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Justin Y Jeon - One of the best experts on this subject based on the ideXlab platform.

  • relationship between Resting Heart Rate and metabolic risk factors in breast cancer patients
    Clinica Chimica Acta, 2018
    Co-Authors: Mikyung Lee, Dong Hoon Lee, Seho Park, Seung Il Kim, Justin Y Jeon
    Abstract:

    Abstract Background Higher Resting Heart Rate (RHR) was associated with poor prognosis in breast cancer survivors, but the mechanism underlying such association has not been fully studied. We investigated the association between RHR and metabolic risk factors in stage I-III breast cancer survivors. Methods Among 11,013 women diagnosed with breast cancer between 2005 and 2013 at the Severance hospital in Seoul, Korea, a total of 4980 patients met our inclusion criteria for the final analysis. Multivariable linear regressions were used to examine the association between RHR and metabolic risk factors, including systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, triglyceride (TG), total cholesterol, high density lipid cholesterol (HDL C), and low density lipid cholesterol. Results The results showed that RHR had significant linear associations with SBP (p = .02), DBP (p  Conclusions We observed a strong positive association of RHR with fasting glucose, TG, and DBP in breast cancer survivors, which may potentially explain the association between RHR and breast cancer prognosis.

  • Resting Heart Rate as a prognostic factor for mortality in patients with breast cancer
    Breast Cancer Research and Treatment, 2016
    Co-Authors: Dong Hoon Lee, Mikyung Lee, Seho Park, Seung Il Kim, Sung Mook Lim, Edward Giovannucci, Joo Heung Kim, Justin Y Jeon
    Abstract:

    Although elevated Resting Heart Rate (RHR) has been shown to be associated with mortality in the general population and patients with certain diseases, no study has examined this association in patients with breast cancer. A total of 4786 patients with stage I–III breast cancer were retrospectively selected from the Severance hospital breast cancer registry in Seoul, Korea. RHR was measured at baseline and the mean follow-up time for all patients was 5.0 ± 2.5 years. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated using Cox regression models. After adjustment for prognostic factors, patients in the highest quintile of RHR (≥85 beat per minute (bpm)) had a significantly higher risk of all-cause mortality (HR: 1.57; 95 %CI 1.05–2.35), breast cancer-specific mortality (HR: 1.69; 95 %CI 1.07–2.68), and cancer recurrence (HR: 1.49; 95 %CI 0.99–2.25), compared to those in the lowest quintile (≤67 bpm). Moreover, every 10 bpm increase in RHR was associated with 15, 22, and 6 % increased risk of all-cause mortality, breast cancer-specific mortality, and cancer recurrence, respectively. However, the association between RHR and cancer recurrence was not statistically significant (p = 0.26). Elevated RHR was associated with an increased risk of mortality in patients with breast cancer. The findings from this study suggest that RHR may be used as a prognostic factor for patients with breast cancer in clinical settings.

  • the association between Resting Heart Rate and type 2 diabetes and hypertension in korean adults
    Heart, 2016
    Co-Authors: Dongil Kim, Mikyung Lee, Hyuk In Yang, Jihye Park, Dongwoo Kang, Jey Sook Chae, Jong Ho Lee, Justin Y Jeon
    Abstract:

    Objective The purpose of this study was to analyse the association between Resting Heart Rate (RHR) and type 2 diabetes and hypertension in Korean adults. Methods A total of 5124 participants, who participated in the exercise programme at the National Health Promotion Center between 2007 and 2010 (male=904, female=4220) were analysed in this study. Anthropometrics, body mass index (BMI), blood pressure (BP) and RHR were measured, and blood samples were collected after fasting for at least 12 hours. Results To investigate the association between RHR and metabolic parameters, participants were divided into quartiles. Participants in the fourth quartile (RHR >80 beats per minute (bpm) showed significantly higher systolic and diastolic BP and glucose compared with participants in the first quartile (RHR Conclusions RHR is significantly associated with type 2 diabetes and hypertension independent of age, gender, BMI, smoking, drinking and family history of disease. RHR in combination with BMI, and multiple linear regression analyses emphasise the importance of the association of RHR with type 2 diabetes and hypertension in Korean adults.

