The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform
Christine M Custer - One of the best experts on this subject based on the ideXlab platform.
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Perfluoroalkyl Contaminant Exposure and Effects in Tree Swallows Nesting at Clarks Marsh, Oscoda, Michigan, USA
Archives of Environmental Contamination and Toxicology, 2019Co-Authors: Christine M Custer, Robert Delaney, Paul Michael Howell Dummer, Thomas W Custer, Sandra Schultz, Natalie Karouna-renierAbstract:A site in northeastern Michigan, Oscoda Township, has some of the highest recorded exposure in birds to perfluorinated substances (PFASs) in the United States. Some egg and plasma concentrations at that location exceeded the lowest Reproductive Effect threshold established for two avian laboratory species. The objectives of this study were to determine whether there were Reproductive Effects or physiological responses in a model bird species, the tree swallow ( Tachycineta bicolor ), associated with this extremely high exposure to PFASs. The lack of exposure above background to other contaminants at this site allowed for an assessment of PFAS Effects without the complication that responses may be caused by other contaminants. A secondary objective was to determine the distribution of PFASs in multiple tissue types to better understand and interpret residues in different tissues. This can best be done at highly exposed locations where tissue concentrations would be expected to be above detectable levels if they are present in that tissue. There were no demonstrable Effects of PFAS exposure on reproduction nor on most physiological responses.
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Perfluoroalkyl Contaminant Exposure and Effects in Tree Swallows Nesting at Clarks Marsh, Oscoda, Michigan, USA.
Archives of environmental contamination and toxicology, 2019Co-Authors: Christine M Custer, Robert Delaney, Paul Michael Howell Dummer, Thomas W Custer, Sandra L. Schultz, Natalie Karouna-renierAbstract:A site in northeastern Michigan, Oscoda Township, has some of the highest recorded exposure in birds to perfluorinated substances (PFASs) in the United States. Some egg and plasma concentrations at that location exceeded the lowest Reproductive Effect threshold established for two avian laboratory species. The objectives of this study were to determine whether there were Reproductive Effects or physiological responses in a model bird species, the tree swallow (Tachycineta bicolor), associated with this extremely high exposure to PFASs. The lack of exposure above background to other contaminants at this site allowed for an assessment of PFAS Effects without the complication that responses may be caused by other contaminants. A secondary objective was to determine the distribution of PFASs in multiple tissue types to better understand and interpret residues in different tissues. This can best be done at highly exposed locations where tissue concentrations would be expected to be above detectable levels if they are present in that tissue. There were no demonstrable Effects of PFAS exposure on reproduction nor on most physiological responses.
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concentrations and spatial patterns of organic contaminants in tree swallow tachycineta bicolor eggs at united states and binational great lakes areas of concern 2010 2015
Environmental Toxicology and Chemistry, 2016Co-Authors: Christine M Custer, Thomas W Custer, Paul M Dummer, Diana R Goldberg, Christian J FransonAbstract:Tree swallows, Tachycineta bicolor, were sampled across the Great Lakes basin in 2010 through 2015 to provide a system-wide assessment of current exposure to organic contaminants. The results provide information identified as critical by regulators to assess the "bird or animal deformity or Reproductive problems" beneficial use impairment. Eggs were collected from 69 sites across all 5 Great Lakes, including 27 Areas of Concern (AOCs), some with multiple sites, and 10 sites not listed as an AOC. Concentrations of organic contaminants in eggs were quantified and compared with background and Reproductive Effect thresholds. Approximately 30% of AOCs had geometric mean concentrations of total polychlorinated biphenyls (PCBs) at or below average background exposure (0.34 μg/g wet wt). Exposure to polybrominated diphenyl ethers (PBDEs) was minimal, and only 3 of 27 AOCs and 1 non-AOC had geometric mean concentrations that exceeded background for tree swallows (96 ng/g wet wt). Concentrations of both PCBs and PBDEs were 10 to 20 times below the lower limit associated with impaired hatching success. In contrast, geometric mean concentrations of polychlorinated dibenzo-p-dioxin and furan (PCDD-F) toxic equivalents (TEQs) at the Saginaw River and Bay AOC and Midland, Michigan, USA (a non-AOC site), exceeded the lower limit for hatching Effects (181 pg/g PCDD-F TEQs). The rest of the sites had geometric mean concentrations of PCDD-F TEQs below background levels (87 pg/g PCDD-F TEQs). Other organic contaminants, including p,p'-dichlorodiphenyldichloroethylene, mirex, heptachlor, and chlordane, were at or below background or adverse Effect concentrations. Environ Toxicol Chem 2016;35:3071-3092. Published 2016 Wiley Periodicals Inc on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
Natalie Karouna-renier - One of the best experts on this subject based on the ideXlab platform.
