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Mara Z Vitolins - One of the best experts on this subject based on the ideXlab platform.
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Reproductive History and oral contraceptive use in relation to risk of triple negative breast cancer
Journal of the National Cancer Institute, 2011Co-Authors: Amanda I Phipps, Rowan T Chlebowski, Ross L Prentice, Anne Mctiernan, Jean Wactawskiwende, Lewis H Kuller, Lucile L Adamscampbell, Dorothy S Lane, Marcia L Stefanick, Mara Z VitolinsAbstract:Results Reproductive History was differentially associated with risk of triple-negative and ER+ breast cancers. Nulliparity was associated with decreased risk of triple-negative breast cancer (HR = 0.61, 95% confidence interval [CI] = 0.37 to 0.97) but increased risk of ER+ breast cancer (HR = 1.35, 95% CI = 1.20 to 1.52). Age-adjusted absolute rates of triple-negative breast cancer were 2.71 and 1.54 per 10 000 person-years in parous and nulliparous women, respectively; by comparison, rates of ER+ breast cancer were 21.10 and 28.16 per 10 000 person-years in the same two groups. Among parous women, the number of births was positively associated with risk of triple-negative disease (HR for three births or more vs one birth = 1.46, 95% CI = 0.82 to 2.63) and inversely associated with risk of ER+ disease (HR = 0.88, 95% CI = 0.74 to 1.04). Ages at menarche and menopause were modestly associated with risk of ER+ but not triple-negative breast cancer; breastfeeding and oral contraceptive use were not associated with either subtype. Conclusion The association between parity and breast cancer risk differs appreciably for ER+ and triple-negative breast cancers. These findings require further confirmation because the biological mechanisms underlying these differences are uncertain.
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Reproductive History and oral contraceptive use in relation to risk of triple negative breast cancer
Journal of the National Cancer Institute, 2011Co-Authors: Amanda I Phipps, Rowan T Chlebowski, Ross L Prentice, Anne Mctiernan, Jean Wactawskiwende, Lewis H Kuller, Lucile L Adamscampbell, Dorothy S Lane, Marcia L Stefanick, Mara Z VitolinsAbstract:Background Triple-negative (ie, estrogen receptor [ER], progesterone receptor, and HER2 negative) breast cancer occurs disproportionately among African American women compared with white women and is associated with a worse prognosis than ER-positive (ER+) breast cancer. Hormonally mediated risk factors may be differentially related to risk of triple-negative and ER+ breast cancers. Methods Using data from 155,723 women enrolled in the Women's Health Initiative, we assessed associations between Reproductive and menstrual History, breastfeeding, oral contraceptive use, and subtype-specific breast cancer risk. We used Cox regression to evaluate associations with triple-negative (N = 307) and ER+ (N = 2610) breast cancers and used partial likelihood methods to test for differences in subtype-specific hazard ratios (HRs). Results Reproductive History was differentially associated with risk of triple-negative and ER+ breast cancers. Nulliparity was associated with decreased risk of triple-negative breast cancer (HR = 0.61, 95% confidence interval [CI] = 0.37 to 0.97) but increased risk of ER+ breast cancer (HR = 1.35, 95% CI = 1.20 to 1.52). Age-adjusted absolute rates of triple-negative breast cancer were 2.71 and 1.54 per 10,000 person-years in parous and nulliparous women, respectively; by comparison, rates of ER+ breast cancer were 21.10 and 28.16 per 10,000 person-years in the same two groups. Among parous women, the number of births was positively associated with risk of triple-negative disease (HR for three births or more vs one birth = 1.46, 95% CI = 0.82 to 2.63) and inversely associated with risk of ER+ disease (HR = 0.88, 95% CI = 0.74 to 1.04). Ages at menarche and menopause were modestly associated with risk of ER+ but not triple-negative breast cancer; breastfeeding and oral contraceptive use were not associated with either subtype. Conclusion The association between parity and breast cancer risk differs appreciably for ER+ and triple-negative breast cancers. These findings require further confirmation because the biological mechanisms underlying these differences are uncertain.
Amanda I Phipps - One of the best experts on this subject based on the ideXlab platform.
