The Experts below are selected from a list of 14367 Experts worldwide ranked by ideXlab platform
Guillén Fernández - One of the best experts on this subject based on the ideXlab platform.
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the Right Hippocampus participates in short term memory maintenance of object location associations
NeuroImage, 2006Co-Authors: Carinne Piekema, Rogier B Mars, Roy P. C. Kessels, Guillén Fernández, Karl Magnus PeterssonAbstract:Doubts have been cast on the strict dissociation between short- and long-term memory systems. Specifically, several neuroimaging studies have shown that the medial temporal lobe, a region almost invariably associated with long-term memory, is involved in active short-term memory maintenance. Furthermore, a recent study in hippocampally lesioned patients has shown that the Hippocampus is critically involved in associating objects and their locations, even when the delay period lasts only 8 s. However, the critical feature that causes the medial temporal lobe, and in particular the Hippocampus, to participate in active maintenance is still unknown. This study was designed in order to explore hippocampal involvement in active maintenance of spatial and non-spatial associations. Eighteen participants performed a delayed-match-to-sample task in which they had to maintain either object–location associations, color–number association, single colors, or single locations. Whole-brain activity was measured using event-related functional magnetic resonance imaging and analyzed using a random effects model. Right lateralized hippocampal activity was evident when participants had to maintain object–location associations, but not when they had to maintain object–color associations or single items. The present results suggest a hippocampal involvement in active maintenance when feature combinations that include spatial information have to be maintained online.
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The Right Hippocampus participates in short-term memory maintenance of object–location associations
NeuroImage, 2006Co-Authors: Carinne Piekema, Rogier B Mars, Roy P. C. Kessels, Karl Magnus Petersson, Guillén FernándezAbstract:Doubts have been cast on the strict dissociation between short- and long-term memory systems. Specifically, several neuroimaging studies have shown that the medial temporal lobe, a region almost invariably associated with long-term memory, is involved in active short-term memory maintenance. Furthermore, a recent study in hippocampally lesioned patients has shown that the Hippocampus is critically involved in associating objects and their locations, even when the delay period lasts only 8 s. However, the critical feature that causes the medial temporal lobe, and in particular the Hippocampus, to participate in active maintenance is still unknown. This study was designed in order to explore hippocampal involvement in active maintenance of spatial and non-spatial associations. Eighteen participants performed a delayed-match-to-sample task in which they had to maintain either object–location associations, color–number association, single colors, or single locations. Whole-brain activity was measured using event-related functional magnetic resonance imaging and analyzed using a random effects model. Right lateralized hippocampal activity was evident when participants had to maintain object–location associations, but not when they had to maintain object–color associations or single items. The present results suggest a hippocampal involvement in active maintenance when feature combinations that include spatial information have to be maintained online.
Carinne Piekema - One of the best experts on this subject based on the ideXlab platform.
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the Right Hippocampus participates in short term memory maintenance of object location associations
NeuroImage, 2006Co-Authors: Carinne Piekema, Rogier B Mars, Roy P. C. Kessels, Guillén Fernández, Karl Magnus PeterssonAbstract:Doubts have been cast on the strict dissociation between short- and long-term memory systems. Specifically, several neuroimaging studies have shown that the medial temporal lobe, a region almost invariably associated with long-term memory, is involved in active short-term memory maintenance. Furthermore, a recent study in hippocampally lesioned patients has shown that the Hippocampus is critically involved in associating objects and their locations, even when the delay period lasts only 8 s. However, the critical feature that causes the medial temporal lobe, and in particular the Hippocampus, to participate in active maintenance is still unknown. This study was designed in order to explore hippocampal involvement in active maintenance of spatial and non-spatial associations. Eighteen participants performed a delayed-match-to-sample task in which they had to maintain either object–location associations, color–number association, single colors, or single locations. Whole-brain activity was measured using event-related functional magnetic resonance imaging and analyzed using a random effects model. Right lateralized hippocampal activity was evident when participants had to maintain object–location associations, but not when they had to maintain object–color associations or single items. The present results suggest a hippocampal involvement in active maintenance when feature combinations that include spatial information have to be maintained online.
