The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Sigita Burneikiene - One of the best experts on this subject based on the ideXlab platform.
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Local Retropharyngeal Space Anesthetic for Dysphagia Reduction after Anterior Cervical Discectomy and Fusion Surgery: A Single-Center, Prospective, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial.
World neurosurgery, 2020Co-Authors: Alan T. Villavicencio, Sharad Rajpal, E. Lee Nelson, Kara D. Beasley, Vinod Kantha, Sigita BurneikieneAbstract:Objective The main objective of this study was to analyze the ability of local anesthetic instillation into the Retropharyngeal Space to reduce dysphagia symptoms and occurrence rates in patients undergoing anterior cervical discectomy and fusion (ACDF) procedures. Methods A single-center, prospective, randomized, double-blinded, and placebo-controlled clinical study was performed. We enrolled patients undergoing one- or two-level ACDF procedures for cervical degenerative disc disease with disc herniation, radiculopathy and/or myelopathy symptoms. The patients were randomly assigned (1:1 ratio) to receive either 0.5% bupivacaine hydrochloride or 0.9% NaCl solution. Results Forty-three (74%) and 41 (77%) of patients reported dysphagia symptoms at the time of discharge in the investigational and control groups, respectively. There were no statistically significant differences in duration of dysphagia symptoms, Swallowing-Quality of Life (SWAL-QOL) survey or pain scores between the investigational and control patient groups at any of the follow-up time points. Controlling for independent variables, only younger age significantly predicted dysphagia symptoms at discharge, 2-week, and 3-month follow-ups (P ≤ 0.03; R ≥ –0.038; OR 0.96, 95% CI 0.93–0.99. Female sex was associated with lower SWAL-QOL scores at discharge (P = 0.046; R = 0.87; OR 2.38, 95% CI 1.02–5.56). A total of 8 (13.8%) and 6 (11.3%) patients in the investigational and control groups, respectively, were referred to a specialist or underwent speech therapy for their dysphagia symptoms. There were no adverse reactions to the study drug observed. Conclusions Local Retropharyngeal Space anesthetic instillation did not reduce dysphagia symptoms or occurrence rates in patients undergoing anterior discectomy and fusion surgeries.
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P22. Local Retropharyngeal Space anesthetic for dysphagia reduction after anterior cervical discectomy and fusion surgery: a single-center, prospective, randomized, double-blinded, placebo-controlled clinical trial
The Spine Journal, 2020Co-Authors: Alan T. Villavicencio, Sharad Rajpal, E. Lee Nelson, Kara D. Beasley, Sigita BurneikieneAbstract:BACKGROUND CONTEXT We hypothesized that a local anesthetic, bupivacaine hydrochloride, may facilitate the sympathetic blockade of the intraoperative stimulation, stabilize the hemodynamic profile and therefore reduce postoperative inflammation and swelling of the esophago-pharyngeal area. PURPOSE The main objective of this study was to analyze the ability of local anesthetic instillation into the Retropharyngeal Space to reduce dysphagia symptoms and occurrence rates in patients undergoing anterior cervical discectomy and fusion (ACDF) procedures. STUDY DESIGN/SETTING A single-center, prospective, randomized, double-blinded, and placebo-controlled clinical study was performed. PATIENT SAMPLE We enrolled 120 patients undergoing one- or two-level ACDF procedures for cervical degenerative disc disease with disc herniation, radiculopathy and/or myelopathy symptoms. OUTCOME MEASURES Swallowing-Quality of Life (SWAL-QOL) survey, occurrence rates, and duration of dysphagia symptoms. METHODS The patients were randomly assigned (1:1 ratio) to receive either 0.5% bupivacaine hydrochloride or 0.9% NaCl solution. RESULTS Twenty-seven (23.7%) patients reported no dysphagia symptoms: 15 (25.9%) in the investigational and 12 (22.6%) in the control groups. There were no statistically significant differences in duration of dysphagia symptoms, Swallowing-Quality of Life (SWAL-QOL) survey or pain scores between the investigational or control patient groups at any of the follow-up time points. Controlling for independent variables, only younger age significantly predicted dysphagia symptoms at discharge, 2-week, and 3-month follow-ups (p -0.038; OR=0.96, 95% CI 0.93 – 0.99. Female gender was associated with lower SWAL-QOL scores at discharge (p=0.046; R=0.87; OR=2.38, 95% CI 1.02-5.56). A total of eight (13.8%) and six (11.3%) patients in the investigational and control groups, respectively, were referred to a specialist or underwent speech therapy for their dysphagia symptoms. There were no adverse reactions to the study drug observed. CONCLUSIONS Local Retropharyngeal Space anesthetic instillation did not reduce dysphagia symptoms or occurrence rates in patients undergoing anterior discectomy and fusion surgeries. FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs.
