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Robin H Bogner - One of the best experts on this subject based on the ideXlab platform.

  • Application of mesoporous silicon dioxide and silicate in oral amorphous drug delivery systems
    Journal of Pharmaceutical Sciences, 2012
    Co-Authors: Ken K Qian, Robin H Bogner
    Abstract:

    Aqueous solubility of an active pharmaceutical ingredient is an important consideration to ensure successful drug development. Mesoporous materials have been investigated as an amorphous drug delivery system owing to their nanosized capillaries and large surface areas. The complex interactions of crystalline compounds with mesoporous media and their implication in drug delivery are not well understood. Molecules interacting with porous media behave very differently than those in bulk phase. Their altered dynamics and thermodynamics play an important role in the properties and product performance of the amorphous system. In this Review, Application of mesoporous silicon dioxide and silicates in drug amorphization is the main focus. First, as background, the nature of gas-porous media interactions is summarized. The synthesis of various types of mesoporous silica, which are used by many investigators in this field, is described. Second, the behavior of molecules confined in mesopores is compared with those in bulk, crystalline phase. The molecular dynamics of compounds due to confinement, analyzed using various techniques, and their consequences in drug delivery are discussed. Finally, the preparation and performance of drug delivery systems using mesoporous silica are examined.

  • Application of mesoporous silicon dioxide and silicate in oral amorphous drug delivery systems
    Journal of Pharmaceutical Sciences, 2012
    Co-Authors: Ken K Qian, Robin H Bogner
    Abstract:

    ABSTRACT: Aqueous solubility of an active pharmaceutical ingredient is an important consideration to ensure successful drug development. Mesoporous materials have been investigated as an amorphous drug delivery system owing to their nanosized capillaries and large surface areas. The complex interactions of crystalline compounds with mesoporous media and their implication in drug delivery are not well understood. Molecules interacting with porous media behave very differently than those in bulk phase. Their altered dynamics and thermodynamics play an important role in the properties and product performance of the amorphous system. In this Review, Application of mesoporous silicon dioxide and silicates in drug amorphization is the main focus. First, as background, the nature of gas–porous media interactions is summarized. The synthesis of various types of mesoporous silica, which are used by many investigators in this field, is described. Second, the behavior of molecules confined in mesopores is compared with those in bulk, crystalline phase. The molecular dynamics of compounds due to confinement, analyzed using various techniques, and their consequences in drug delivery are discussed. Finally, the preparation and performance of drug delivery systems using mesoporous silica are examined. © 2011 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:444–463, 2012

Ken K Qian - One of the best experts on this subject based on the ideXlab platform.

  • Application of mesoporous silicon dioxide and silicate in oral amorphous drug delivery systems
    Journal of Pharmaceutical Sciences, 2012
    Co-Authors: Ken K Qian, Robin H Bogner
    Abstract:

    Aqueous solubility of an active pharmaceutical ingredient is an important consideration to ensure successful drug development. Mesoporous materials have been investigated as an amorphous drug delivery system owing to their nanosized capillaries and large surface areas. The complex interactions of crystalline compounds with mesoporous media and their implication in drug delivery are not well understood. Molecules interacting with porous media behave very differently than those in bulk phase. Their altered dynamics and thermodynamics play an important role in the properties and product performance of the amorphous system. In this Review, Application of mesoporous silicon dioxide and silicates in drug amorphization is the main focus. First, as background, the nature of gas-porous media interactions is summarized. The synthesis of various types of mesoporous silica, which are used by many investigators in this field, is described. Second, the behavior of molecules confined in mesopores is compared with those in bulk, crystalline phase. The molecular dynamics of compounds due to confinement, analyzed using various techniques, and their consequences in drug delivery are discussed. Finally, the preparation and performance of drug delivery systems using mesoporous silica are examined.

