The Experts below are selected from a list of 483 Experts worldwide ranked by ideXlab platform
Tibor Gracza - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and antitumour activity of varitriol and its analogues
Arkivoc, 2012Co-Authors: Oľga Caletková, Angelika Lásiková, Petr Dzubak, Marian Hajduch, Tibor GraczaAbstract:Novel analogues of (+)-varitriol have been synthesised via Julia-Kocienski olefination from -DRibonolactone. Newly prepared compounds were screened for their in vitro cytotoxicity towards certain human tumours and NCI60 cancer cell line panel.
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an efficient total synthesisof varitriol from d Ribonolactone
Synthesis, 2010Co-Authors: Ol’ga Karlubíková, Angelika Lásiková, Miroslav Palík, Tibor GraczaAbstract:A short and efficient total synthesis of cytotoxic natural (+)-varitriol has been accomplished in eight steps from γ-D-Ribonolactone and 2,3-dimethylanisole in 41% overall yield. The key features include a highly stereoselective introduction of methyl at a carbonyl group and installation of the side chain with the aromatic portion by Julia-Kocienski olefination at C5 of the starting carbon skeleton.
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An Efficient Total Synthesisof (+)-Varitriol from d-Ribonolactone
Synthesis, 2010Co-Authors: Ol’ga Karlubíková, Angelika Lásiková, Miroslav Palík, Tibor GraczaAbstract:A short and efficient total synthesis of cytotoxic natural (+)-varitriol has been accomplished in eight steps from γ-D-Ribonolactone and 2,3-dimethylanisole in 41% overall yield. The key features include a highly stereoselective introduction of methyl at a carbonyl group and installation of the side chain with the aromatic portion by Julia-Kocienski olefination at C5 of the starting carbon skeleton.
Ol’ga Karlubíková - One of the best experts on this subject based on the ideXlab platform.
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an efficient total synthesisof varitriol from d Ribonolactone
Synthesis, 2010Co-Authors: Ol’ga Karlubíková, Angelika Lásiková, Miroslav Palík, Tibor GraczaAbstract:A short and efficient total synthesis of cytotoxic natural (+)-varitriol has been accomplished in eight steps from γ-D-Ribonolactone and 2,3-dimethylanisole in 41% overall yield. The key features include a highly stereoselective introduction of methyl at a carbonyl group and installation of the side chain with the aromatic portion by Julia-Kocienski olefination at C5 of the starting carbon skeleton.
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An Efficient Total Synthesisof (+)-Varitriol from d-Ribonolactone
Synthesis, 2010Co-Authors: Ol’ga Karlubíková, Angelika Lásiková, Miroslav Palík, Tibor GraczaAbstract:A short and efficient total synthesis of cytotoxic natural (+)-varitriol has been accomplished in eight steps from γ-D-Ribonolactone and 2,3-dimethylanisole in 41% overall yield. The key features include a highly stereoselective introduction of methyl at a carbonyl group and installation of the side chain with the aromatic portion by Julia-Kocienski olefination at C5 of the starting carbon skeleton.
Leroy B. Townsend - One of the best experts on this subject based on the ideXlab platform.
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Organic Syntheses - D‐Ribonolactone and 2,3‐Isopropylidene(D‐Ribonolactone)
Organic Syntheses, 2005Co-Authors: John D. Williams, Vivekanand P. Kamath, Philip E. Morris, Leroy B. TownsendAbstract:d-Ribose Sodium bicarbonate Bromine Sodium bisulfite d-Ribonolactone 2,2-Dimethoxypropane Silver carbonate Keywords: Ribonolactone; isopropylidene (d-Ribonolactone); epimerization; oxidation; nucleoside analogs; natural products
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d Ribonolactone and 2 3 isopropylidene d Ribonolactone
Organic Syntheses, 2005Co-Authors: John D. Williams, Vivekanand P. Kamath, Philip E. Morris, Leroy B. TownsendAbstract:d-Ribose Sodium bicarbonate Bromine Sodium bisulfite d-Ribonolactone 2,2-Dimethoxypropane Silver carbonate Keywords: Ribonolactone; isopropylidene (d-Ribonolactone); epimerization; oxidation; nucleoside analogs; natural products
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The synthesis of 4-deazaformycin A.