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Perfluoroalkyl Contaminant Exposure and Effects in Tree Swallows Nesting at Clarks Marsh, Oscoda, Michigan, USA
Archives of Environmental Contamination and Toxicology, 2019Co-Authors: Christine M Custer, Robert Delaney, Paul Michael Howell Dummer, Thomas W Custer, Sandra Schultz, Natalie Karouna-renierAbstract:A site in northeastern Michigan, Oscoda Township, has some of the highest recorded exposure in birds to perfluorinated substances (PFASs) in the United States. Some egg and plasma concentrations at that location exceeded the lowest Reproductive Effect threshold established for two avian laboratory species. The objectives of this study were to determine whether there were Reproductive Effects or physiological responses in a model bird species, the tree swallow ( Tachycineta bicolor ), associated with this extremely high exposure to PFASs. The lack of exposure above background to other contaminants at this site allowed for an assessment of PFAS Effects without the complication that responses may be caused by other contaminants. A secondary objective was to determine the distribution of PFASs in multiple tissue types to better understand and interpret residues in different tissues. This can best be done at highly exposed locations where tissue concentrations would be expected to be above detectable levels if they are present in that tissue. There were no demonstrable Effects of PFAS exposure on reproduction nor on most physiological responses.
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Perfluoroalkyl Contaminant Exposure and Effects in Tree Swallows Nesting at Clarks Marsh, Oscoda, Michigan, USA.
Archives of environmental contamination and toxicology, 2019Co-Authors: Christine M Custer, Robert Delaney, Paul Michael Howell Dummer, Thomas W Custer, Sandra L. Schultz, Natalie Karouna-renierAbstract:A site in northeastern Michigan, Oscoda Township, has some of the highest recorded exposure in birds to perfluorinated substances (PFASs) in the United States. Some egg and plasma concentrations at that location exceeded the lowest Reproductive Effect threshold established for two avian laboratory species. The objectives of this study were to determine whether there were Reproductive Effects or physiological responses in a model bird species, the tree swallow (Tachycineta bicolor), associated with this extremely high exposure to PFASs. The lack of exposure above background to other contaminants at this site allowed for an assessment of PFAS Effects without the complication that responses may be caused by other contaminants. A secondary objective was to determine the distribution of PFASs in multiple tissue types to better understand and interpret residues in different tissues. This can best be done at highly exposed locations where tissue concentrations would be expected to be above detectable levels if they are present in that tissue. There were no demonstrable Effects of PFAS exposure on reproduction nor on most physiological responses.
Thomas W Custer - One of the best experts on this subject based on the ideXlab platform.
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Perfluoroalkyl Contaminant Exposure and Effects in Tree Swallows Nesting at Clarks Marsh, Oscoda, Michigan, USA
Archives of Environmental Contamination and Toxicology, 2019Co-Authors: Christine M Custer, Robert Delaney, Paul Michael Howell Dummer, Thomas W Custer, Sandra Schultz, Natalie Karouna-renierAbstract:A site in northeastern Michigan, Oscoda Township, has some of the highest recorded exposure in birds to perfluorinated substances (PFASs) in the United States. Some egg and plasma concentrations at that location exceeded the lowest Reproductive Effect threshold established for two avian laboratory species. The objectives of this study were to determine whether there were Reproductive Effects or physiological responses in a model bird species, the tree swallow ( Tachycineta bicolor ), associated with this extremely high exposure to PFASs. The lack of exposure above background to other contaminants at this site allowed for an assessment of PFAS Effects without the complication that responses may be caused by other contaminants. A secondary objective was to determine the distribution of PFASs in multiple tissue types to better understand and interpret residues in different tissues. This can best be done at highly exposed locations where tissue concentrations would be expected to be above detectable levels if they are present in that tissue. There were no demonstrable Effects of PFAS exposure on reproduction nor on most physiological responses.
