The Experts below are selected from a list of 267 Experts worldwide ranked by ideXlab platform
K. Falke - One of the best experts on this subject based on the ideXlab platform.
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A new method for PO.1 measurement using standard Respiratory Equipment
Intensive Care Medicine, 1995Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Rossaint, K. FalkeAbstract:The airway occlusion pressure, P0.1, is an index for the neuro-muscular activation of the Respiratory system. It has been shown to be a very useful indicator for the ability of patients receiving ventilatory support to be weaned from mechanical ventilation. Since the standard measurement technically complex, it is not widely available for clinical purposes. For that reason a P0.1 measurement technique was developed as an integrated function in a standard respirator (Evita, Dräger, Lübeck, Germany). This technique is easy to use and does not need any further Equipment. We validated this new technique by comparing it to standard P0.1 measurements in a mechanical lung model as well as in ventilated patients. In the lung model we found a correlation between the Evita measurement and standard measurements of r =0.99. In 6 ventilated patients the correlation was r =0.78. Since the Evita P0.1 and the standard measurement had to be performed during two different breaths, this little poorer correlation in patients may be due to a significant breath-by-breath variability in P0.1. Comparing the Evita P0.1 and the standard measurement within one breath resulted in a clearly better correlation ( r =0.89). We conclude that this new measurement technique provides and easy and accurate P0.1 measurement using standard Respiratory Equipment when tested in a lung model. In patient measurements the method is less precise, which is probably due to the variable waveforms of the inspiratory driving pressure seen in patients, for example when intrinsic PEEP is present. However, the new method makes the P0.1 measurement as a “bed-side” method clinically available, although the values should be interpreted cautiously.
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a new method for p0 1 measurement using standard Respiratory Equipment
Intensive Care Medicine, 1995Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Rossaint, K. FalkeAbstract:The airway occlusion pressure, P0.1, is an index for the neuro-muscular activation of the Respiratory system. It has been shown to be a very useful indicator for the ability of patients receiving ventilatory support to be weaned from mechanical ventilation. Since the standard measurement technically complex, it is not widely available for clinical purposes. For that reason a P0.1 measurement technique was developed as an integrated function in a standard respirator (Evita, Drager, Lubeck, Germany). This technique is easy to use and does not need any further Equipment. We validated this new technique by comparing it to standard P0.1 measurements in a mechanical lung model as well as in ventilated patients. In the lung model we found a correlation between the Evita measurement and standard measurements ofr=0.99. In 6 ventilated patients the correlation wasr=0.78. Since the Evita P0.1 and the standard measurement had to be performed during two different breaths, this little poorer correlation in patients may be due to a significant breath-by-breath variability in P0.1. Comparing the Evita P0.1 and the standard measurement within one breath resulted in a clearly better correlation (r=0.89). We conclude that this new measurement technique provides and easy and accurate P0.1 measurement using standard Respiratory Equipment when tested in a lung model. In patient measurements the method is less precise, which is probably due to the variable waveforms of the inspiratory driving pressure seen in patients, for example when intrinsic PEEP is present. However, the new method makes the P0.1 measurement as a “bed-side” method clinically available, although the values should be interpreted cautiously.
