of potential risk factors. Maternal diabetes (type 1, type 2, and gestational) has been evaluated extensively as a risk factor for other congenital malformations, but only a limited number of studies have assessed the association between diabetes and Renal Agenesis. METHODS: We conducted a population-based case-control study of deliveries after 20 weeks gestation in Texas Health Service Region 6 (Houston/Galveston area) from January 1, 2000 to December 31, 2002. Cases of Renal Agenesis/dysgenesis (n = 89) were ascertained from the Texas Birth Defects Registry. Cumulative incidence sampling was used to randomly select, from birth and fetal death records, 356 controls frequency matched to cases by delivery year and vital status. Maternal diabetes and other covariates were collected from vital records. RESULTS: The odds of Renal Agenesis/dysgenesis were 3.1 (95% confidence interval [CI], 1.1–9.3) times greater among deliveries of mothers with diabetes compared to deliveries of mothers without diabetes, controlling for matching factors. CONCLUSIONS: Our results are consistent with prior, but limited, research identifying diabetes as a risk factor for Renal Agenesis/dysgenesis. While these data did not differentiate diabetes diagnoses by type, the results suggest that maternal diabetes may be associated with Renal malformations. Further study is warranted. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc.