  • the association of Resting Heart Rate with diabetes hypertension and metabolic syndrome in the korean adult population the fifth korea national health and nutrition examination survey
    Clinica Chimica Acta, 2016
    Co-Authors: Hyuk In Yang, Hyeon Chang Kim, Justin Y Jeon
    Abstract:

    Objective Investigate the association of Resting Heart Rate (RHR) with diabetes, hypertension and metabolic syndrome in a data set that represents the whole Korean adult population. Methods The data of 18,640 adults, that represent the whole Korean adult population, was used to examine the association of Resting Heart Rate (RHR) with blood related variables, diabetes, hypertension and metabolic syndrome. Results Compared to participants with a RHR of < 60 beats per minute (bpm), participants with a RHR of ≥ 90 bpm had higher odds of diabetes {3.85 [95% confidence interval (CI) 2.14–6.90], 3.34 (95% CI 1.83–6.10)} and metabolic syndrome [3.55 (95% CI 2.19–5.74), 2.15 (95% CI 1.37–3.35)], for men and women, respectively. Furthermore, compared to the participants with normal BMI (< 23 kg/m2) normal RHR (< 80 bpm), participants with high BMI (≥ 23 kg/m2) high RHR (≥ 80 bpm) had higher odds of diabetes [2.51 (95% CI 1.83–3.46), 4.89 (95% CI 3.63–6.58)], hypertension [3.88 (95% CI 3.00–5.01), 2.61 (95% CI 2.07–3.28)], and metabolic syndrome [9.67 (95% CI 7.42–12.61), 13.09 (95% CI 10.25–16.73)], for men and women, respectively. RHR shows a positive dose response relationship with the prevalence of diabetes and metabolic syndrome. The combined association of RHR with BMI increases the potency of RHR as a marker of diabetes, hypertension and metabolic syndrome. Conclusions This study shows that RHR has an important role to play as a potential clinical measurement and prognostic marker.

Dag S Thelle - One of the best experts on this subject based on the ideXlab platform.

  • physical activity Resting Heart Rate and atrial fibrillation the tromso study
    European Heart Journal, 2016
    Co-Authors: Bente Morseth, Dag S Thelle, Sidsel Graffiversen, Bjarne K Jacobsen, Lone Jorgensen, Audhild Nyrnes, Peter Vestergaard, Majalisa Lochen
    Abstract:

    Aims The objective was to examine the association of physical activity and Resting Heart Rate (RHR) with hospital-diagnosed atrial fibrillation (AF) in a Norwegian cohort. Methods and results This prospective study included 20 484 adults (50.3% men) who participated in the third Tromso Study survey in 1986–87. At baseline, physical activity was assessed by a validated questionnaire, and RHR was objectively measured. Participants were followed from baseline through 2010 with respect to incident cases of hospital-diagnosed AF documented on an electrocardiogram. During a mean follow-up period of 20 years (409 045 person-years), 750 participants (70.5% men) were diagnosed with AF. Compared with the low physical activity group, modeRately active individuals had a 19% lower risk of any AF [adjusted hazard ratio (HR) 0.81, 95% confidence interval (CI) 0.68–0.97], whereas highly active had similar risk of AF. Vigorously active individuals showed a non-significantly higher risk of AF (adjusted HR 1.37, 95% CI 0.77–2.43). Risk of AF increased with decreasing RHR (adjusted HR 0.92, 95% CI 0.86–0.98 for each 10 b.p.m. increase in RHR), and RHR < 50 b.p.m. was a risk factor for AF ( P < 0.05). Conclusion In this prospective cohort study, leisure time physical activity was associated with AF in a J-shaped pattern. ModeRate physical activity was associated with a reduced risk of AF, whereas higher activity levels attenuated the benefits of modeRate activity. Low RHR was a risk factor for AF. Our results support the hypothesis that modeRate and vigorous physical activity may affect AF risk via different pathophysiological mechanisms.

