The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Bokyung Koh - One of the best experts on this subject based on the ideXlab platform.
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a newly synthesized photostable Retinol Derivative retinyl n formyl aspartamate for photodamaged skin profilometric evaluation of 24 week study
Journal of The American Academy of Dermatology, 2006Co-Authors: Minsuk Lee, Kyung Ho Lee, Hongsig Sin, Jinwou Kim, Bokyung KohAbstract:Background Retinol (vitamin A) is used in the cosmetics industry as an antiwrinkle agent. However, its photoinstability and skin irritation potential make it challenging to use in general cosmetic formulations. Objective The aim of this study was to assess the efficacy of a newly synthesized photostable Retinol Derivative (retinyl N-formyl aspartamate) in patients with photodamaged skin. Retinyl N-formyl aspartamate is a newly synthesized Retinol Derivative with higher photostability, and a similar effect on collagenase expression level as Retinol. Methods In all, 29 Korean women (age range: 31-54 years), who were not pregnant, nursing, or undergoing any concurrent therapy, were enrolled in this study. A total of 24 patients completed a 24-week trial of retinyl N-formyl aspartamate twice daily on the left half of the face and a placebo on the right half of the face. A clinical evaluation, photographs, and silicone replicas of both crow's-feet areas were taken at baseline and at weeks 12, 20, and 24. Skin replicas were then analyzed using an optical profilometry technique. The standard wrinkle and roughness features were then calculated and statistically analyzed. The tolerance profile of the product was also clinically evaluated during the study. Results The 24 women who completed this study showed more improvement on the left side of the crow's-feet area in terms of the signs of photodamage than on the right side according to both their own ( P P P Limitations Pigmentation changes were not assessed, investigators were not blinded, and the study size was relatively small. Conclusion In this small study retinyl N-formyl aspartamate applied on a photodamaged face twice daily was significantly more effective than a placebo without severe side effects.
Minsuk Lee - One of the best experts on this subject based on the ideXlab platform.
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a newly synthesized photostable Retinol Derivative retinyl n formyl aspartamate for photodamaged skin profilometric evaluation of 24 week study
Journal of The American Academy of Dermatology, 2006Co-Authors: Minsuk Lee, Kyung Ho Lee, Hongsig Sin, Jinwou Kim, Bokyung KohAbstract:Background Retinol (vitamin A) is used in the cosmetics industry as an antiwrinkle agent. However, its photoinstability and skin irritation potential make it challenging to use in general cosmetic formulations. Objective The aim of this study was to assess the efficacy of a newly synthesized photostable Retinol Derivative (retinyl N-formyl aspartamate) in patients with photodamaged skin. Retinyl N-formyl aspartamate is a newly synthesized Retinol Derivative with higher photostability, and a similar effect on collagenase expression level as Retinol. Methods In all, 29 Korean women (age range: 31-54 years), who were not pregnant, nursing, or undergoing any concurrent therapy, were enrolled in this study. A total of 24 patients completed a 24-week trial of retinyl N-formyl aspartamate twice daily on the left half of the face and a placebo on the right half of the face. A clinical evaluation, photographs, and silicone replicas of both crow's-feet areas were taken at baseline and at weeks 12, 20, and 24. Skin replicas were then analyzed using an optical profilometry technique. The standard wrinkle and roughness features were then calculated and statistically analyzed. The tolerance profile of the product was also clinically evaluated during the study. Results The 24 women who completed this study showed more improvement on the left side of the crow's-feet area in terms of the signs of photodamage than on the right side according to both their own ( P P P Limitations Pigmentation changes were not assessed, investigators were not blinded, and the study size was relatively small. Conclusion In this small study retinyl N-formyl aspartamate applied on a photodamaged face twice daily was significantly more effective than a placebo without severe side effects.
Kyung Ho Lee - One of the best experts on this subject based on the ideXlab platform.