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Reproductive History breast feeding and risk of triple negative breast cancer the breast cancer etiology in minorities bem study
International Journal of Cancer, 2018Co-Authors: Esther M John, Amanda I Phipps, Lisa M Hines, Jocelyn Koo, Teri A Longacre, Sue A Ingles, Kathy B Baumgartner, Martha L SlatteryAbstract:Few risk factors have been identified for triple negative breast cancer (TNBC) which lacks expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). This more aggressive subtype disproportionately affects some racial/ethnic minorities and is associated with lower survival. We pooled data from three population-based studies (558 TNBC and 5,111 controls) and examined associations of TNBC risk with Reproductive History and breast-feeding. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression. For younger women, aged <50 years, TNBC risk was increased two-fold for parous women who never breast-fed compared to nulliparous women (OR = 2.02, 95% CI = 1.12-3.63). For younger parous women, longer duration of lifetime breast-feeding was associated with a borderline reduced risk (≥24 vs. 0 months: OR = 0.52, 95% CI = 0.26-1.04, Ptrend = 0.06). Considering the joint effect of parity and breast-feeding, risk was increased two-fold for women with ≥3 full-term pregnancies (FTPs) and no or short-term (<12 months) breast-feeding compared to women with 1-2 FTPs and breast-feeding ≥12 months (OR = 2.56, 95% CI = 1.22-5.35). None of these associations were observed among older women (≥50 years). Differences in Reproductive patterns possibly contribute to the ethnic differences in TNBC incidence. Among controls aged <50 years, the prevalence of no or short-term breast-feeding and ≥3 FTPs was highest for Hispanics (22%), followed by African Americans (18%), Asian Americans (15%) and non-Hispanic whites (6%). Breast-feeding is a modifiable behavioral factor that may lower TNBC risk and mitigate the effect of FTPs in women under age 50 years.
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Reproductive History and oral contraceptive use in relation to risk of triple negative breast cancer
Journal of the National Cancer Institute, 2011Co-Authors: Amanda I Phipps, Rowan T Chlebowski, Ross L Prentice, Anne Mctiernan, Jean Wactawskiwende, Lewis H Kuller, Lucile L Adamscampbell, Dorothy S Lane, Marcia L Stefanick, Mara Z VitolinsAbstract:Results Reproductive History was differentially associated with risk of triple-negative and ER+ breast cancers. Nulliparity was associated with decreased risk of triple-negative breast cancer (HR = 0.61, 95% confidence interval [CI] = 0.37 to 0.97) but increased risk of ER+ breast cancer (HR = 1.35, 95% CI = 1.20 to 1.52). Age-adjusted absolute rates of triple-negative breast cancer were 2.71 and 1.54 per 10 000 person-years in parous and nulliparous women, respectively; by comparison, rates of ER+ breast cancer were 21.10 and 28.16 per 10 000 person-years in the same two groups. Among parous women, the number of births was positively associated with risk of triple-negative disease (HR for three births or more vs one birth = 1.46, 95% CI = 0.82 to 2.63) and inversely associated with risk of ER+ disease (HR = 0.88, 95% CI = 0.74 to 1.04). Ages at menarche and menopause were modestly associated with risk of ER+ but not triple-negative breast cancer; breastfeeding and oral contraceptive use were not associated with either subtype. Conclusion The association between parity and breast cancer risk differs appreciably for ER+ and triple-negative breast cancers. These findings require further confirmation because the biological mechanisms underlying these differences are uncertain.
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Reproductive History and oral contraceptive use in relation to risk of triple negative breast cancer
Journal of the National Cancer Institute, 2011Co-Authors: Amanda I Phipps, Rowan T Chlebowski, Ross L Prentice, Anne Mctiernan, Jean Wactawskiwende, Lewis H Kuller, Lucile L Adamscampbell, Dorothy S Lane, Marcia L Stefanick, Mara Z VitolinsAbstract:Background Triple-negative (ie, estrogen receptor [ER], progesterone receptor, and HER2 negative) breast cancer occurs disproportionately among African American women compared with white women and is associated with a worse prognosis than ER-positive (ER+) breast cancer. Hormonally mediated risk factors may be differentially related to risk of triple-negative and ER+ breast cancers. Methods Using data from 155,723 women enrolled in the Women's Health Initiative, we assessed associations between Reproductive and menstrual History, breastfeeding, oral contraceptive use, and subtype-specific breast cancer risk. We used Cox regression to evaluate associations with triple-negative (N = 307) and ER+ (N = 2610) breast cancers and used partial likelihood methods to test for differences in subtype-specific hazard ratios (HRs). Results Reproductive History was differentially associated with risk of triple-negative and ER+ breast cancers. Nulliparity was associated with decreased risk of triple-negative breast cancer (HR = 0.61, 95% confidence interval [CI] = 0.37 to 0.97) but increased risk of ER+ breast cancer (HR = 1.35, 95% CI = 1.20 to 1.52). Age-adjusted absolute rates of triple-negative breast cancer were 2.71 and 1.54 per 10,000 person-years in parous and nulliparous women, respectively; by comparison, rates of ER+ breast cancer were 21.10 and 28.16 per 10,000 person-years in the same two groups. Among parous women, the number of births was positively associated with risk of triple-negative disease (HR for three births or more vs one birth = 1.46, 95% CI = 0.82 to 2.63) and inversely associated with risk of ER+ disease (HR = 0.88, 95% CI = 0.74 to 1.04). Ages at menarche and menopause were modestly associated with risk of ER+ but not triple-negative breast cancer; breastfeeding and oral contraceptive use were not associated with either subtype. Conclusion The association between parity and breast cancer risk differs appreciably for ER+ and triple-negative breast cancers. These findings require further confirmation because the biological mechanisms underlying these differences are uncertain.