R. Kuhlen - One of the best experts on this subject based on the ideXlab platform.
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Validation and clinical application of a continuous P0.1 measurement using standard Respiratory Equipment
Technology and Health Care, 1996Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Mohnhaupt, Rolf Rossaint, K FalkeAbstract:The airway occlusion pressure, P0.1, is the negative airway pressure generated during the first 100 msec of an occluded inspiration. P0.1 is a parameter for the neuro-muscular activation of the Respiratory system, which is an important determinant for the work of breathing. It has been shown to be a good predictor for successful weaning from mechanical ventilation. Standard P0.1 measurement techniques are based on a total occlusion of the inspiration for more than 100 msec. These measurements are technically complex and therefore not useful for clinical purposes. Furthermore, a significant breath-by-breath variability has been shown for P0.1, which is neglected by any single point measurement technique. Therefore, we have developed a continuous on-line measurement for breath-by-breath determination of P0.1 using the Siemens Servo 900C respirator. In triggered mechanical ventilation the delay time between the onset of the patients inspiration and flow delivery from the respirator is more than 100 msec for this respirator. During that time the inspiration is occluded. Therefore, the trigger effort was proposed to be a good estimate of P0.1. Based on this, we calculated P0.1 as followsc airway pressure (Paw) was registered at the endotracheal tube site of the Respiratory tubing, digitized and acquired by a personal computer at 100 Hz. The recorder output of the Servo 900C was connected to the same computer, delivering the electronical signal for the inspiratory valve to open when the inspiratory effort has exceeded the trigger threshold, which needs a minimal delay time of 80 msec. Around 20 msec after this signal flow is delivered from the respirator. The computer runs an algorithm, which recognizes this signal and calculates P0.1 (Servo P0.1) as the slope of the pressure drop during this 100 msec. Paw tracings and the calculated P0.1 values were displayed on the computer screen and stored on disk. This method was validated by comparing it to the standard technique, using a Hans-Rudolph valve for inspiratory occlusion and calculating P0.1 from Paw tracings during the occluded inspiration. For validation we used a mechanical lung model which generated P0.1 values ranging between 1.1-10.3 mbar. For a given adjustment of the lung model two standard measurements (standard P0.1) were made and compared to the Servo P0.1. In a total of 21 measurements the mean Servo P0.1 was 4.9\pm 2.9 mbar; the mean standard P0.1 was 4.3\pm 2.5 mbar. The mean difference between Servo P0.1 and standard P0.1 was 0.6\pm 0.6 mbar (range: -0.3-1.8 mbar). The regression equation for linear regression analysis was: Servo {\rm P}0.1 = 1.15 * {\rm standard\ P}0.1-0.05. This correlation was significant (r=0.99, p
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A new method for PO.1 measurement using standard Respiratory Equipment
Intensive Care Medicine, 1995Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Rossaint, K. FalkeAbstract:The airway occlusion pressure, P0.1, is an index for the neuro-muscular activation of the Respiratory system. It has been shown to be a very useful indicator for the ability of patients receiving ventilatory support to be weaned from mechanical ventilation. Since the standard measurement technically complex, it is not widely available for clinical purposes. For that reason a P0.1 measurement technique was developed as an integrated function in a standard respirator (Evita, Dräger, Lübeck, Germany). This technique is easy to use and does not need any further Equipment. We validated this new technique by comparing it to standard P0.1 measurements in a mechanical lung model as well as in ventilated patients. In the lung model we found a correlation between the Evita measurement and standard measurements of r =0.99. In 6 ventilated patients the correlation was r =0.78. Since the Evita P0.1 and the standard measurement had to be performed during two different breaths, this little poorer correlation in patients may be due to a significant breath-by-breath variability in P0.1. Comparing the Evita P0.1 and the standard measurement within one breath resulted in a clearly better correlation ( r =0.89). We conclude that this new measurement technique provides and easy and accurate P0.1 measurement using standard Respiratory Equipment when tested in a lung model. In patient measurements the method is less precise, which is probably due to the variable waveforms of the inspiratory driving pressure seen in patients, for example when intrinsic PEEP is present. However, the new method makes the P0.1 measurement as a “bed-side” method clinically available, although the values should be interpreted cautiously.
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a new method for p0 1 measurement using standard Respiratory Equipment
Intensive Care Medicine, 1995Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Rossaint, K. FalkeAbstract:The airway occlusion pressure, P0.1, is an index for the neuro-muscular activation of the Respiratory system. It has been shown to be a very useful indicator for the ability of patients receiving ventilatory support to be weaned from mechanical ventilation. Since the standard measurement technically complex, it is not widely available for clinical purposes. For that reason a P0.1 measurement technique was developed as an integrated function in a standard respirator (Evita, Drager, Lubeck, Germany). This technique is easy to use and does not need any further Equipment. We validated this new technique by comparing it to standard P0.1 measurements in a mechanical lung model as well as in ventilated patients. In the lung model we found a correlation between the Evita measurement and standard measurements ofr=0.99. In 6 ventilated patients the correlation wasr=0.78. Since the Evita P0.1 and the standard measurement had to be performed during two different breaths, this little poorer correlation in patients may be due to a significant breath-by-breath variability in P0.1. Comparing the Evita P0.1 and the standard measurement within one breath resulted in a clearly better correlation (r=0.89). We conclude that this new measurement technique provides and easy and accurate P0.1 measurement using standard Respiratory Equipment when tested in a lung model. In patient measurements the method is less precise, which is probably due to the variable waveforms of the inspiratory driving pressure seen in patients, for example when intrinsic PEEP is present. However, the new method makes the P0.1 measurement as a “bed-side” method clinically available, although the values should be interpreted cautiously.
