The Experts below are selected from a list of 210 Experts worldwide ranked by ideXlab platform

Martin Sandig - One of the best experts on this subject based on the ideXlab platform.

  • the development of a virtual 3d model of the Renal Corpuscle from serial histological sections for e learning environments
    Anatomical Sciences Education, 2015
    Co-Authors: Jeremy Roth, Timothy D Wilson, Martin Sandig
    Abstract:

    Histology is a core subject in the anatomical sciences where learners are challenged to interpret two-dimensional (2D) information (gained from histological sections) to extrapolate and understand the three-dimensional (3D) morphology of cells, tissues, and organs. In gross anatomical education 3D models and learning tools have been associated with improved learning outcomes, but similar tools have not been created for histology education to visualize complex cellular structure–function relationships. This study outlines steps in creating a virtual 3D model of the Renal Corpuscle from serial, semi-thin, histological sections obtained from epoxy resin-embedded kidney tissue. The virtual Renal Corpuscle model was generated by digital segmentation to identify: Bowman's capsule, nuclei of epithelial cells in the parietal capsule, afferent arteriole, efferent arteriole, proximal convoluted tubule, distal convoluted tubule, glomerular capillaries, podocyte nuclei, nuclei of extraglomerular mesangial cells, nuclei of epithelial cells of the macula densa in the distal convoluted tubule. In addition to the imported images of the original sections the software generates, and allows for visualization of, images of virtual sections generated in any desired orientation, thus serving as a “virtual microtome”. These sections can be viewed separately or with the 3D model in transparency. This approach allows for the development of interactive e-learning tools designed to enhance histology education of microscopic structures with complex cellular interrelationships. Future studies will focus on testing the efficacy of interactive virtual 3D models for histology education. Anat Sci Educ 8: 574–583. © 2015 American Association of Anatomists.

  • The development of a virtual 3D model of the Renal Corpuscle from serial histological sections for E‐learning environments
    Anatomical Sciences Education, 2015
    Co-Authors: Jeremy Roth, Timothy D Wilson, Martin Sandig
    Abstract:

    Histology is a core subject in the anatomical sciences where learners are challenged to interpret two-dimensional (2D) information (gained from histological sections) to extrapolate and understand the three-dimensional (3D) morphology of cells, tissues, and organs. In gross anatomical education 3D models and learning tools have been associated with improved learning outcomes, but similar tools have not been created for histology education to visualize complex cellular structure–function relationships. This study outlines steps in creating a virtual 3D model of the Renal Corpuscle from serial, semi-thin, histological sections obtained from epoxy resin-embedded kidney tissue. The virtual Renal Corpuscle model was generated by digital segmentation to identify: Bowman's capsule, nuclei of epithelial cells in the parietal capsule, afferent arteriole, efferent arteriole, proximal convoluted tubule, distal convoluted tubule, glomerular capillaries, podocyte nuclei, nuclei of extraglomerular mesangial cells, nuclei of epithelial cells of the macula densa in the distal convoluted tubule. In addition to the imported images of the original sections the software generates, and allows for visualization of, images of virtual sections generated in any desired orientation, thus serving as a “virtual microtome”. These sections can be viewed separately or with the 3D model in transparency. This approach allows for the development of interactive e-learning tools designed to enhance histology education of microscopic structures with complex cellular interrelationships. Future studies will focus on testing the efficacy of interactive virtual 3D models for histology education. Anat Sci Educ 8: 574–583. © 2015 American Association of Anatomists.

J. H. Youson - One of the best experts on this subject based on the ideXlab platform.

  • Pronephric regression during larval life in the sea lamprey, Petromyzon marinus L.
    Anatomy and Embryology, 1990
    Co-Authors: L C Ellis, J. H. Youson
    Abstract:

    The regression of the pronephric kidney of the lamprey, Petromyzon marinus , is described using histochemical and ultrastructural techniques. Regression begins in the third year of larval life, and by the time the animal enters metamorphosis the tubules have all disappeared. The nephrostomes and the Renal Corpuscle, however, persist for the remainder of the life cycle and undergo little change in the larva. Iron is present within the tubular epithelium prior to the beginning of degeneration, but as degeneration proceeds iron is observed within the tubule lumina. Acid phosphatase is noted within the tubule epithelia prior to degeneration, but as degeneration proceeds acid phosphatase is also observed within the intertubular area. Features of tubular regression include a prominent and highly folded basal lamina, numerous cytoplasmic inclusions, and dense bodies in the epithelia and lumina. The intertubular region is invaded by lymphocytes, granulocytes, plasma cells, and macrophages. The process of pronephric regression possesses many features of the process of apoptosis, which has been noted in the regression of larval organs in other vertebrates.