Maza Villanera, María Rosario - One of the best experts on this subject based on the ideXlab platform.
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Prevalencia de seroreactores positivos a Brucella canis por inmunodifusión en Agar Gel en el distrito de Los Olivos
'Universidad Nacional Mayor de San Marcos Vicerectorado de Investigacion', 2016Co-Authors: Maza Villanera, María RosarioAbstract:--- Canine Brucellosis is an infectious disease caused by the Brucella canis bacterium (B. canis) characterized by the presentation of various Reproductive disorders. Moreover, due to its zoonotic nature, is considered an occupational disease in human beings. This study evaluated the prevalence of seroreactors to B. canis in the district of Los Olivos through serological diagnostic method: Agar Gel Immunodiffusion (AGID). For this purpose, 288 blood samples were collected from dogs from areas north, south, east and west of the district. From these samples we obtained 1 milliliter of blood serum. The AGID with antigen B. canis was performed in order to determine canine brucellosis seropositivity. The results showed a corrected prevalence of 5.43% (IC ± 2.31%) of seroreactors to B. canis. The results of the univariate analysis did not show significant statistical association between the variables included in the study (age, sex, physiological condition, walking habits, Reproductive History) on the results of serology to B. canis (p> .05).Multivariate analysis using multinomial logistic regression (MLR) and subsequent analysis using the Likelihood ratio test (LRTest) indicated that the age of the dogs (animals older than 1 year vs animals less than 1 year) and the Reproductive History (animals without a History of animal crossings History vs. crosses) are the variables that best explain the results of seropositivity to B. canis in the study (LRTest regression model with age and Reproductive History p 0.05). El análisis multivariado mediante el modelo de regresión logística multinomial (RLM) y el posterior análisis mediante el test de razón de Verosimilitud (LRTest) indicó que la edad de los perros (animales mayores de 1 año vs animales menores de 1 año) así como la historia reproductiva (animales sin historia de cruces vs animales con historia de cruces) son las variables que mejor explican los resultados de seropositividad a B. canis en el estudio. (LRTest Modelo regresión con edad e historia reproductiva p
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Prevalencia de seroreactores positivos a Brucella canis por inmunodifusión en Agar Gel en el distrito de Los Olivos
'Universidad Nacional Mayor de San Marcos Vicerectorado de Investigacion', 2013Co-Authors: Maza Villanera, María RosarioAbstract:La brucelosis canina es una enfermedad infecciosa ocasionada por la bacteria Brucella canis (B. canis) que se caracteriza por la presentación de diversos transtornos reproductivos. Además, debido a su carácter zoonótico, es considerada una enfermedad ocupacional en seres humanos. El presente estudio evaluó la prevalencia de seroreactores a B. canis en el distrito de Los Olivos a través del método de diagnóstico serológico: Inmunodifusión en Agar Gel (IDAG). Con este fin se recolectaron 288 muestras de sangre de caninos provenientes de los sectores norte, sur, este y oeste del distrito. A partir de estas muestras se obtuvieron 1 mililitro de suero sanguíneo. Se realizó la prueba de IGDA con antígeno de B .canis para determinar seropositividad a brucelosis canina. Los resultados indicaron una prevalencia corregida de 5.43% (IC ± 2.31%) de seroreactores a B. canis. Los resultados del análisis univariado no demostraron asociación estadística significativa entre las variables incluidas en el estudio (edad, sexo, condición fisiológica, hábitos de paseo e historia reproductiva) sobre los resultados de serología a B. canis (p>0.05). El análisis multivariado mediante el modelo de regresión logística multinomial (RLM) y el posterior análisis mediante el test de razón de Verosimilitud (LRTest) indicó que la edad de los perros (animales mayores de 1 año vs animales menores de 1 año) así como la historia reproductiva (animales sin historia de cruces vs animales con historia de cruces) son las variables que mejor explican los resultados de seropositividad a B. canis en el estudio. (LRTest Modelo regresión con edad e historia reproductiva p .05).Multivariate analysis using multinomial logistic regression (MLR) and subsequent analysis using the Likelihood ratio test (LRTest) indicated that the age of the dogs (animals older than 1 year vs animals less than 1 year) and the Reproductive History (animals without a History of animal crossings History vs. crosses) are the variables that best explain the results of seropositivity to B. canis in the study (LRTest regression model with age and Reproductive History p
Paula Duarteguterman - One of the best experts on this subject based on the ideXlab platform.
