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Barbara Luke - One of the best experts on this subject based on the ideXlab platform.
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pregnancy and birth outcomes in couples with infertility with and without assisted Reproductive Technology with an emphasis on us population based studies
American Journal of Obstetrics and Gynecology, 2017Co-Authors: Barbara LukeAbstract:Infertility, defined as the inability to conceive within 1 year of unprotected intercourse, affects an estimated 80 million individuals worldwide, or 10-15% of couples of Reproductive age. Assisted Reproductive Technology includes all infertility treatments to achieve conception; in vitro fertilization is the process by which an oocyte is fertilized by semen outside the body; non-in vitro fertilization assisted Reproductive Technology treatments include ovulation induction, artificial insemination, and intrauterine insemination. Use of assisted Reproductive Technology has risen steadily in the United States during the past 2 decades due to several reasons, including childbearing at older maternal ages and increasing insurance coverage. The number of in vitro fertilization cycles in the United States has nearly doubled from 2000 through 2013 and currently 1.7% of all live births in the United States are the result of this Technology. Since the birth of the first child from in vitro fertilization >35 years ago, >5 million babies have been born from in vitro fertilization, half within the past 6 years. It is estimated that 1% of singletons, 19% of twins, and 25% of triplet or higher multiples are due to in vitro fertilization, and 4%, 21%, and 52%, respectively, are due to non-in vitro fertilization assisted Reproductive Technology. Higher plurality at birth results in a >10-fold increase in the risks for prematurity and low birthweight in twins vs singletons (adjusted odds ratio, 11.84; 95% confidence interval, 10.56–13.27 and adjusted odds ratio, 10.68; 95% confidence interval, 9.45–12.08, respectively). The use of donor oocytes is associated with increased risks for pregnancy-induced hypertension (adjusted odds ratio, 1.43; 95% confidence interval, 1.14–1.78) and prematurity (adjusted odds ratio, 1.43; 95% confidence interval, 1.11–1.83). The use of thawed embryos is associated with higher risks for pregnancy-induced hypertension (adjusted odds ratio, 1.30; 95% confidence interval, 1.08–1.57) and large-for-gestation birthweight (adjusted odds ratio, 1.74; 95% confidence interval, 1.45–2.08). Among singletons, in vitro fertilization is associated with increased risk of severe maternal morbidity compared with fertile deliveries (vaginal: adjusted odds ratio, 2.27; 95% confidence interval, 1.78–2.88; cesarean: adjusted odds ratio, 1.67; 95% confidence interval, 1.40–1.98, respectively) and subfertile deliveries (vaginal: adjusted odds ratio, 1.97; 95% confidence interval, 1.30–3.00; cesarean: adjusted odds ratio, 1.75; 95% confidence interval, 1.30–2.35, respectively). Among twins, cesarean in vitro fertilization deliveries have significantly greater severe maternal morbidity compared to cesarean fertile deliveries (adjusted odds ratio, 1.48; 95% confidence interval, 1.14–1.93). Subfertility, with or without in vitro fertilization or non-in vitro fertilization infertility treatments to achieve a pregnancy, is associated with increased risks of adverse maternal and perinatal outcomes. The major risk from in vitro fertilization treatments of multiple births (and the associated excess of perinatal morbidity) has been reduced over time, with fewer and better-quality embryos being transferred.