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Perfluoroalkyl Contaminant Exposure and Effects in Tree Swallows Nesting at Clarks Marsh, Oscoda, Michigan, USA.
Archives of environmental contamination and toxicology, 2019Co-Authors: Christine M Custer, Robert Delaney, Paul Michael Howell Dummer, Thomas W Custer, Sandra L. Schultz, Natalie Karouna-renierAbstract:A site in northeastern Michigan, Oscoda Township, has some of the highest recorded exposure in birds to perfluorinated substances (PFASs) in the United States. Some egg and plasma concentrations at that location exceeded the lowest Reproductive Effect threshold established for two avian laboratory species. The objectives of this study were to determine whether there were Reproductive Effects or physiological responses in a model bird species, the tree swallow (Tachycineta bicolor), associated with this extremely high exposure to PFASs. The lack of exposure above background to other contaminants at this site allowed for an assessment of PFAS Effects without the complication that responses may be caused by other contaminants. A secondary objective was to determine the distribution of PFASs in multiple tissue types to better understand and interpret residues in different tissues. This can best be done at highly exposed locations where tissue concentrations would be expected to be above detectable levels if they are present in that tissue. There were no demonstrable Effects of PFAS exposure on reproduction nor on most physiological responses.
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concentrations and spatial patterns of organic contaminants in tree swallow tachycineta bicolor eggs at united states and binational great lakes areas of concern 2010 2015
Environmental Toxicology and Chemistry, 2016Co-Authors: Christine M Custer, Thomas W Custer, Paul M Dummer, Diana R Goldberg, Christian J FransonAbstract:Tree swallows, Tachycineta bicolor, were sampled across the Great Lakes basin in 2010 through 2015 to provide a system-wide assessment of current exposure to organic contaminants. The results provide information identified as critical by regulators to assess the "bird or animal deformity or Reproductive problems" beneficial use impairment. Eggs were collected from 69 sites across all 5 Great Lakes, including 27 Areas of Concern (AOCs), some with multiple sites, and 10 sites not listed as an AOC. Concentrations of organic contaminants in eggs were quantified and compared with background and Reproductive Effect thresholds. Approximately 30% of AOCs had geometric mean concentrations of total polychlorinated biphenyls (PCBs) at or below average background exposure (0.34 μg/g wet wt). Exposure to polybrominated diphenyl ethers (PBDEs) was minimal, and only 3 of 27 AOCs and 1 non-AOC had geometric mean concentrations that exceeded background for tree swallows (96 ng/g wet wt). Concentrations of both PCBs and PBDEs were 10 to 20 times below the lower limit associated with impaired hatching success. In contrast, geometric mean concentrations of polychlorinated dibenzo-p-dioxin and furan (PCDD-F) toxic equivalents (TEQs) at the Saginaw River and Bay AOC and Midland, Michigan, USA (a non-AOC site), exceeded the lower limit for hatching Effects (181 pg/g PCDD-F TEQs). The rest of the sites had geometric mean concentrations of PCDD-F TEQs below background levels (87 pg/g PCDD-F TEQs). Other organic contaminants, including p,p'-dichlorodiphenyldichloroethylene, mirex, heptachlor, and chlordane, were at or below background or adverse Effect concentrations. Environ Toxicol Chem 2016;35:3071-3092. Published 2016 Wiley Periodicals Inc on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
Deborah Moll - One of the best experts on this subject based on the ideXlab platform.
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a review of nitrates in drinking water maternal exposure and adverse Reproductive and developmental outcomes
Ciencia & Saude Coletiva, 2007Co-Authors: Deana M Manassaram, Lorraine C Backer, Deborah MollAbstract:In this review, we present an update on maternal exposure to nitrates in drinking water in relation to possible adverse Reproductive and developmental Effects, and discuss nitrates in drinking water in the United States. The current standard for nitrates in drinking water is based on retrospective studies and approximates a level that protects infants from methemoglobinemia, but no safety factor is built into the standard. The current standard applies only to public water systems. Animal studies have found adverse Reproductive Effects resulting from higher doses of nitrate or nitrite. The epidemiologic evidence of a direct exposure-response relationship between drinking water nitrate level and adverse Reproductive Effect is still not clear. However, some reports have suggested an association between exposure to nitrates in drinking water and spontaneous abortions, intrauterine growth restriction, and various birth defects. Uncertainties in epidemiologic studies include the lack of individual exposure assessment that would rule out confounding of the exposure with some other cause. We conclude that the current literature does not provide sufficient evidence of a causal relationship between exposure to nitrates in drinking water and adverse Reproductive Effects.
