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Cynthia A Thomson - One of the best experts on this subject based on the ideXlab platform.
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vegetable protein intake is associated with lower gallbladder disease risk findings from the women s health initiative prospective cohort
Preventive Medicine, 2016Co-Authors: Eric M Lander, Betsy C Wertheim, Stephanie M Koch, Zhao Chen, Chiuhsieh Hsu, Cynthia A ThomsonAbstract:Objective This study aimed to measure associations between gallbladder disease and protein intake patterns, separated by quantity and type (vegetable vs. animal), among postmenopausal women. Methods Analyses were based on 130,859 postmenopausal women enrolled from 1993 to 1998 at 40 U.S. clinical centers in the Women's Health Initiative clinical trials and observational study. Women were excluded if they Reported a history of gallbladder disease prior to baseline. Cox proportional hazards regression models, adjusted for gallbladder disease risk factors, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between energy-adjusted protein intake and gallbladder disease. Results In this study sample, 8.1% of postmenopausal women self-Reported Incident gallbladder disease. In multivariate analysis, women in the highest quintile of energy-adjusted vegetable protein intake (> 24.0 g/d) had a lower risk of gallbladder disease (HR, 0.87; 95% CI, 0.81–0.93) as compared to women in the lowest quintile (< 16.3 g/d) (Ptrend < 0.001). Total protein intake was modestly protective against gallbladder disease (Ptrend < 0.021). Animal protein intake was not associated with gallbladder disease risk. The protective effect of vegetable protein held stable only for women without history of diabetes (HR, 0.86; 95% CI, 0.80–0.92) and without recent weight loss (HR, 0.88; 95% CI, 0.80–0.97). Conclusions Vegetable protein intake is inversely associated with gallbladder disease risk in our sample of postmenopausal women. In addition to weight management, healthcare providers could emphasize vegetable protein as an additional dietary modality to promote lower risk for gallbladder disease.
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vegetable protein intake is associated with lower gallbladder disease risk findings from the women s health initiative prospective cohort
Preventive Medicine, 2016Co-Authors: Eric M Lander, Betsy C Wertheim, Stephanie M Koch, Zhao Chen, Chiuhsieh Hsu, Cynthia A ThomsonAbstract:Abstract Objective This study aimed to measure associations between gallbladder disease and protein intake patterns, separated by quantity and type (vegetable vs. animal), among postmenopausal women. Methods Analyses were based on 130,859 postmenopausal women enrolled from 1993 to 1998 at 40 U.S. clinical centers in the Women's Health Initiative clinical trials and observational study. Women were excluded if they Reported a history of gallbladder disease prior to baseline. Cox proportional hazards regression models, adjusted for gallbladder disease risk factors, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between energy-adjusted protein intake and gallbladder disease. Results In this study sample, 8.1% of postmenopausal women self-Reported Incident gallbladder disease. In multivariate analysis, women in the highest quintile of energy-adjusted vegetable protein intake (> 24.0 g/d) had a lower risk of gallbladder disease (HR, 0.87; 95% CI, 0.81–0.93) as compared to women in the lowest quintile ( Conclusions Vegetable protein intake is inversely associated with gallbladder disease risk in our sample of postmenopausal women. In addition to weight management, healthcare providers could emphasize vegetable protein as an additional dietary modality to promote lower risk for gallbladder disease.
Eric M Lander - One of the best experts on this subject based on the ideXlab platform.
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vegetable protein intake is associated with lower gallbladder disease risk findings from the women s health initiative prospective cohort
Preventive Medicine, 2016Co-Authors: Eric M Lander, Betsy C Wertheim, Stephanie M Koch, Zhao Chen, Chiuhsieh Hsu, Cynthia A ThomsonAbstract:Objective This study aimed to measure associations between gallbladder disease and protein intake patterns, separated by quantity and type (vegetable vs. animal), among postmenopausal women. Methods Analyses were based on 130,859 postmenopausal women enrolled from 1993 to 1998 at 40 U.S. clinical centers in the Women's Health Initiative clinical trials and observational study. Women were excluded if they Reported a history of gallbladder disease prior to baseline. Cox proportional hazards regression models, adjusted for gallbladder disease risk factors, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between energy-adjusted protein intake and gallbladder disease. Results In this study sample, 8.1% of postmenopausal women self-Reported Incident gallbladder disease. In multivariate analysis, women in the highest quintile of energy-adjusted vegetable protein intake (> 24.0 g/d) had a lower risk of gallbladder disease (HR, 0.87; 95% CI, 0.81–0.93) as compared to women in the lowest quintile (< 16.3 g/d) (Ptrend < 0.001). Total protein intake was modestly protective against gallbladder disease (Ptrend < 0.021). Animal protein intake was not associated with gallbladder disease risk. The protective effect of vegetable protein held stable only for women without history of diabetes (HR, 0.86; 95% CI, 0.80–0.92) and without recent weight loss (HR, 0.88; 95% CI, 0.80–0.97). Conclusions Vegetable protein intake is inversely associated with gallbladder disease risk in our sample of postmenopausal women. In addition to weight management, healthcare providers could emphasize vegetable protein as an additional dietary modality to promote lower risk for gallbladder disease.