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validation of birth outcomes from the society for assisted Reproductive Technology clinic outcome reporting system sart cors population based analysis from the massachusetts outcome study of assisted Reproductive Technology mosart
Fertility and Sterility, 2016Co-Authors: Judy E. Stern, Daksha Gopal, Rebecca F Liberman, Marlene Anderka, Milton Kotelchuck, Barbara LukeAbstract:Objective To assess the validity of outcome data reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) compared with data from vital records and the birth defects registry in Massachusetts. Design Longitudinal cohort. Setting Not applicable. Participant(s) A total of 342,035 live births and fetal deaths from Massachusetts mothers giving birth in the state from July 1, 2004, to December 31, 2008; 9,092 births and fetal deaths were from mothers who had conceived with the use of assisted Reproductive Technology (ART) and whose cycle data had been reported to the SART CORS. Intervention(s) Not applicable. Main Outcome Measure(s) Percentage agreement between maternal race and ethnicity, delivery outcome (live birth or fetal death), plurality (singleton, twin, or triplet+), delivery date, and singleton birth weight reported in the SART CORS versus vital records; sensitivity and specificity for birth defects among singletons as reported in the SART CORS versus the Massachusetts Birth Defects Monitoring Program (BDMP). Result(s) There was >95% agreement between the SART CORS and vital records for fields of maternal race/ethnicity, live birth/fetal death, and plurality; birth outcome date was within 1 day with 94.9% agreement and birth weight was within 100 g with 89.6% agreement. In contrast, sensitivity for report of any birth defect was 38.6%, with a range of 18.4%–50.0%, for specific birth defect categories. Conclusion(s) Although most SART CORS outcome fields are accurately reported, birth defect variables showed poor sensitivity compared with the gold standard data from the BDMP. We suggest that reporting of birth defects be discontinued.
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accuracy of self reported survey data on assisted Reproductive Technology treatment parameters and Reproductive history
American Journal of Obstetrics and Gynecology, 2016Co-Authors: Judy E. Stern, Barbara Luke, Alexander C Mclain, Germaine Buck M Louis, Edwina H YeungAbstract:Background It is unknown whether data obtained from maternal self-report for assisted Reproductive Technology treatment parameters and Reproductive history are accurate for use in research studies. Objectives We evaluated the accuracy of self-reported in assisted Reproductive Technology treatment and Reproductive history from the Upstate KIDS study in comparison with clinical data reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Study Design Upstate KIDS maternal questionnaire data from deliveries between 2008 and 2010 were linked to data reported to Society for Assisted Reproductive Technology Clinic Outcome Reporting System. The 617 index deliveries were compared as to treatment type (frozen embryo transfer and donor egg or sperm) and use of intracytoplasmic sperm injection and assisted hatching. Use of injectable medications, self-report for assisted Reproductive Technology, or frozen embryo transfer prior to the index deliveries were also compared. We report agreement in which both sources had yes or both no and sensitivity of maternal report using Society for Assisted Reproductive Technology Clinic Outcome Reporting System as the gold standard. Significance was determined using χ 2 at P Results Universal agreement was not reached on any parameter but was best for treatment type of frozen embryo transfer (agreement, 96%; sensitivity, 93%) and use of donor eggs (agreement, 97%; sensitivity, 82%) or sperm (agreement, 98%; sensitivity, 82%). Use of intracytoplasmic sperm injection (agreement, 78%: sensitivity, 78%) and assisted hatching (agreement, 57%; sensitivity, 38%) agreed less well with self-reported use ( P P Conclusion Women accurately report in vitro fertilization treatment but are less accurate about procedures handled in the laboratory (intracytoplasmic sperm injection or assisted hatching). Clinics might better communicate with patients on the use of these procedures, and researchers should use caution when using self-reported treatment data.
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Society for Assisted Reproductive Technology and assisted Reproductive Technology in the United States: a 2016 update
Fertility and Sterility, 2016Co-Authors: James P. Toner, Charles C. Coddington, Kevin J. Doody, Brad Van Voorhis, David B. Seifer, G. David Ball, Barbara Luke, Ethan WantmanAbstract:The Society for Assisted Reproductive Technology (SART) was established within a few years of assisted Reproductive Technology (ART) in the United States, and has not only reported on the evolution of infertility care, but also guided it toward improved success and safety. Moving beyond its initial role as a registry, SART has expanded its role to include quality assurance, data validation, practice and advertising guidelines, research, patient education and advocacy, and membership support. The success of ART in this country has greatly benefited from SART's role, as highlighted by a series of graphs. SART continues to set the standard and lead the way.
