The Experts below are selected from a list of 108 Experts worldwide ranked by ideXlab platform
John Lach - One of the best experts on this subject based on the ideXlab platform.
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inferring Respiratory Minute Volume from wrist motion
International Conference of the IEEE Engineering in Medicine and Biology Society, 2019Co-Authors: Ridwan Alam, David B Peden, Benjamin Ghaemmaghami, John LachAbstract:Exposure to air pollutants poses major health risk for patients with chronic pulmonary diseases such as asthma, bronchitis, and emphysema. Such risk can be mitigated by continuous exposure tracking. The effective dose of exposure is directly proportional to the Respiratory Minute Volume, aka Minute ventilation (VE). Till date, the clinical standard for measuring VE is Spirometry, a highly invasive and cumbersome modality, which is not suitable for continuous day-to-day use. This paper presents a novel non-invasive method toward continuous assessment of VE using a wrist-mount wearable motion sensor. Data from 25 healthy subjects were collected while they performed ambulatory and sedentary activities and physical exercises. Noise and artifacts of the motion signal are removed and the processed signal is used to extract explanatory features. The features are used to train and evaluate multiple regression models, among which, the probabilistic Gaussian process regression achieves the best performance in inferring VE from the wearable motion signal. The effects of inter- and intra-personal variations are explored to demonstrate the potential of the proposed method for continuously monitoring pollutant exposure risk in Respiratory health applications.
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EMBC - Inferring Respiratory Minute Volume from Wrist Motion
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Inte, 2019Co-Authors: Ridwan Alam, David B Peden, Benjamin Ghaemmaghami, John LachAbstract:Exposure to air pollutants poses major health risk for patients with chronic pulmonary diseases such as asthma, bronchitis, and emphysema. Such risk can be mitigated by continuous exposure tracking. The effective dose of exposure is directly proportional to the Respiratory Minute Volume, aka Minute ventilation (VE). Till date, the clinical standard for measuring VE is Spirometry, a highly invasive and cumbersome modality, which is not suitable for continuous day-to-day use. This paper presents a novel non-invasive method toward continuous assessment of VE using a wrist-mount wearable motion sensor. Data from 25 healthy subjects were collected while they performed ambulatory and sedentary activities and physical exercises. Noise and artifacts of the motion signal are removed and the processed signal is used to extract explanatory features. The features are used to train and evaluate multiple regression models, among which, the probabilistic Gaussian process regression achieves the best performance in inferring VE from the wearable motion signal. The effects of inter- and intra-personal variations are explored to demonstrate the potential of the proposed method for continuously monitoring pollutant exposure risk in Respiratory health applications.
Ridwan Alam - One of the best experts on this subject based on the ideXlab platform.
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inferring Respiratory Minute Volume from wrist motion
International Conference of the IEEE Engineering in Medicine and Biology Society, 2019Co-Authors: Ridwan Alam, David B Peden, Benjamin Ghaemmaghami, John LachAbstract:Exposure to air pollutants poses major health risk for patients with chronic pulmonary diseases such as asthma, bronchitis, and emphysema. Such risk can be mitigated by continuous exposure tracking. The effective dose of exposure is directly proportional to the Respiratory Minute Volume, aka Minute ventilation (VE). Till date, the clinical standard for measuring VE is Spirometry, a highly invasive and cumbersome modality, which is not suitable for continuous day-to-day use. This paper presents a novel non-invasive method toward continuous assessment of VE using a wrist-mount wearable motion sensor. Data from 25 healthy subjects were collected while they performed ambulatory and sedentary activities and physical exercises. Noise and artifacts of the motion signal are removed and the processed signal is used to extract explanatory features. The features are used to train and evaluate multiple regression models, among which, the probabilistic Gaussian process regression achieves the best performance in inferring VE from the wearable motion signal. The effects of inter- and intra-personal variations are explored to demonstrate the potential of the proposed method for continuously monitoring pollutant exposure risk in Respiratory health applications.