Dinesh K Chhetri - One of the best experts on this subject based on the ideXlab platform.
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BENIGN AND MALIGNANT LIPOGENIC TUMORS OF THE Retropharyngeal Space
2013Co-Authors: Dk Chhetri, Dinesh K ChhetriAbstract:Lipogenic tumors of the Retropharyngeal Space are neoplasms that can grow to a considerable size before becoming symptomatic. Careful inspection of preoperative imaging will heighten suspicion for malignancy, which is critical in planning treatment. In this study we compare clinical, radiologic, and histologic findings of benign and malignant lipogenic tumors of the Retropharyngeal Space. Key words: lipogenic tumor, Retropharyngeal Lipoma is a common benign mesenchymal soft tissue tumor, which may arise within any site of the body. It occurs in the head and neck region in about 13 % of all cases. It typically presents as a soft, mobile, subcutaneous mass without significant symptoms and is treated wit
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S143 – Benign and Malignant Lipogenic Tumors of the Retropharynx
Otolaryngology-Head and Neck Surgery, 2008Co-Authors: Abie H. Mendelsohn, Paul Kedeshian, Marc Cohen, Dinesh K ChhetriAbstract:ObjectivesLipogenic tumors of the Retropharyngeal Space are neoplasms that can grow to a considerable size before becoming symptomatic. In this study we compare clinical, radiologic, and histologic...
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S143 – Benign and Malignant Lipogenic Tumors of the Retropharynx
Otolaryngology–Head and Neck Surgery, 2008Co-Authors: Abie Mendelsohn, Paul Kedeshian, Marc Cohen, Dinesh K ChhetriAbstract:Objectives Lipogenic tumors of the Retropharyngeal Space are neoplasms that can grow to a considerable size before becoming symptomatic. In this study we compare clinical, radiologic, and histologic findings of benign versus malignant lipogenic tumors of the Retropharyngeal Space. Methods Retrospective review of a case series. Results 2 patients were identified with large lipogenic tumors of the retropharynx. The first patient was 66-year-old female with a 6-week history of progressive airway difficulty and dysphagia requiring tracheostomy and gastrostomy-tube placement. Preoperative imaging revealed a lipoma of the retropharynx. A transcervical excision of her Retropharyngeal mass revealed a 10⋉9⋉4.8 cm lipoma. The second patient was a 57-year-old female with a 4-week history of progressive left neck swelling, airway compromise, and odynophagia. Preoperative imaging revealed a heterogeneous mass in the retropharynx with fatty and solid components. After an initial awake tracheostomy a transcervical excision of a 15⋉5.5⋉4.0 cm mass was performed. Pathology revealed liposarcoma with scattered dedifferentiated regions. Postoperative radiation therapy was given for focally positive surgical margins. Both patients are recurrence-free at 36 months follow-up. Conclusions Although lipogenic tumors of the Retropharyngeal Space are rare these cases illustrate that they present at advanced stages, often requiring tracheostomy for airway control. The clinical course of lipomas and liposarcomas can be similar. However, careful inspection of preoperative imaging will heighten suspicion for malignancy, which is critical in surgical planning.
Alan T. Villavicencio - One of the best experts on this subject based on the ideXlab platform.
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Local Retropharyngeal Space Anesthetic for Dysphagia Reduction after Anterior Cervical Discectomy and Fusion Surgery: A Single-Center, Prospective, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial.