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adverse pregnancy and birth outcomes associated with underlying diagnosis with and without assisted Reproductive Technology treatment
Fertility and Sterility, 2015Co-Authors: Judy E. Stern, Barbara Luke, Mark D Hornstein, Daksha Gopal, Michael Tobias, Hafsatou DiopAbstract:Objective To compare the risks for adverse pregnancy and birth outcomes by diagnoses with and without assisted Reproductive Technology (ART) treatment to non-ART pregnancies in fertile women. Design Historical cohort of Massachusetts vital records linked to ART clinic data from Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Setting Not applicable. Patient(s) Diagnoses included male factor (ART only), endometriosis, ovulation disorders, tubal (ART only), and Reproductive inflammatory disorders (non-ART only). Pregnancies resulting in singleton and twin live births from 2004 to 2008 were linked to hospital discharges in women who had ART treatment (n = 3,689), women with no ART treatment in the current pregnancy (n = 4,098), and non-ART pregnancies in fertile women (n = 297,987). Intervention(s) None. Main Outcome Measure(s) Risks of gestational diabetes, prenatal hospitalizations, prematurity, low birth weight, and small for gestational age were modeled using multivariate logistic regression with fertile deliveries as the reference group adjusted for maternal age, race/ethnicity, education, chronic hypertension, diabetes mellitus, and plurality (adjusted odds ratios [AORs] and 95% confidence intervals [CIs]). Result(s) Risk of prenatal hospital admissions was increased for endometriosis (ART: 1.97, 1.38–2.80; non-ART: 3.34, 2.59–4.31), ovulation disorders (ART: 2.31, 1.81–2.96; non-ART: 2.56, 2.05–3.21), tubal factor (ART: 1.51, 1.14–2.01), and Reproductive inflammation (non-ART: 2.79, 2.47–3.15). Gestational diabetes was increased for women with ovulation disorders (ART: 2.17, 1.72–2.73; non-ART: 1.94, 1.52–2.48). Preterm delivery (AORs, 1.24–1.93) and low birth weight (AORs, 1.27–1.60) were increased in all groups except in endometriosis with ART. Conclusion(s) The findings indicate substantial excess perinatal morbidities associated with underlying infertility-related diagnoses in both ART-treated and non-ART-treated women.
Judy E. Stern - One of the best experts on this subject based on the ideXlab platform.
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validation of birth outcomes from the society for assisted Reproductive Technology clinic outcome reporting system sart cors population based analysis from the massachusetts outcome study of assisted Reproductive Technology mosart
Fertility and Sterility, 2016Co-Authors: Judy E. Stern, Daksha Gopal, Rebecca F Liberman, Marlene Anderka, Milton Kotelchuck, Barbara LukeAbstract:Objective To assess the validity of outcome data reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) compared with data from vital records and the birth defects registry in Massachusetts. Design Longitudinal cohort. Setting Not applicable. Participant(s) A total of 342,035 live births and fetal deaths from Massachusetts mothers giving birth in the state from July 1, 2004, to December 31, 2008; 9,092 births and fetal deaths were from mothers who had conceived with the use of assisted Reproductive Technology (ART) and whose cycle data had been reported to the SART CORS. Intervention(s) Not applicable. Main Outcome Measure(s) Percentage agreement between maternal race and ethnicity, delivery outcome (live birth or fetal death), plurality (singleton, twin, or triplet+), delivery date, and singleton birth weight reported in the SART CORS versus vital records; sensitivity and specificity for birth defects among singletons as reported in the SART CORS versus the Massachusetts Birth Defects Monitoring Program (BDMP). Result(s) There was >95% agreement between the SART CORS and vital records for fields of maternal race/ethnicity, live birth/fetal death, and plurality; birth outcome date was within 1 day with 94.9% agreement and birth weight was within 100 g with 89.6% agreement. In contrast, sensitivity for report of any birth defect was 38.6%, with a range of 18.4%–50.0%, for specific birth defect categories. Conclusion(s) Although most SART CORS outcome fields are accurately reported, birth defect variables showed poor sensitivity compared with the gold standard data from the BDMP. We suggest that reporting of birth defects be discontinued.