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vegetable protein intake is associated with lower gallbladder disease risk findings from the women s health initiative prospective cohort
Preventive Medicine, 2016Co-Authors: Eric M Lander, Betsy C Wertheim, Stephanie M Koch, Zhao Chen, Chiuhsieh Hsu, Cynthia A ThomsonAbstract:Abstract Objective This study aimed to measure associations between gallbladder disease and protein intake patterns, separated by quantity and type (vegetable vs. animal), among postmenopausal women. Methods Analyses were based on 130,859 postmenopausal women enrolled from 1993 to 1998 at 40 U.S. clinical centers in the Women's Health Initiative clinical trials and observational study. Women were excluded if they Reported a history of gallbladder disease prior to baseline. Cox proportional hazards regression models, adjusted for gallbladder disease risk factors, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between energy-adjusted protein intake and gallbladder disease. Results In this study sample, 8.1% of postmenopausal women self-Reported Incident gallbladder disease. In multivariate analysis, women in the highest quintile of energy-adjusted vegetable protein intake (> 24.0 g/d) had a lower risk of gallbladder disease (HR, 0.87; 95% CI, 0.81–0.93) as compared to women in the lowest quintile ( Conclusions Vegetable protein intake is inversely associated with gallbladder disease risk in our sample of postmenopausal women. In addition to weight management, healthcare providers could emphasize vegetable protein as an additional dietary modality to promote lower risk for gallbladder disease.
Meir J Stampfer - One of the best experts on this subject based on the ideXlab platform.
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body habitus across the lifespan and risk of pituitary adenoma
The Journal of Clinical Endocrinology and Metabolism, 2021Co-Authors: David J Cote, Timothy R Smith, Ursula B Kaiser, Edward R Laws, Meir J StampferAbstract:CONTEXT No studies have examined the association between body habitus and incidence of pituitary adenoma. OBJECTIVE To determine if body mass index (BMI), waist circumference, body somatotype, or height are associated with risk of pituitary adenoma. DESIGN Pooled analysis of 3 prospective cohort studies. SETTING Population-based study. PARTICIPANTS Participants of the Nurses' Health Study (NHS), Nurses' Health Study II (NHSII), and the Health Professionals Follow-Up Study (HPFS), totaling 284 946 American health professionals. EXPOSURES BMI, waist circumference, body somatotype, and height. OUTCOME MEASURES Self-Reported Incident pituitary adenoma. Multivariable (MV)-adjusted hazard ratios (HRs) of pituitary adenoma were estimated using Cox proportional hazards models. RESULTS During 7 350 156 person-years of follow-up, 387 Incident pituitary adenomas were Reported. Comparing BMI of ≥30 to <25 kg/m2, higher adult BMI was associated with higher risk of pituitary adenoma (MV HR = 1.74; 95% CI, 1.33-2.28), as was higher maximum adult BMI (MV HR = 1.76; 95% CI, 1.34-2.30), higher waist circumference (MV HR = 1.06; 95% CI, 1.04-1.09 per inch), and higher BMI during early adulthood (at age 18 to 21, MV HR = 2.65; 95% CI, 1.56-4.49). Taller adult height was associated with pituitary adenoma (MV HR = 1.05; 95% CI, 1.01-1.09 per inch). Overall findings were similar in women and men, although power was limited in men (n = 62 cases). Sensitivity analyses demonstrated that the association between adult BMI and pituitary adenoma extended to at least 14 years prior to diagnosis and that the results were not affected when analyses were restricted to participants with similar healthcare utilization. CONCLUSION Higher BMI and waist circumference, from early adulthood to the time of diagnosis, were associated with higher risk of pituitary adenoma.