World neurosurgery, 2020Co-Authors: Alan T. Villavicencio, Sharad Rajpal, E. Lee Nelson, Kara D. Beasley, Vinod Kantha, Sigita BurneikieneAbstract:Objective The main objective of this study was to analyze the ability of local anesthetic instillation into the Retropharyngeal Space to reduce dysphagia symptoms and occurrence rates in patients undergoing anterior cervical discectomy and fusion (ACDF) procedures. Methods A single-center, prospective, randomized, double-blinded, and placebo-controlled clinical study was performed. We enrolled patients undergoing one- or two-level ACDF procedures for cervical degenerative disc disease with disc herniation, radiculopathy and/or myelopathy symptoms. The patients were randomly assigned (1:1 ratio) to receive either 0.5% bupivacaine hydrochloride or 0.9% NaCl solution. Results Forty-three (74%) and 41 (77%) of patients reported dysphagia symptoms at the time of discharge in the investigational and control groups, respectively. There were no statistically significant differences in duration of dysphagia symptoms, Swallowing-Quality of Life (SWAL-QOL) survey or pain scores between the investigational and control patient groups at any of the follow-up time points. Controlling for independent variables, only younger age significantly predicted dysphagia symptoms at discharge, 2-week, and 3-month follow-ups (P ≤ 0.03; R ≥ –0.038; OR 0.96, 95% CI 0.93–0.99. Female sex was associated with lower SWAL-QOL scores at discharge (P = 0.046; R = 0.87; OR 2.38, 95% CI 1.02–5.56). A total of 8 (13.8%) and 6 (11.3%) patients in the investigational and control groups, respectively, were referred to a specialist or underwent speech therapy for their dysphagia symptoms. There were no adverse reactions to the study drug observed. Conclusions Local Retropharyngeal Space anesthetic instillation did not reduce dysphagia symptoms or occurrence rates in patients undergoing anterior discectomy and fusion surgeries.
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P22. Local Retropharyngeal Space anesthetic for dysphagia reduction after anterior cervical discectomy and fusion surgery: a single-center, prospective, randomized, double-blinded, placebo-controlled clinical trial
The Spine Journal, 2020Co-Authors: Alan T. Villavicencio, Sharad Rajpal, E. Lee Nelson, Kara D. Beasley, Sigita BurneikieneAbstract:BACKGROUND CONTEXT We hypothesized that a local anesthetic, bupivacaine hydrochloride, may facilitate the sympathetic blockade of the intraoperative stimulation, stabilize the hemodynamic profile and therefore reduce postoperative inflammation and swelling of the esophago-pharyngeal area. PURPOSE The main objective of this study was to analyze the ability of local anesthetic instillation into the Retropharyngeal Space to reduce dysphagia symptoms and occurrence rates in patients undergoing anterior cervical discectomy and fusion (ACDF) procedures. STUDY DESIGN/SETTING A single-center, prospective, randomized, double-blinded, and placebo-controlled clinical study was performed. PATIENT SAMPLE We enrolled 120 patients undergoing one- or two-level ACDF procedures for cervical degenerative disc disease with disc herniation, radiculopathy and/or myelopathy symptoms. OUTCOME MEASURES Swallowing-Quality of Life (SWAL-QOL) survey, occurrence rates, and duration of dysphagia symptoms. METHODS The patients were randomly assigned (1:1 ratio) to receive either 0.5% bupivacaine hydrochloride or 0.9% NaCl solution. RESULTS Twenty-seven (23.7%) patients reported no dysphagia symptoms: 15 (25.9%) in the investigational and 12 (22.6%) in the control groups. There were no statistically significant differences in duration of dysphagia symptoms, Swallowing-Quality of Life (SWAL-QOL) survey or pain scores between the investigational or control patient groups at any of the follow-up time points. Controlling for independent variables, only younger age significantly predicted dysphagia symptoms at discharge, 2-week, and 3-month follow-ups (p -0.038; OR=0.96, 95% CI 0.93 – 0.99. Female gender was associated with lower SWAL-QOL scores at discharge (p=0.046; R=0.87; OR=2.38, 95% CI 1.02-5.56). A total of eight (13.8%) and six (11.3%) patients in the investigational and control groups, respectively, were referred to a specialist or underwent speech therapy for their dysphagia symptoms. There were no adverse reactions to the study drug observed. CONCLUSIONS Local Retropharyngeal Space anesthetic instillation did not reduce dysphagia symptoms or occurrence rates in patients undergoing anterior discectomy and fusion surgeries. FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs.
Sharad Rajpal - One of the best experts on this subject based on the ideXlab platform.
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Local Retropharyngeal Space Anesthetic for Dysphagia Reduction after Anterior Cervical Discectomy and Fusion Surgery: A Single-Center, Prospective, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial.
