The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform

Erin B. Lavik - One of the best experts on this subject based on the ideXlab platform.

  • A tissue-engineered approach towards Retinal repair: Scaffolds for cell transplantation to the subRetinal space
    Graefe's Archive for Clinical and Experimental Ophthalmology, 2010
    Co-Authors: Sara Royce Hynes, Erin B. Lavik
    Abstract:

    Background Several mechanisms of Retina Degeneration result in the deterioration of the outer Retina and can lead to blindness. Currently, with the exception of anti-angiogenic treatments for wet age-related macular Degeneration, there are no treatments that can restore lost vision. There is evidence that photoreceptors and embryonic Retinal tissue, transplanted to the subRetinal space, can form new synapses with surviving host neurons. However, these transplants have yet to result in a clinical treatment for Retinal Degeneration. Methods This article reviews the current literature on the transplantation of scaffolds with Retinal and Retinal pigmented epithelial (RPE) cells to the subRetinal space. We discuss the types of cells and materials that have been investigated for transplantation to the subRetinal space, summarize the current findings, and present opportunities for future research and the next generation of scaffolds for Retinal repair. Results Challenges to cell transplantation include limited survival upon implantation and the formation of abnormal cell architectures in vivo . Scaffolds have been shown to enhance cell survival and direct cell differentiation and organization in a number of models of Retinal Degeneration. Conclusions The transplantation of cells within a scaffold represents a possible treatment to repair Retinal Degeneration and restore vision in effected patients. Materials have been developed for the delivery of Retinal and RPE cells separately however, the development of a combined tissue-engineered scaffold targeting both cell populations represents a promising direction for Retinal repair.

  • A tissue-engineered approach towards Retinal repair: Scaffolds for cell transplantation to the subRetinal space
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2010
    Co-Authors: Sara Royce Hynes, Erin B. Lavik
    Abstract:

    Several mechanisms of Retina Degeneration result in the deterioration of the outer Retina and can lead to blindness. Currently, with the exception of anti-angiogenic treatments for wet age-related macular Degeneration, there are no treatments that can restore lost vision. There is evidence that photoreceptors and embryonic Retinal tissue, transplanted to the subRetinal space, can form new synapses with surviving host neurons. However, these transplants have yet to result in a clinical treatment for Retinal Degeneration. This article reviews the current literature on the transplantation of scaffolds with Retinal and Retinal pigmented epithelial (RPE) cells to the subRetinal space. We discuss the types of cells and materials that have been investigated for transplantation to the subRetinal space, summarize the current findings, and present opportunities for future research and the next generation of scaffolds for Retinal repair. Challenges to cell transplantation include limited survival upon implantation and the formation of abnormal cell architectures in vivo. Scaffolds have been shown to enhance cell survival and direct cell differentiation and organization in a number of models of Retinal Degeneration. The transplantation of cells within a scaffold represents a possible treatment to repair Retinal Degeneration and restore vision in effected patients. Materials have been developed for the delivery of Retinal and RPE cells separately however, the development of a combined tissue-engineered scaffold targeting both cell populations represents a promising direction for Retinal repair.

Raymond D. Lund - One of the best experts on this subject based on the ideXlab platform.

  • Morphological changes in the Royal College of Surgeons rat Retina during photoreceptor Degeneration and after cell-based therapy
    The Journal of comparative neurology, 2005
    Co-Authors: Shaomei Wang, Raymond D. Lund
    Abstract:

    There are concomitant morphological and functional changes in the inner Retina during the course of photoreceptor Degeneration in a range of animal models of Retina Degeneration and in humans with eye disease. One concern that has been raised is that the changes occurring in the inner Retina might compromise attempts to rescue or restore visual input by various interventional approaches. It is known that cell-based therapy can preserve significant visual capability for many months. In this study, we examine the overall changes in the Royal College of Surgeons (RCS) rat during Degeneration and the effects of cell transplantation by means of immunohistochemistry and confocal microscopy. The degenerative changes are complex, and they progress with age. They involve the neurons with which both rods and cones interconnect--Retinal second- and third-order neurons underwent dramatic modification, including sprouting, retraction as photoreceptor loss progressed--as well as Müller glia and secondary vascular changes, which were associated at later times with neuronal migration. The pathological vascular changes led to major disruption of inner Retina. After introducing a Retinal pigment epithelial cell line to the subRetinal space early in the progress of photoreceptor Degeneration, most inner Retinal changes were held in abeyance for up to at least 10 months of age. Given the concern that has been raised regarding whether inner Retinal changes might compromise any graft-related benefit, this is an encouraging finding.

