The Experts below are selected from a list of 429 Experts worldwide ranked by ideXlab platform
Nevi Hidayati - One of the best experts on this subject based on the ideXlab platform.
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Prenatal Factors on Schizophrenia
2014Co-Authors: Nevi Hidayati, Nining FebriyanaAbstract:Schizophrenia is a chronic severe mental disorder with poor prognosis, and lifelong health, social, and financial burden. To the recent time, scientists still try to understand the etiologic mechanism of the disorder. Neurodevelopmental theory emerged as a model to explain the etiologic mechanism of schizophrenia. In the view of neurodevelopmental model, genetic and environmental risk factor of schizophrenia operate in prenatal periode, interfere in early development process of the central nervous system and emerge symptoms later in life. Known environmental factors in prenatal periode that increase risk of schizophrenia are gestational diabetes, fetal growth retardation, Rhesus Incompatibility, preeclampsia, perinatal bleeding, some birth complication caused hipoxia, infections, nutritional disturbance, and maternal stress. Searching how prenatal factors work, would be a valuable contribution to understanding schizophrenia, and establishing a proper treatment, and posible prevention strategies in the future.
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Prenatal Factors on Schizophrenia Faktor Prenatal pada Skizofrenia
2014Co-Authors: Nevi Hidayati, Daftar Pustaka, C Villard, J BoucrautAbstract:Schizophrenia is a chronic severe mental disorder with poor prognosis, and lifelong health, social, and financial burden. To the recent time, scientists still try to understand the etiologic mechanism of the disorder. Neurodevelopmental theory emerged as a model to explain the etiologic mechanism of schizophrenia. In the view of neurodevelopmental model, genetic and environmental risk factor of schizophrenia operate in prenatal periode, interfere in early development process of the central nervous system and emerge symptoms later in life. Known environmental factors in prenatal periode that increase risk of schizophrenia are gestational diabetes, fetal growth retardation, Rhesus Incompatibility, preeclampsia, perinatal bleeding, some birth complication caused hipoxia, infections, nutritional disturbance, and maternal stress. Searching how prenatal factors work, would be a valuable contribution to understanding schizophrenia, and establishing a proper treatment, and posible prevention strategies in the future.
Hein J. Odendaal - One of the best experts on this subject based on the ideXlab platform.
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The outcome of babies of mothers with severe Rhesus Incompatibility treated at Tygerberg Hospital, 1980-1993.
South African Medical Journal, 1995Co-Authors: G F Kirsten, L Geerts, S Riphagen, R De Beer, J Kriel, J Smith, L. M. M. Muller, Hein J. OdendaalAbstract:OBJECTIVE: To determine the outcome of babies of mothers with severe Rhesus (Rh) Incompatibility treated by elective delivery when the amniotic optical density at 450 nm crossed Whitfield's action line (group 1), by plasmapheresis and immunotherapy (group 2) or by means of intra-uterine intravascular transfusions (group 3). STUDY DESIGN: A retrospective study of 55 mothers and their 57 fetuses with severe Rh Incompatibility at < 34 weeks' pregnancy duration. MAIN OUTCOME PARAMETERS: Number of mothers in each treatment group, prevalence of intra-uterine death, hydrops, intra-uterine intravascular transfusions, cord haematocrit, cord bilirubin, number of liveborn babies, birth weight, neonatal death, hyaline membrane disease (HMD) and exchange transfusions. STUDY POPULATION AND SETTING: All mothers and babies with severe Rh Incompatibility (defined as an amniotic optical density of 450 nm in the upper and upper-mid zone on the Liley chart at < 34 weeks' pregnancy duration, previous fetal hydrops or Rh-related intra-uterine death (IUD), fetal hydrops on ultrasound or a fetal haematocrit < 30% at cordocentesis) treated at Tygerberg Hospital between January 1980 and January 1993. There were 20 fetuses each in groups 1 and 3, and 17 in group 2. RESULTS: A total of 48 babies (84%) were liveborn and of these 74% survived the neonatal period. (ABSTRACT TRUNCATED AT 250 WORDS)
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Amniocentesis--still important in the management of severe Rhesus Incompatibility.