L C Ellis - One of the best experts on this subject based on the ideXlab platform.

  • the anionic charge barrier in the Renal Corpuscle of the pronephros in the lamprey petromyzon marinus l
    Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology, 1991
    Co-Authors: L C Ellis, John H Youson
    Abstract:

    : The charge barrier within the Renal Corpuscle of the pronephric kidney of the lamprey, Petromyzon marinus, was investigated at two life cycle intervals using cationized ferritin and polyethyleneimine. In the larval Renal Corpuscle the endothelium of the glomerular capillaries and the laminae rarae externa and interna of the glomerular basement membrane show regularly-spaced deposits of the tracers. The lamina densa remains unstained. Concomitant with a loss of major processes of the visceral epithelial podocytes and development of an extensive mesangial matrix in late adult life are alterations in the distribution of the anionic sites. The lamina rara interna is no longer a distinct entity and the mesangium contains irregularly-distributed anionic sites surrounding electron-dense deposits. The results indicate that the distribution of the anionic sites during adult life most likely affects the ability of the Renal Corpuscle to act as an efficient filtration device. This charge distribution is consistent with that seen during some Renal pathologies of higher vertebrates.

  • Pronephric regression during larval life in the sea lamprey, Petromyzon marinus L.
    Anatomy and Embryology, 1990
    Co-Authors: L C Ellis, J. H. Youson
    Abstract:

    The regression of the pronephric kidney of the lamprey, Petromyzon marinus , is described using histochemical and ultrastructural techniques. Regression begins in the third year of larval life, and by the time the animal enters metamorphosis the tubules have all disappeared. The nephrostomes and the Renal Corpuscle, however, persist for the remainder of the life cycle and undergo little change in the larva. Iron is present within the tubular epithelium prior to the beginning of degeneration, but as degeneration proceeds iron is observed within the tubule lumina. Acid phosphatase is noted within the tubule epithelia prior to degeneration, but as degeneration proceeds acid phosphatase is also observed within the intertubular area. Features of tubular regression include a prominent and highly folded basal lamina, numerous cytoplasmic inclusions, and dense bodies in the epithelia and lumina. The intertubular region is invaded by lymphocytes, granulocytes, plasma cells, and macrophages. The process of pronephric regression possesses many features of the process of apoptosis, which has been noted in the regression of larval organs in other vertebrates.

Jeremy Roth - One of the best experts on this subject based on the ideXlab platform.

  • the development of a virtual 3d model of the Renal Corpuscle from serial histological sections for e learning environments
    Anatomical Sciences Education, 2015
    Co-Authors: Jeremy Roth, Timothy D Wilson, Martin Sandig
    Abstract:

    Histology is a core subject in the anatomical sciences where learners are challenged to interpret two-dimensional (2D) information (gained from histological sections) to extrapolate and understand the three-dimensional (3D) morphology of cells, tissues, and organs. In gross anatomical education 3D models and learning tools have been associated with improved learning outcomes, but similar tools have not been created for histology education to visualize complex cellular structure–function relationships. This study outlines steps in creating a virtual 3D model of the Renal Corpuscle from serial, semi-thin, histological sections obtained from epoxy resin-embedded kidney tissue. The virtual Renal Corpuscle model was generated by digital segmentation to identify: Bowman's capsule, nuclei of epithelial cells in the parietal capsule, afferent arteriole, efferent arteriole, proximal convoluted tubule, distal convoluted tubule, glomerular capillaries, podocyte nuclei, nuclei of extraglomerular mesangial cells, nuclei of epithelial cells of the macula densa in the distal convoluted tubule. In addition to the imported images of the original sections the software generates, and allows for visualization of, images of virtual sections generated in any desired orientation, thus serving as a “virtual microtome”. These sections can be viewed separately or with the 3D model in transparency. This approach allows for the development of interactive e-learning tools designed to enhance histology education of microscopic structures with complex cellular interrelationships. Future studies will focus on testing the efficacy of interactive virtual 3D models for histology education. Anat Sci Educ 8: 574–583. © 2015 American Association of Anatomists.