K. Slama - One of the best experts on this subject based on the ideXlab platform.
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Validation and clinical application of a continuous P0.1 measurement using standard Respiratory Equipment
Technology and Health Care, 1996Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Mohnhaupt, Rolf Rossaint, K FalkeAbstract:The airway occlusion pressure, P0.1, is the negative airway pressure generated during the first 100 msec of an occluded inspiration. P0.1 is a parameter for the neuro-muscular activation of the Respiratory system, which is an important determinant for the work of breathing. It has been shown to be a good predictor for successful weaning from mechanical ventilation. Standard P0.1 measurement techniques are based on a total occlusion of the inspiration for more than 100 msec. These measurements are technically complex and therefore not useful for clinical purposes. Furthermore, a significant breath-by-breath variability has been shown for P0.1, which is neglected by any single point measurement technique. Therefore, we have developed a continuous on-line measurement for breath-by-breath determination of P0.1 using the Siemens Servo 900C respirator. In triggered mechanical ventilation the delay time between the onset of the patients inspiration and flow delivery from the respirator is more than 100 msec for this respirator. During that time the inspiration is occluded. Therefore, the trigger effort was proposed to be a good estimate of P0.1. Based on this, we calculated P0.1 as followsc airway pressure (Paw) was registered at the endotracheal tube site of the Respiratory tubing, digitized and acquired by a personal computer at 100 Hz. The recorder output of the Servo 900C was connected to the same computer, delivering the electronical signal for the inspiratory valve to open when the inspiratory effort has exceeded the trigger threshold, which needs a minimal delay time of 80 msec. Around 20 msec after this signal flow is delivered from the respirator. The computer runs an algorithm, which recognizes this signal and calculates P0.1 (Servo P0.1) as the slope of the pressure drop during this 100 msec. Paw tracings and the calculated P0.1 values were displayed on the computer screen and stored on disk. This method was validated by comparing it to the standard technique, using a Hans-Rudolph valve for inspiratory occlusion and calculating P0.1 from Paw tracings during the occluded inspiration. For validation we used a mechanical lung model which generated P0.1 values ranging between 1.1-10.3 mbar. For a given adjustment of the lung model two standard measurements (standard P0.1) were made and compared to the Servo P0.1. In a total of 21 measurements the mean Servo P0.1 was 4.9\pm 2.9 mbar; the mean standard P0.1 was 4.3\pm 2.5 mbar. The mean difference between Servo P0.1 and standard P0.1 was 0.6\pm 0.6 mbar (range: -0.3-1.8 mbar). The regression equation for linear regression analysis was: Servo {\rm P}0.1 = 1.15 * {\rm standard\ P}0.1-0.05. This correlation was significant (r=0.99, p
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A new method for PO.1 measurement using standard Respiratory Equipment
Intensive Care Medicine, 1995Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Rossaint, K. FalkeAbstract:The airway occlusion pressure, P0.1, is an index for the neuro-muscular activation of the Respiratory system. It has been shown to be a very useful indicator for the ability of patients receiving ventilatory support to be weaned from mechanical ventilation. Since the standard measurement technically complex, it is not widely available for clinical purposes. For that reason a P0.1 measurement technique was developed as an integrated function in a standard respirator (Evita, Dräger, Lübeck, Germany). This technique is easy to use and does not need any further Equipment. We validated this new technique by comparing it to standard P0.1 measurements in a mechanical lung model as well as in ventilated patients. In the lung model we found a correlation between the Evita measurement and standard measurements of r =0.99. In 6 ventilated patients the correlation was r =0.78. Since the Evita P0.1 and the standard measurement had to be performed during two different breaths, this little poorer correlation in patients may be due to a significant breath-by-breath variability in P0.1. Comparing the Evita P0.1 and the standard measurement within one breath resulted in a clearly better correlation ( r =0.89). We conclude that this new measurement technique provides and easy and accurate P0.1 measurement using standard Respiratory Equipment when tested in a lung model. In patient measurements the method is less precise, which is probably due to the variable waveforms of the inspiratory driving pressure seen in patients, for example when intrinsic PEEP is present. However, the new method makes the P0.1 measurement as a “bed-side” method clinically available, although the values should be interpreted cautiously.