South African Medical Journal, 1992Co-Authors: D. W. Steyn, R C Pattinson, Hein J. OdendaalAbstract:OBJECTIVE: To determine the role of amniocentesis in the management of severe Rhesus (Rh), Incompatibility. DESIGN: A 10-year retrospective descriptive study. SETTING: Department of Obstetrics and Gynaecology, Tygerberg Hospital, CP. STUDY POPULATION: 111 pregnancies complicated by severe Rh Incompatibility where management had been based on results obtained from amniocentesis. MAIN OUTCOME MEASUREMENTS: Neonatal haemoglobin values, neonatal survival and short-term morbidity as compared with the position on the Liley chart after amniocentesis immediately before delivery. RESULTS: Average neonatal haemoglobin value decreased for the group in the lower zone through the midzone to the upper zone, but wide scattering of individual values between the various zones occurred. Perinatal mortality rate was 93/1,000 deliveries with Rh-related deaths occurring only in the upper midzone and upper zones. One death and 7 cases of morbidity occurred after acting on misleading information from the Liley curve. CONCLUSION: Amniotic fluid bilirubin values are at best an indirect evaluation of the state of disease. No serious complications are likely to occur when these values fall in the lower or lower mid-zones of the Liley chart. When bilirubin values fall in the upper midzone or upper zone, cordocentesis should be performed to prevent overreaction or to perform an intra-uterine transfusion.
Wahn - One of the best experts on this subject based on the ideXlab platform.
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High-dose immunoglobulin therapy of hyperbilirubinemia in Rhesus Incompatibility
Infusionstherapie Und Transfusionsmedizin, 1993Co-Authors: Rübo J, WahnAbstract:We conducted a multicenter controlled trial to test the hypothesis that high intravenous doses of immunoglobulin (HDivIg) can modulate the bilirubin production and reduce the frequency of exchange transfusions in newborn infants with Rhesus Incompatibility. Thirty-four patients with Rhesus Incompatibility proven by positive direct antiglobulin test (Coombs test) were randomly assigned to conventional treatment including phototherapy, with or without additional HDivIg at 500 mg/kg given over 2 h, as soon as the diagnosis was established. Exchange transfusions were performed if serum bilirubin concentrations exceeded the modified curves of Polacek by more than 2 mg/dl. The results in 32 infants were analyzed. In the HdivIg-treated group, 2 of 16 (12.5%) children required exchange transfusions, whereas it became necessary in 11 of 16 (69%) in the control group (p < 0.005). Bilirubin levels in the HDivIg-treated group were lower despite a reduced frequency of exchange transfusions. We conclude that HDivIg by a yet unknown mechanism reduces bilirubin serum levels in children with Rhesus Incompatibility and the need for exchange transfusions.
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A trial with high-dose gamma globulin therapy in 3 children with hyperbilirubinemia in Rhesus Incompatibility
Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft für Kinderheilkunde, 1990Co-Authors: Rübo J, WahnAbstract:The influence of high-dose intravenous gammaglobulin (HDivGG) on the course of hyperbilirubinemia was investigated in three newborn infants with Rhesus hemolytic disease. In addition to phototherapy and appropriate hydration all children received gammaglobulin (Polyglobulin N, Tropon-Cutter, Cologne, FRG) at a dose of 500 mg/kg body weight intravenously. All three infants showed a marked decrease in bilirubin levels after HDivGG. In two cases exchange transfusion could be avoided. In the third an elevated bilirubin level after blood exchange dropped following HDivGG, and a further exchange transfusion became unnecessary. The suspected effect of HDivGG in Rhesus Incompatibility may be due to a blockade of Fc-receptors of the reticuloendothelial system, which prevents further hemolysis and bilirubin production. We propose, that the efficacy of this new mode of treatment should be evaluated in a controlled study.
G F Kirsten - One of the best experts on this subject based on the ideXlab platform.
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The outcome of babies of mothers with severe Rhesus Incompatibility treated at Tygerberg Hospital, 1980-1993.