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body habitus across the lifespan and risk of pituitary adenoma
The Journal of Clinical Endocrinology and Metabolism, 2021Co-Authors: David J Cote, Timothy R Smith, Ursula B Kaiser, Edward R Laws, Meir J StampferAbstract:CONTEXT No studies have examined the association between body habitus and incidence of pituitary adenoma. OBJECTIVE To determine if body mass index (BMI), waist circumference, body somatotype, or height are associated with risk of pituitary adenoma. DESIGN Pooled analysis of three prospective cohort studies. SETTING Population-based study. PARTICIPANTS Participants of the NHS, NHSII, and HPFS, totaling 284,946 American health professionals. EXPOSURES BMI, waist circumference, body somatotype, and height. OUTCOME MEASURES Self-Reported Incident pituitary adenoma. Multivariable (MV)-adjusted hazard ratios of pituitary adenoma were estimated using Cox proportional hazards models. RESULTS During 7,350,156 person-years of follow up, 387 Incident pituitary adenomas were Reported. Comparing BMI of ≥30 to <25 kg/m 2, higher adult BMI was associated with higher risk of pituitary adenoma (MV HR=1.74, 95%CI:1.33-2.28), as was higher maximum adult BMI (MV HR=1.76, 95%CI:1.34-2.30), higher waist circumference (MV HR=1.06, 95%CI: 1.04-1.09 per inch), and higher BMI during early adulthood (at age 18-21, MV HR=2.65, 95%CI:1.56-4.49). Taller adult height was associated with pituitary adenoma (MV HR=1.05, 95%CI:1.01-1.09 per inch). Overall findings were similar in women and men, although power was limited in men (n=62 cases). Sensitivity analyses demonstrated that the association between adult BMI and pituitary adenoma extended to at least 14 years prior to diagnosis and that the results were not affected when analyses were restricted to participants with similar healthcare utilization. CONCLUSION Higher BMI and waist circumference, from early adulthood to the time of diagnosis, were associated with higher risk of pituitary adenoma.
Chiuhsieh Hsu - One of the best experts on this subject based on the ideXlab platform.
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vegetable protein intake is associated with lower gallbladder disease risk findings from the women s health initiative prospective cohort
Preventive Medicine, 2016Co-Authors: Eric M Lander, Betsy C Wertheim, Stephanie M Koch, Zhao Chen, Chiuhsieh Hsu, Cynthia A ThomsonAbstract:Objective This study aimed to measure associations between gallbladder disease and protein intake patterns, separated by quantity and type (vegetable vs. animal), among postmenopausal women. Methods Analyses were based on 130,859 postmenopausal women enrolled from 1993 to 1998 at 40 U.S. clinical centers in the Women's Health Initiative clinical trials and observational study. Women were excluded if they Reported a history of gallbladder disease prior to baseline. Cox proportional hazards regression models, adjusted for gallbladder disease risk factors, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between energy-adjusted protein intake and gallbladder disease. Results In this study sample, 8.1% of postmenopausal women self-Reported Incident gallbladder disease. In multivariate analysis, women in the highest quintile of energy-adjusted vegetable protein intake (> 24.0 g/d) had a lower risk of gallbladder disease (HR, 0.87; 95% CI, 0.81–0.93) as compared to women in the lowest quintile (< 16.3 g/d) (Ptrend < 0.001). Total protein intake was modestly protective against gallbladder disease (Ptrend < 0.021). Animal protein intake was not associated with gallbladder disease risk. The protective effect of vegetable protein held stable only for women without history of diabetes (HR, 0.86; 95% CI, 0.80–0.92) and without recent weight loss (HR, 0.88; 95% CI, 0.80–0.97). Conclusions Vegetable protein intake is inversely associated with gallbladder disease risk in our sample of postmenopausal women. In addition to weight management, healthcare providers could emphasize vegetable protein as an additional dietary modality to promote lower risk for gallbladder disease.
