Restless Legs Syndrome

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Tobias Kurth - One of the best experts on this subject based on the ideXlab platform.

  • Restless Legs Syndrome and Cognitive Function: A Population-based Cross-sectional Study
    The American journal of medicine, 2015
    Co-Authors: Pamela M. Rist, Alexis Elbaz, Carole Dufouil, Christophe Tzourio, Tobias Kurth
    Abstract:

    Abstract Background Restless Legs Syndrome has been speculated to be linked to cognitive impairment through vascular risk factors or through its effect on sleep deprivation. Previous studies on the association between Restless Legs Syndrome and cognitive function have been inconclusive. We performed a cross-sectional analysis of the association between Restless Legs Syndrome and cognitive function using data from a large population-based study of elderly individuals residing in France. Methods We used information from 2070 individuals from the Dijon, France center of the Three-City study who had available information on Restless Legs Syndrome and cognitive functioning measures. Restless Legs Syndrome was assessed using the 4 minimal diagnostic criteria of the International Restless Legs Study Group. During the same wave in which Restless Legs Syndrome status was assessed, cognitive functions also were assessed using 4 tests: Isaacs' test of verbal/category fluency, the Benton Visual Retention Test, the Trail Making Test B, and the Mini-Mental State Examination. We created a summary global cognitive score by summing the z scores for the 4 tests and used analysis of covariance to explore the association between Restless Legs Syndrome and cognitive function. Results We did not observe any statistically significant differences in any cognitive z -score between those with Restless Legs Syndrome and those without Restless Legs Syndrome. The mean global z -score after multivariate adjustment was −0.003 (SE 0.173) for those with Restless Legs Syndrome and −0.007 (SE 0.129) for those without Restless Legs Syndrome ( P -value = .98). Conclusion Data from this large, population-based study do not suggest that Restless Legs Syndrome is associated with prevalent cognitive deficits in elderly individuals.

  • Vascular risk factors, cardiovascular disease, and Restless Legs Syndrome in men.
    The American journal of medicine, 2013
    Co-Authors: Anke C Winter, Klaus Berger, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Markus Schürks, Tobias Kurth
    Abstract:

    Abstract Background The prevalence of vascular risk factors, cardiovascular disease, and Restless Legs Syndrome increases with age. Prior studies analyzing the associations between vascular risk factors, cardiovascular disease, and Restless Legs Syndrome found controversial results. We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and Restless Legs Syndrome. Methods We conducted a cross-sectional study among 22,786 participants of the US Physicians' Health Studies I and II. Restless Legs Syndrome was classified according to the 4 minimal diagnostic criteria. Vascular risk factors and Restless Legs Syndrome symptoms were self-reported. Prevalent cardiovascular disease events, including major cardiovascular disease, stroke, and myocardial infarction, were confirmed by medical record review. Age- and multivariable-adjusted logistic regression models were used to evaluate the association among vascular risk factors, prevalent cardiovascular disease events, and Restless Legs Syndrome. Results The mean age of the cohort was 67.8 years. The prevalence of Restless Legs Syndrome was 7.5% and increased significantly with age. Diabetes significantly increased the odds of Restless Legs Syndrome (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.21-1.65), whereas frequent exercise (OR, 0.78; 95% CI, 0.67-0.91) and alcohol consumption of 1 or more drinks per day (OR, 0.80; 95% CI, 0.69-0.92) significantly reduced the odds of Restless Legs Syndrome in multivariable-adjusted models. Prevalent stroke showed an increased multivariable-adjusted OR of 1.40 (1.05-1.86), whereas men with prevalent myocardial infarction had a decreased OR of 0.73 (0.55-0.97) for Restless Legs Syndrome. Conclusions The Restless Legs Syndrome prevalence among US male physicians is similar to that of men of the same age group in other western countries. A history of diabetes is the most consistent risk factor associated with Restless Legs Syndrome. Prevalent stroke and myocardial infarction are related to Restless Legs Syndrome prevalence.