  • Resting Heart Rate and physical activity as risk factors for lone atrial fibrillation a prospective study of 309 540 men and women
    Heart, 2013
    Co-Authors: Dag S Thelle, Randi Selmer, Knut Gjesdal, Solveig Sakshaug, Astanand Jugessur, Sidsel Graffiversen
    Abstract:

    Objective To study the impact of Resting Heart Rate and leisure time physical activity at middle age on long term risk of drug treated lone atrial fibrillation (AF). Design Longitudinal cohort study of 309 540 Norwegian men and women aged 40–45 years examined during 1985–1999 followed from 2005 through 2009. Setting Data from a national health screening programme were linked to the Norwegian Prescription Database (NorPD). Patients The cohort comprised 162 078 women and 147 462 men; 575 (0.4%) men and 288 women (0.2%) received flecainide and 568 men and 256 women sotalol and were defined as patients with AF. Interventions No interventions. Main outcome measures The outcome was lone fibrillation defined by having at least one prescription of flecainide or sotalol registered in NorPD between 2005 and 2009. Cox proportional hazard regression models were used to assess time to first prescription. Results The risk for being prescribed these drugs increased with decreasing baseline Resting Heart. Adjusted hazard ratio (HR) per 10 beats/min decrease in Resting Heart Rate for flecainide prescription was 1.26 in men (95% CI 1.17 to 1.35) and 1.15 (95% CI 1.05 to 1.27) in women. Similar effects were seen for sotalol in men, but not in women. Men who reported intensive physical activity were more often prescribed flecainide than those in the sedentary group (adjusted HR=3.14, 95% CI 2.17 to 4.54). Conclusions This population based study supports the hypothesis that the risk of drug treated lone AF increases with declining Resting Heart Rate in both sexes, and with increasing levels of self-reported physical activity in men.

David Nanchen - One of the best experts on this subject based on the ideXlab platform.

  • Resting Heart Rate and the risk of Heart failure in healthy adults the rotterdam study
    Circulation-heart Failure, 2013
    Co-Authors: David Nanchen, Maarten J G Leening, Isabella Locatelli, Jacques Cornuz, Jan A Kors, Jan Heeringa, Jaap W Deckers, Albert Hofman, Oscar H Franco, Bruno H Stricker
    Abstract:

    Background—An elevated Resting Heart Rate is associated with rehospitalization for Heart failure and is a modifiable risk factor in Heart failure patients. We aimed to examine the association betwe...

  • Resting Heart Rate and incident Heart failure and cardiovascular mortality in older adults role of inflammation and endothelial dysfunction the prosper study
    European Journal of Heart Failure, 2013
    Co-Authors: David Nanchen, Jacques Cornuz, Jacobijn Gussekloo, David J Stott, Simon P Mooijaart, Rudi G J Westendorp, Wouter J Jukema, Peter W Macfarlane, Nicolas Rodondi
    Abstract:

    Aims Resting Heart Rate is a promising modifiable cardiovascular risk marker in older adults, but the mechanisms linking Heart Rate to cardiovascular disease are not fully understood. We aimed to assess the association between Resting Heart Rate and incident Heart failure (HF) and cardiovascular mortality, and to examine whether these associations might be attributable to systemic inflammation and endothelial dysfunction. Methods and results We studied 4084 older adults aged 70–82 years with known cardiovascular risk factors or previous cardiovascular disease, without pre-existing HF or beta-blockers in the PROSPER study. Over a 3.2-year follow-up period, we examined incident HF hospitalization and cardiovascular mortality according to Resting Heart Rate, along with C-reactive protein (CRP), interleukin-6 (IL-6), tissue plasminogen activator (tPA), and von Willebrand factor (vWf). Mean Heart Rate was 67 b.p.m. for men and 70 b.p.m. for women. CRP, IL-6, tPA, and vWf levels were all positively correlated with Heart Rate. After multivariate adjustment, Heart Rate was associated with HF hospitalization [hazard ratio (HR) 1.78 for highest vs. lowest distribution third, 95% confidence interval (CI) 1.21–2.63, P= 0.003] and cardiovascular mortality (HR 1.74, 95% CI 1.23–2.47, P= 0.002). Further adjustment for both IL-6 and vWf levels decreased HR to 1.60 (95% CI 1.08–2.38, P= 0.020) for HF and to 1.50 (95% CI 1.04–2.15, P= 0.028) for cardiovascular mortality. Conclusion Increased Heart Rate is associated with increased systemic inflammation and endothelial dysfunction. These factors are likely to contribute to, but do not fully explain, the risk of HF and cardiovascular death associated with increased Heart Rate in older age.