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a new method for p0 1 measurement using standard Respiratory Equipment
Intensive Care Medicine, 1995Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Rossaint, K. FalkeAbstract:The airway occlusion pressure, P0.1, is an index for the neuro-muscular activation of the Respiratory system. It has been shown to be a very useful indicator for the ability of patients receiving ventilatory support to be weaned from mechanical ventilation. Since the standard measurement technically complex, it is not widely available for clinical purposes. For that reason a P0.1 measurement technique was developed as an integrated function in a standard respirator (Evita, Drager, Lubeck, Germany). This technique is easy to use and does not need any further Equipment. We validated this new technique by comparing it to standard P0.1 measurements in a mechanical lung model as well as in ventilated patients. In the lung model we found a correlation between the Evita measurement and standard measurements ofr=0.99. In 6 ventilated patients the correlation wasr=0.78. Since the Evita P0.1 and the standard measurement had to be performed during two different breaths, this little poorer correlation in patients may be due to a significant breath-by-breath variability in P0.1. Comparing the Evita P0.1 and the standard measurement within one breath resulted in a clearly better correlation (r=0.89). We conclude that this new measurement technique provides and easy and accurate P0.1 measurement using standard Respiratory Equipment when tested in a lung model. In patient measurements the method is less precise, which is probably due to the variable waveforms of the inspiratory driving pressure seen in patients, for example when intrinsic PEEP is present. However, the new method makes the P0.1 measurement as a “bed-side” method clinically available, although the values should be interpreted cautiously.
S. Hausmann - One of the best experts on this subject based on the ideXlab platform.
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Validation and clinical application of a continuous P0.1 measurement using standard Respiratory Equipment
Technology and Health Care, 1996Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Mohnhaupt, Rolf Rossaint, K FalkeAbstract:The airway occlusion pressure, P0.1, is the negative airway pressure generated during the first 100 msec of an occluded inspiration. P0.1 is a parameter for the neuro-muscular activation of the Respiratory system, which is an important determinant for the work of breathing. It has been shown to be a good predictor for successful weaning from mechanical ventilation. Standard P0.1 measurement techniques are based on a total occlusion of the inspiration for more than 100 msec. These measurements are technically complex and therefore not useful for clinical purposes. Furthermore, a significant breath-by-breath variability has been shown for P0.1, which is neglected by any single point measurement technique. Therefore, we have developed a continuous on-line measurement for breath-by-breath determination of P0.1 using the Siemens Servo 900C respirator. In triggered mechanical ventilation the delay time between the onset of the patients inspiration and flow delivery from the respirator is more than 100 msec for this respirator. During that time the inspiration is occluded. Therefore, the trigger effort was proposed to be a good estimate of P0.1. Based on this, we calculated P0.1 as followsc airway pressure (Paw) was registered at the endotracheal tube site of the Respiratory tubing, digitized and acquired by a personal computer at 100 Hz. The recorder output of the Servo 900C was connected to the same computer, delivering the electronical signal for the inspiratory valve to open when the inspiratory effort has exceeded the trigger threshold, which needs a minimal delay time of 80 msec. Around 20 msec after this signal flow is delivered from the respirator. The computer runs an algorithm, which recognizes this signal and calculates P0.1 (Servo P0.1) as the slope of the pressure drop during this 100 msec. Paw tracings and the calculated P0.1 values were displayed on the computer screen and stored on disk. This method was validated by comparing it to the standard technique, using a Hans-Rudolph valve for inspiratory occlusion and calculating P0.1 from Paw tracings during the occluded inspiration. For validation we used a mechanical lung model which generated P0.1 values ranging between 1.1-10.3 mbar. For a given adjustment of the lung model two standard measurements (standard P0.1) were made and compared to the Servo P0.1. In a total of 21 measurements the mean Servo P0.1 was 4.9\pm 2.9 mbar; the mean standard P0.1 was 4.3\pm 2.5 mbar. The mean difference between Servo P0.1 and standard P0.1 was 0.6\pm 0.6 mbar (range: -0.3-1.8 mbar). The regression equation for linear regression analysis was: Servo {\rm P}0.1 = 1.15 * {\rm standard\ P}0.1-0.05. This correlation was significant (r=0.99, p
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A new method for PO.1 measurement using standard Respiratory Equipment