  • Vascular risk factors, cardiovascular disease, and Restless Legs Syndrome in men.
    The American journal of medicine, 2013
    Co-Authors: Anke C Winter, Klaus Berger, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Markus Schürks, Tobias Kurth
    Abstract:

    The prevalence of vascular risk factors, cardiovascular disease, and Restless Legs Syndrome increases with age. Prior studies analyzing the associations between vascular risk factors, cardiovascular disease, and Restless Legs Syndrome found controversial results. We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and Restless Legs Syndrome. We conducted a cross-sectional study among 22,786 participants of the US Physicians' Health Studies I and II. Restless Legs Syndrome was classified according to the 4 minimal diagnostic criteria. Vascular risk factors and Restless Legs Syndrome symptoms were self-reported. Prevalent cardiovascular disease events, including major cardiovascular disease, stroke, and myocardial infarction, were confirmed by medical record review. Age- and multivariable-adjusted logistic regression models were used to evaluate the association among vascular risk factors, prevalent cardiovascular disease events, and Restless Legs Syndrome. The mean age of the cohort was 67.8 years. The prevalence of Restless Legs Syndrome was 7.5% and increased significantly with age. Diabetes significantly increased the odds of Restless Legs Syndrome (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.21-1.65), whereas frequent exercise (OR, 0.78; 95% CI, 0.67-0.91) and alcohol consumption of 1 or more drinks per day (OR, 0.80; 95% CI, 0.69-0.92) significantly reduced the odds of Restless Legs Syndrome in multivariable-adjusted models. Prevalent stroke showed an increased multivariable-adjusted OR of 1.40 (1.05-1.86), whereas men with prevalent myocardial infarction had a decreased OR of 0.73 (0.55-0.97) for Restless Legs Syndrome. The Restless Legs Syndrome prevalence among US male physicians is similar to that of men of the same age group in other western countries. A history of diabetes is the most consistent risk factor associated with Restless Legs Syndrome. Prevalent stroke and myocardial infarction are related to Restless Legs Syndrome prevalence. Copyright © 2013 Elsevier Inc. All rights reserved.

Anke C Winter - One of the best experts on this subject based on the ideXlab platform.

  • Vascular risk factors, cardiovascular disease, and Restless Legs Syndrome in men.
    The American journal of medicine, 2013
    Co-Authors: Anke C Winter, Klaus Berger, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Markus Schürks, Tobias Kurth
    Abstract:

    Abstract Background The prevalence of vascular risk factors, cardiovascular disease, and Restless Legs Syndrome increases with age. Prior studies analyzing the associations between vascular risk factors, cardiovascular disease, and Restless Legs Syndrome found controversial results. We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and Restless Legs Syndrome. Methods We conducted a cross-sectional study among 22,786 participants of the US Physicians' Health Studies I and II. Restless Legs Syndrome was classified according to the 4 minimal diagnostic criteria. Vascular risk factors and Restless Legs Syndrome symptoms were self-reported. Prevalent cardiovascular disease events, including major cardiovascular disease, stroke, and myocardial infarction, were confirmed by medical record review. Age- and multivariable-adjusted logistic regression models were used to evaluate the association among vascular risk factors, prevalent cardiovascular disease events, and Restless Legs Syndrome. Results The mean age of the cohort was 67.8 years. The prevalence of Restless Legs Syndrome was 7.5% and increased significantly with age. Diabetes significantly increased the odds of Restless Legs Syndrome (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.21-1.65), whereas frequent exercise (OR, 0.78; 95% CI, 0.67-0.91) and alcohol consumption of 1 or more drinks per day (OR, 0.80; 95% CI, 0.69-0.92) significantly reduced the odds of Restless Legs Syndrome in multivariable-adjusted models. Prevalent stroke showed an increased multivariable-adjusted OR of 1.40 (1.05-1.86), whereas men with prevalent myocardial infarction had a decreased OR of 0.73 (0.55-0.97) for Restless Legs Syndrome. Conclusions The Restless Legs Syndrome prevalence among US male physicians is similar to that of men of the same age group in other western countries. A history of diabetes is the most consistent risk factor associated with Restless Legs Syndrome. Prevalent stroke and myocardial infarction are related to Restless Legs Syndrome prevalence.

  • Vascular risk factors, cardiovascular disease, and Restless Legs Syndrome in men.
    The American journal of medicine, 2013
    Co-Authors: Anke C Winter, Klaus Berger, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Markus Schürks, Tobias Kurth
    Abstract:

    The prevalence of vascular risk factors, cardiovascular disease, and Restless Legs Syndrome increases with age. Prior studies analyzing the associations between vascular risk factors, cardiovascular disease, and Restless Legs Syndrome found controversial results. We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and Restless Legs Syndrome. We conducted a cross-sectional study among 22,786 participants of the US Physicians' Health Studies I and II. Restless Legs Syndrome was classified according to the 4 minimal diagnostic criteria. Vascular risk factors and Restless Legs Syndrome symptoms were self-reported. Prevalent cardiovascular disease events, including major cardiovascular disease, stroke, and myocardial infarction, were confirmed by medical record review. Age- and multivariable-adjusted logistic regression models were used to evaluate the association among vascular risk factors, prevalent cardiovascular disease events, and Restless Legs Syndrome. The mean age of the cohort was 67.8 years. The prevalence of Restless Legs Syndrome was 7.5% and increased significantly with age. Diabetes significantly increased the odds of Restless Legs Syndrome (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.21-1.65), whereas frequent exercise (OR, 0.78; 95% CI, 0.67-0.91) and alcohol consumption of 1 or more drinks per day (OR, 0.80; 95% CI, 0.69-0.92) significantly reduced the odds of Restless Legs Syndrome in multivariable-adjusted models. Prevalent stroke showed an increased multivariable-adjusted OR of 1.40 (1.05-1.86), whereas men with prevalent myocardial infarction had a decreased OR of 0.73 (0.55-0.97) for Restless Legs Syndrome. The Restless Legs Syndrome prevalence among US male physicians is similar to that of men of the same age group in other western countries. A history of diabetes is the most consistent risk factor associated with Restless Legs Syndrome. Prevalent stroke and myocardial infarction are related to Restless Legs Syndrome prevalence. Copyright © 2013 Elsevier Inc. All rights reserved.

Klaus Berger - One of the best experts on this subject based on the ideXlab platform.

  • Vascular risk factors, cardiovascular disease, and Restless Legs Syndrome in men.
    The American journal of medicine, 2013
    Co-Authors: Anke C Winter, Klaus Berger, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Markus Schürks, Tobias Kurth
    Abstract:

    Abstract Background The prevalence of vascular risk factors, cardiovascular disease, and Restless Legs Syndrome increases with age. Prior studies analyzing the associations between vascular risk factors, cardiovascular disease, and Restless Legs Syndrome found controversial results. We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and Restless Legs Syndrome. Methods We conducted a cross-sectional study among 22,786 participants of the US Physicians' Health Studies I and II. Restless Legs Syndrome was classified according to the 4 minimal diagnostic criteria. Vascular risk factors and Restless Legs Syndrome symptoms were self-reported. Prevalent cardiovascular disease events, including major cardiovascular disease, stroke, and myocardial infarction, were confirmed by medical record review. Age- and multivariable-adjusted logistic regression models were used to evaluate the association among vascular risk factors, prevalent cardiovascular disease events, and Restless Legs Syndrome. Results The mean age of the cohort was 67.8 years. The prevalence of Restless Legs Syndrome was 7.5% and increased significantly with age. Diabetes significantly increased the odds of Restless Legs Syndrome (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.21-1.65), whereas frequent exercise (OR, 0.78; 95% CI, 0.67-0.91) and alcohol consumption of 1 or more drinks per day (OR, 0.80; 95% CI, 0.69-0.92) significantly reduced the odds of Restless Legs Syndrome in multivariable-adjusted models. Prevalent stroke showed an increased multivariable-adjusted OR of 1.40 (1.05-1.86), whereas men with prevalent myocardial infarction had a decreased OR of 0.73 (0.55-0.97) for Restless Legs Syndrome. Conclusions The Restless Legs Syndrome prevalence among US male physicians is similar to that of men of the same age group in other western countries. A history of diabetes is the most consistent risk factor associated with Restless Legs Syndrome. Prevalent stroke and myocardial infarction are related to Restless Legs Syndrome prevalence.

  • Vascular risk factors, cardiovascular disease, and Restless Legs Syndrome in men.
    The American journal of medicine, 2013
    Co-Authors: Anke C Winter, Klaus Berger, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Markus Schürks, Tobias Kurth
    Abstract:

    The prevalence of vascular risk factors, cardiovascular disease, and Restless Legs Syndrome increases with age. Prior studies analyzing the associations between vascular risk factors, cardiovascular disease, and Restless Legs Syndrome found controversial results. We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and Restless Legs Syndrome. We conducted a cross-sectional study among 22,786 participants of the US Physicians' Health Studies I and II. Restless Legs Syndrome was classified according to the 4 minimal diagnostic criteria. Vascular risk factors and Restless Legs Syndrome symptoms were self-reported. Prevalent cardiovascular disease events, including major cardiovascular disease, stroke, and myocardial infarction, were confirmed by medical record review. Age- and multivariable-adjusted logistic regression models were used to evaluate the association among vascular risk factors, prevalent cardiovascular disease events, and Restless Legs Syndrome. The mean age of the cohort was 67.8 years. The prevalence of Restless Legs Syndrome was 7.5% and increased significantly with age. Diabetes significantly increased the odds of Restless Legs Syndrome (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.21-1.65), whereas frequent exercise (OR, 0.78; 95% CI, 0.67-0.91) and alcohol consumption of 1 or more drinks per day (OR, 0.80; 95% CI, 0.69-0.92) significantly reduced the odds of Restless Legs Syndrome in multivariable-adjusted models. Prevalent stroke showed an increased multivariable-adjusted OR of 1.40 (1.05-1.86), whereas men with prevalent myocardial infarction had a decreased OR of 0.73 (0.55-0.97) for Restless Legs Syndrome. The Restless Legs Syndrome prevalence among US male physicians is similar to that of men of the same age group in other western countries. A history of diabetes is the most consistent risk factor associated with Restless Legs Syndrome. Prevalent stroke and myocardial infarction are related to Restless Legs Syndrome prevalence. Copyright © 2013 Elsevier Inc. All rights reserved.