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EMBC - Inferring Respiratory Minute Volume from Wrist Motion
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Inte, 2019Co-Authors: Ridwan Alam, David B Peden, Benjamin Ghaemmaghami, John LachAbstract:Exposure to air pollutants poses major health risk for patients with chronic pulmonary diseases such as asthma, bronchitis, and emphysema. Such risk can be mitigated by continuous exposure tracking. The effective dose of exposure is directly proportional to the Respiratory Minute Volume, aka Minute ventilation (VE). Till date, the clinical standard for measuring VE is Spirometry, a highly invasive and cumbersome modality, which is not suitable for continuous day-to-day use. This paper presents a novel non-invasive method toward continuous assessment of VE using a wrist-mount wearable motion sensor. Data from 25 healthy subjects were collected while they performed ambulatory and sedentary activities and physical exercises. Noise and artifacts of the motion signal are removed and the processed signal is used to extract explanatory features. The features are used to train and evaluate multiple regression models, among which, the probabilistic Gaussian process regression achieves the best performance in inferring VE from the wearable motion signal. The effects of inter- and intra-personal variations are explored to demonstrate the potential of the proposed method for continuously monitoring pollutant exposure risk in Respiratory health applications.
Richard A. Gillis - One of the best experts on this subject based on the ideXlab platform.
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CardioRespiratory effects produced by blockade of excitatory amino acid receptors in cats
European Journal of Pharmacology, 1993Co-Authors: T.patrick Abrahams, Paul Hamosh, Angelo M. Taveira Dasilva, John E. Mcmanigle, Richard A. GillisAbstract:Abstract The aim of our study was to determine the role of excitatory amino acids in controlling cardioRespiratory activity. For this purpose we administered an antagonist of both N-methyl-D-aspartate (NMDA) and non-NMDA receptors (kynurenic acid), and an antagonist of the NMDA receptor complex (dizocilpine, more commonly known as MK-801) i.v. to chloralose-anesthetized cats while monitoring tracheal air flow, tidal Volume, Respiratory rate, inspiratory and expiratory durations, end tidal CO2, arterial blood pressure and heart rate. Administration of kynurenic acid in doses of 350 and 500 mg/kg produced Respiratory depression as reflected by decreases in Respiratory Minute Volume and increases in end tidal CO2. Inspiratory duration was increased with both doses and apnea (occurring during expiration) was observed with the high dose. Apnea was preceded by an apneustic pattern of breathing. Both doses resulted in an increase in blood pressure and, with the high dose, a later decrease in blood pressure was noted. Dizocilpine in doses ranging from 0.03 to 1 mg/kg produced dose-related decreases in Respiratory Minute Volume, and increases in end tidal CO2. In addition, dizocilpine produced increases in inspiratory duration, an apneustic pattern of breathing and apnea (occurring during inspiration). Effects on blood pressure were similar to those observed with kynurenic acid. It is concluded that blockade of excitatory amino acid receptors results in pronounced effects on cardiorespiratoty activity.
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A beta-carboline derivative (ZK 93426) counteracts the cardioRespiratory depressant effects of intravenous midazolam.
Pharmacology, 1992Co-Authors: A. M. Taveira Da Silva, S. Pineo, Richard A. GillisAbstract:The purpose of this study was to test the effects of the new β-carboline ZK 93426 on midazolam-induced cardioRespiratory depression. Seven pentobarbital-anesthetized (35 mg/kg i.p.) cats were treated with intravenous midazolam (2 mg/kg) while monitoring the Respiratory Minute Volume (VE), tidal Volume, Respiratory rate, blood pressure, heart rate and expired CO2. Midazolam caused significant decreases in VE (p
Henrique Rigatto - One of the best experts on this subject based on the ideXlab platform.