  • morphological changes in the royal college of surgeons rat Retina during photoreceptor Degeneration and after cell based therapy
    The Journal of Comparative Neurology, 2005
    Co-Authors: Shaomei Wang, Raymond D. Lund
    Abstract:

    There are concomitant morphological and functional changes in the inner Retina during the course of photoreceptor Degeneration in a range of animal models of Retina Degeneration and in humans with eye disease. One concern that has been raised is that the changes occurring in the inner Retina might compromise attempts to rescue or restore visual input by various interventional approaches. It is known that cell-based therapy can preserve significant visual capability for many months. In this study, we examine the overall changes in the Royal College of Surgeons (RCS) rat during Degeneration and the effects of cell transplantation by means of immunohistochemistry and confocal microscopy. The degenerative changes are complex, and they progress with age. They involve the neurons with which both rods and cones interconnect—Retinal second- and third-order neurons underwent dramatic modification, including sprouting, retraction as photoreceptor loss progressed—as well as Muller glia and secondary vascular changes, which were associated at later times with neuronal migration. The pathological vascular changes led to major disruption of inner Retina. After introducing a Retinal pigment epithelial cell line to the subRetinal space early in the progress of photoreceptor Degeneration, most inner Retinal changes were held in abeyance for up to at least 10 months of age. Given the concern that has been raised regarding whether inner Retinal changes might compromise any graft-related benefit, this is an encouraging finding. J. Comp. Neurol. 491:400–417, 2005. © 2005 Wiley-Liss, Inc.

Sara Royce Hynes - One of the best experts on this subject based on the ideXlab platform.

  • A tissue-engineered approach towards Retinal repair: Scaffolds for cell transplantation to the subRetinal space
    Graefe's Archive for Clinical and Experimental Ophthalmology, 2010
    Co-Authors: Sara Royce Hynes, Erin B. Lavik
    Abstract:

    Background Several mechanisms of Retina Degeneration result in the deterioration of the outer Retina and can lead to blindness. Currently, with the exception of anti-angiogenic treatments for wet age-related macular Degeneration, there are no treatments that can restore lost vision. There is evidence that photoreceptors and embryonic Retinal tissue, transplanted to the subRetinal space, can form new synapses with surviving host neurons. However, these transplants have yet to result in a clinical treatment for Retinal Degeneration. Methods This article reviews the current literature on the transplantation of scaffolds with Retinal and Retinal pigmented epithelial (RPE) cells to the subRetinal space. We discuss the types of cells and materials that have been investigated for transplantation to the subRetinal space, summarize the current findings, and present opportunities for future research and the next generation of scaffolds for Retinal repair. Results Challenges to cell transplantation include limited survival upon implantation and the formation of abnormal cell architectures in vivo . Scaffolds have been shown to enhance cell survival and direct cell differentiation and organization in a number of models of Retinal Degeneration. Conclusions The transplantation of cells within a scaffold represents a possible treatment to repair Retinal Degeneration and restore vision in effected patients. Materials have been developed for the delivery of Retinal and RPE cells separately however, the development of a combined tissue-engineered scaffold targeting both cell populations represents a promising direction for Retinal repair.