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accuracy of self reported survey data on assisted Reproductive Technology treatment parameters and Reproductive history
American Journal of Obstetrics and Gynecology, 2016Co-Authors: Judy E. Stern, Barbara Luke, Alexander C Mclain, Germaine Buck M Louis, Edwina H YeungAbstract:Background It is unknown whether data obtained from maternal self-report for assisted Reproductive Technology treatment parameters and Reproductive history are accurate for use in research studies. Objectives We evaluated the accuracy of self-reported in assisted Reproductive Technology treatment and Reproductive history from the Upstate KIDS study in comparison with clinical data reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Study Design Upstate KIDS maternal questionnaire data from deliveries between 2008 and 2010 were linked to data reported to Society for Assisted Reproductive Technology Clinic Outcome Reporting System. The 617 index deliveries were compared as to treatment type (frozen embryo transfer and donor egg or sperm) and use of intracytoplasmic sperm injection and assisted hatching. Use of injectable medications, self-report for assisted Reproductive Technology, or frozen embryo transfer prior to the index deliveries were also compared. We report agreement in which both sources had yes or both no and sensitivity of maternal report using Society for Assisted Reproductive Technology Clinic Outcome Reporting System as the gold standard. Significance was determined using χ 2 at P Results Universal agreement was not reached on any parameter but was best for treatment type of frozen embryo transfer (agreement, 96%; sensitivity, 93%) and use of donor eggs (agreement, 97%; sensitivity, 82%) or sperm (agreement, 98%; sensitivity, 82%). Use of intracytoplasmic sperm injection (agreement, 78%: sensitivity, 78%) and assisted hatching (agreement, 57%; sensitivity, 38%) agreed less well with self-reported use ( P P Conclusion Women accurately report in vitro fertilization treatment but are less accurate about procedures handled in the laboratory (intracytoplasmic sperm injection or assisted hatching). Clinics might better communicate with patients on the use of these procedures, and researchers should use caution when using self-reported treatment data.
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adverse pregnancy and birth outcomes associated with underlying diagnosis with and without assisted Reproductive Technology treatment
Fertility and Sterility, 2015Co-Authors: Judy E. Stern, Barbara Luke, Mark D Hornstein, Daksha Gopal, Michael Tobias, Hafsatou DiopAbstract:Objective To compare the risks for adverse pregnancy and birth outcomes by diagnoses with and without assisted Reproductive Technology (ART) treatment to non-ART pregnancies in fertile women. Design Historical cohort of Massachusetts vital records linked to ART clinic data from Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Setting Not applicable. Patient(s) Diagnoses included male factor (ART only), endometriosis, ovulation disorders, tubal (ART only), and Reproductive inflammatory disorders (non-ART only). Pregnancies resulting in singleton and twin live births from 2004 to 2008 were linked to hospital discharges in women who had ART treatment (n = 3,689), women with no ART treatment in the current pregnancy (n = 4,098), and non-ART pregnancies in fertile women (n = 297,987). Intervention(s) None. Main Outcome Measure(s) Risks of gestational diabetes, prenatal hospitalizations, prematurity, low birth weight, and small for gestational age were modeled using multivariate logistic regression with fertile deliveries as the reference group adjusted for maternal age, race/ethnicity, education, chronic hypertension, diabetes mellitus, and plurality (adjusted odds ratios [AORs] and 95% confidence intervals [CIs]). Result(s) Risk of prenatal hospital admissions was increased for endometriosis (ART: 1.97, 1.38–2.80; non-ART: 3.34, 2.59–4.31), ovulation disorders (ART: 2.31, 1.81–2.96; non-ART: 2.56, 2.05–3.21), tubal factor (ART: 1.51, 1.14–2.01), and Reproductive inflammation (non-ART: 2.79, 2.47–3.15). Gestational diabetes was increased for women with ovulation disorders (ART: 2.17, 1.72–2.73; non-ART: 1.94, 1.52–2.48). Preterm delivery (AORs, 1.24–1.93) and low birth weight (AORs, 1.27–1.60) were increased in all groups except in endometriosis with ART. Conclusion(s) The findings indicate substantial excess perinatal morbidities associated with underlying infertility-related diagnoses in both ART-treated and non-ART-treated women.