South African Medical Journal, 1995Co-Authors: G F Kirsten, L Geerts, S Riphagen, R De Beer, J Kriel, J Smith, L. M. M. Muller, Hein J. OdendaalAbstract:OBJECTIVE: To determine the outcome of babies of mothers with severe Rhesus (Rh) Incompatibility treated by elective delivery when the amniotic optical density at 450 nm crossed Whitfield's action line (group 1), by plasmapheresis and immunotherapy (group 2) or by means of intra-uterine intravascular transfusions (group 3). STUDY DESIGN: A retrospective study of 55 mothers and their 57 fetuses with severe Rh Incompatibility at < 34 weeks' pregnancy duration. MAIN OUTCOME PARAMETERS: Number of mothers in each treatment group, prevalence of intra-uterine death, hydrops, intra-uterine intravascular transfusions, cord haematocrit, cord bilirubin, number of liveborn babies, birth weight, neonatal death, hyaline membrane disease (HMD) and exchange transfusions. STUDY POPULATION AND SETTING: All mothers and babies with severe Rh Incompatibility (defined as an amniotic optical density of 450 nm in the upper and upper-mid zone on the Liley chart at < 34 weeks' pregnancy duration, previous fetal hydrops or Rh-related intra-uterine death (IUD), fetal hydrops on ultrasound or a fetal haematocrit < 30% at cordocentesis) treated at Tygerberg Hospital between January 1980 and January 1993. There were 20 fetuses each in groups 1 and 3, and 17 in group 2. RESULTS: A total of 48 babies (84%) were liveborn and of these 74% survived the neonatal period. (ABSTRACT TRUNCATED AT 250 WORDS)
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The outcome of babies of mothers with severe Rhesus Incompatibility treated at Tygerberg Hospital, 1980-1993.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1995Co-Authors: G F Kirsten, D. W. Steyn, L Muller, L Geerts, S Riphagen, R De Beer, J Kriel, J Smith, H J OdendaalAbstract:To determine the outcome of babies of mothers with severe Rhesus (Rh) Incompatibility treated by elective delivery when the amniotic optical density at 450 nm crossed Whitfield's action line (group 1), by plasmapheresis and immunotherapy (group 2) or by means of intra-uterine intravascular transfusions (group 3). A retrospective study of 55 mothers and their 57 fetuses with severe Rh Incompatibility at < 34 weeks' pregnancy duration. Number of mothers in each treatment group, prevalence of intra-uterine death, hydrops, intra-uterine intravascular transfusions, cord haematocrit, cord bilirubin, number of liveborn babies, birth weight, neonatal death, hyaline membrane disease (HMD) and exchange transfusions. All mothers and babies with severe Rh Incompatibility (defined as an amniotic optical density of 450 nm in the upper and upper-mid zone on the Liley chart at < 34 weeks' pregnancy duration, previous fetal hydrops or Rh-related intra-uterine death (IUD), fetal hydrops on ultrasound or a fetal haematocrit < 30% at cordocentesis) treated at Tygerberg Hospital between January 1980 and January 1993. There were 20 fetuses each in groups 1 and 3, and 17 in group 2. A total of 48 babies (84%) were liveborn and of these 74% survived the neonatal period. (ABSTRACT TRUNCATED AT 250 WORDS)
Nining Febriyana - One of the best experts on this subject based on the ideXlab platform.
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Prenatal Factors on Schizophrenia
2014Co-Authors: Nevi Hidayati, Nining FebriyanaAbstract:Schizophrenia is a chronic severe mental disorder with poor prognosis, and lifelong health, social, and financial burden. To the recent time, scientists still try to understand the etiologic mechanism of the disorder. Neurodevelopmental theory emerged as a model to explain the etiologic mechanism of schizophrenia. In the view of neurodevelopmental model, genetic and environmental risk factor of schizophrenia operate in prenatal periode, interfere in early development process of the central nervous system and emerge symptoms later in life. Known environmental factors in prenatal periode that increase risk of schizophrenia are gestational diabetes, fetal growth retardation, Rhesus Incompatibility, preeclampsia, perinatal bleeding, some birth complication caused hipoxia, infections, nutritional disturbance, and maternal stress. Searching how prenatal factors work, would be a valuable contribution to understanding schizophrenia, and establishing a proper treatment, and posible prevention strategies in the future.