  • A tissue-engineered approach towards Retinal repair: Scaffolds for cell transplantation to the subRetinal space
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2010
    Co-Authors: Sara Royce Hynes, Erin B. Lavik
    Abstract:

    Several mechanisms of Retina Degeneration result in the deterioration of the outer Retina and can lead to blindness. Currently, with the exception of anti-angiogenic treatments for wet age-related macular Degeneration, there are no treatments that can restore lost vision. There is evidence that photoreceptors and embryonic Retinal tissue, transplanted to the subRetinal space, can form new synapses with surviving host neurons. However, these transplants have yet to result in a clinical treatment for Retinal Degeneration. This article reviews the current literature on the transplantation of scaffolds with Retinal and Retinal pigmented epithelial (RPE) cells to the subRetinal space. We discuss the types of cells and materials that have been investigated for transplantation to the subRetinal space, summarize the current findings, and present opportunities for future research and the next generation of scaffolds for Retinal repair. Challenges to cell transplantation include limited survival upon implantation and the formation of abnormal cell architectures in vivo. Scaffolds have been shown to enhance cell survival and direct cell differentiation and organization in a number of models of Retinal Degeneration. The transplantation of cells within a scaffold represents a possible treatment to repair Retinal Degeneration and restore vision in effected patients. Materials have been developed for the delivery of Retinal and RPE cells separately however, the development of a combined tissue-engineered scaffold targeting both cell populations represents a promising direction for Retinal repair.

Ahmed Chebil - One of the best experts on this subject based on the ideXlab platform.

  • Posterior staphylomas in non-highly myopic eyes with retinitis pigmentosa
    International Ophthalmology, 2020
    Co-Authors: Leila Matri, Yousra Falfoul, Khaled Matri, Issam Euch, Hela Ghali, Imen Habibi, Asma Hassairi, Nibrass Chaker, Daniel Schorderet, Ahmed Chebil
    Abstract:

    Purpose Our aim was to highlight the presence and the frequency of posterior staphyloma (PS) in non-highly myopic retinitis pigmentosa (RP) patients and to study the relationship between PS and choroidal thickness (CT). Methods This was a retrospective case–control study of 77 eyes (39 patients) with RP, axial length inferior to 26 mm and clinically preserved macular area. All patients underwent fundus photography, A- and B-scan ocular ultrasonography, fundus autofluorescence (FAF) and swept source optical coherence tomography (SS-OCT). PS was defined by an outward bowing of the sclera on SS-OCT and B-scans. The relationship between the PS and SS-OCT layers thicknesses was determined. Results Over 77 RP eyes of 39 patients studied, a PS was identified in 17 eyes (22%) of nine patients. Fifteen eyes had a narrow macular staphyloma (NMS), and two eyes had a wide macular staphyloma (WMS). Mean age in this group was 34.2 years (range 19–53 years), mean axial length was 23.60 ± 0.61 mm and mean CT was 185.7 ± 71 um versus 259.7 um in eyes without PS. The staphyloma edges corresponded to area of outer Retina loss on SS-OCT and were larger than the hyperautofluorescent ring on FAF. We found a significant association between PS and CT in our RP patients ( p  = 0.003). The mean CT was significantly thinner in PS eyes compared to eyes without staphyloma. There was no significant association between PS and with visual acuity, years of progression, Retinal thickness nor FAF findings. Conclusions PS was present in 22% of non-highly myopic eyes with RP. Narrow macular staphyloma was the most common type observed in our series. A marked thinning of the choroid was noted in PS eyes when compared to RP eyes without PS, as well as the outer Retina Degeneration.

  • Posterior staphylomas in non-highly myopic eyes with retinitis pigmentosa.
    International ophthalmology, 2020
    Co-Authors: Leila Matri, Yousra Falfoul, Khaled Matri, Issam Euch, Hela Ghali, Imen Habibi, Asma Hassairi, Nibrass Chaker, Daniel Schorderet, Ahmed Chebil
    Abstract:

    Our aim was to highlight the presence and the frequency of posterior staphyloma (PS) in non-highly myopic retinitis pigmentosa (RP) patients and to study the relationship between PS and choroidal thickness (CT). This was a retrospective case-control study of 77 eyes (39 patients) with RP, axial length inferior to 26 mm and clinically preserved macular area. All patients underwent fundus photography, A- and B-scan ocular ultrasonography, fundus autofluorescence (FAF) and swept source optical coherence tomography (SS-OCT). PS was defined by an outward bowing of the sclera on SS-OCT and B-scans. The relationship between the PS and SS-OCT layers thicknesses was determined. Over 77 RP eyes of 39 patients studied, a PS was identified in 17 eyes (22%) of nine patients. Fifteen eyes had a narrow macular staphyloma (NMS), and two eyes had a wide macular staphyloma (WMS). Mean age in this group was 34.2 years (range 19-53 years), mean axial length was 23.60 ± 0.61 mm and mean CT was 185.7 ± 71 um versus 259.7 um in eyes without PS. The staphyloma edges corresponded to area of outer Retina loss on SS-OCT and were larger than the hyperautofluorescent ring on FAF. We found a significant association between PS and CT in our RP patients (p = 0.003). The mean CT was significantly thinner in PS eyes compared to eyes without staphyloma. There was no significant association between PS and with visual acuity, years of progression, Retinal thickness nor FAF findings. PS was present in 22% of non-highly myopic eyes with RP. Narrow macular staphyloma was the most common type observed in our series. A marked thinning of the choroid was noted in PS eyes when compared to RP eyes without PS, as well as the outer Retina Degeneration.

Shaomei Wang - One of the best experts on this subject based on the ideXlab platform.

  • Morphological changes in the Royal College of Surgeons rat Retina during photoreceptor Degeneration and after cell-based therapy
    The Journal of comparative neurology, 2005
    Co-Authors: Shaomei Wang, Raymond D. Lund
    Abstract:

    There are concomitant morphological and functional changes in the inner Retina during the course of photoreceptor Degeneration in a range of animal models of Retina Degeneration and in humans with eye disease. One concern that has been raised is that the changes occurring in the inner Retina might compromise attempts to rescue or restore visual input by various interventional approaches. It is known that cell-based therapy can preserve significant visual capability for many months. In this study, we examine the overall changes in the Royal College of Surgeons (RCS) rat during Degeneration and the effects of cell transplantation by means of immunohistochemistry and confocal microscopy. The degenerative changes are complex, and they progress with age. They involve the neurons with which both rods and cones interconnect--Retinal second- and third-order neurons underwent dramatic modification, including sprouting, retraction as photoreceptor loss progressed--as well as Müller glia and secondary vascular changes, which were associated at later times with neuronal migration. The pathological vascular changes led to major disruption of inner Retina. After introducing a Retinal pigment epithelial cell line to the subRetinal space early in the progress of photoreceptor Degeneration, most inner Retinal changes were held in abeyance for up to at least 10 months of age. Given the concern that has been raised regarding whether inner Retinal changes might compromise any graft-related benefit, this is an encouraging finding.

  • morphological changes in the royal college of surgeons rat Retina during photoreceptor Degeneration and after cell based therapy
    The Journal of Comparative Neurology, 2005
    Co-Authors: Shaomei Wang, Raymond D. Lund
    Abstract:

    There are concomitant morphological and functional changes in the inner Retina during the course of photoreceptor Degeneration in a range of animal models of Retina Degeneration and in humans with eye disease. One concern that has been raised is that the changes occurring in the inner Retina might compromise attempts to rescue or restore visual input by various interventional approaches. It is known that cell-based therapy can preserve significant visual capability for many months. In this study, we examine the overall changes in the Royal College of Surgeons (RCS) rat during Degeneration and the effects of cell transplantation by means of immunohistochemistry and confocal microscopy. The degenerative changes are complex, and they progress with age. They involve the neurons with which both rods and cones interconnect—Retinal second- and third-order neurons underwent dramatic modification, including sprouting, retraction as photoreceptor loss progressed—as well as Muller glia and secondary vascular changes, which were associated at later times with neuronal migration. The pathological vascular changes led to major disruption of inner Retina. After introducing a Retinal pigment epithelial cell line to the subRetinal space early in the progress of photoreceptor Degeneration, most inner Retinal changes were held in abeyance for up to at least 10 months of age. Given the concern that has been raised regarding whether inner Retinal changes might compromise any graft-related benefit, this is an encouraging finding. J. Comp. Neurol. 491:400–417, 2005. © 2005 Wiley-Liss, Inc.