The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform

Vitaliy V. Khutoryanskiy - One of the best experts on this subject based on the ideXlab platform.

  • in situ gelling systems based on pluronic f127 pluronic f68 formulations for ocular drug delivery
    International Journal of Pharmaceutics, 2016
    Co-Authors: Kosai Al Khateb, Elvira K. Ozhmukhametova, Marat N. Mussin, Serzhan K. Seilkhanov, Tolebai K. Rakhypbekov, Vitaliy V. Khutoryanskiy
    Abstract:

    This Study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in aqueous solutions of Pluronic F127, Pluronic F68 as well as their binary mixtures using differential scanning calorimetry, rheological measurements, and dynamic light scattering. It was established that the formation of transparent gels at physiologically relevant temperatures is observed only in the case of 20 wt% of Pluronic F127. The addition of Pluronic F68 to Pluronic F127 solutions increases the gelation temperature of binary formulation to above physiological range of temperatures. The biocompatibility evaluation of these formulations using slug mucosa irritation assay and bovine corneal erosion studies revealed that these polymers and their combinations do not cause significant irritation. In vitro drug Retention Study on glass surfaces and freshly excised bovine cornea showed superior performance of 20 wt% Pluronic F127 compared to other formulations. In addition, in vivo studies in rabbits demonstrated better Retention performance of 20 wt% Pluronic F127 compared to Pluronic F68. These results confirmed that 20 wt% Pluronic F127 offers an attractive ocular formulation that can form a transparent gel in situ under physiological conditions with minimal irritation.

  • In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery
    International Journal of Pharmaceutics, 2016
    Co-Authors: Kosai Al Khateb, Elvira K. Ozhmukhametova, Marat N. Mussin, Serzhan K. Seilkhanov, Tolebai K. Rakhypbekov, Wing Man Lau, Vitaliy V. Khutoryanskiy
    Abstract:

    This Study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in aqueous solutions of Pluronic F127, Pluronic F68 as well as their binary mixtures using differential scanning calorimetry, rheological measurements, and dynamic light scattering. It was established that the formation of transparent gels at physiologically relevant temperatures is observed only in the case of 20 wt% of Pluronic F127. The addition of Pluronic F68 to Pluronic F127 solutions increases the gelation temperature of binary formulation to above physiological range of temperatures. The biocompatibility evaluation of these formulations using slug mucosa irritation assay and bovine corneal erosion studies revealed that these polymers and their combinations do not cause significant irritation. In vitro drug Retention Study on glass surfaces and freshly excised bovine cornea showed superior performance of 20 wt% Pluronic F127 compared to other formulations. In addition, in vivo studies in rabbits demonstrated better Retention performance of 20 wt% Pluronic F127 compared to Pluronic F68. These results confirmed that 20 wt% Pluronic F127 offers an attractive ocular formulation that can form a transparent gel in situ under physiological conditions with minimal irritation.

Tuba Yilmaz - One of the best experts on this subject based on the ideXlab platform.

  • student perceptions of computer science a Retention Study comparing graduating seniors with cs leavers
    Technical Symposium on Computer Science Education, 2008
    Co-Authors: Maureen Biggers, Anne L Brauer, Tuba Yilmaz
    Abstract:

    Students who develop a strong interest in another field can hardly be fair target for Retention efforts. There are others, however, who might do very well in this field but who leave computer science because of misunderstandings about and a negative experience in this academic major. Retention literature suggests and provides numerous examples of initiatives that improve student Retention. To determine how best to impact student Retention in your computer science department, a comprehensive understanding of the student experience of your major is essential. Not only is it important to know why students leave your major, but an understanding of why they stay can be useful in developing high impact initiatives. The current Study involves a comparative examination of students who graduated from the computer science (CS) major at Georgia Institute of Technology in Atlanta, Georgia (Stayers) with students who chose to leave the major (Leavers). Specifically, perceptions and experiences of computer science as a field in general and the climate of the major were studied. Comparative data collected provided insights into reasons why they entered into the major, about belief of adequate preparation and confidence going into the major, definitions of CS and other related factors. Results were analyzed to identify potential target areas and concrete implementation strategies are suggested for improved Retention in the computer science major at this institution.