  • Application of mesoporous silicon dioxide and silicate in oral amorphous drug delivery systems
    Journal of Pharmaceutical Sciences, 2012
    Co-Authors: Ken K Qian, Robin H Bogner
    Abstract:

    ABSTRACT: Aqueous solubility of an active pharmaceutical ingredient is an important consideration to ensure successful drug development. Mesoporous materials have been investigated as an amorphous drug delivery system owing to their nanosized capillaries and large surface areas. The complex interactions of crystalline compounds with mesoporous media and their implication in drug delivery are not well understood. Molecules interacting with porous media behave very differently than those in bulk phase. Their altered dynamics and thermodynamics play an important role in the properties and product performance of the amorphous system. In this Review, Application of mesoporous silicon dioxide and silicates in drug amorphization is the main focus. First, as background, the nature of gas–porous media interactions is summarized. The synthesis of various types of mesoporous silica, which are used by many investigators in this field, is described. Second, the behavior of molecules confined in mesopores is compared with those in bulk, crystalline phase. The molecular dynamics of compounds due to confinement, analyzed using various techniques, and their consequences in drug delivery are discussed. Finally, the preparation and performance of drug delivery systems using mesoporous silica are examined. © 2011 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:444–463, 2012

Michael A Quilliam - One of the best experts on this subject based on the ideXlab platform.

  • lc ms ms analysis of diarrhetic shellfish poisoning dsp toxins okadaic acid and dinophysistoxin analogues and other lipophilic toxins
    Analytical Sciences, 2011
    Co-Authors: Michael A Quilliam
    Abstract:

    Diarrhetic shellfish poisoning (DSP) is a severe gastrointestinal illness caused by consumption of shellfish contaminated with DSP toxins that are originally produced by toxic dinoflagellates. Based on their structures, DSP toxins were initially classified into three groups, okadaic acid (OA)/dinophysistoxin (DTX) analogues, pectenotoxins (PTXs), and yessotoxins (YTXs). Because PTXs and YTXs have been subsequently shown to have no diarrhetic activities, PTXs and YTXs have recently been eliminated from the definition of DSP toxins. Mouse bioassay (MBA), which is the official testing method of DSP in Japan and many countries, also detects PTXs and YTXs, and thus alternative testing methods detecting only OA/DTX analogues are required in DSP monitoring. Electrospray ionization (ESI) liquid chromatography-mass spectrometry (LC-MS) is a very powerful tool for the detection, identification and quantification of DSP and other lipophilic toxins. In the present Review, Application of ESI LC-MS techniques to the analysis of each toxin group is described.

  • lc ms ms analysis of diarrhetic shellfish poisoning dsp toxins okadaic acid and dinophysistoxin analogues and other lipophilic toxins
    Analytical Sciences, 2011
    Co-Authors: Michael A Quilliam
    Abstract:

    Diarrhetic shellfish poisoning (DSP) is a severe gastrointestinal illness caused by consumption of shellfish contaminated with DSP toxins that are originally produced by toxic dinoflagellates. Based on their structures, DSP toxins were initially classified into three groups, okadaic acid (OA)/dinophysistoxin (DTX) analogues, pectenotoxins (PTXs), and yessotoxins (YTXs). Because PTXs and YTXs have been subsequently shown to have no diarrhetic activities, PTXs and YTXs have recently been eliminated from the definition of DSP toxins. Mouse bioassay (MBA), which is the official testing method of DSP in Japan and many countries, also detects PTXs and YTXs, and thus alternative testing methods detecting only OA/DTX analogues are required in DSP monitoring. Electrospray ionization (ESI) liquid chromatography-mass spectrometry (LC-MS) is a very powerful tool for the detection, identification and quantification of DSP and other lipophilic toxins. In the present Review, Application of ESI LC-MS techniques to the analysis of each toxin group is described.

Kadambot H M Siddique - One of the best experts on this subject based on the ideXlab platform.