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a review of nitrates in drinking water maternal exposure and adverse Reproductive and developmental outcomes
Environmental Health Perspectives, 2006Co-Authors: Deana M Manassaram, Lorraine C Backer, Deborah MollAbstract:In this review we present an update on maternal exposure to nitrates in drinking water in relation to possible adverse Reproductive and developmental Effects, and also discuss nitrates in drinking water in the United States. The current standard for nitrates in drinking water is based on retrospective studies and approximates a level that protects infants from methemoglobinemia, but no safety factor is built into the standard. The current standard applies only to public water systems. Drinking water source was related to nitrate exposure (i.e., private systems water was more likely than community system water to have nitrate levels above the maximum contaminant limit). Animal studies have found adverse Reproductive Effects resulting from higher doses of nitrate or nitrite. The epidemiologic evidence of a direct exposure–response relationship between drinking water nitrate level and adverse Reproductive Effect is still not clear. However, some reports have suggested an association between exposure to nitrates in drinking water and spontaneous abortions, intrauterine growth restriction, and various birth defects. Uncertainties in epidemiologic studies include the lack of individual exposure assessment that would rule out confounding of the exposure with some other cause. Nitrates may be just one of the contaminants in drinking water contributing to adverse outcomes. We conclude that the current literature does not provide sufficient evidence of a causal relationship between exposure to nitrates in drinking water and adverse Reproductive Effects. Future studies incorporating individual exposure assessment about users of private wells—the population most at risk—should be considered.
Paul Michael Howell Dummer - One of the best experts on this subject based on the ideXlab platform.
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Perfluoroalkyl Contaminant Exposure and Effects in Tree Swallows Nesting at Clarks Marsh, Oscoda, Michigan, USA
Archives of Environmental Contamination and Toxicology, 2019Co-Authors: Christine M Custer, Robert Delaney, Paul Michael Howell Dummer, Thomas W Custer, Sandra Schultz, Natalie Karouna-renierAbstract:A site in northeastern Michigan, Oscoda Township, has some of the highest recorded exposure in birds to perfluorinated substances (PFASs) in the United States. Some egg and plasma concentrations at that location exceeded the lowest Reproductive Effect threshold established for two avian laboratory species. The objectives of this study were to determine whether there were Reproductive Effects or physiological responses in a model bird species, the tree swallow ( Tachycineta bicolor ), associated with this extremely high exposure to PFASs. The lack of exposure above background to other contaminants at this site allowed for an assessment of PFAS Effects without the complication that responses may be caused by other contaminants. A secondary objective was to determine the distribution of PFASs in multiple tissue types to better understand and interpret residues in different tissues. This can best be done at highly exposed locations where tissue concentrations would be expected to be above detectable levels if they are present in that tissue. There were no demonstrable Effects of PFAS exposure on reproduction nor on most physiological responses.
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Perfluoroalkyl Contaminant Exposure and Effects in Tree Swallows Nesting at Clarks Marsh, Oscoda, Michigan, USA.
Archives of environmental contamination and toxicology, 2019Co-Authors: Christine M Custer, Robert Delaney, Paul Michael Howell Dummer, Thomas W Custer, Sandra L. Schultz, Natalie Karouna-renierAbstract:A site in northeastern Michigan, Oscoda Township, has some of the highest recorded exposure in birds to perfluorinated substances (PFASs) in the United States. Some egg and plasma concentrations at that location exceeded the lowest Reproductive Effect threshold established for two avian laboratory species. The objectives of this study were to determine whether there were Reproductive Effects or physiological responses in a model bird species, the tree swallow (Tachycineta bicolor), associated with this extremely high exposure to PFASs. The lack of exposure above background to other contaminants at this site allowed for an assessment of PFAS Effects without the complication that responses may be caused by other contaminants. A secondary objective was to determine the distribution of PFASs in multiple tissue types to better understand and interpret residues in different tissues. This can best be done at highly exposed locations where tissue concentrations would be expected to be above detectable levels if they are present in that tissue. There were no demonstrable Effects of PFAS exposure on reproduction nor on most physiological responses.