  • SIGCSE - Student perceptions of computer science: a Retention Study comparing graduating seniors with cs leavers
    Proceedings of the 39th SIGCSE technical symposium on Computer science education - SIGCSE '08, 2008
    Co-Authors: Maureen Biggers, Anne L Brauer, Tuba Yilmaz
    Abstract:

    Students who develop a strong interest in another field can hardly be fair target for Retention efforts. There are others, however, who might do very well in this field but who leave computer science because of misunderstandings about and a negative experience in this academic major. Retention literature suggests and provides numerous examples of initiatives that improve student Retention. To determine how best to impact student Retention in your computer science department, a comprehensive understanding of the student experience of your major is essential. Not only is it important to know why students leave your major, but an understanding of why they stay can be useful in developing high impact initiatives. The current Study involves a comparative examination of students who graduated from the computer science (CS) major at Georgia Institute of Technology in Atlanta, Georgia (Stayers) with students who chose to leave the major (Leavers). Specifically, perceptions and experiences of computer science as a field in general and the climate of the major were studied. Comparative data collected provided insights into reasons why they entered into the major, about belief of adequate preparation and confidence going into the major, definitions of CS and other related factors. Results were analyzed to identify potential target areas and concrete implementation strategies are suggested for improved Retention in the computer science major at this institution.

Kosai Al Khateb - One of the best experts on this subject based on the ideXlab platform.

  • in situ gelling systems based on pluronic f127 pluronic f68 formulations for ocular drug delivery
    International Journal of Pharmaceutics, 2016
    Co-Authors: Kosai Al Khateb, Elvira K. Ozhmukhametova, Marat N. Mussin, Serzhan K. Seilkhanov, Tolebai K. Rakhypbekov, Vitaliy V. Khutoryanskiy
    Abstract:

    This Study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in aqueous solutions of Pluronic F127, Pluronic F68 as well as their binary mixtures using differential scanning calorimetry, rheological measurements, and dynamic light scattering. It was established that the formation of transparent gels at physiologically relevant temperatures is observed only in the case of 20 wt% of Pluronic F127. The addition of Pluronic F68 to Pluronic F127 solutions increases the gelation temperature of binary formulation to above physiological range of temperatures. The biocompatibility evaluation of these formulations using slug mucosa irritation assay and bovine corneal erosion studies revealed that these polymers and their combinations do not cause significant irritation. In vitro drug Retention Study on glass surfaces and freshly excised bovine cornea showed superior performance of 20 wt% Pluronic F127 compared to other formulations. In addition, in vivo studies in rabbits demonstrated better Retention performance of 20 wt% Pluronic F127 compared to Pluronic F68. These results confirmed that 20 wt% Pluronic F127 offers an attractive ocular formulation that can form a transparent gel in situ under physiological conditions with minimal irritation.

  • In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery
    International Journal of Pharmaceutics, 2016
    Co-Authors: Kosai Al Khateb, Elvira K. Ozhmukhametova, Marat N. Mussin, Serzhan K. Seilkhanov, Tolebai K. Rakhypbekov, Wing Man Lau, Vitaliy V. Khutoryanskiy
    Abstract:

    This Study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in aqueous solutions of Pluronic F127, Pluronic F68 as well as their binary mixtures using differential scanning calorimetry, rheological measurements, and dynamic light scattering. It was established that the formation of transparent gels at physiologically relevant temperatures is observed only in the case of 20 wt% of Pluronic F127. The addition of Pluronic F68 to Pluronic F127 solutions increases the gelation temperature of binary formulation to above physiological range of temperatures. The biocompatibility evaluation of these formulations using slug mucosa irritation assay and bovine corneal erosion studies revealed that these polymers and their combinations do not cause significant irritation. In vitro drug Retention Study on glass surfaces and freshly excised bovine cornea showed superior performance of 20 wt% Pluronic F127 compared to other formulations. In addition, in vivo studies in rabbits demonstrated better Retention performance of 20 wt% Pluronic F127 compared to Pluronic F68. These results confirmed that 20 wt% Pluronic F127 offers an attractive ocular formulation that can form a transparent gel in situ under physiological conditions with minimal irritation.

Maureen Biggers - One of the best experts on this subject based on the ideXlab platform.

  • student perceptions of computer science a Retention Study comparing graduating seniors with cs leavers
    Technical Symposium on Computer Science Education, 2008
    Co-Authors: Maureen Biggers, Anne L Brauer, Tuba Yilmaz
    Abstract:

    Students who develop a strong interest in another field can hardly be fair target for Retention efforts. There are others, however, who might do very well in this field but who leave computer science because of misunderstandings about and a negative experience in this academic major. Retention literature suggests and provides numerous examples of initiatives that improve student Retention. To determine how best to impact student Retention in your computer science department, a comprehensive understanding of the student experience of your major is essential. Not only is it important to know why students leave your major, but an understanding of why they stay can be useful in developing high impact initiatives. The current Study involves a comparative examination of students who graduated from the computer science (CS) major at Georgia Institute of Technology in Atlanta, Georgia (Stayers) with students who chose to leave the major (Leavers). Specifically, perceptions and experiences of computer science as a field in general and the climate of the major were studied. Comparative data collected provided insights into reasons why they entered into the major, about belief of adequate preparation and confidence going into the major, definitions of CS and other related factors. Results were analyzed to identify potential target areas and concrete implementation strategies are suggested for improved Retention in the computer science major at this institution.