Robert J. Glynn - One of the best experts on this subject based on the ideXlab platform.

  • Vascular risk factors, cardiovascular disease, and Restless Legs Syndrome in men.
    The American journal of medicine, 2013
    Co-Authors: Anke C Winter, Klaus Berger, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Markus Schürks, Tobias Kurth
    Abstract:

    Abstract Background The prevalence of vascular risk factors, cardiovascular disease, and Restless Legs Syndrome increases with age. Prior studies analyzing the associations between vascular risk factors, cardiovascular disease, and Restless Legs Syndrome found controversial results. We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and Restless Legs Syndrome. Methods We conducted a cross-sectional study among 22,786 participants of the US Physicians' Health Studies I and II. Restless Legs Syndrome was classified according to the 4 minimal diagnostic criteria. Vascular risk factors and Restless Legs Syndrome symptoms were self-reported. Prevalent cardiovascular disease events, including major cardiovascular disease, stroke, and myocardial infarction, were confirmed by medical record review. Age- and multivariable-adjusted logistic regression models were used to evaluate the association among vascular risk factors, prevalent cardiovascular disease events, and Restless Legs Syndrome. Results The mean age of the cohort was 67.8 years. The prevalence of Restless Legs Syndrome was 7.5% and increased significantly with age. Diabetes significantly increased the odds of Restless Legs Syndrome (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.21-1.65), whereas frequent exercise (OR, 0.78; 95% CI, 0.67-0.91) and alcohol consumption of 1 or more drinks per day (OR, 0.80; 95% CI, 0.69-0.92) significantly reduced the odds of Restless Legs Syndrome in multivariable-adjusted models. Prevalent stroke showed an increased multivariable-adjusted OR of 1.40 (1.05-1.86), whereas men with prevalent myocardial infarction had a decreased OR of 0.73 (0.55-0.97) for Restless Legs Syndrome. Conclusions The Restless Legs Syndrome prevalence among US male physicians is similar to that of men of the same age group in other western countries. A history of diabetes is the most consistent risk factor associated with Restless Legs Syndrome. Prevalent stroke and myocardial infarction are related to Restless Legs Syndrome prevalence.

  • Vascular risk factors, cardiovascular disease, and Restless Legs Syndrome in men.
    The American journal of medicine, 2013
    Co-Authors: Anke C Winter, Klaus Berger, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Markus Schürks, Tobias Kurth
    Abstract:

    The prevalence of vascular risk factors, cardiovascular disease, and Restless Legs Syndrome increases with age. Prior studies analyzing the associations between vascular risk factors, cardiovascular disease, and Restless Legs Syndrome found controversial results. We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and Restless Legs Syndrome. We conducted a cross-sectional study among 22,786 participants of the US Physicians' Health Studies I and II. Restless Legs Syndrome was classified according to the 4 minimal diagnostic criteria. Vascular risk factors and Restless Legs Syndrome symptoms were self-reported. Prevalent cardiovascular disease events, including major cardiovascular disease, stroke, and myocardial infarction, were confirmed by medical record review. Age- and multivariable-adjusted logistic regression models were used to evaluate the association among vascular risk factors, prevalent cardiovascular disease events, and Restless Legs Syndrome. The mean age of the cohort was 67.8 years. The prevalence of Restless Legs Syndrome was 7.5% and increased significantly with age. Diabetes significantly increased the odds of Restless Legs Syndrome (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.21-1.65), whereas frequent exercise (OR, 0.78; 95% CI, 0.67-0.91) and alcohol consumption of 1 or more drinks per day (OR, 0.80; 95% CI, 0.69-0.92) significantly reduced the odds of Restless Legs Syndrome in multivariable-adjusted models. Prevalent stroke showed an increased multivariable-adjusted OR of 1.40 (1.05-1.86), whereas men with prevalent myocardial infarction had a decreased OR of 0.73 (0.55-0.97) for Restless Legs Syndrome. The Restless Legs Syndrome prevalence among US male physicians is similar to that of men of the same age group in other western countries. A history of diabetes is the most consistent risk factor associated with Restless Legs Syndrome. Prevalent stroke and myocardial infarction are related to Restless Legs Syndrome prevalence. Copyright © 2013 Elsevier Inc. All rights reserved.

