The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform

Hiroyuki Moriuchi - One of the best experts on this subject based on the ideXlab platform.

  • Retrospective Diagnosis of congenital cytomegalovirus infection in children with autism spectrum disorder but no other major neurologic deficit
    Brain & Development, 2015
    Co-Authors: Ayako Sakamoto, Hiroyuki Moriuchi, Junko Matsuzaki, Kazunori Motoyama, Masako Moriuchi
    Abstract:

    Abstract Aim: Congenital cytomegalovirus (CMV) infection can cause a variety of neurological deficits of delayed onset in infants who are asymptomatic at birth. The aim of this study was to investigate the prevalence of congenital CMV infection among children with autism spectrum disorder (ASD) in Nagasaki, Japan. Methods: Twenty-nine children with ASD who were born in Nagasaki and had no other major neurological deficits were recruited. Two of the patients were excluded due to significant perinatal events. The remaining 27 children were investigated Retrospectively for congenital CMV infection by analyzing dried blood spot samples or dried umbilical cords for CMV DNA using real-time PCR. Results: CMV DNA was detected in two (7.4%) of the 27 children. Neither of the patients had perinatal histories suggestive of congenital CMV disease or other neurological deficits, including hearing impairment and epilepsy. The severity of their autistic disorders varied considerably. Conclusions: The rate of congenital CMV infection in this study (two of 27 children with ASD), which was significantly ( p =0.004) higher than the incidence of congenital CMV infection in Nagasaki (0.31%, 10/3230 live births), suggests the involvement of congenital CMV infection in a portion of children with ASD, although definite Diagnosis was not obtained due to limited clinical data of the study subjects.

  • Retrospective Diagnosis of Congenital Cytomegalovirus Infection at a School for the Deaf by Using Preserved Dried Umbilical Cord
    The Journal of pediatrics, 2009
    Co-Authors: Masato Tagawa, Masako Moriuchi, Hideo Tanaka, Hiroyuki Moriuchi
    Abstract:

    A Retrospective Diagnosis of congenital cytomegalovirus infection was made for 3 of 26 students (12%) with either bilateral profound or severe sensorineural hearing loss at a School for the Deaf in Japan by detecting viral DNA with real-time polymerase chain reaction from dried umbilical cords that had been preserved at home.

  • Retrospective Diagnosis of congenital cytomegalovirus infection using umbilical cord.
    Pediatric neurology, 2006
    Co-Authors: Syuzo Ikeda, Akira Tsuru, Masako Moriuchi, Hiroyuki Moriuchi
    Abstract:

    Approximately 90% of infants congenitally infected with cytomegalovirus are asymptomatic at birth, but a number of them later develop central nervous system disorders. However, Diagnosis of congenital infection with virologic or serologic evidence had been almost impossible beyond the neonatal period. Recently, dried blood spots on Guthrie cards have been demonstrated to be useful for Retrospective Diagnosis of congenital cytomegalovirus infection; however, they are usually stored for only 1 year. In Japan, the umbilical cord is kept clean and dry as a symbol of the mother-to-child bond, and in recent studies, cytomegalovirus deoxyribonucleic acid was successfully detected from dried umbilical cord of two 1-year-old children who were clinically suspected of having had congenital cytomegalovirus infection. This report describes a 4-year-old male with various central nervous system disorders who was diagnosed with congenital cytomegalovirus infection by detecting cytomegalovirus deoxyribonucleic acid from dried umbilical cord.

María Teresa Rives-ferreiro - One of the best experts on this subject based on the ideXlab platform.

B. Lawson - One of the best experts on this subject based on the ideXlab platform.

  • Chlamydiosis in British Garden Birds (2005–2011): Retrospective Diagnosis and Chlamydia psittaci Genotype Determination
    EcoHealth, 2014
    Co-Authors: K. M. Beckmann, A. M. Pocknell, S. K. John, Mark P Dagleish, A A Cunningham, Konrad Sachse, Andreas Pospischil, Nicole Borel, B. Lawson
    Abstract:

    The significance of chlamydiosis as a cause of mortality in wild passerines (Order Passeriformes), and the role of these birds as a potential source of zoonotic Chlamydia psittaci infection, is unknown. We reviewed wild bird mortality incidents (2005–2011). Where species composition or post-mortem findings were indicative of chlamydiosis, we examined archived tissues for C. psittaci infection using PCR and ArrayTube Microarray assays. Twenty-one of 40 birds tested positive: 8 dunnocks ( Prunella modularis ), 7 great tits ( Parus major ), 3 blue tits ( Cyanistes caeruleus ), 2 collared doves ( Streptopelia decaocto , Order Columbiformes), and 1 robin ( Erithacus rubecula ). Chlamydia psittaci genotype A was identified in all positive passerines and in a further three dunnocks and three robins diagnosed with chlamydiosis from a previous study. Two collared doves had genotype E. Ten of the 21 C. psittaci -positive birds identified in the current study had histological lesions consistent with chlamydiosis and co-localizing Chlamydia spp. antigens on immunohistochemistry. Our results indicate that chlamydiosis may be a more common disease of British passerines than was previously recognized. Wild passerines may be a source of C. psittaci zoonotic infection, and people should be advised to take appropriate hygiene precautions when handling bird feeders or wild birds.