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a newly synthesized photostable Retinol Derivative retinyl n formyl aspartamate for photodamaged skin profilometric evaluation of 24 week study
Journal of The American Academy of Dermatology, 2006Co-Authors: Minsuk Lee, Kyung Ho Lee, Hongsig Sin, Jinwou Kim, Bokyung KohAbstract:Background Retinol (vitamin A) is used in the cosmetics industry as an antiwrinkle agent. However, its photoinstability and skin irritation potential make it challenging to use in general cosmetic formulations. Objective The aim of this study was to assess the efficacy of a newly synthesized photostable Retinol Derivative (retinyl N-formyl aspartamate) in patients with photodamaged skin. Retinyl N-formyl aspartamate is a newly synthesized Retinol Derivative with higher photostability, and a similar effect on collagenase expression level as Retinol. Methods In all, 29 Korean women (age range: 31-54 years), who were not pregnant, nursing, or undergoing any concurrent therapy, were enrolled in this study. A total of 24 patients completed a 24-week trial of retinyl N-formyl aspartamate twice daily on the left half of the face and a placebo on the right half of the face. A clinical evaluation, photographs, and silicone replicas of both crow's-feet areas were taken at baseline and at weeks 12, 20, and 24. Skin replicas were then analyzed using an optical profilometry technique. The standard wrinkle and roughness features were then calculated and statistically analyzed. The tolerance profile of the product was also clinically evaluated during the study. Results The 24 women who completed this study showed more improvement on the left side of the crow's-feet area in terms of the signs of photodamage than on the right side according to both their own ( P P P Limitations Pigmentation changes were not assessed, investigators were not blinded, and the study size was relatively small. Conclusion In this small study retinyl N-formyl aspartamate applied on a photodamaged face twice daily was significantly more effective than a placebo without severe side effects.
Hongsig Sin - One of the best experts on this subject based on the ideXlab platform.
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a newly synthesized photostable Retinol Derivative retinyl n formyl aspartamate for photodamaged skin profilometric evaluation of 24 week study
Journal of The American Academy of Dermatology, 2006Co-Authors: Minsuk Lee, Kyung Ho Lee, Hongsig Sin, Jinwou Kim, Bokyung KohAbstract:Background Retinol (vitamin A) is used in the cosmetics industry as an antiwrinkle agent. However, its photoinstability and skin irritation potential make it challenging to use in general cosmetic formulations. Objective The aim of this study was to assess the efficacy of a newly synthesized photostable Retinol Derivative (retinyl N-formyl aspartamate) in patients with photodamaged skin. Retinyl N-formyl aspartamate is a newly synthesized Retinol Derivative with higher photostability, and a similar effect on collagenase expression level as Retinol. Methods In all, 29 Korean women (age range: 31-54 years), who were not pregnant, nursing, or undergoing any concurrent therapy, were enrolled in this study. A total of 24 patients completed a 24-week trial of retinyl N-formyl aspartamate twice daily on the left half of the face and a placebo on the right half of the face. A clinical evaluation, photographs, and silicone replicas of both crow's-feet areas were taken at baseline and at weeks 12, 20, and 24. Skin replicas were then analyzed using an optical profilometry technique. The standard wrinkle and roughness features were then calculated and statistically analyzed. The tolerance profile of the product was also clinically evaluated during the study. Results The 24 women who completed this study showed more improvement on the left side of the crow's-feet area in terms of the signs of photodamage than on the right side according to both their own ( P P P Limitations Pigmentation changes were not assessed, investigators were not blinded, and the study size was relatively small. Conclusion In this small study retinyl N-formyl aspartamate applied on a photodamaged face twice daily was significantly more effective than a placebo without severe side effects.
Jinwou Kim - One of the best experts on this subject based on the ideXlab platform.
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a newly synthesized photostable Retinol Derivative retinyl n formyl aspartamate for photodamaged skin profilometric evaluation of 24 week study
Journal of The American Academy of Dermatology, 2006Co-Authors: Minsuk Lee, Kyung Ho Lee, Hongsig Sin, Jinwou Kim, Bokyung KohAbstract:Background Retinol (vitamin A) is used in the cosmetics industry as an antiwrinkle agent. However, its photoinstability and skin irritation potential make it challenging to use in general cosmetic formulations. Objective The aim of this study was to assess the efficacy of a newly synthesized photostable Retinol Derivative (retinyl N-formyl aspartamate) in patients with photodamaged skin. Retinyl N-formyl aspartamate is a newly synthesized Retinol Derivative with higher photostability, and a similar effect on collagenase expression level as Retinol. Methods In all, 29 Korean women (age range: 31-54 years), who were not pregnant, nursing, or undergoing any concurrent therapy, were enrolled in this study. A total of 24 patients completed a 24-week trial of retinyl N-formyl aspartamate twice daily on the left half of the face and a placebo on the right half of the face. A clinical evaluation, photographs, and silicone replicas of both crow's-feet areas were taken at baseline and at weeks 12, 20, and 24. Skin replicas were then analyzed using an optical profilometry technique. The standard wrinkle and roughness features were then calculated and statistically analyzed. The tolerance profile of the product was also clinically evaluated during the study. Results The 24 women who completed this study showed more improvement on the left side of the crow's-feet area in terms of the signs of photodamage than on the right side according to both their own ( P P P Limitations Pigmentation changes were not assessed, investigators were not blinded, and the study size was relatively small. Conclusion In this small study retinyl N-formyl aspartamate applied on a photodamaged face twice daily was significantly more effective than a placebo without severe side effects.