Julie E. Buring - One of the best experts on this subject based on the ideXlab platform.

  • Vascular risk factors, cardiovascular disease, and Restless Legs Syndrome in men.
    The American journal of medicine, 2013
    Co-Authors: Anke C Winter, Klaus Berger, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Markus Schürks, Tobias Kurth
    Abstract:

    Abstract Background The prevalence of vascular risk factors, cardiovascular disease, and Restless Legs Syndrome increases with age. Prior studies analyzing the associations between vascular risk factors, cardiovascular disease, and Restless Legs Syndrome found controversial results. We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and Restless Legs Syndrome. Methods We conducted a cross-sectional study among 22,786 participants of the US Physicians' Health Studies I and II. Restless Legs Syndrome was classified according to the 4 minimal diagnostic criteria. Vascular risk factors and Restless Legs Syndrome symptoms were self-reported. Prevalent cardiovascular disease events, including major cardiovascular disease, stroke, and myocardial infarction, were confirmed by medical record review. Age- and multivariable-adjusted logistic regression models were used to evaluate the association among vascular risk factors, prevalent cardiovascular disease events, and Restless Legs Syndrome. Results The mean age of the cohort was 67.8 years. The prevalence of Restless Legs Syndrome was 7.5% and increased significantly with age. Diabetes significantly increased the odds of Restless Legs Syndrome (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.21-1.65), whereas frequent exercise (OR, 0.78; 95% CI, 0.67-0.91) and alcohol consumption of 1 or more drinks per day (OR, 0.80; 95% CI, 0.69-0.92) significantly reduced the odds of Restless Legs Syndrome in multivariable-adjusted models. Prevalent stroke showed an increased multivariable-adjusted OR of 1.40 (1.05-1.86), whereas men with prevalent myocardial infarction had a decreased OR of 0.73 (0.55-0.97) for Restless Legs Syndrome. Conclusions The Restless Legs Syndrome prevalence among US male physicians is similar to that of men of the same age group in other western countries. A history of diabetes is the most consistent risk factor associated with Restless Legs Syndrome. Prevalent stroke and myocardial infarction are related to Restless Legs Syndrome prevalence.

  • Vascular risk factors, cardiovascular disease, and Restless Legs Syndrome in men.
    The American journal of medicine, 2013
    Co-Authors: Anke C Winter, Klaus Berger, Robert J. Glynn, Julie E. Buring, J. Michael Gaziano, Markus Schürks, Tobias Kurth
    Abstract:

    The prevalence of vascular risk factors, cardiovascular disease, and Restless Legs Syndrome increases with age. Prior studies analyzing the associations between vascular risk factors, cardiovascular disease, and Restless Legs Syndrome found controversial results. We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and Restless Legs Syndrome. We conducted a cross-sectional study among 22,786 participants of the US Physicians' Health Studies I and II. Restless Legs Syndrome was classified according to the 4 minimal diagnostic criteria. Vascular risk factors and Restless Legs Syndrome symptoms were self-reported. Prevalent cardiovascular disease events, including major cardiovascular disease, stroke, and myocardial infarction, were confirmed by medical record review. Age- and multivariable-adjusted logistic regression models were used to evaluate the association among vascular risk factors, prevalent cardiovascular disease events, and Restless Legs Syndrome. The mean age of the cohort was 67.8 years. The prevalence of Restless Legs Syndrome was 7.5% and increased significantly with age. Diabetes significantly increased the odds of Restless Legs Syndrome (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.21-1.65), whereas frequent exercise (OR, 0.78; 95% CI, 0.67-0.91) and alcohol consumption of 1 or more drinks per day (OR, 0.80; 95% CI, 0.69-0.92) significantly reduced the odds of Restless Legs Syndrome in multivariable-adjusted models. Prevalent stroke showed an increased multivariable-adjusted OR of 1.40 (1.05-1.86), whereas men with prevalent myocardial infarction had a decreased OR of 0.73 (0.55-0.97) for Restless Legs Syndrome. The Restless Legs Syndrome prevalence among US male physicians is similar to that of men of the same age group in other western countries. A history of diabetes is the most consistent risk factor associated with Restless Legs Syndrome. Prevalent stroke and myocardial infarction are related to Restless Legs Syndrome prevalence. Copyright © 2013 Elsevier Inc. All rights reserved.