The Experts below are selected from a list of 279 Experts worldwide ranked by ideXlab platform

Jose A M Prates - One of the best experts on this subject based on the ideXlab platform.

  • diet supplementation with the cis 9 trans 11 conjugated linoleic acid isomer affects the size of adipocytes in wistar rats
    Nutrition Research, 2008
    Co-Authors: Paula Lopes, Susana V Martins, Mario Pinho, Cristina M Alfaia, Carlos M G A Fontes, P O Rodrigues, Graca S L Morais, Matilde Castro, Rui Pinto, Jose A M Prates
    Abstract:

    Abstract Previous reports have demonstrated that conjugated linoleic acid (CLA) acts on body Fat accumulation in a variety of animal models. The aim of the present study was to investigate the effect of cis (c)-9, trans (t)-11 and t10,c12 CLA isomers on the number and size of adipocytes from the inguinal and Retroperitoneal Fats in Wistar male rats. A 5.1% palm oil–based diet was supplemented with CLA isomers as follows: 0.6% of c9,t11, 0.6% of t10,c12, 1.3% of c9,t11 and t10,c12 isomers in mixture, and a control nonsupplemented group for comparative purposes. Fat tissues were prepared on microscope slides for histologic examination using an image-analysis software to count the number of adipocytes and measure cell sizes. The results showed that CLA isomers did not affect ( P > .05) either final body and Fat depot weights or serum lipids (with the exception of triacylglycerols) and adipocytokines (leptin and adiponectin). Animals fed the c9,t11 CLA isomer diet showed larger adipocytes when compared to other groups. Independently of the CLA dietary treatment, Retroperitoneal Fat showed larger adipocytes (3319 μ m 2 ) and therefore a smaller number of adipocytes per unit of area, compared to inguinal Fat (3055 μ m 2 ). Taken together, the data suggest that a palm oil–based diet supplemented with the c9,t11 CLA isomer in Wistar rats, in contrast to the t10,c12 isomer and the mixture of both isomers, increases adipocyte dimensions in inguinal and Retroperitoneal Fat depots, while having a minor effect in serum lipids and adipocytokines.

Helenir Medri De Souza - One of the best experts on this subject based on the ideXlab platform.

  • pioglitazone improves insulin sensitivity and reduces weight loss in walker 256 tumor bearing rats
    Life Sciences, 2017
    Co-Authors: Flaviane De Fatima Silva, Milene Ortizsilva, Winny Beatriz De Souza Galia, Priscila Cassolla, Maria Fernanda Rodrigues Graciano, Cassia T B V Zaia, Dimas A M Zaia, ângelo Rafael Carpinelli, Francemilson Goulart Da Silva, Helenir Medri De Souza
    Abstract:

    Abstract Aim The lipogenic effect of pioglitazone (PGZ), an insulin (INS) sensitizer, is well established. However, few studies have evaluated PGZ effects in preventing weight loss in cancer. We investigated PGZ effects, alone or associated with INS, on INS resistance, cachexia and metabolic abnormalities induced by Walker-256 tumor in rats. Main methods PGZ (5.0 mg·kg − 1 , oral) or PGZ + INS (NPH, 1.0 UI·kg − 1 , sc), were once-daily administered during 12 days, starting on the day inoculation of Walker-256 tumor cells. Rats were separated in small (about 17 g) and big (about 30 g) tumor-bearing. Key findings Big tumor-bearing rats showed greater cachexia, blood triacylglycerol and free Fatty acids and INS resistance. PGZ and PGZ + INS treatments did not change tumor growth and food intake, but reduced several abnormalities such as INS resistance, increased blood free Fatty acids, Retroperitoneal Fat wasting and body weight loss in small tumor-bearing rats. The prevention of Retroperitoneal Fat wasting did not involve reduction of tumor necrosis factor-α expression increased. In big tumor-bearing rats, PGZ and PGZ + INS treatments reversed the high blood triacylglycerol and free Fatty acids levels, but had no effect on other parameters. Significance PGZ and PGZ + INS improved INS peripheral sensitivity, possibly by decreasing blood free Fatty acids, and reduced Fat tissue wasting and body weight loss in small tumor-bearing rats. The results suggest clinical benefits of PGZ in preventing INS resistance, adipose tissue wasting and weight loss when the tumor is small, i.e. , in less severe cachexia.