Intensive Care Medicine, 1995Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Rossaint, K. FalkeAbstract:The airway occlusion pressure, P0.1, is an index for the neuro-muscular activation of the Respiratory system. It has been shown to be a very useful indicator for the ability of patients receiving ventilatory support to be weaned from mechanical ventilation. Since the standard measurement technically complex, it is not widely available for clinical purposes. For that reason a P0.1 measurement technique was developed as an integrated function in a standard respirator (Evita, Dräger, Lübeck, Germany). This technique is easy to use and does not need any further Equipment. We validated this new technique by comparing it to standard P0.1 measurements in a mechanical lung model as well as in ventilated patients. In the lung model we found a correlation between the Evita measurement and standard measurements of r =0.99. In 6 ventilated patients the correlation was r =0.78. Since the Evita P0.1 and the standard measurement had to be performed during two different breaths, this little poorer correlation in patients may be due to a significant breath-by-breath variability in P0.1. Comparing the Evita P0.1 and the standard measurement within one breath resulted in a clearly better correlation ( r =0.89). We conclude that this new measurement technique provides and easy and accurate P0.1 measurement using standard Respiratory Equipment when tested in a lung model. In patient measurements the method is less precise, which is probably due to the variable waveforms of the inspiratory driving pressure seen in patients, for example when intrinsic PEEP is present. However, the new method makes the P0.1 measurement as a “bed-side” method clinically available, although the values should be interpreted cautiously.
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a new method for p0 1 measurement using standard Respiratory Equipment
Intensive Care Medicine, 1995Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Rossaint, K. FalkeAbstract:The airway occlusion pressure, P0.1, is an index for the neuro-muscular activation of the Respiratory system. It has been shown to be a very useful indicator for the ability of patients receiving ventilatory support to be weaned from mechanical ventilation. Since the standard measurement technically complex, it is not widely available for clinical purposes. For that reason a P0.1 measurement technique was developed as an integrated function in a standard respirator (Evita, Drager, Lubeck, Germany). This technique is easy to use and does not need any further Equipment. We validated this new technique by comparing it to standard P0.1 measurements in a mechanical lung model as well as in ventilated patients. In the lung model we found a correlation between the Evita measurement and standard measurements ofr=0.99. In 6 ventilated patients the correlation wasr=0.78. Since the Evita P0.1 and the standard measurement had to be performed during two different breaths, this little poorer correlation in patients may be due to a significant breath-by-breath variability in P0.1. Comparing the Evita P0.1 and the standard measurement within one breath resulted in a clearly better correlation (r=0.89). We conclude that this new measurement technique provides and easy and accurate P0.1 measurement using standard Respiratory Equipment when tested in a lung model. In patient measurements the method is less precise, which is probably due to the variable waveforms of the inspiratory driving pressure seen in patients, for example when intrinsic PEEP is present. However, the new method makes the P0.1 measurement as a “bed-side” method clinically available, although the values should be interpreted cautiously.
D. Pappert - One of the best experts on this subject based on the ideXlab platform.
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Validation and clinical application of a continuous P0.1 measurement using standard Respiratory Equipment
Technology and Health Care, 1996Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Mohnhaupt, Rolf Rossaint, K FalkeAbstract:The airway occlusion pressure, P0.1, is the negative airway pressure generated during the first 100 msec of an occluded inspiration. P0.1 is a parameter for the neuro-muscular activation of the Respiratory system, which is an important determinant for the work of breathing. It has been shown to be a good predictor for successful weaning from mechanical ventilation. Standard P0.1 measurement techniques are based on a total occlusion of the inspiration for more than 100 msec. These measurements are technically complex and therefore not useful for clinical purposes. Furthermore, a significant breath-by-breath variability has been shown for P0.1, which is neglected by any single point measurement technique. Therefore, we have developed a continuous on-line measurement for breath-by-breath determination of P0.1 using the Siemens Servo 900C respirator. In triggered mechanical ventilation the delay time between the onset of the patients inspiration and flow delivery from the respirator is more than 100 msec for this respirator. During that time the inspiration is occluded. Therefore, the trigger effort was proposed to be a good estimate of P0.1. Based on this, we calculated P0.1 as followsc airway pressure (Paw) was registered at the endotracheal tube site of the Respiratory tubing, digitized and acquired