  • the role of allelopathy in agricultural pest management
    Pest Management Science, 2011
    Co-Authors: Muhammad Farooq, Khawar Jabran, Z A Cheema, Abdul Wahid, Kadambot H M Siddique
    Abstract:

    Allelopathy is a naturally occurring ecological phenomenon of interference among organisms that may be employed for managing weeds, insect pests and diseases in field crops. In field crops, allelopathy can be used following rotation, using cover crops, mulching and plant extracts for natural pest management. Application of allelopathic plant extracts can effectively control weeds and insect pests. However, mixtures of allelopathic water extracts are more effective than the Application of single-plant extract in this regard. Combined Application of allelopathic extract and reduced herbicide dose (up to half the standard dose) give as much weed control as the standard herbicide dose in several field crops. Lower doses of herbicides may help to reduce the development of herbicide resistance in weed ecotypes. Allelopathy thus offers an attractive environmentally friendly alternative to pesticides in agricultural pest management. In this Review, Application of allelopathy for natural pest management, particularly in small-farm intensive agricultural systems, is discussed. Copyright © 2011 Society of Chemical Industry

  • The role of allelopathy in agricultural pest management.
    Pest Management Science, 2011
    Co-Authors: Muhammad Farooq, Khawar Jabran, Z A Cheema, Abdul Wahid, Kadambot H M Siddique
    Abstract:

    Allelopathy is a naturally occurring ecological phenomenon of interference among organisms that may be employed for managing weeds, insect pests and diseases in field crops. In field crops, allelopathy can be used following rotation, using cover crops, mulching and plant extracts for natural pest management. Application of allelopathic plant extracts can effectively control weeds and insect pests. However, mixtures of allelopathic water extracts are more effective than the Application of single-plant extract in this regard. Combined Application of allelopathic extract and reduced herbicide dose (up to half the standard dose) give as much weed control as the standard herbicide dose in several field crops. Lower doses of herbicides may help to reduce the development of herbicide resistance in weed ecotypes. Allelopathy thus offers an attractive environmentally friendly alternative to pesticides in agricultural pest management. In this Review, Application of allelopathy for natural pest management, particularly in small-farm intensive agricultural systems, is discussed.

Muhammad Farooq - One of the best experts on this subject based on the ideXlab platform.

  • the role of allelopathy in agricultural pest management
    Pest Management Science, 2011
    Co-Authors: Muhammad Farooq, Khawar Jabran, Z A Cheema, Abdul Wahid, Kadambot H M Siddique
    Abstract:

    Allelopathy is a naturally occurring ecological phenomenon of interference among organisms that may be employed for managing weeds, insect pests and diseases in field crops. In field crops, allelopathy can be used following rotation, using cover crops, mulching and plant extracts for natural pest management. Application of allelopathic plant extracts can effectively control weeds and insect pests. However, mixtures of allelopathic water extracts are more effective than the Application of single-plant extract in this regard. Combined Application of allelopathic extract and reduced herbicide dose (up to half the standard dose) give as much weed control as the standard herbicide dose in several field crops. Lower doses of herbicides may help to reduce the development of herbicide resistance in weed ecotypes. Allelopathy thus offers an attractive environmentally friendly alternative to pesticides in agricultural pest management. In this Review, Application of allelopathy for natural pest management, particularly in small-farm intensive agricultural systems, is discussed. Copyright © 2011 Society of Chemical Industry

  • The role of allelopathy in agricultural pest management.
    Pest Management Science, 2011
    Co-Authors: Muhammad Farooq, Khawar Jabran, Z A Cheema, Abdul Wahid, Kadambot H M Siddique
    Abstract:

    Allelopathy is a naturally occurring ecological phenomenon of interference among organisms that may be employed for managing weeds, insect pests and diseases in field crops. In field crops, allelopathy can be used following rotation, using cover crops, mulching and plant extracts for natural pest management. Application of allelopathic plant extracts can effectively control weeds and insect pests. However, mixtures of allelopathic water extracts are more effective than the Application of single-plant extract in this regard. Combined Application of allelopathic extract and reduced herbicide dose (up to half the standard dose) give as much weed control as the standard herbicide dose in several field crops. Lower doses of herbicides may help to reduce the development of herbicide resistance in weed ecotypes. Allelopathy thus offers an attractive environmentally friendly alternative to pesticides in agricultural pest management. In this Review, Application of allelopathy for natural pest management, particularly in small-farm intensive agricultural systems, is discussed.