World neurosurgery, 2020Co-Authors: Alan T. Villavicencio, Sharad Rajpal, E. Lee Nelson, Kara D. Beasley, Vinod Kantha, Sigita BurneikieneAbstract:Objective The main objective of this study was to analyze the ability of local anesthetic instillation into the Retropharyngeal Space to reduce dysphagia symptoms and occurrence rates in patients undergoing anterior cervical discectomy and fusion (ACDF) procedures. Methods A single-center, prospective, randomized, double-blinded, and placebo-controlled clinical study was performed. We enrolled patients undergoing one- or two-level ACDF procedures for cervical degenerative disc disease with disc herniation, radiculopathy and/or myelopathy symptoms. The patients were randomly assigned (1:1 ratio) to receive either 0.5% bupivacaine hydrochloride or 0.9% NaCl solution. Results Forty-three (74%) and 41 (77%) of patients reported dysphagia symptoms at the time of discharge in the investigational and control groups, respectively. There were no statistically significant differences in duration of dysphagia symptoms, Swallowing-Quality of Life (SWAL-QOL) survey or pain scores between the investigational and control patient groups at any of the follow-up time points. Controlling for independent variables, only younger age significantly predicted dysphagia symptoms at discharge, 2-week, and 3-month follow-ups (P ≤ 0.03; R ≥ –0.038; OR 0.96, 95% CI 0.93–0.99. Female sex was associated with lower SWAL-QOL scores at discharge (P = 0.046; R = 0.87; OR 2.38, 95% CI 1.02–5.56). A total of 8 (13.8%) and 6 (11.3%) patients in the investigational and control groups, respectively, were referred to a specialist or underwent speech therapy for their dysphagia symptoms. There were no adverse reactions to the study drug observed. Conclusions Local Retropharyngeal Space anesthetic instillation did not reduce dysphagia symptoms or occurrence rates in patients undergoing anterior discectomy and fusion surgeries.
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P22. Local Retropharyngeal Space anesthetic for dysphagia reduction after anterior cervical discectomy and fusion surgery: a single-center, prospective, randomized, double-blinded, placebo-controlled clinical trial
The Spine Journal, 2020Co-Authors: Alan T. Villavicencio, Sharad Rajpal, E. Lee Nelson, Kara D. Beasley, Sigita BurneikieneAbstract:BACKGROUND CONTEXT We hypothesized that a local anesthetic, bupivacaine hydrochloride, may facilitate the sympathetic blockade of the intraoperative stimulation, stabilize the hemodynamic profile and therefore reduce postoperative inflammation and swelling of the esophago-pharyngeal area. PURPOSE The main objective of this study was to analyze the ability of local anesthetic instillation into the Retropharyngeal Space to reduce dysphagia symptoms and occurrence rates in patients undergoing anterior cervical discectomy and fusion (ACDF) procedures. STUDY DESIGN/SETTING A single-center, prospective, randomized, double-blinded, and placebo-controlled clinical study was performed. PATIENT SAMPLE We enrolled 120 patients undergoing one- or two-level ACDF procedures for cervical degenerative disc disease with disc herniation, radiculopathy and/or myelopathy symptoms. OUTCOME MEASURES Swallowing-Quality of Life (SWAL-QOL) survey, occurrence rates, and duration of dysphagia symptoms. METHODS The patients were randomly assigned (1:1 ratio) to receive either 0.5% bupivacaine hydrochloride or 0.9% NaCl solution. RESULTS Twenty-seven (23.7%) patients reported no dysphagia symptoms: 15 (25.9%) in the investigational and 12 (22.6%) in the control groups. There were no statistically significant differences in duration of dysphagia symptoms, Swallowing-Quality of Life (SWAL-QOL) survey or pain scores between the investigational or control patient groups at any of the follow-up time points. Controlling for independent variables, only younger age significantly predicted dysphagia symptoms at discharge, 2-week, and 3-month follow-ups (p -0.038; OR=0.96, 95% CI 0.93 – 0.99. Female gender was associated with lower SWAL-QOL scores at discharge (p=0.046; R=0.87; OR=2.38, 95% CI 1.02-5.56). A total of eight (13.8%) and six (11.3%) patients in the investigational and control groups, respectively, were referred to a specialist or underwent speech therapy for their dysphagia symptoms. There were no adverse reactions to the study drug observed. CONCLUSIONS Local Retropharyngeal Space anesthetic instillation did not reduce dysphagia symptoms or occurrence rates in patients undergoing anterior discectomy and fusion surgeries. FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs.
Kara D. Beasley - One of the best experts on this subject based on the ideXlab platform.
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Local Retropharyngeal Space Anesthetic for Dysphagia Reduction after Anterior Cervical Discectomy and Fusion Surgery: A Single-Center, Prospective, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial.
