The Experts below are selected from a list of 246 Experts worldwide ranked by ideXlab platform
J C Amiard - One of the best experts on this subject based on the ideXlab platform.
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estradiol 17β and testosterone concentrations in male and female mya arenaria mollusca bivalvia during the Reproductive Cycle
General and Comparative Endocrinology, 2006Co-Authors: S Gauthierclerc, J Pellerin, J C AmiardAbstract:Abstract Perturbation of the Reproductive Cycle as well as vitellin-like protein synthesis have already been reported in Mya arenaria sampled in contaminated areas of the St. Lawrence maritime estuary (Quebec, Canada). To assess the potential role of endocrine disruptors in modulating the Reproductive Cycle in clams, the role of sex steroids has to be clarified. We determined the levels of estradiol-17β and testosterone during the Reproductive Cycle in female and male M. arenaria . Both steroids were measured by ELISA in the gonads and no differences in steroid profiles appeared between sexes. Estrogen levels varied between 150 and 400 pg g −1 wet weight over gametogenesis and were near 10 times higher than testosterone levels. Results showed transient increases of both steroids at the onset of vitellogenesis in females and during the spawning stage in both sexes. These findings indicate that these hormones could have a role as endogenous modulators of gametogenesis. Further studies are, however, needed to describe the pathway of steroid synthesis in clam gonad and elucidate steroid involvement in controlling gametogenesis and as well as their relationship with neurohormones since these latter are required to promote sexual maturation.
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estradiol 17β and testosterone concentrations in male and female mya arenaria mollusca bivalvia during the Reproductive Cycle
General and Comparative Endocrinology, 2006Co-Authors: S Gauthierclerc, J Pellerin, J C AmiardAbstract:Perturbation of the Reproductive Cycle as well as vitellin-like protein synthesis have already been reported in Mya arenaria sampled in contaminated areas of the St. Lawrence maritime estuary (Quebec, Canada). To assess the potential role of endocrine disruptors in modulating the Reproductive Cycle in clams, the role of sex steroids has to be clarified. We determined the levels of estradiol-17beta and testosterone during the Reproductive Cycle in female and male M. arenaria. Both steroids were measured by ELISA in the gonads and no differences in steroid profiles appeared between sexes. Estrogen levels varied between 150 and 400 pg g(-1) wet weight over gametogenesis and were near 10 times higher than testosterone levels. Results showed transient increases of both steroids at the onset of vitellogenesis in females and during the spawning stage in both sexes. These findings indicate that these hormones could have a role as endogenous modulators of gametogenesis. Further studies are, however, needed to describe the pathway of steroid synthesis in clam gonad and elucidate steroid involvement in controlling gametogenesis and as well as their relationship with neurohormones since these latter are required to promote sexual maturation.
S Gauthierclerc - One of the best experts on this subject based on the ideXlab platform.
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estradiol 17β and testosterone concentrations in male and female mya arenaria mollusca bivalvia during the Reproductive Cycle
General and Comparative Endocrinology, 2006Co-Authors: S Gauthierclerc, J Pellerin, J C AmiardAbstract:Abstract Perturbation of the Reproductive Cycle as well as vitellin-like protein synthesis have already been reported in Mya arenaria sampled in contaminated areas of the St. Lawrence maritime estuary (Quebec, Canada). To assess the potential role of endocrine disruptors in modulating the Reproductive Cycle in clams, the role of sex steroids has to be clarified. We determined the levels of estradiol-17β and testosterone during the Reproductive Cycle in female and male M. arenaria . Both steroids were measured by ELISA in the gonads and no differences in steroid profiles appeared between sexes. Estrogen levels varied between 150 and 400 pg g −1 wet weight over gametogenesis and were near 10 times higher than testosterone levels. Results showed transient increases of both steroids at the onset of vitellogenesis in females and during the spawning stage in both sexes. These findings indicate that these hormones could have a role as endogenous modulators of gametogenesis. Further studies are, however, needed to describe the pathway of steroid synthesis in clam gonad and elucidate steroid involvement in controlling gametogenesis and as well as their relationship with neurohormones since these latter are required to promote sexual maturation.