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vegetable protein intake is associated with lower gallbladder disease risk findings from the women s health initiative prospective cohort
Preventive Medicine, 2016Co-Authors: Eric M Lander, Betsy C Wertheim, Stephanie M Koch, Zhao Chen, Chiuhsieh Hsu, Cynthia A ThomsonAbstract:Abstract Objective This study aimed to measure associations between gallbladder disease and protein intake patterns, separated by quantity and type (vegetable vs. animal), among postmenopausal women. Methods Analyses were based on 130,859 postmenopausal women enrolled from 1993 to 1998 at 40 U.S. clinical centers in the Women's Health Initiative clinical trials and observational study. Women were excluded if they Reported a history of gallbladder disease prior to baseline. Cox proportional hazards regression models, adjusted for gallbladder disease risk factors, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between energy-adjusted protein intake and gallbladder disease. Results In this study sample, 8.1% of postmenopausal women self-Reported Incident gallbladder disease. In multivariate analysis, women in the highest quintile of energy-adjusted vegetable protein intake (> 24.0 g/d) had a lower risk of gallbladder disease (HR, 0.87; 95% CI, 0.81–0.93) as compared to women in the lowest quintile ( Conclusions Vegetable protein intake is inversely associated with gallbladder disease risk in our sample of postmenopausal women. In addition to weight management, healthcare providers could emphasize vegetable protein as an additional dietary modality to promote lower risk for gallbladder disease.
Zhao Chen - One of the best experts on this subject based on the ideXlab platform.
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vegetable protein intake is associated with lower gallbladder disease risk findings from the women s health initiative prospective cohort
Preventive Medicine, 2016Co-Authors: Eric M Lander, Betsy C Wertheim, Stephanie M Koch, Zhao Chen, Chiuhsieh Hsu, Cynthia A ThomsonAbstract:Objective This study aimed to measure associations between gallbladder disease and protein intake patterns, separated by quantity and type (vegetable vs. animal), among postmenopausal women. Methods Analyses were based on 130,859 postmenopausal women enrolled from 1993 to 1998 at 40 U.S. clinical centers in the Women's Health Initiative clinical trials and observational study. Women were excluded if they Reported a history of gallbladder disease prior to baseline. Cox proportional hazards regression models, adjusted for gallbladder disease risk factors, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between energy-adjusted protein intake and gallbladder disease. Results In this study sample, 8.1% of postmenopausal women self-Reported Incident gallbladder disease. In multivariate analysis, women in the highest quintile of energy-adjusted vegetable protein intake (> 24.0 g/d) had a lower risk of gallbladder disease (HR, 0.87; 95% CI, 0.81–0.93) as compared to women in the lowest quintile (< 16.3 g/d) (Ptrend < 0.001). Total protein intake was modestly protective against gallbladder disease (Ptrend < 0.021). Animal protein intake was not associated with gallbladder disease risk. The protective effect of vegetable protein held stable only for women without history of diabetes (HR, 0.86; 95% CI, 0.80–0.92) and without recent weight loss (HR, 0.88; 95% CI, 0.80–0.97). Conclusions Vegetable protein intake is inversely associated with gallbladder disease risk in our sample of postmenopausal women. In addition to weight management, healthcare providers could emphasize vegetable protein as an additional dietary modality to promote lower risk for gallbladder disease.
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vegetable protein intake is associated with lower gallbladder disease risk findings from the women s health initiative prospective cohort
Preventive Medicine, 2016Co-Authors: Eric M Lander, Betsy C Wertheim, Stephanie M Koch, Zhao Chen, Chiuhsieh Hsu, Cynthia A ThomsonAbstract:Abstract Objective This study aimed to measure associations between gallbladder disease and protein intake patterns, separated by quantity and type (vegetable vs. animal), among postmenopausal women. Methods Analyses were based on 130,859 postmenopausal women enrolled from 1993 to 1998 at 40 U.S. clinical centers in the Women's Health Initiative clinical trials and observational study. Women were excluded if they Reported a history of gallbladder disease prior to baseline. Cox proportional hazards regression models, adjusted for gallbladder disease risk factors, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between energy-adjusted protein intake and gallbladder disease. Results In this study sample, 8.1% of postmenopausal women self-Reported Incident gallbladder disease. In multivariate analysis, women in the highest quintile of energy-adjusted vegetable protein intake (> 24.0 g/d) had a lower risk of gallbladder disease (HR, 0.87; 95% CI, 0.81–0.93) as compared to women in the lowest quintile ( Conclusions Vegetable protein intake is inversely associated with gallbladder disease risk in our sample of postmenopausal women. In addition to weight management, healthcare providers could emphasize vegetable protein as an additional dietary modality to promote lower risk for gallbladder disease.