The Experts below are selected from a list of 192 Experts worldwide ranked by ideXlab platform

Takanori Hirose - One of the best experts on this subject based on the ideXlab platform.

  • dedifferentiated liposarcoma with Rhabdomyoblastic differentiation
    Virchows Archiv, 2005
    Co-Authors: Shio Shimada, Kouichi Kamada, Keisuke Ishizawa, Takashi Ishizawa, Takanori Hirose
    Abstract:

    Dedifferentiated areas of dedifferentiated liposarcoma (DDL) usually show malignant fibrous histiocytoma (MFH)- or fibrosarcoma-like features and lack any histologic signs of specific differentiation. However, some reports have demonstrated specific differentiation in these areas, with histologic features resembling those of rhabdomyosarcoma, leiomyosarcoma, and osteosarcoma. We report here a pathologic and genetic analysis of three cases of DDLs with rhabdomyosarcomatous areas. MFH- or fibrosarcoma-like areas of one primary DDL and two recurrent DDLs contained various amounts of Rhabdomyoblasts, which were immunoreactive for desmin, myoglobin, muscle actin (HHF-35), and myogenin. An ultrastructural examination demonstrated Rhabdomyoblasts with abundant cytoplasm containing thin and thick filaments and Z-bands. By real-time PCR, amplification of mdm2 and cdk4 was confirmed in both well-differentiated and dedifferentiated areas with Rhabdomyoblasts of all cases. To our knowledge, only seven cases of DDLs with rhabdomyosarcomatous components have been reported, and furthermore, the genetic profiles of the rhabdomyosarcomatous components in DDLs have not been investigated. This study demonstrates that DDLs with rhabdomyosarcomatous areas have genetic alterations that are common to well-differentiated/dedifferentiated liposarcomas.

Ting-chang Chang - One of the best experts on this subject based on the ideXlab platform.

  • Malignant rhabdoid tumor of the uterine corpus.
    Gynecologic oncology, 1996
    Co-Authors: Swei Hsueh, Ting-chang Chang
    Abstract:

    Malignant rhabdoid tumor (MRT) was first described as a variant of Wilms' tumor but was subsequently found to be a highly malignant tumor composed of primitive cells that resemble Rhabdomyoblasts. In the past decade, extrarenal MRTs were reported in different locations and organs throughout the body including the female genital tract. We here report an MRT that arose in the corpus uteri, the second such case reported.

Claes Silfverswärd - One of the best experts on this subject based on the ideXlab platform.

  • Benign mixed Müllerian tumor of the ovary.
    Acta obstetricia et gynecologica Scandinavica, 1992
    Co-Authors: Folke Flam, Claes Silfverswärd
    Abstract:

    A case of benign Mullerian tumor of the ovary in a 53-year old woman is reported. The stromal element consisted of Rhabdomyoblasts which clearly indicate that this tumor belongs to the Mullerian family. She remains free of disease 12 months following an abdominal hysterectomy and bilateral salpingo-oophorectomy.

P Pillay - One of the best experts on this subject based on the ideXlab platform.

  • Primary myxoid liposarcoma with Rhabdomyoblastic differentiation.
    Archives of pathology & laboratory medicine, 1998
    Co-Authors: D Govender, P Pillay
    Abstract:

    We report a unique case of primary myxoid liposarcoma of the floor of the mouth, in which well-differentiated Rhabdomyoblasts were present. The tumor was incompletely excised. The patient is free of recurrence or metastasis following a course of radiotherapy. Heterologous components found in a liposarcoma include leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, osteosarcoma, and angiosarcoma. These elements have been described mainly in dedifferentiated liposarcomas situated in the retroperitoneum. To our knowledge, there has been only one report of a liposarcoma with rhabdomyosarcomatous differentiation occurring in the absence of a dedifferentiated component. The clinical implications of the presence of heterologous components without dedifferentiation are unclear.

Shio Shimada - One of the best experts on this subject based on the ideXlab platform.

  • dedifferentiated liposarcoma with Rhabdomyoblastic differentiation
    Virchows Archiv, 2005
    Co-Authors: Shio Shimada, Kouichi Kamada, Keisuke Ishizawa, Takashi Ishizawa, Takanori Hirose
    Abstract:

    Dedifferentiated areas of dedifferentiated liposarcoma (DDL) usually show malignant fibrous histiocytoma (MFH)- or fibrosarcoma-like features and lack any histologic signs of specific differentiation. However, some reports have demonstrated specific differentiation in these areas, with histologic features resembling those of rhabdomyosarcoma, leiomyosarcoma, and osteosarcoma. We report here a pathologic and genetic analysis of three cases of DDLs with rhabdomyosarcomatous areas. MFH- or fibrosarcoma-like areas of one primary DDL and two recurrent DDLs contained various amounts of Rhabdomyoblasts, which were immunoreactive for desmin, myoglobin, muscle actin (HHF-35), and myogenin. An ultrastructural examination demonstrated Rhabdomyoblasts with abundant cytoplasm containing thin and thick filaments and Z-bands. By real-time PCR, amplification of mdm2 and cdk4 was confirmed in both well-differentiated and dedifferentiated areas with Rhabdomyoblasts of all cases. To our knowledge, only seven cases of DDLs with rhabdomyosarcomatous components have been reported, and furthermore, the genetic profiles of the rhabdomyosarcomatous components in DDLs have not been investigated. This study demonstrates that DDLs with rhabdomyosarcomatous areas have genetic alterations that are common to well-differentiated/dedifferentiated liposarcomas.