The Journal of organic chemistry, 2003Co-Authors: Vassilios N. Kourafalos, Nicole Pouli, Panagiotis Marakos, Leroy B. TownsendAbstract:The preparation of 4-deazaformycin A has been achieved. The synthesis features the condensation of a suitably substituted, lithiated 4-picoline with 2,3,5-tri-O-benzyl-d-Ribonolactone, dehydration of the resulting hemiacetal, and ionic hydrogenation, followed by manipulation of the protecting groups and subsequent ring closure with the formation of 7-amino-3-(β-d-ribofuranosyl)pyrazolo[3,4-c]pyridine.
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The Synthesis of a New Pyrazolo[3,4-c]pyridine C-Nucleoside, StructurallyRelated to Formycin B
Synlett, 2002Co-Authors: Vassilios N. Kourafalos, Nicole Pouli, Panagiotis Marakos, Leroy B. TownsendAbstract:The first preparation of the 4-deaza analogue of formycin B is described, via the reaction of 3-acetamido-2-methoxy-4-methylpyridine with a suitably protected Ribonolactone and subsequent ring closure to result in the 3-substituted pyrazolo[3,4-c]pyridine riboside 12.
Miroslav Palík - One of the best experts on this subject based on the ideXlab platform.
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an efficient total synthesisof varitriol from d Ribonolactone
Synthesis, 2010Co-Authors: Ol’ga Karlubíková, Angelika Lásiková, Miroslav Palík, Tibor GraczaAbstract:A short and efficient total synthesis of cytotoxic natural (+)-varitriol has been accomplished in eight steps from γ-D-Ribonolactone and 2,3-dimethylanisole in 41% overall yield. The key features include a highly stereoselective introduction of methyl at a carbonyl group and installation of the side chain with the aromatic portion by Julia-Kocienski olefination at C5 of the starting carbon skeleton.
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An Efficient Total Synthesisof (+)-Varitriol from d-Ribonolactone
Synthesis, 2010Co-Authors: Ol’ga Karlubíková, Angelika Lásiková, Miroslav Palík, Tibor GraczaAbstract:A short and efficient total synthesis of cytotoxic natural (+)-varitriol has been accomplished in eight steps from γ-D-Ribonolactone and 2,3-dimethylanisole in 41% overall yield. The key features include a highly stereoselective introduction of methyl at a carbonyl group and installation of the side chain with the aromatic portion by Julia-Kocienski olefination at C5 of the starting carbon skeleton.
Angelika Lásiková - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and antitumour activity of varitriol and its analogues
Arkivoc, 2012Co-Authors: Oľga Caletková, Angelika Lásiková, Petr Dzubak, Marian Hajduch, Tibor GraczaAbstract:Novel analogues of (+)-varitriol have been synthesised via Julia-Kocienski olefination from -DRibonolactone. Newly prepared compounds were screened for their in vitro cytotoxicity towards certain human tumours and NCI60 cancer cell line panel.
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an efficient total synthesisof varitriol from d Ribonolactone
Synthesis, 2010Co-Authors: Ol’ga Karlubíková, Angelika Lásiková, Miroslav Palík, Tibor GraczaAbstract:A short and efficient total synthesis of cytotoxic natural (+)-varitriol has been accomplished in eight steps from γ-D-Ribonolactone and 2,3-dimethylanisole in 41% overall yield. The key features include a highly stereoselective introduction of methyl at a carbonyl group and installation of the side chain with the aromatic portion by Julia-Kocienski olefination at C5 of the starting carbon skeleton.
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An Efficient Total Synthesisof (+)-Varitriol from d-Ribonolactone
Synthesis, 2010Co-Authors: Ol’ga Karlubíková, Angelika Lásiková, Miroslav Palík, Tibor GraczaAbstract:A short and efficient total synthesis of cytotoxic natural (+)-varitriol has been accomplished in eight steps from γ-D-Ribonolactone and 2,3-dimethylanisole in 41% overall yield. The key features include a highly stereoselective introduction of methyl at a carbonyl group and installation of the side chain with the aromatic portion by Julia-Kocienski olefination at C5 of the starting carbon skeleton.