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Cumulative birth rates with linked assisted Reproductive Technology cycles
The New England Journal of Medicine, 2012Co-Authors: Barbara Luke, Ethan Wantman, Morton B. Brown, A. Lederman, William E. Gibbons, Glenn L. Schattman, Rogerio A. Lobo, Richard E. Leach, Judy E. SternAbstract:Background Live-birth rates after treatment with assisted Reproductive Technology have traditionally been reported on a per-cycle basis. For women receiving continued treatment, cumulative success rates are a more important measure. Methods We linked data from cycles of assisted Reproductive Technology in the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for the period from 2004 through 2009 to individual women in order to estimate cumulative live-birth rates. Conservative estimates assumed that women who did not return for treatment would not have a live birth; optimal estimates assumed that these women would have live-birth rates similar to those for women continuing treatment. Results The data were from 246,740 women, with 471,208 cycles and 140,859 live births. Live-birth rates declined with increasing maternal age and increasing cycle number with autologous, but not donor, oocytes. By the third cycle, the conservative and optimal estimates of live-birth rates w...
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the effect of increasing obesity on the response to and outcome of assisted Reproductive Technology a national study
Fertility and Sterility, 2011Co-Authors: Barbara Luke, Morton B. Brown, Richard E. Leach, Stacey A Missmer, Orhan Bukulmez, Judy E. SternAbstract:Objective To evaluate the effect of increasing female obesity on response to and outcome of assisted Reproductive Technology (ART) treatment. Design Historical cohort study. Setting Clinic-based data. Patient(s) A total of 152,500 ART cycle starts from the Society for Assisted Reproductive Technology Clinical Outcomes Reporting System for 2007–2008, limited to women with documented height and grouped by body mass index (BMI, [weight/height 2 ]). Intervention(s) None. Main Outcome Measure(s) Cycle cancellation overall, cycle cancellation due to low response, treatment failure (not pregnant vs. pregnant), and pregnancy failure (fetal loss or stillbirth vs. live birth), as adjusted odds ratios and 95% confidence intervals, with cycles among normal-weight women as the reference group. Result(s) Cycle cancellation overall and cancellation due to low response using autologous oocytes significantly paralleled increasing BMI. The odds of treatment failure rose significantly with autologous-fresh cycles, from 1.03 for cycles among overweight women (BMI 25.0–29.9) to 1.53 for cycles among women with BMIs ≥50.0 kg/m 2 . Likewise, the odds of pregnancy failure were most significant with increasing BMI among women with autologous-fresh cycles, increasing from 1.10 for cycles to overweight women to 2.29 for cycles to women with BMI ≥50.0 kg/m 2 . Conclusion(s) These results indicate significantly higher odds of cycle cancellation. In addition, treatment and pregnancy failures with increasing obesity significantly increased starting with overweight women.
Laura A Schieve - One of the best experts on this subject based on the ideXlab platform.