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estradiol 17β and testosterone concentrations in male and female mya arenaria mollusca bivalvia during the Reproductive Cycle
General and Comparative Endocrinology, 2006Co-Authors: S Gauthierclerc, J Pellerin, J C AmiardAbstract:Perturbation of the Reproductive Cycle as well as vitellin-like protein synthesis have already been reported in Mya arenaria sampled in contaminated areas of the St. Lawrence maritime estuary (Quebec, Canada). To assess the potential role of endocrine disruptors in modulating the Reproductive Cycle in clams, the role of sex steroids has to be clarified. We determined the levels of estradiol-17beta and testosterone during the Reproductive Cycle in female and male M. arenaria. Both steroids were measured by ELISA in the gonads and no differences in steroid profiles appeared between sexes. Estrogen levels varied between 150 and 400 pg g(-1) wet weight over gametogenesis and were near 10 times higher than testosterone levels. Results showed transient increases of both steroids at the onset of vitellogenesis in females and during the spawning stage in both sexes. These findings indicate that these hormones could have a role as endogenous modulators of gametogenesis. Further studies are, however, needed to describe the pathway of steroid synthesis in clam gonad and elucidate steroid involvement in controlling gametogenesis and as well as their relationship with neurohormones since these latter are required to promote sexual maturation.
J Pellerin - One of the best experts on this subject based on the ideXlab platform.
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estradiol 17β and testosterone concentrations in male and female mya arenaria mollusca bivalvia during the Reproductive Cycle
General and Comparative Endocrinology, 2006Co-Authors: S Gauthierclerc, J Pellerin, J C AmiardAbstract:Abstract Perturbation of the Reproductive Cycle as well as vitellin-like protein synthesis have already been reported in Mya arenaria sampled in contaminated areas of the St. Lawrence maritime estuary (Quebec, Canada). To assess the potential role of endocrine disruptors in modulating the Reproductive Cycle in clams, the role of sex steroids has to be clarified. We determined the levels of estradiol-17β and testosterone during the Reproductive Cycle in female and male M. arenaria . Both steroids were measured by ELISA in the gonads and no differences in steroid profiles appeared between sexes. Estrogen levels varied between 150 and 400 pg g −1 wet weight over gametogenesis and were near 10 times higher than testosterone levels. Results showed transient increases of both steroids at the onset of vitellogenesis in females and during the spawning stage in both sexes. These findings indicate that these hormones could have a role as endogenous modulators of gametogenesis. Further studies are, however, needed to describe the pathway of steroid synthesis in clam gonad and elucidate steroid involvement in controlling gametogenesis and as well as their relationship with neurohormones since these latter are required to promote sexual maturation.
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estradiol 17β and testosterone concentrations in male and female mya arenaria mollusca bivalvia during the Reproductive Cycle
General and Comparative Endocrinology, 2006Co-Authors: S Gauthierclerc, J Pellerin, J C AmiardAbstract:Perturbation of the Reproductive Cycle as well as vitellin-like protein synthesis have already been reported in Mya arenaria sampled in contaminated areas of the St. Lawrence maritime estuary (Quebec, Canada). To assess the potential role of endocrine disruptors in modulating the Reproductive Cycle in clams, the role of sex steroids has to be clarified. We determined the levels of estradiol-17beta and testosterone during the Reproductive Cycle in female and male M. arenaria. Both steroids were measured by ELISA in the gonads and no differences in steroid profiles appeared between sexes. Estrogen levels varied between 150 and 400 pg g(-1) wet weight over gametogenesis and were near 10 times higher than testosterone levels. Results showed transient increases of both steroids at the onset of vitellogenesis in females and during the spawning stage in both sexes. These findings indicate that these hormones could have a role as endogenous modulators of gametogenesis. Further studies are, however, needed to describe the pathway of steroid synthesis in clam gonad and elucidate steroid involvement in controlling gametogenesis and as well as their relationship with neurohormones since these latter are required to promote sexual maturation.
Lena Lampe - One of the best experts on this subject based on the ideXlab platform.
