The Experts below are selected from a list of 4710 Experts worldwide ranked by ideXlab platform
Christopher L Drake - One of the best experts on this subject based on the ideXlab platform.
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stress related sleep disturbance and polysomnographic response to caffeine
Sleep Medicine, 2006Co-Authors: Christopher L Drake, Catherine Jefferson, Timothy Roehrs, Thomas RothAbstract:Abstract Background and purpose To determine the sleep response to caffeine in individuals vulnerable to stress-related sleep disturbance as measured by polysomnography. Patients and methods Eleven healthy individuals without insomnia scoring low (4 women, mean age=32.64±15.46 years) and 10 healthy individuals also without insomnia scoring high (6 women, mean age=34.20±13.73 years) on a measure of Vulnerability to stress-related sleep disturbance were studied in a laboratory protocol. A moderate-low dose of caffeine (3 mg/kg) was administered 1 h prior to lights-out and compared to a counterbalanced control night with each condition separated by 1 week. Standard polysomnographic measures were assessed (i.e. total sleep time, sleep efficiency, latency to persistent sleep, and sleep stage percentages) for both control and caffeine nights. Results There were no between-group differences in sleep on the control night. Importantly, individuals Reporting Vulnerability to stress-related sleep disturbance had significantly prolonged latency to persistent sleep in response to the caffeine challenge (interaction; P Conclusion Normal sleepers with an identified Vulnerability to stress-induced sleep disturbance exhibited greater objectively verifiable sleep-reactivity in response to a caffeine challenge compared to non-vulnerable individuals. These results suggest that the construct of individual differences in Vulnerability to sleep disturbance applies to a pharmacological ‘stressor’ (i.e. caffeine) as well as to previously assessed stressors such as a first-night effect. This finding provides further support for generalized trait Vulnerability by demonstrating a sleep disturbance to a wake-promoting pharmacological challenge in specific a priori identified individuals.
Thomas Roth - One of the best experts on this subject based on the ideXlab platform.
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stress related sleep disturbance and polysomnographic response to caffeine
Sleep Medicine, 2006Co-Authors: Christopher L Drake, Catherine Jefferson, Timothy Roehrs, Thomas RothAbstract:Abstract Background and purpose To determine the sleep response to caffeine in individuals vulnerable to stress-related sleep disturbance as measured by polysomnography. Patients and methods Eleven healthy individuals without insomnia scoring low (4 women, mean age=32.64±15.46 years) and 10 healthy individuals also without insomnia scoring high (6 women, mean age=34.20±13.73 years) on a measure of Vulnerability to stress-related sleep disturbance were studied in a laboratory protocol. A moderate-low dose of caffeine (3 mg/kg) was administered 1 h prior to lights-out and compared to a counterbalanced control night with each condition separated by 1 week. Standard polysomnographic measures were assessed (i.e. total sleep time, sleep efficiency, latency to persistent sleep, and sleep stage percentages) for both control and caffeine nights. Results There were no between-group differences in sleep on the control night. Importantly, individuals Reporting Vulnerability to stress-related sleep disturbance had significantly prolonged latency to persistent sleep in response to the caffeine challenge (interaction; P Conclusion Normal sleepers with an identified Vulnerability to stress-induced sleep disturbance exhibited greater objectively verifiable sleep-reactivity in response to a caffeine challenge compared to non-vulnerable individuals. These results suggest that the construct of individual differences in Vulnerability to sleep disturbance applies to a pharmacological ‘stressor’ (i.e. caffeine) as well as to previously assessed stressors such as a first-night effect. This finding provides further support for generalized trait Vulnerability by demonstrating a sleep disturbance to a wake-promoting pharmacological challenge in specific a priori identified individuals.
Catherine Jefferson - One of the best experts on this subject based on the ideXlab platform.
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stress related sleep disturbance and polysomnographic response to caffeine
Sleep Medicine, 2006Co-Authors: Christopher L Drake, Catherine Jefferson, Timothy Roehrs, Thomas RothAbstract:Abstract Background and purpose To determine the sleep response to caffeine in individuals vulnerable to stress-related sleep disturbance as measured by polysomnography. Patients and methods Eleven healthy individuals without insomnia scoring low (4 women, mean age=32.64±15.46 years) and 10 healthy individuals also without insomnia scoring high (6 women, mean age=34.20±13.73 years) on a measure of Vulnerability to stress-related sleep disturbance were studied in a laboratory protocol. A moderate-low dose of caffeine (3 mg/kg) was administered 1 h prior to lights-out and compared to a counterbalanced control night with each condition separated by 1 week. Standard polysomnographic measures were assessed (i.e. total sleep time, sleep efficiency, latency to persistent sleep, and sleep stage percentages) for both control and caffeine nights. Results There were no between-group differences in sleep on the control night. Importantly, individuals Reporting Vulnerability to stress-related sleep disturbance had significantly prolonged latency to persistent sleep in response to the caffeine challenge (interaction; P Conclusion Normal sleepers with an identified Vulnerability to stress-induced sleep disturbance exhibited greater objectively verifiable sleep-reactivity in response to a caffeine challenge compared to non-vulnerable individuals. These results suggest that the construct of individual differences in Vulnerability to sleep disturbance applies to a pharmacological ‘stressor’ (i.e. caffeine) as well as to previously assessed stressors such as a first-night effect. This finding provides further support for generalized trait Vulnerability by demonstrating a sleep disturbance to a wake-promoting pharmacological challenge in specific a priori identified individuals.
Timothy Roehrs - One of the best experts on this subject based on the ideXlab platform.
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stress related sleep disturbance and polysomnographic response to caffeine
Sleep Medicine, 2006Co-Authors: Christopher L Drake, Catherine Jefferson, Timothy Roehrs, Thomas RothAbstract:Abstract Background and purpose To determine the sleep response to caffeine in individuals vulnerable to stress-related sleep disturbance as measured by polysomnography. Patients and methods Eleven healthy individuals without insomnia scoring low (4 women, mean age=32.64±15.46 years) and 10 healthy individuals also without insomnia scoring high (6 women, mean age=34.20±13.73 years) on a measure of Vulnerability to stress-related sleep disturbance were studied in a laboratory protocol. A moderate-low dose of caffeine (3 mg/kg) was administered 1 h prior to lights-out and compared to a counterbalanced control night with each condition separated by 1 week. Standard polysomnographic measures were assessed (i.e. total sleep time, sleep efficiency, latency to persistent sleep, and sleep stage percentages) for both control and caffeine nights. Results There were no between-group differences in sleep on the control night. Importantly, individuals Reporting Vulnerability to stress-related sleep disturbance had significantly prolonged latency to persistent sleep in response to the caffeine challenge (interaction; P Conclusion Normal sleepers with an identified Vulnerability to stress-induced sleep disturbance exhibited greater objectively verifiable sleep-reactivity in response to a caffeine challenge compared to non-vulnerable individuals. These results suggest that the construct of individual differences in Vulnerability to sleep disturbance applies to a pharmacological ‘stressor’ (i.e. caffeine) as well as to previously assessed stressors such as a first-night effect. This finding provides further support for generalized trait Vulnerability by demonstrating a sleep disturbance to a wake-promoting pharmacological challenge in specific a priori identified individuals.