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A Population-Based Study of Maternal and Perinatal Outcomes Associated with Assisted Reproductive Technology in Massachusetts
Maternal and Child Health Journal, 2007Co-Authors: Laura A Schieve, Cynthia Ferre, Gary Jeng, Meredith A Reynolds, Maurizio Macaluso, Bruce Cohen, Angela Nannini, Zi Zhang, Victoria C WrightAbstract:Objective : To assess associations between assisted Reproductive Technology (ART) and adverse maternal and infant outcomes, with an emphasis on singletons. Methods: We linked data from the US ART surveillance system with Massachusetts live birth-infant death records data for resident births in 1997–1998 and compared births conceived with ART ( N = 3316) with births not conceived with ART or infertility medications ( N = 157,066) on: maternal chronic conditions, pregnancy complications, labor and delivery complications, and perinatal and infant outcomes. Results: Overall, ART was strongly associated with numerous adverse outcomes. The magnitude was reduced for several outcomes when analyses were limited to singletons. After further exclusion of maternal subsets with rare ART births (maternal age
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ectopic pregnancy risk with assisted Reproductive Technology procedures
Obstetrics & Gynecology, 2006Co-Authors: Heather B Clayton, Denise J. Jamieson, Laura A Schieve, Herbert B Peterson, Meredith A Reynolds, Victoria C WrightAbstract:OBJECTIVE:To assess the ectopic pregnancy risk among women who conceived with assisted Reproductive Technology (ART) procedures.METHODS:The ectopic rate for ART pregnancies was calculated from population-based data of pregnancies conceived with ART in U.S. clinics in 1999–2001. Variation in ectopic
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perinatal outcome among singleton infants conceived through assisted Reproductive Technology in the united states
Obstetrics & Gynecology, 2004Co-Authors: Laura A Schieve, Cynthia Ferre, Herbert B Peterson, Meredith A Reynolds, Maurizio Macaluso, Victoria C WrightAbstract:OBJECTIVE:To examine perinatal outcome among singleton infants conceived with assisted Reproductive Technology (ART) in the United States.METHODS:Subjects were 62,551 infants born after ART treatments performed in 1996–2000. Secular trends in low birth weight (LBW), very low birth weight (VLBW), pre
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low and very low birth weight in infants conceived with use of assisted Reproductive Technology
The New England Journal of Medicine, 2002Co-Authors: Laura A Schieve, Susan F Meikle, Cynthia Ferre, Herbert B Peterson, Gary Jeng, Lynne S WilcoxAbstract:Background The increased risk of low birth weight associated with the use of assisted Reproductive Technology has been attributed largely to the higher rate of multiple gestations associated with such Technology. It is uncertain, however, whether singleton infants conceived with the use of assisted Reproductive Technology may also have a higher risk of low birth weight than those who are conceived spontaneously. Methods We used population-based data to compare the rates of low birth weight (≤2500 g) and very low birth weight (<1500 g) among infants conceived with assisted Reproductive Technology with the rates in the general population. Results We studied 42,463 infants who were born in 1996 and 1997 and conceived with assisted Reproductive Technology and used as a comparison group 3,389,098 infants born in the United States in 1997. Among singleton infants born at 37 weeks of gestation or later, those conceived with assisted Reproductive Technology had a risk of low birth weight that was 2.6 times that i...
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assisted Reproductive Technology in the united states 1997 results generated from the american society for Reproductive medicine society for assisted Reproductive Technology registry commentary
Fertility and Sterility, 2000Co-Authors: Laura A Schieve, Sonja A Rasmussen, Adolfo Correa, John S Santelli, Lilith Tatham, Lynne S WilcoxAbstract:Objective: To summarize the procedures and outcomes of assisted Reproductive Technology (ART) initiated in the United States in 1997. Design: Data were collected electronically by using Society for Assisted Reproductive Technology Clinical Outcome Reporting System software and were submitted to the American Society for Reproductive Medicine/ Society for Assisted Reproductive Technology Registry. Participant(s): 335 programs submitted data on procedures performed in 1997. Data were collated after November 1998 so that the outcome of all pregnancies established would be known. Main Outcome Measure(s): Incidence of clinical pregnancy, ectopic pregnancy, abortion, stillbirth, delivery, and structural and functional abnormalities. Result(s): Programs reported initiating 73,069 cycles of ART treatment. Of these, 51,344 cycles involved IVF (with and without micromanipulation), with a delivery rate per retrieval of 27.9%; 1,943 were cycles of GIFT, with a delivery rate per retrieval of 30.0%; and 1,104 were cycles of zygote intrafallopian transfer, with a delivery rate per retrieval of 28.0%. The following additional ART procedures were also initiated: 4,616 donor oocyte cycles, with a delivery rate per transfer of 40.0%; 10,181 frozen embryo transfer procedures, with a delivery rate per transfer of 18.8%; 1,584 frozen embryo transfers using donated oocytes, with a delivery rate per transfer of 22.2%; and 600 cycles using a host uterus, with a delivery rate per transfer of 34.6%. Furthermore, 1,173 cycles were reported as combinations or more than one treatment type, 40 cycles as research, 258 as embryo banking, and 226 as other (unclassified) cycle types. As a result of all procedures, 17,311 deliveries resulting in 25,059 babies were reported. Conclusion(s): In 1997, more programs reported ART treatment and the number of reported cycles increased significantly (10.9%) compared with 1996. In comparable cycle types, the overall success rate (deliveries per retrieval) increased by 1.8%. which represents an increase of 6.9% compared with the success rate for 1996.