  • chlamydiosis in british garden birds 2005 2011 Retrospective Diagnosis and chlamydia psittaci genotype determination
    Ecohealth, 2014
    Co-Authors: K. M. Beckmann, A. M. Pocknell, S. K. John, Mark P Dagleish, A A Cunningham, Konrad Sachse, Andreas Pospischil, Nicole Borel, B. Lawson
    Abstract:

    The significance of chlamydiosis as a cause of mortality in wild passerines (Order Passeriformes), and the role of these birds as a potential source of zoonotic Chlamydia psittaci infection, is unknown. We reviewed wild bird mortality incidents (2005–2011). Where species composition or post-mortem findings were indicative of chlamydiosis, we examined archived tissues for C. psittaci infection using PCR and ArrayTube Microarray assays. Twenty-one of 40 birds tested positive: 8 dunnocks (Prunella modularis), 7 great tits (Parus major), 3 blue tits (Cyanistes caeruleus), 2 collared doves (Streptopelia decaocto, Order Columbiformes), and 1 robin (Erithacus rubecula). Chlamydia psittaci genotype A was identified in all positive passerines and in a further three dunnocks and three robins diagnosed with chlamydiosis from a previous study. Two collared doves had genotype E. Ten of the 21 C. psittaci-positive birds identified in the current study had histological lesions consistent with chlamydiosis and co-localizing Chlamydia spp. antigens on immunohistochemistry. Our results indicate that chlamydiosis may be a more common disease of British passerines than was previously recognized. Wild passerines may be a source of C. psittaci zoonotic infection, and people should be advised to take appropriate hygiene precautions when handling bird feeders or wild birds.

Masako Moriuchi - One of the best experts on this subject based on the ideXlab platform.

  • Retrospective Diagnosis of congenital cytomegalovirus infection in children with autism spectrum disorder but no other major neurologic deficit
    Brain & Development, 2015
    Co-Authors: Ayako Sakamoto, Hiroyuki Moriuchi, Junko Matsuzaki, Kazunori Motoyama, Masako Moriuchi
    Abstract:

    Abstract Aim: Congenital cytomegalovirus (CMV) infection can cause a variety of neurological deficits of delayed onset in infants who are asymptomatic at birth. The aim of this study was to investigate the prevalence of congenital CMV infection among children with autism spectrum disorder (ASD) in Nagasaki, Japan. Methods: Twenty-nine children with ASD who were born in Nagasaki and had no other major neurological deficits were recruited. Two of the patients were excluded due to significant perinatal events. The remaining 27 children were investigated Retrospectively for congenital CMV infection by analyzing dried blood spot samples or dried umbilical cords for CMV DNA using real-time PCR. Results: CMV DNA was detected in two (7.4%) of the 27 children. Neither of the patients had perinatal histories suggestive of congenital CMV disease or other neurological deficits, including hearing impairment and epilepsy. The severity of their autistic disorders varied considerably. Conclusions: The rate of congenital CMV infection in this study (two of 27 children with ASD), which was significantly ( p =0.004) higher than the incidence of congenital CMV infection in Nagasaki (0.31%, 10/3230 live births), suggests the involvement of congenital CMV infection in a portion of children with ASD, although definite Diagnosis was not obtained due to limited clinical data of the study subjects.

  • Retrospective Diagnosis of Congenital Cytomegalovirus Infection at a School for the Deaf by Using Preserved Dried Umbilical Cord
    The Journal of pediatrics, 2009
    Co-Authors: Masato Tagawa, Masako Moriuchi, Hideo Tanaka, Hiroyuki Moriuchi
    Abstract:

    A Retrospective Diagnosis of congenital cytomegalovirus infection was made for 3 of 26 students (12%) with either bilateral profound or severe sensorineural hearing loss at a School for the Deaf in Japan by detecting viral DNA with real-time polymerase chain reaction from dried umbilical cords that had been preserved at home.

  • Retrospective Diagnosis of congenital cytomegalovirus infection using umbilical cord.
    Pediatric neurology, 2006
    Co-Authors: Syuzo Ikeda, Akira Tsuru, Masako Moriuchi, Hiroyuki Moriuchi
    Abstract:

    Approximately 90% of infants congenitally infected with cytomegalovirus are asymptomatic at birth, but a number of them later develop central nervous system disorders. However, Diagnosis of congenital infection with virologic or serologic evidence had been almost impossible beyond the neonatal period. Recently, dried blood spots on Guthrie cards have been demonstrated to be useful for Retrospective Diagnosis of congenital cytomegalovirus infection; however, they are usually stored for only 1 year. In Japan, the umbilical cord is kept clean and dry as a symbol of the mother-to-child bond, and in recent studies, cytomegalovirus deoxyribonucleic acid was successfully detected from dried umbilical cord of two 1-year-old children who were clinically suspected of having had congenital cytomegalovirus infection. This report describes a 4-year-old male with various central nervous system disorders who was diagnosed with congenital cytomegalovirus infection by detecting cytomegalovirus deoxyribonucleic acid from dried umbilical cord.

Isabel Vives-oñós - One of the best experts on this subject based on the ideXlab platform.