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premarin has opposing effects on spatial learning neural activation and serum cytokine levels in middle aged female rats depending on Reproductive History
Neurobiology of Aging, 2018Co-Authors: Liisa A M Galea, Meighen M Roes, Christina J Dimech, Cherylemiliane T Chow, Rand Mahmoud, Stephanie E Lieblich, Paula DuartegutermanAbstract:Abstract Menopause is associated with cognitive decline, and hormone therapies (HTs) may improve cognition depending on type and timing of HTs. Previous parity may influence cognition in later life. We investigated how primiparity and long-term ovariectomy influence cognition, neurogenesis, hormones, cytokines, and neuronal activation in middle-aged rats in response to Premarin, an HT. Nulliparous and primiparous rats were sham-ovariectomized or ovariectomized, administered vehicle or Premarin 6 months later, and all rats were trained in the Morris water maze. Premarin improved early spatial learning and memory in nulliparous rats but impaired early learning in primiparous rats. With training, primiparity increased hippocampal neurogenesis, and Premarin decreased immature neurons, regardless of parity. Moreover, Premarin increased serum tumor necrosis factor α and the CXC chemokine ligand 1 (CXCL1) in trained nulliparous, but not primiparous, rats. However, Premarin decreased the expression of the immediate early gene zif268 in the dorsal CA3 region in primiparous rats after training. Thus, primiparity alters how Premarin affects spatial learning, neuronal activation, and serum cytokines. These findings have implications for the treatment of age-associated cognitive decline in women.
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premarin has opposing effects on spatial learning neural activiation and serum cytokine levels in middle age dependent on Reproductive History
bioRxiv, 2017Co-Authors: Liisa A M Galea, Meighen M Roes, Cherylemiliane T Chow, Rand Mahmoud, Stephanie E Lieblich, Van Den Brink C, Paula DuartegutermanAbstract:Menopause is associated with cognitive decline, and hormone therapies (HT) can improve cognition dependent on time since menopause. Previous parity also influences cognition in later life. The present study investigated how primiparity and long-term ovariectomy influence cognition, hippocampal neurogenesis, and neuronal activation in middle-aged rats in response to the HT, Premarin. Nulliparous and primiparous rats were sham-ovariectomized or ovariectomized, administered vehicle or Premarin six months later, and trained in the Morris water maze. Premarin improved spatial learning and memory in nulliparous rats, but impaired spatial and reversal learning in primiparous rats. Primiparity increased hippocampal neurogenesis, whereas Premarin treatment decreased immature neurons in both primiparous and nulliparous middle-aged rats in a region-specific manner. Moreover, Premarin increased serum TNFα and KC/GRO in nulliparous, but not primiparous, rats, whereas Premarin increased zif268 expression in the CA3 region of the hippocampus in primiparous rats. Thus, primiparity alters how Premarin affects spatial learning, neuronal activation, serum cytokines, and adrenal mass. These findings have implications for the tailored treatment of age-associated cognitive decline in women.
Marcia L Stefanick - One of the best experts on this subject based on the ideXlab platform.
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age at menopause Reproductive History and venous thromboembolism risk among postmenopausal women the women s health initiative hormone therapy clinical trials
Menopause, 2014Co-Authors: Marianne Canonico, Marcia L Stefanick, Genevieve Plubureau, Mary Jo Osullivan, Barbara B Cochrane, Pierre Yves Scarabin, Joann E MansonAbstract:This study aims to investigate venous thromboembolism (VTE) risk in relation to age at menopause, age at menarche, parity, bilateral oophorectomy, and time since menopause, as well as any interaction with randomized hormone therapy (HT) assignment, among postmenopausal women. Using pooled data from the Women's Health Initiative HT clinical trials including 27,035 postmenopausal women aged 50 to 79 years who had no History of VTE, we assessed the risk of VTE in relation to age at menopause, age at menarche, parity, bilateral oophorectomy, and time since menopause by Cox proportional hazards models. Linear trends, quadratic relationships, and interactions of Reproductive life characteristics with HT on VTE risk were systematically tested. During follow-up, 426 women reported a first VTE, including 294 non-procedure-related events. No apparent interaction of Reproductive life characteristics with HT assignment on VTE risk was detected, and there was not a significant association between VTE and age at menarche, age at menopause, parity, oophorectomy, or time since menopause. However, analyses restricted to non-procedure-related VTE showed a U-shaped relationship between age at menopause and thrombotic risk that persisted after multivariable analysis (P 55 y) had a significantly increased VTE risk (hazard ratio [95% CI]: 1.8 [1.2-2.7] and 1.5 [1.0-2.4], respectively). Reproductive life characteristics have little association with VTE and do not seem to influence the effect of HT on thrombotic risk among postmenopausal women. Nevertheless, early and late onset of menopause might be newly identified risk factors for non-procedure-related VTE.