  • Resting Heart Rate and the risk of Heart failure in healthy adults the rotterdam study
    Circulation-heart Failure, 2013
    Co-Authors: David Nanchen, Maarten J G Leening, Isabella Locatelli, Jacques Cornuz, Jan A Kors, Jan Heeringa, Jaap W Deckers, Albert Hofman, Oscar H Franco, Bruno H Stricker
    Abstract:

    Background —An elevated Resting Heart Rate is associated with re-hospitalization for Heart failure and is a modifiable risk factor in Heart failure patients. We aimed to examine the association between Resting Heart Rate and incident Heart failure in a population-based cohort study of healthy adults without pre-existing overt Heart disease. Methods and Results —We studied 4,768 men and women aged 55 years or older from the population-based Rotterdam Study. We excluded participants with prevalent Heart failure, coronary Heart disease, pacemaker, atrial fibrillation, atrio-ventricular block, and those using beta-blockers or calcium channel blockers. We used extended Cox-models allowing for time-dependent variation of Resting Heart Rate along follow-up. Over a median of 14.6 years of follow-up, 656 participants developed Heart failure. The risk of Heart failure was higher in men with higher Resting Heart Rate. For each increment of 10 beats per minute, the multivariable adjusted hazard ratios in men were 1.16 (95% confidence interval [CI], 1.05-1.28, p=0.005) in the time-fixed Heart Rate model and 1.13 (95% CI 1.02-1.25, p=0.017) in the time-dependent Heart Rate model. The association could not be demonstRated in women (p for interaction = 0.004). Censoring participants for incident coronary Heart disease, or using time-dependent models to account for the use of beta-blockers or calcium channel blockers during follow-up did not alter the results. Conclusions —Baseline or persistent higher Resting Heart Rate is an independent risk factor for the development of Heart failure in healthy older men in the general population.

Sidsel Graffiversen - One of the best experts on this subject based on the ideXlab platform.

  • physical activity Resting Heart Rate and atrial fibrillation the tromso study
    European Heart Journal, 2016
    Co-Authors: Bente Morseth, Dag S Thelle, Sidsel Graffiversen, Bjarne K Jacobsen, Lone Jorgensen, Audhild Nyrnes, Peter Vestergaard, Majalisa Lochen
    Abstract:

    Aims The objective was to examine the association of physical activity and Resting Heart Rate (RHR) with hospital-diagnosed atrial fibrillation (AF) in a Norwegian cohort. Methods and results This prospective study included 20 484 adults (50.3% men) who participated in the third Tromso Study survey in 1986–87. At baseline, physical activity was assessed by a validated questionnaire, and RHR was objectively measured. Participants were followed from baseline through 2010 with respect to incident cases of hospital-diagnosed AF documented on an electrocardiogram. During a mean follow-up period of 20 years (409 045 person-years), 750 participants (70.5% men) were diagnosed with AF. Compared with the low physical activity group, modeRately active individuals had a 19% lower risk of any AF [adjusted hazard ratio (HR) 0.81, 95% confidence interval (CI) 0.68–0.97], whereas highly active had similar risk of AF. Vigorously active individuals showed a non-significantly higher risk of AF (adjusted HR 1.37, 95% CI 0.77–2.43). Risk of AF increased with decreasing RHR (adjusted HR 0.92, 95% CI 0.86–0.98 for each 10 b.p.m. increase in RHR), and RHR < 50 b.p.m. was a risk factor for AF ( P < 0.05). Conclusion In this prospective cohort study, leisure time physical activity was associated with AF in a J-shaped pattern. ModeRate physical activity was associated with a reduced risk of AF, whereas higher activity levels attenuated the benefits of modeRate activity. Low RHR was a risk factor for AF. Our results support the hypothesis that modeRate and vigorous physical activity may affect AF risk via different pathophysiological mechanisms.