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Physiologic changes induced by theophylline in the treatment of apnea in preterm infants
The Journal of Pediatrics, 2006Co-Authors: Maria Davi, Koravangattu Sankaran, Keith J. Simons, F. Estelle R. Simons, Mary Seshia, Henrique RigattoAbstract:Ten preterm infants (birth weight 0.970 to 2.495 kg) with apnea due to periodic breathing (apneic interval = 5 to 10 seconds) or with "serious apnea" (greater than or equal to 20 seconds) were studied before and after the administration of theophylline. We determined the incidence of apnea, Respiratory Minute Volume, alveolar gases, arterial gases and pH, "specific" compliance, functional residual capacity, and work of breathing. Theophylline decreased the incidence of apnea (P less than .05), increased Respiratory Minute Volume (P less than 0.001), decreased (PACO2 (and PaCO2 P less than 0.001), increased the slope of the CO2 response curve (P less than 0.02) with a significant shift to the left (P less than 0.02). These findings suggest that the decreased incidence of apnea after theophylline is associated with an increase in alveolar ventilation and increased sensitivity to CO2 with a pronounced shift of the CO2 response curve to the left. These data are consistent with the idea that apnea is a reflection of a depressed Respiratory system.
U. Sulkowski - One of the best experts on this subject based on the ideXlab platform.
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Beatmung in Bauchlage beim akuten Lungenversagen
Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie, 1991Co-Authors: B. Thülig, T. Hachenberg, M. Wendt, W. Wiesmann, U. SulkowskiAbstract:A patient is presented in whom an acute Respiratory distress syndrome (ARDS) developed after severe lung contusion. Exchange of gas was markedly restricted under aggressive respiration (FiO2 = 1.0, PEEP = 10 mmHg, breathing time quotient = 0.5, Respiratory Minute Volume = 16 litres; gas exchange values: PaO2 = 67 mmHg, PaCO2 = 45 mmHg, PA-aO2 = 461 mmHg). After control of the computed tomogram of the lungs showed marked densifications in those parts of the lung that are lower most by gravitation according to the positioning of the patient at a particular time the patient was ventilated in ventricumbent (prone) position for 60 hours. After having remained in this position for 48 hours, there was a significant improvement in the gas exchange (PaO2 = 89 mmHg, PaCO2 = 36 mmHg, PA-aO2 = 77 mmHg at FiO2 = 0.3, PEEP = 6 mmHg, breathing time quotient = 0.5 and Respiratory Minute Volume = 9 litres). The control CT in dorsal position showed that the dorsal densifications had disappeared completely. Five days later the patient could be extubated. Respiration in ventricumbent (prone) position may considerably improve oxygenation by perfusion of well-ventilated regions of the lung that are lower-most by gravitation according to the relative positioning of the patient. Besides regions not well ventilated or not ventilated at all (according to the patient's position) may be better ventilated or re-opened and made accessible to ventilation by this method.
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Artificial respiration in the prone position in a case of acute Respiratory distress syndrome
Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie : AINS, 1991Co-Authors: B. Thülig, T. Hachenberg, M. Wendt, W. Wiesmann, U. SulkowskiAbstract:A patient is presented in whom an acute Respiratory distress syndrome (ARDS) developed after severe lung contusion. Exchange of gas was markedly restricted under aggressive respiration (FiO2 = 1.0, PEEP = 10 mmHg, breathing time quotient = 0.5, Respiratory Minute Volume = 16 litres; gas exchange values: PaO2 = 67 mmHg, PaCO2 = 45 mmHg, PA-aO2 = 461 mmHg). After control of the computed tomogram of the lungs showed marked densifications in those parts of the lung that are lower most by gravitation according to the positioning of the patient at a particular time the patient was ventilated in ventricumbent (prone) position for 60 hours. After having remained in this position for 48 hours, there was a significant improvement in the gas exchange (PaO2 = 89 mmHg, PaCO2 = 36 mmHg, PA-aO2 = 77 mmHg at FiO2 = 0.3, PEEP = 6 mmHg, breathing time quotient = 0.5 and Respiratory Minute Volume = 9 litres). The control CT in dorsal position showed that the dorsal densifications had disappeared completely. Five days later the patient could be extubated. Respiration in ventricumbent (prone) position may considerably improve oxygenation by perfusion of well-ventilated regions of the lung that are lower-most by gravitation according to the relative positioning of the patient. Besides regions not well ventilated or not ventilated at all (according to the patient's position) may be better ventilated or re-opened and made accessible to ventilation by this method.