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metabolic balancing by mir 276 shapes the mosquito Reproductive Cycle and plasmodium falciparum development
Nature Communications, 2019Co-Authors: Lena Lampe, Marius Jentzsch, Sylwia Kierszniowska, Elena A. LevashinaAbstract:The blood-feeding behavior of Anopheles females delivers essential nutrients for egg development and drives parasite transmission between humans. Plasmodium growth is adapted to the vector Reproductive Cycle, but how changes in the Reproductive Cycle impact parasite development remains unclear. Here, we show that the bloodmeal-induced miR-276-5p fine-tunes the expression of branched-chain amino acid transferase to terminate the Reproductive Cycle. Silencing of miR-276 prolongs high rates of amino acid (AA) catabolism and increases female fertility, suggesting that timely termination of AA catabolism restricts mosquito investment into reproduction. Prolongation of AA catabolism in P. falciparum-infected females also compromises the development of the transmissible sporozoite forms. Our results suggest that Plasmodium sporogony exploits the surplus mosquito resources available after Reproductive investment and demonstrate the crucial role of the mosquito AA metabolism in within-vector parasite proliferation and malaria transmission.
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Metabolic balancing by miR-276 shapes the mosquito Reproductive Cycle and Plasmodium falciparum development
2019Co-Authors: Lena Lampe, Marius Jentzsch, Elena A. LevashinaAbstract:Anopheles mosquitoes are obligate vectors of the human malaria parasite Plasmodium falciparum. The blood-feeding behavior of Anopheles females delivers essential nutrients for egg development and drives transmission from one human host to another. Plasmodium growth is adapted to the vector Reproductive Cycle, but how changes in the Reproductive Cycle impact parasite development is poorly understood. Here, we show that the blood meal-induced miR-276-5p fine-tunes the duration of the mosquito Reproductive Cycle. Silencing of miR-276 prolonged amino acid catabolism and increased female fertility rates, suggesting that timely termination of the Reproductive Cycle restricts mosquito investment into reproduction. Prolongation of the Reproductive period in P. falciparum-infected females compromised the development of the transmissible parasite form called sporozoite. Our results suggest that Plasmodium sporogony exploits surplus resources after mosquito Reproductive investment and demonstrate the crucial role of the mosquito amino acid metabolism in parasite within-vector proliferation and malaria transmission.
Julio Vallejo - One of the best experts on this subject based on the ideXlab platform.
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Female Reproductive Cycle and obsessive-compulsive disorder.
The Journal of clinical psychiatry, 2005Co-Authors: Javier Labad, José M. Menchón, Pino Alonso, Cinto Segalàs, Susana Jiménez, Julio VallejoAbstract:BACKGROUND: The aim of our study was to assess whether there is a relationship between Reproductive Cycle events and the initiation or changes in symptoms of obsessive-compulsive disorder (OCD). METHOD: Forty-six female outpatients meeting DSM-IV criteria for OCD completed a semistructured interview at our OCD unit to assess the relationship between Reproductive Cycle events and OCD. Dates of data collection were from January 2001 to December 2003. RESULTS: In our sample, OCD onset occurred in the same year as menarche in 22% (N = 10), at pregnancy in 2% (N = 1), at postpartum in 7% (N = 3), and at menopause in 2% (N = 1). Worsening of preexisting OCD was reported by 20% of patients (9/45) at premenstruum, 8% (1/12) at pregnancy, 50% (6/12) at postpartum, and 8% (1/12) at menopause. The number of premenstrual mood symptoms, which included anxiety, irritability, mood lability and depressed mood, was associated with both premenstrual worsening of OCD (OR = 5.1, p < .01) and onset or worsening of OCD at postpartum (OR = 2.7, p < .05). Patients with an onset or worsening of OCD at postpartum also more frequently reported pre-menstrual worsening of OCD and previous history of major depressive disorder, including postpartum depression (p < or =.05 for all). CONCLUSION: In a substantial number of patients, the onset or worsening of OCD was related to Reproductive Cycle events, especially at menarche and postpartum. Certain women with OCD seem to be vulnerable to worsening of OCD at different Reproductive periods that imply hormonal fluctuations, and premenstruum and post-partum were the 2 Reproductive events with a greater vulnerability. Those patients whose OCD symptoms appeared to be related to Reproductive events also exhibited a greater history of mood symptoms (premenstrual depression and major depressive episodes).