Victoria C Wright - One of the best experts on this subject based on the ideXlab platform.
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A Population-Based Study of Maternal and Perinatal Outcomes Associated with Assisted Reproductive Technology in Massachusetts
Maternal and Child Health Journal, 2007Co-Authors: Laura A Schieve, Cynthia Ferre, Gary Jeng, Meredith A Reynolds, Maurizio Macaluso, Bruce Cohen, Angela Nannini, Zi Zhang, Victoria C WrightAbstract:Objective : To assess associations between assisted Reproductive Technology (ART) and adverse maternal and infant outcomes, with an emphasis on singletons. Methods: We linked data from the US ART surveillance system with Massachusetts live birth-infant death records data for resident births in 1997–1998 and compared births conceived with ART ( N = 3316) with births not conceived with ART or infertility medications ( N = 157,066) on: maternal chronic conditions, pregnancy complications, labor and delivery complications, and perinatal and infant outcomes. Results: Overall, ART was strongly associated with numerous adverse outcomes. The magnitude was reduced for several outcomes when analyses were limited to singletons. After further exclusion of maternal subsets with rare ART births (maternal age
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ectopic pregnancy risk with assisted Reproductive Technology procedures
Obstetrics & Gynecology, 2006Co-Authors: Heather B Clayton, Denise J. Jamieson, Laura A Schieve, Herbert B Peterson, Meredith A Reynolds, Victoria C WrightAbstract:OBJECTIVE:To assess the ectopic pregnancy risk among women who conceived with assisted Reproductive Technology (ART) procedures.METHODS:The ectopic rate for ART pregnancies was calculated from population-based data of pregnancies conceived with ART in U.S. clinics in 1999–2001. Variation in ectopic
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perinatal outcome among singleton infants conceived through assisted Reproductive Technology in the united states
Obstetrics & Gynecology, 2004Co-Authors: Laura A Schieve, Cynthia Ferre, Herbert B Peterson, Meredith A Reynolds, Maurizio Macaluso, Victoria C WrightAbstract:OBJECTIVE:To examine perinatal outcome among singleton infants conceived with assisted Reproductive Technology (ART) in the United States.METHODS:Subjects were 62,551 infants born after ART treatments performed in 1996–2000. Secular trends in low birth weight (LBW), very low birth weight (VLBW), pre
Mark D Hornstein - One of the best experts on this subject based on the ideXlab platform.
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adverse pregnancy and birth outcomes associated with underlying diagnosis with and without assisted Reproductive Technology treatment
Fertility and Sterility, 2015Co-Authors: Judy E. Stern, Barbara Luke, Mark D Hornstein, Daksha Gopal, Michael Tobias, Hafsatou DiopAbstract:Objective To compare the risks for adverse pregnancy and birth outcomes by diagnoses with and without assisted Reproductive Technology (ART) treatment to non-ART pregnancies in fertile women. Design Historical cohort of Massachusetts vital records linked to ART clinic data from Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Setting Not applicable. Patient(s) Diagnoses included male factor (ART only), endometriosis, ovulation disorders, tubal (ART only), and Reproductive inflammatory disorders (non-ART only). Pregnancies resulting in singleton and twin live births from 2004 to 2008 were linked to hospital discharges in women who had ART treatment (n = 3,689), women with no ART treatment in the current pregnancy (n = 4,098), and non-ART pregnancies in fertile women (n = 297,987). Intervention(s) None. Main Outcome Measure(s) Risks of gestational diabetes, prenatal hospitalizations, prematurity, low birth weight, and small for gestational age were modeled using multivariate logistic regression with fertile deliveries as the reference group adjusted for maternal age, race/ethnicity, education, chronic hypertension, diabetes mellitus, and plurality (adjusted odds ratios [AORs] and 95% confidence intervals [CIs]). Result(s) Risk of prenatal hospital admissions was increased for endometriosis (ART: 1.97, 1.38–2.80; non-ART: 3.34, 2.59–4.31), ovulation disorders (ART: 2.31, 1.81–2.96; non-ART: 2.56, 2.05–3.21), tubal factor (ART: 1.51, 1.14–2.01), and Reproductive inflammation (non-ART: 2.79, 2.47–3.15). Gestational diabetes was increased for women with ovulation disorders (ART: 2.17, 1.72–2.73; non-ART: 1.94, 1.52–2.48). Preterm delivery (AORs, 1.24–1.93) and low birth weight (AORs, 1.27–1.60) were increased in all groups except in endometriosis with ART. Conclusion(s) The findings indicate substantial excess perinatal morbidities associated with underlying infertility-related diagnoses in both ART-treated and non-ART-treated women.