  • The development of a virtual 3D model of the Renal Corpuscle from serial histological sections for E‐learning environments
    Anatomical Sciences Education, 2015
    Co-Authors: Jeremy Roth, Timothy D Wilson, Martin Sandig
    Abstract:

    Histology is a core subject in the anatomical sciences where learners are challenged to interpret two-dimensional (2D) information (gained from histological sections) to extrapolate and understand the three-dimensional (3D) morphology of cells, tissues, and organs. In gross anatomical education 3D models and learning tools have been associated with improved learning outcomes, but similar tools have not been created for histology education to visualize complex cellular structure–function relationships. This study outlines steps in creating a virtual 3D model of the Renal Corpuscle from serial, semi-thin, histological sections obtained from epoxy resin-embedded kidney tissue. The virtual Renal Corpuscle model was generated by digital segmentation to identify: Bowman's capsule, nuclei of epithelial cells in the parietal capsule, afferent arteriole, efferent arteriole, proximal convoluted tubule, distal convoluted tubule, glomerular capillaries, podocyte nuclei, nuclei of extraglomerular mesangial cells, nuclei of epithelial cells of the macula densa in the distal convoluted tubule. In addition to the imported images of the original sections the software generates, and allows for visualization of, images of virtual sections generated in any desired orientation, thus serving as a “virtual microtome”. These sections can be viewed separately or with the 3D model in transparency. This approach allows for the development of interactive e-learning tools designed to enhance histology education of microscopic structures with complex cellular interrelationships. Future studies will focus on testing the efficacy of interactive virtual 3D models for histology education. Anat Sci Educ 8: 574–583. © 2015 American Association of Anatomists.

Timothy D Wilson - One of the best experts on this subject based on the ideXlab platform.

  • the development of a virtual 3d model of the Renal Corpuscle from serial histological sections for e learning environments
    Anatomical Sciences Education, 2015
    Co-Authors: Jeremy Roth, Timothy D Wilson, Martin Sandig
    Abstract:

    Histology is a core subject in the anatomical sciences where learners are challenged to interpret two-dimensional (2D) information (gained from histological sections) to extrapolate and understand the three-dimensional (3D) morphology of cells, tissues, and organs. In gross anatomical education 3D models and learning tools have been associated with improved learning outcomes, but similar tools have not been created for histology education to visualize complex cellular structure–function relationships. This study outlines steps in creating a virtual 3D model of the Renal Corpuscle from serial, semi-thin, histological sections obtained from epoxy resin-embedded kidney tissue. The virtual Renal Corpuscle model was generated by digital segmentation to identify: Bowman's capsule, nuclei of epithelial cells in the parietal capsule, afferent arteriole, efferent arteriole, proximal convoluted tubule, distal convoluted tubule, glomerular capillaries, podocyte nuclei, nuclei of extraglomerular mesangial cells, nuclei of epithelial cells of the macula densa in the distal convoluted tubule. In addition to the imported images of the original sections the software generates, and allows for visualization of, images of virtual sections generated in any desired orientation, thus serving as a “virtual microtome”. These sections can be viewed separately or with the 3D model in transparency. This approach allows for the development of interactive e-learning tools designed to enhance histology education of microscopic structures with complex cellular interrelationships. Future studies will focus on testing the efficacy of interactive virtual 3D models for histology education. Anat Sci Educ 8: 574–583. © 2015 American Association of Anatomists.

  • The development of a virtual 3D model of the Renal Corpuscle from serial histological sections for E‐learning environments
    Anatomical Sciences Education, 2015
    Co-Authors: Jeremy Roth, Timothy D Wilson, Martin Sandig
    Abstract:

    Histology is a core subject in the anatomical sciences where learners are challenged to interpret two-dimensional (2D) information (gained from histological sections) to extrapolate and understand the three-dimensional (3D) morphology of cells, tissues, and organs. In gross anatomical education 3D models and learning tools have been associated with improved learning outcomes, but similar tools have not been created for histology education to visualize complex cellular structure–function relationships. This study outlines steps in creating a virtual 3D model of the Renal Corpuscle from serial, semi-thin, histological sections obtained from epoxy resin-embedded kidney tissue. The virtual Renal Corpuscle model was generated by digital segmentation to identify: Bowman's capsule, nuclei of epithelial cells in the parietal capsule, afferent arteriole, efferent arteriole, proximal convoluted tubule, distal convoluted tubule, glomerular capillaries, podocyte nuclei, nuclei of extraglomerular mesangial cells, nuclei of epithelial cells of the macula densa in the distal convoluted tubule. In addition to the imported images of the original sections the software generates, and allows for visualization of, images of virtual sections generated in any desired orientation, thus serving as a “virtual microtome”. These sections can be viewed separately or with the 3D model in transparency. This approach allows for the development of interactive e-learning tools designed to enhance histology education of microscopic structures with complex cellular interrelationships. Future studies will focus on testing the efficacy of interactive virtual 3D models for histology education. Anat Sci Educ 8: 574–583. © 2015 American Association of Anatomists.