by a personal computer at 100 Hz. The recorder output of the Servo 900C was connected to the same computer, delivering the electronical signal for the inspiratory valve to open when the inspiratory effort has exceeded the trigger threshold, which needs a minimal delay time of 80 msec. Around 20 msec after this signal flow is delivered from the respirator. The computer runs an algorithm, which recognizes this signal and calculates P0.1 (Servo P0.1) as the slope of the pressure drop during this 100 msec. Paw tracings and the calculated P0.1 values were displayed on the computer screen and stored on disk. This method was validated by comparing it to the standard technique, using a Hans-Rudolph valve for inspiratory occlusion and calculating P0.1 from Paw tracings during the occluded inspiration. For validation we used a mechanical lung model which generated P0.1 values ranging between 1.1-10.3 mbar. For a given adjustment of the lung model two standard measurements (standard P0.1) were made and compared to the Servo P0.1. In a total of 21 measurements the mean Servo P0.1 was 4.9\pm 2.9 mbar; the mean standard P0.1 was 4.3\pm 2.5 mbar. The mean difference between Servo P0.1 and standard P0.1 was 0.6\pm 0.6 mbar (range: -0.3-1.8 mbar). The regression equation for linear regression analysis was: Servo {\rm P}0.1 = 1.15 * {\rm standard\ P}0.1-0.05. This correlation was significant (r=0.99, p
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A new method for PO.1 measurement using standard Respiratory Equipment
Intensive Care Medicine, 1995Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Rossaint, K. FalkeAbstract:The airway occlusion pressure, P0.1, is an index for the neuro-muscular activation of the Respiratory system. It has been shown to be a very useful indicator for the ability of patients receiving ventilatory support to be weaned from mechanical ventilation. Since the standard measurement technically complex, it is not widely available for clinical purposes. For that reason a P0.1 measurement technique was developed as an integrated function in a standard respirator (Evita, Dräger, Lübeck, Germany). This technique is easy to use and does not need any further Equipment. We validated this new technique by comparing it to standard P0.1 measurements in a mechanical lung model as well as in ventilated patients. In the lung model we found a correlation between the Evita measurement and standard measurements of r =0.99. In 6 ventilated patients the correlation was r =0.78. Since the Evita P0.1 and the standard measurement had to be performed during two different breaths, this little poorer correlation in patients may be due to a significant breath-by-breath variability in P0.1. Comparing the Evita P0.1 and the standard measurement within one breath resulted in a clearly better correlation ( r =0.89). We conclude that this new measurement technique provides and easy and accurate P0.1 measurement using standard Respiratory Equipment when tested in a lung model. In patient measurements the method is less precise, which is probably due to the variable waveforms of the inspiratory driving pressure seen in patients, for example when intrinsic PEEP is present. However, the new method makes the P0.1 measurement as a “bed-side” method clinically available, although the values should be interpreted cautiously.
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a new method for p0 1 measurement using standard Respiratory Equipment
Intensive Care Medicine, 1995Co-Authors: R. Kuhlen, S. Hausmann, D. Pappert, K. Slama, R. Rossaint, K. FalkeAbstract:The airway occlusion pressure, P0.1, is an index for the neuro-muscular activation of the Respiratory system. It has been shown to be a very useful indicator for the ability of patients receiving ventilatory support to be weaned from mechanical ventilation. Since the standard measurement technically complex, it is not widely available for clinical purposes. For that reason a P0.1 measurement technique was developed as an integrated function in a standard respirator (Evita, Drager, Lubeck, Germany). This technique is easy to use and does not need any further Equipment. We validated this new technique by comparing it to standard P0.1 measurements in a mechanical lung model as well as in ventilated patients. In the lung model we found a correlation between the Evita measurement and standard measurements ofr=0.99. In 6 ventilated patients the correlation wasr=0.78. Since the Evita P0.1 and the standard measurement had to be performed during two different breaths, this little poorer correlation in patients may be due to a significant breath-by-breath variability in P0.1. Comparing the Evita P0.1 and the standard measurement within one breath resulted in a clearly better correlation (r=0.89). We conclude that this new measurement technique provides and easy and accurate P0.1 measurement using standard Respiratory Equipment when tested in a lung model. In patient measurements the method is less precise, which is probably due to the variable waveforms of the inspiratory driving pressure seen in patients, for example when intrinsic PEEP is present. However, the new method makes the P0.1 measurement as a “bed-side” method clinically available, although the values should be interpreted cautiously.