  • SIGCSE - Student perceptions of computer science: a Retention Study comparing graduating seniors with cs leavers
    Proceedings of the 39th SIGCSE technical symposium on Computer science education - SIGCSE '08, 2008
    Co-Authors: Maureen Biggers, Anne L Brauer, Tuba Yilmaz
    Abstract:

    Students who develop a strong interest in another field can hardly be fair target for Retention efforts. There are others, however, who might do very well in this field but who leave computer science because of misunderstandings about and a negative experience in this academic major. Retention literature suggests and provides numerous examples of initiatives that improve student Retention. To determine how best to impact student Retention in your computer science department, a comprehensive understanding of the student experience of your major is essential. Not only is it important to know why students leave your major, but an understanding of why they stay can be useful in developing high impact initiatives. The current Study involves a comparative examination of students who graduated from the computer science (CS) major at Georgia Institute of Technology in Atlanta, Georgia (Stayers) with students who chose to leave the major (Leavers). Specifically, perceptions and experiences of computer science as a field in general and the climate of the major were studied. Comparative data collected provided insights into reasons why they entered into the major, about belief of adequate preparation and confidence going into the major, definitions of CS and other related factors. Results were analyzed to identify potential target areas and concrete implementation strategies are suggested for improved Retention in the computer science major at this institution.

Serzhan K. Seilkhanov - One of the best experts on this subject based on the ideXlab platform.

  • in situ gelling systems based on pluronic f127 pluronic f68 formulations for ocular drug delivery
    International Journal of Pharmaceutics, 2016
    Co-Authors: Kosai Al Khateb, Elvira K. Ozhmukhametova, Marat N. Mussin, Serzhan K. Seilkhanov, Tolebai K. Rakhypbekov, Vitaliy V. Khutoryanskiy
    Abstract:

    This Study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in aqueous solutions of Pluronic F127, Pluronic F68 as well as their binary mixtures using differential scanning calorimetry, rheological measurements, and dynamic light scattering. It was established that the formation of transparent gels at physiologically relevant temperatures is observed only in the case of 20 wt% of Pluronic F127. The addition of Pluronic F68 to Pluronic F127 solutions increases the gelation temperature of binary formulation to above physiological range of temperatures. The biocompatibility evaluation of these formulations using slug mucosa irritation assay and bovine corneal erosion studies revealed that these polymers and their combinations do not cause significant irritation. In vitro drug Retention Study on glass surfaces and freshly excised bovine cornea showed superior performance of 20 wt% Pluronic F127 compared to other formulations. In addition, in vivo studies in rabbits demonstrated better Retention performance of 20 wt% Pluronic F127 compared to Pluronic F68. These results confirmed that 20 wt% Pluronic F127 offers an attractive ocular formulation that can form a transparent gel in situ under physiological conditions with minimal irritation.

  • In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery
    International Journal of Pharmaceutics, 2016
    Co-Authors: Kosai Al Khateb, Elvira K. Ozhmukhametova, Marat N. Mussin, Serzhan K. Seilkhanov, Tolebai K. Rakhypbekov, Wing Man Lau, Vitaliy V. Khutoryanskiy
    Abstract:

    This Study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in aqueous solutions of Pluronic F127, Pluronic F68 as well as their binary mixtures using differential scanning calorimetry, rheological measurements, and dynamic light scattering. It was established that the formation of transparent gels at physiologically relevant temperatures is observed only in the case of 20 wt% of Pluronic F127. The addition of Pluronic F68 to Pluronic F127 solutions increases the gelation temperature of binary formulation to above physiological range of temperatures. The biocompatibility evaluation of these formulations using slug mucosa irritation assay and bovine corneal erosion studies revealed that these polymers and their combinations do not cause significant irritation. In vitro drug Retention Study on glass surfaces and freshly excised bovine cornea showed superior performance of 20 wt% Pluronic F127 compared to other formulations. In addition, in vivo studies in rabbits demonstrated better Retention performance of 20 wt% Pluronic F127 compared to Pluronic F68. These results confirmed that 20 wt% Pluronic F127 offers an attractive ocular formulation that can form a transparent gel in situ under physiological conditions with minimal irritation.