C. Papavassiliou - One of the best experts on this subject based on the ideXlab platform.

  • Characterization of pheochromocytomas using quantitati analysis of the parameter T2 of the mass (T2-QMRI)
    Magma: Magnetic Resonance Materials in Physics Biology and Medicine, 1994
    Co-Authors: A. Stefanaki, Thomas G. Maris, Athanassios Gouliamos, A. Kalovidouris, G. Kordas, F. Milia, G. Papavassiliou, L. J. Vlahos, C. Papavassiliou
    Abstract:

    The usefullness of MR imaging in the characterization of pheochromocytomas was evaluated in 9 patients with 13 pheochromocytomas and 1 paraganglioma. In two patients the tumors were multiple and in one, extra-adrenal. Two patients conformed to MEN2 syndrome. Adrenal masses were characterized using several parameters: (a) visual inspection of the signal intensities in T1-, T2-, and Gd-DTPA-enhanced T1-weighted images; (b) observed signal intensity and observed signal intensity ratios (adrenal mass/liver, adrenal mass/Retroperitoneal Fat and adrenal mass/ subcutaneous Fat) in the T2-weighted images; (c) calculated T2 relaxation times and calculated T2 relaxation time ratios (adrenal mass/liver, adrenal mass/Retroperitoneal Fat and adrenal mass/subcutaneous Fat) of the adrenal masses.

Lee-ming Chuang - One of the best experts on this subject based on the ideXlab platform.

Ann Reed - One of the best experts on this subject based on the ideXlab platform.

  • Diagnostic Accuracy of Tissue Impedance Measurement Interpretation for Correct Veress Needle Placement in Feline Cadavers: Tissue Impedance Measurement Interpretation for Veress Needle Placement in Cats
    Veterinary surgery : VS, 2013
    Co-Authors: Sara Hyink, Jacqueline C. Whittemore, Amanda Mitchell, Ann Reed
    Abstract:

    To determine the diagnostic accuracy of tissue impedance measurement interpretation (TIMI) for determining correct versus incorrect Veress needle placement in feline cadavers. Prospective, randomized, blinded trial. Cat cadavers (n = 24). Two laparoscopists (1 experienced, 1 novice), blinded to TIMI, placed reusable Veress needles in study subjects in a randomized order. A third individual interpreted impedance measurements as consistent with correct versus incorrect placement. Veress needle tip locations were marked by injecting contrasting colors of India ink. Tissue dissection was performed to localize ink. Sensitivity, specificity, accuracy, precision, and kappa statistics for TIMI for placements by the experienced and novice laparoscopist were determined. P < .05 was considered significant. TIMI identified 36/38 correct and 2/10 incorrect placements. TIMI identified 2/2 bowel perforations but was unable to identify 8 inappropriate placements in the Retroperitoneal Fat pad. Impedance measurement interpretation had 94.7% sensitivity, 20% specificity, 79.2% accuracy, and 81% precision overall. Agreement between TIMI and Veress needle location was absent (kappa = -0.15, P = .01) for placements by the experienced laparoscopist and substantial (kappa = 0.78, P < .01) for the novice laparoscopist. Failure of TIMI to identify placement in the Retroperitoneal Fat pad resulted in poor accuracy. Small cat size limited the number of appropriate placement sites, perhaps resulting in excessively dorsal placements. Use of TIMI may increase detection of clinically significant inappropriate Veress needle placements, like bowel perforations, and decrease installment phase complications. Further evaluation of Veress needle placement with and without TIMI is warranted. © Copyright 2013 by The American College of Veterinary Surgeons.