  • Resting Heart Rate and physical activity as risk factors for lone atrial fibrillation a prospective study of 309 540 men and women
    Heart, 2013
    Co-Authors: Dag S Thelle, Randi Selmer, Knut Gjesdal, Solveig Sakshaug, Astanand Jugessur, Sidsel Graffiversen
    Abstract:

    Objective To study the impact of Resting Heart Rate and leisure time physical activity at middle age on long term risk of drug treated lone atrial fibrillation (AF). Design Longitudinal cohort study of 309 540 Norwegian men and women aged 40–45 years examined during 1985–1999 followed from 2005 through 2009. Setting Data from a national health screening programme were linked to the Norwegian Prescription Database (NorPD). Patients The cohort comprised 162 078 women and 147 462 men; 575 (0.4%) men and 288 women (0.2%) received flecainide and 568 men and 256 women sotalol and were defined as patients with AF. Interventions No interventions. Main outcome measures The outcome was lone fibrillation defined by having at least one prescription of flecainide or sotalol registered in NorPD between 2005 and 2009. Cox proportional hazard regression models were used to assess time to first prescription. Results The risk for being prescribed these drugs increased with decreasing baseline Resting Heart. Adjusted hazard ratio (HR) per 10 beats/min decrease in Resting Heart Rate for flecainide prescription was 1.26 in men (95% CI 1.17 to 1.35) and 1.15 (95% CI 1.05 to 1.27) in women. Similar effects were seen for sotalol in men, but not in women. Men who reported intensive physical activity were more often prescribed flecainide than those in the sedentary group (adjusted HR=3.14, 95% CI 2.17 to 4.54). Conclusions This population based study supports the hypothesis that the risk of drug treated lone AF increases with declining Resting Heart Rate in both sexes, and with increasing levels of self-reported physical activity in men.

David P Farrington - One of the best experts on this subject based on the ideXlab platform.

  • The Longitudinal Association between Resting Heart Rate and Psychopathic Traits from a Normative Personality Perspective
    American Journal of Criminal Justice, 2019
    Co-Authors: Nicholas Kavish, David P Farrington, Henriette Bergstrøm, Alex R. Piquero, Brian B. Boutwell
    Abstract:

    A large body of research has accumulated investigating the possibility of an association between Resting Heart Rate and psychopathic traits, with meta-analysis suggesting a modest, negative association. Some recent research suggests that prior findings of an association between Heart Rate and psychopathy may be influenced by inclusion of antisocial behavior in the assessment of psychopathic traits. The current study explores this possibility in a longitudinal sample of British males by comparing Resting Heart Rate at age 18 to psychopathy assessed from a Five Factor Model perspective and from the Psychopathy Checklist: Screening Version (PCL:SV) at age 48. Our psychopathic personality scale, created using the Big Five Inventory (BFI), was significantly correlated with the PCL:SV and was most related to the antisocial factor. In correlation analyses, Resting Heart Rate at age 18 was not significantly related to BFI psychopathy, but was positively related to BFI Openness and Conscientiousness, and these associations held up after controlling for childhood SES, BMI at 18, and whether the participant smoked during the age 18 assessment. Additional analyses controlling for smoking status were conducted to address the biasing effect of smoking on Heart Rate during the age 18 assessment and a significant, albeit weak, negative association between Resting Heart Rate and BFI psychopathy emerged. Future research should replicate these results using other normative personality approaches to assess psychopathic traits.

  • Resting Heart Rate and antisocial behavior an updated systematic review and meta analysis
    Aggression and Violent Behavior, 2015
    Co-Authors: Jill Portnoy, David P Farrington
    Abstract:

    Prior meta-analyses have concluded that low Resting Heart Rate is associated with higher levels of antisocial behavior. These reviews, however, have had important limitations that preclude firm conclusions about both the relationship between Resting Heart Rate and antisocial behavior and potential moderators of this association. The goal of the current article was to address these limitations by conducting an updated systematic review and meta-analysis of Resting Heart Rate versus antisocial behavior that included both published and unpublished results. 114 reports and 115 independent effect sizes yielded a summary effect size of d = −.20 (SE =.039, p FINDINGS confirm the importance of low Resting Heart Rate as a robust biological correlate of antisocial behavior.

  • does Resting Heart Rate at age 18 distinguish general and violent offending up to age 50 findings from the cambridge study in delinquent development
    Journal of Criminal Justice, 2013
    Co-Authors: Wesley G Jennings, Alexis R Piquero, David P Farrington
    Abstract:

    There is a sizable literature documenting the relationship between Resting Heart Rate and antisocial behavior in children and adolescents. Absent from the literature is the extent to which Heart Rate has long-term prediction into late middle adulthood and the extent to which such effects are specific to certain crime types, such as violence, or whether Heart Rate effects are more general.