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Reproductive History and oral contraceptive use in relation to risk of triple negative breast cancer
Journal of the National Cancer Institute, 2011Co-Authors: Amanda I Phipps, Rowan T Chlebowski, Ross L Prentice, Anne Mctiernan, Jean Wactawskiwende, Lewis H Kuller, Lucile L Adamscampbell, Dorothy S Lane, Marcia L Stefanick, Mara Z VitolinsAbstract:Results Reproductive History was differentially associated with risk of triple-negative and ER+ breast cancers. Nulliparity was associated with decreased risk of triple-negative breast cancer (HR = 0.61, 95% confidence interval [CI] = 0.37 to 0.97) but increased risk of ER+ breast cancer (HR = 1.35, 95% CI = 1.20 to 1.52). Age-adjusted absolute rates of triple-negative breast cancer were 2.71 and 1.54 per 10 000 person-years in parous and nulliparous women, respectively; by comparison, rates of ER+ breast cancer were 21.10 and 28.16 per 10 000 person-years in the same two groups. Among parous women, the number of births was positively associated with risk of triple-negative disease (HR for three births or more vs one birth = 1.46, 95% CI = 0.82 to 2.63) and inversely associated with risk of ER+ disease (HR = 0.88, 95% CI = 0.74 to 1.04). Ages at menarche and menopause were modestly associated with risk of ER+ but not triple-negative breast cancer; breastfeeding and oral contraceptive use were not associated with either subtype. Conclusion The association between parity and breast cancer risk differs appreciably for ER+ and triple-negative breast cancers. These findings require further confirmation because the biological mechanisms underlying these differences are uncertain.
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Reproductive History and oral contraceptive use in relation to risk of triple negative breast cancer
Journal of the National Cancer Institute, 2011Co-Authors: Amanda I Phipps, Rowan T Chlebowski, Ross L Prentice, Anne Mctiernan, Jean Wactawskiwende, Lewis H Kuller, Lucile L Adamscampbell, Dorothy S Lane, Marcia L Stefanick, Mara Z VitolinsAbstract:Background Triple-negative (ie, estrogen receptor [ER], progesterone receptor, and HER2 negative) breast cancer occurs disproportionately among African American women compared with white women and is associated with a worse prognosis than ER-positive (ER+) breast cancer. Hormonally mediated risk factors may be differentially related to risk of triple-negative and ER+ breast cancers. Methods Using data from 155,723 women enrolled in the Women's Health Initiative, we assessed associations between Reproductive and menstrual History, breastfeeding, oral contraceptive use, and subtype-specific breast cancer risk. We used Cox regression to evaluate associations with triple-negative (N = 307) and ER+ (N = 2610) breast cancers and used partial likelihood methods to test for differences in subtype-specific hazard ratios (HRs). Results Reproductive History was differentially associated with risk of triple-negative and ER+ breast cancers. Nulliparity was associated with decreased risk of triple-negative breast cancer (HR = 0.61, 95% confidence interval [CI] = 0.37 to 0.97) but increased risk of ER+ breast cancer (HR = 1.35, 95% CI = 1.20 to 1.52). Age-adjusted absolute rates of triple-negative breast cancer were 2.71 and 1.54 per 10,000 person-years in parous and nulliparous women, respectively; by comparison, rates of ER+ breast cancer were 21.10 and 28.16 per 10,000 person-years in the same two groups. Among parous women, the number of births was positively associated with risk of triple-negative disease (HR for three births or more vs one birth = 1.46, 95% CI = 0.82 to 2.63) and inversely associated with risk of ER+ disease (HR = 0.88, 95% CI = 0.74 to 1.04). Ages at menarche and menopause were modestly associated with risk of ER+ but not triple-negative breast cancer; breastfeeding and oral contraceptive use were not associated with either subtype. Conclusion The association between parity and breast cancer risk differs appreciably for ER+ and triple-negative breast cancers. These findings require further confirmation because the biological mechanisms underlying these differences are uncertain.