World neurosurgery, 2020Co-Authors: Alan T. Villavicencio, Sharad Rajpal, E. Lee Nelson, Kara D. Beasley, Vinod Kantha, Sigita BurneikieneAbstract:Objective The main objective of this study was to analyze the ability of local anesthetic instillation into the Retropharyngeal Space to reduce dysphagia symptoms and occurrence rates in patients undergoing anterior cervical discectomy and fusion (ACDF) procedures. Methods A single-center, prospective, randomized, double-blinded, and placebo-controlled clinical study was performed. We enrolled patients undergoing one- or two-level ACDF procedures for cervical degenerative disc disease with disc herniation, radiculopathy and/or myelopathy symptoms. The patients were randomly assigned (1:1 ratio) to receive either 0.5% bupivacaine hydrochloride or 0.9% NaCl solution. Results Forty-three (74%) and 41 (77%) of patients reported dysphagia symptoms at the time of discharge in the investigational and control groups, respectively. There were no statistically significant differences in duration of dysphagia symptoms, Swallowing-Quality of Life (SWAL-QOL) survey or pain scores between the investigational and control patient groups at any of the follow-up time points. Controlling for independent variables, only younger age significantly predicted dysphagia symptoms at discharge, 2-week, and 3-month follow-ups (P ≤ 0.03; R ≥ –0.038; OR 0.96, 95% CI 0.93–0.99. Female sex was associated with lower SWAL-QOL scores at discharge (P = 0.046; R = 0.87; OR 2.38, 95% CI 1.02–5.56). A total of 8 (13.8%) and 6 (11.3%) patients in the investigational and control groups, respectively, were referred to a specialist or underwent speech therapy for their dysphagia symptoms. There were no adverse reactions to the study drug observed. Conclusions Local Retropharyngeal Space anesthetic instillation did not reduce dysphagia symptoms or occurrence rates in patients undergoing anterior discectomy and fusion surgeries.
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P22. Local Retropharyngeal Space anesthetic for dysphagia reduction after anterior cervical discectomy and fusion surgery: a single-center, prospective, randomized, double-blinded, placebo-controlled clinical trial
The Spine Journal, 2020Co-Authors: Alan T. Villavicencio, Sharad Rajpal, E. Lee Nelson, Kara D. Beasley, Sigita BurneikieneAbstract:BACKGROUND CONTEXT We hypothesized that a local anesthetic, bupivacaine hydrochloride, may facilitate the sympathetic blockade of the intraoperative stimulation, stabilize the hemodynamic profile and therefore reduce postoperative inflammation and swelling of the esophago-pharyngeal area. PURPOSE The main objective of this study was to analyze the ability of local anesthetic instillation into the Retropharyngeal Space to reduce dysphagia symptoms and occurrence rates in patients undergoing anterior cervical discectomy and fusion (ACDF) procedures. STUDY DESIGN/SETTING A single-center, prospective, randomized, double-blinded, and placebo-controlled clinical study was performed. PATIENT SAMPLE We enrolled 120 patients undergoing one- or two-level ACDF procedures for cervical degenerative disc disease with disc herniation, radiculopathy and/or myelopathy symptoms. OUTCOME MEASURES Swallowing-Quality of Life (SWAL-QOL) survey, occurrence rates, and duration of dysphagia symptoms. METHODS The patients were randomly assigned (1:1 ratio) to receive either 0.5% bupivacaine hydrochloride or 0.9% NaCl solution. RESULTS Twenty-seven (23.7%) patients reported no dysphagia symptoms: 15 (25.9%) in the investigational and 12 (22.6%) in the control groups. There were no statistically significant differences in duration of dysphagia symptoms, Swallowing-Quality of Life (SWAL-QOL) survey or pain scores between the investigational or control patient groups at any of the follow-up time points. Controlling for independent variables, only younger age significantly predicted dysphagia symptoms at discharge, 2-week, and 3-month follow-ups (p -0.038; OR=0.96, 95% CI 0.93 – 0.99. Female gender was associated with lower SWAL-QOL scores at discharge (p=0.046; R=0.87; OR=2.38, 95% CI 1.02-5.56). A total of eight (13.8%) and six (11.3%) patients in the investigational and control groups, respectively, were referred to a specialist or underwent speech therapy for their dysphagia symptoms. There were no adverse reactions to the study drug observed. CONCLUSIONS Local Retropharyngeal Space anesthetic instillation did not reduce dysphagia symptoms or occurrence rates in patients undergoing anterior discectomy and fusion surgeries. FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs.