The Experts below are selected from a list of 51990 Experts worldwide ranked by ideXlab platform

Robson A.s. Santos - One of the best experts on this subject based on the ideXlab platform.

  • Counter-regulatory Renin-Angiotensin System in cardiovascular disease
    Nature reviews. Cardiology, 2019
    Co-Authors: María Paz Ocaranza, Jaime A. Riquelme, Lorena García, Jorge E. Jalil, Mario Chiong, Robson A.s. Santos, Sergio Lavandero
    Abstract:

    The Renin-Angiotensin System is an important component of the cardiovascular System. Mounting evidence suggests that the metabolic products of angiotensin I and II - initially thought to be biologically inactive - have key roles in cardiovascular physiology and pathophysiology. This non-canonical axis of the Renin-Angiotensin System consists of angiotensin 1-7, angiotensin 1-9, angiotensin-converting enzyme 2, the type 2 angiotensin II receptor (AT2R), the proto-oncogene Mas receptor and the Mas-related G protein-coupled receptor member D. Each of these components has been shown to counteract the effects of the classical Renin-Angiotensin System. This counter-regulatory Renin-Angiotensin System has a central role in the pathogenesis and development of various cardiovascular diseases and, therefore, represents a potential therapeutic target. In this Review, we provide the latest insights into the complexity and interplay of the components of the non-canonical Renin-Angiotensin System, and discuss the function and therapeutic potential of targeting this System to treat cardiovascular disease.

  • the ace2 angiotensin 1 7 mas axis of the renin angiotensin System focus on angiotensin 1 7
    Physical Review, 2018
    Co-Authors: Robson A.s. Santos, Michael Bader, Walkyria O Sampaio, Andreia Carvalho Alzamora, Daisy Mottasantos, Natalia Alenina, Maria Jose Campagnolesantos
    Abstract:

    The Renin-Angiotensin System (RAS) is a key player in the control of the cardiovascular System and hydroelectrolyte balance, with an influence on organs and functions throughout the body. The class...

  • similarities and differences of x and y chromosome homologous genes sry and sox3 in regulating the renin angiotensin System promoters
    Physiological Genomics, 2015
    Co-Authors: Fabiano C Araujo, Robson A.s. Santos, Amy Milsted, Ingrid Kazue Mizuno Watanabe, Helen L Del Puerto, Jozef Lazar, Fernando M Reis, Jeremy W Prokop
    Abstract:

    The Renin-Angiotensin System (RAS) is subject to sex-specific modulation by hormones and gene products. However, sex differences in the balance between the vasoconstrictor/proliferative ACE/ANG II/...

Gerald F Dibona - One of the best experts on this subject based on the ideXlab platform.

  • peripheral and central interactions between the renin angiotensin System and the renal sympathetic nerves in control of renal function
    Annals of the New York Academy of Sciences, 2006
    Co-Authors: Gerald F Dibona
    Abstract:

    : Increases in renal sympathetic nerve activity (RSNA) regulate the functions of the nephron, the vasculature, and the renin-containing juxtaglomerular granular cells. As increased activity of the Renin-Angiotensin System can also influence nephron and vascular function, it is important to understand the interactions between RSNA and the Renin-Angiotensin System in the control of renal function. These interactions can be intrarenal, that is, the direct (via specific innervation) and indirect (via angiotensin II) contributions of increased RSNA to the regulation of renal function. The effects of increased RSNA on renal function are attenuated when the activity of the Renin-Angiotensin System is suppressed or antagonized with angiotensin-converting enzyme inhibitors or angiotensin II-type AT1 receptor antagonists. The effects of intrarenal administration of angiotensin II are attenuated following renal denervation. These interactions can also be extrarenal, that is, in the central nervous System, wherein RSNA and its arterial baroreflex control are modulated by changes in activity of the Renin-Angiotensin System. In addition to the circumventricular organs, the permeable blood-brain barrier of which permits interactions with circulating angiotensin II, there are interactions at sites behind the blood-brain barrier that depend on the influence of local angiotensin II. The responses to central administration of angiotensin II type AT1 receptor antagonists, into the ventricular System or microinjected into the rostral ventrolateral medulla, are modulated by changes in activity of the Renin-Angiotensin System produced by physiological changes in dietary sodium intake. Similar modulation is observed in pathophysiological models wherein activity of both the Renin-Angiotensin and sympathetic nervous Systems is increased (e.g., congestive heart failure). Thus, both renal and extrarenal sites of interaction between the Renin-Angiotensin System and RSNA are involved in influencing the neural control of renal function.

  • nervous kidney interaction between renal sympathetic nerves and the renin angiotensin System in the control of renal function
    Hypertension, 2000
    Co-Authors: Gerald F Dibona
    Abstract:

    Increases in renal sympathetic nerve activity regulate the functions of the nephron, the vasculature, and the renin-containing juxtaglomerular granular cells. Because increased activity of the Renin-Angiotensin System can also influence nephron and vascular function, it is important to understand the interactions between the renal sympathetic nerves and the Renin-Angiotensin System in the control of renal function. These interactions can be intrarenal, for example, the direct (by specific innervation) and indirect (by angiotensin II) contributions of increased renal sympathetic nerve activity to the regulation of renal function. The effects of increased renal sympathetic nerve activity on renal function are attenuated when the activity of the Renin-Angiotensin System is suppressed or antagonized with ACE inhibitors or angiotensin II-type AT(1)-receptor antagonists. The effects of intrarenal administration of angiotensin II are attenuated after renal denervation. These interactions can also be extrarenal, for example, in the central nervous System, wherein renal sympathetic nerve activity and its arterial baroreflex control are modulated by changes in activity of the Renin-Angiotensin System. In addition to the circumventricular organs, whose permeable blood-brain barrier permits interactions with circulating angiotensin II, there are interactions at sites behind the blood-brain barrier that depend on the influence of local angiotensin II. The responses to central administration of angiotensin II-type AT(1)-receptor antagonists into the ventricular System or microinjected into the rostral ventrolateral medulla are modulated by changes in activity of the Renin-Angiotensin System produced by physiological changes in dietary sodium intake. Similar modulation is observed in pathophysiological models wherein activity of both the Renin-Angiotensin and sympathetic nervous Systems is increased (eg, congestive heart failure). Thus, both renal and extrarenal sites of interaction between the Renin-Angiotensin System and renal sympathetic nerve activity are involved in influencing the neural control of renal function.

Gavin Y. Oudit - One of the best experts on this subject based on the ideXlab platform.

  • angiotensin converting enzyme 2 sars cov 2 receptor and regulator of the renin angiotensin System celebrating the 20th anniversary of the discovery of ace2
    Circulation Research, 2020
    Co-Authors: Mahmoud Gheblawi, Jiu-chang Zhong, Kaiming Wang, Anissa Viveiros, Anthony J Turner, Maria B. Grant, Quynh Nguyen, Mohan K. Raizada, Gavin Y. Oudit
    Abstract:

    ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that revolve around its trivalent function: a negative regulator of the Renin-Angiotensin System, facilitator of ami...

  • characterization of the intrarenal renin angiotensin System in experimental alport syndrome
    American Journal of Pathology, 2015
    Co-Authors: Ana Konvalinka, Vanessa Williams, Nicholas Maksimowski, Xuewen Song, Rohan John, Shaoling Zhang, Gavin Y. Oudit, Fei Fang, Xiaohua Zhou, James W. Scholey
    Abstract:

    Blockade of the Renin-Angiotensin System attenuates the progression of experimental and clinical Alport syndrome (AS); however, the underlying mechanism(s) remains largely unknown. We evaluated the Renin-Angiotensin System in 4- and 7-week-old homozygous for collagen, type IV, α3 gene ( Col4A3 −/− ) and wild-type mice, a model of AS characterized by proteinuria and progressive renal injury. Renal angiotensin (Ang) II levels increased, whereas renal Ang-(1–7) levels decreased in 7-week-old Col4a3 −/− mice compared with age-matched controls; these changes were partially reversed by recombinant angiotensin-converting enzyme 2 (ACE2) treatment. The expression of both the angiotensinogen and renin protein increased in Col4a3 −/− compared with wild-type mice. Consistent with the Ang-(1–7) levels, the expression and activity of kidney ACE2 decreased in 7-week-old Col4a3 −/− mice. The urinary excretion rate of ACE2 paralleled the decline in tissue expression. Expression of an Ang II-induced gene, heme oxygenase-1, was up-regulated in the kidneys of 7-week-old Col4a3 −/− mice compared with wild-type mice by microarray analysis. Heme oxygenase-1 (HO-1) protein expression was increased in kidneys of Col4a3 −/− mice and normalized by treatment with ACE inhibitor. Urinary HO-1 excretion paralleled renal HO-1 expression. In conclusion, progressive kidney injury in AS is associated with changes in expression of intrarenal renin Ang System components and Ang peptides. HO-1 and ACE2 may represent novel markers of AS-associated kidney injury, whereas administration of recombinant ACE2 and/or Ang-(1–7) may represent novel therapeutic approaches in AS.

Sergio Lavandero - One of the best experts on this subject based on the ideXlab platform.

  • Counter-regulatory Renin-Angiotensin System in cardiovascular disease
    Nature reviews. Cardiology, 2019
    Co-Authors: María Paz Ocaranza, Jaime A. Riquelme, Lorena García, Jorge E. Jalil, Mario Chiong, Robson A.s. Santos, Sergio Lavandero
    Abstract:

    The Renin-Angiotensin System is an important component of the cardiovascular System. Mounting evidence suggests that the metabolic products of angiotensin I and II - initially thought to be biologically inactive - have key roles in cardiovascular physiology and pathophysiology. This non-canonical axis of the Renin-Angiotensin System consists of angiotensin 1-7, angiotensin 1-9, angiotensin-converting enzyme 2, the type 2 angiotensin II receptor (AT2R), the proto-oncogene Mas receptor and the Mas-related G protein-coupled receptor member D. Each of these components has been shown to counteract the effects of the classical Renin-Angiotensin System. This counter-regulatory Renin-Angiotensin System has a central role in the pathogenesis and development of various cardiovascular diseases and, therefore, represents a potential therapeutic target. In this Review, we provide the latest insights into the complexity and interplay of the components of the non-canonical Renin-Angiotensin System, and discuss the function and therapeutic potential of targeting this System to treat cardiovascular disease.

Masatsugu Horiuchi - One of the best experts on this subject based on the ideXlab platform.