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calculating cumulative live birth rates from linked cycles of assisted Reproductive Technology art data from the massachusetts sart cors
Fertility and Sterility, 2010Co-Authors: Judy E. Stern, Barbara Luke, Ethan Wantman, Morton B. Brown, A. Lederman, Stacey A Missmer, Mark D HornsteinAbstract:Objective To determine the feasibility of linking assisted Reproductive Technology (ART) cycles for individual women to compare per-cycle and cumulative live-birth rates. Design Historical cohort study. Setting Clinic-based data. Patient(s) A total of 27,906 ART cycles with residency or treatment in Massachusetts during 2004–2006 and reported to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System (SART CORS) on-line database. Intervention(s) None. Main Outcome Measure(s) Per-cycle and cumulative live-birth rates. Result(s) Linkage of cycles up to and including the first live-birth delivery revealed 14,265 women who averaged 1.9 ± 1.2 SD cycles (range 1–11). These cycles yielded 9,452 pregnancies resulting in 7,675 live-birth deliveries. From cycle 1 to cycle 4, the cumulative live-birth rate for all patients increased from 30.4% to 43.3%, 49.1%, and 51.9%, respectively, and plateaued thereafter at about 53%. The cumulative live-birth rate after three cycles using donor oocytes was ∼60% for women aged 50% for women ≥43 years; for autologous oocytes it was 60.1% for ages Conclusion(s) The results demonstrate the feasibility of linking ART cycles for individual women from SART CORS to characterize cumulative live-birth rates.
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racial and ethnic disparities in assisted Reproductive Technology outcomes in the united states
Fertility and Sterility, 2010Co-Authors: Victor Y Fujimoto, Barbara Luke, Morton B. Brown, Tarun Jain, Alicia Y Armstrong, David A Grainger, Mark D HornsteinAbstract:Objective To evaluate ethnic differences in assisted Reproductive Technology (ART) outcomes in the United States. Design Historical cohort study. Setting Clinic-based data. Patient(s) A total of 139,027 ART cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System online database for 2004–2006, limited to white, Asian, black, and Hispanic women. Intervention(s) None. Main Outcome Measure(s) Logistic regression was used to model the odds of pregnancy and live birth; among singletons and twins, the odds of preterm birth and fetal growth restriction. Results are presented as adjusted odds ratios, with white women as the reference group. Result(s) The odds of pregnancy were reduced for Asians (0.86), and the odds of live birth were reduced for all groups: Asian (0.90), black (0.62), and Hispanic (0.87) women. Among singletons, moderate and severe growth restriction were increased for all infants in all three minority groups (Asians [1.78, 2.05]; blacks [1.81, 2.17]; Hispanics [1.36, 1.64]), and preterm birth was increased among black (1.79) and Hispanic women (1.22). Among twins, the odds for moderate growth restriction were increased for infants of Asian (1.30) and black women (1.97), and severe growth restriction was increased among black women (3.21). The odds of preterm birth were increased for blacks (1.64) and decreased for Asians (0.70). Conclusion(s) There are significant disparities in ART outcomes according to ethnicity.