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The Right Hippocampus participates in short-term memory maintenance of object–location associations
NeuroImage, 2006Co-Authors: Carinne Piekema, Rogier B Mars, Roy P. C. Kessels, Karl Magnus Petersson, Guillén FernándezAbstract:Doubts have been cast on the strict dissociation between short- and long-term memory systems. Specifically, several neuroimaging studies have shown that the medial temporal lobe, a region almost invariably associated with long-term memory, is involved in active short-term memory maintenance. Furthermore, a recent study in hippocampally lesioned patients has shown that the Hippocampus is critically involved in associating objects and their locations, even when the delay period lasts only 8 s. However, the critical feature that causes the medial temporal lobe, and in particular the Hippocampus, to participate in active maintenance is still unknown. This study was designed in order to explore hippocampal involvement in active maintenance of spatial and non-spatial associations. Eighteen participants performed a delayed-match-to-sample task in which they had to maintain either object–location associations, color–number association, single colors, or single locations. Whole-brain activity was measured using event-related functional magnetic resonance imaging and analyzed using a random effects model. Right lateralized hippocampal activity was evident when participants had to maintain object–location associations, but not when they had to maintain object–color associations or single items. The present results suggest a hippocampal involvement in active maintenance when feature combinations that include spatial information have to be maintained online.
Frank Angenstein - One of the best experts on this subject based on the ideXlab platform.
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low frequency pulse stimulation of schaffer collaterals in trpm4 knockout rats differently affects baseline bold signals in target regions of the Right Hippocampus but not bold responses at the site of stimulation
NeuroImage, 2019Co-Authors: Marta Bovetcarmona, Karla Krautwald, Aurélie Menigoz, Rudi Vennekens, Detlef Balschun, Frank AngensteinAbstract:Abstract Electrical stimulation of Right Schaffer collateral in Trpm4−/− knockout and wild type rats were used to study the role of Trpm4 channels for signal processing in the hippocampal formation. Stimulation induced neuronal activity was simultaneously monitored in the CA1 region by in vivo extracellular field recordings and in the entire brain by BOLD fMRI measurements. In wild type and Trpm4−/− knockout rats, consecutive 5 Hz pulse trains elicited similar neuronal responses in the CA1 region and similar BOLD responses in the stimulated Right Hippocampus. Stimulus-related positive BOLD responses were also found in the left dorsal Hippocampus. In contrast to the Right dorsal Hippocampus, baseline BOLD signals in the left Hippocampus significantly decreased during consecutive stimulation trains. Similarly, slowly developing significant declines in baseline BOLD signals, in absence of any positive BOLD responses, were also observed in the Right entorhinal, Right piriform cortex, Right basolateral amygdala and Right dorsal striatum whereas baseline BOLD signals remained almost stable in the corresponding left regions. Furthermore, significant declines in baseline BOLD signals were found in the prefrontal cortex and prelimbic/infralimbic cortex. Because significant baseline BOLD declines were only observed in target regions of the Right dorsal Hippocampus, it might reflect functional connectivity between these regions. In all observed regions the decline in baseline BOLD signals was significantly delayed and less pronounced in Trpm4−/− knockout rats when compared to wild type rats. Thus, either Trpm4 channels are involved in mediating these baseline BOLD shifts or functional connectivity of the Hippocampus is impaired in Trpm4−/− knockout rats.
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Low frequency pulse stimulation of Schaffer collaterals in Trpm4-/- knockout rats differently affects baseline BOLD signals in target regions of the Right Hippocampus but not BOLD responses at the site of stimulation.
NeuroImage, 2018Co-Authors: Marta Bovet-carmona, Karla Krautwald, Aurélie Menigoz, Rudi Vennekens, Detlef Balschun, Frank AngensteinAbstract:Abstract Electrical stimulation of Right Schaffer collateral in Trpm4−/− knockout and wild type rats were used to study the role of Trpm4 channels for signal processing in the hippocampal formation. Stimulation induced neuronal activity was simultaneously monitored in the CA1 region by in vivo extracellular field recordings and in the entire brain by BOLD fMRI measurements. In wild type and Trpm4−/− knockout rats, consecutive 5 Hz pulse trains elicited similar neuronal responses in the CA1 region and similar BOLD responses in the stimulated Right Hippocampus. Stimulus-related positive BOLD responses were also found in the left dorsal Hippocampus. In contrast to the Right dorsal Hippocampus, baseline BOLD signals in the left Hippocampus significantly decreased during consecutive stimulation trains. Similarly, slowly developing significant declines in baseline BOLD signals, in absence of any positive BOLD responses, were also observed in the Right entorhinal, Right piriform cortex, Right basolateral amygdala and Right dorsal striatum whereas baseline BOLD signals remained almost stable in the corresponding left regions. Furthermore, significant declines in baseline BOLD signals were found in the prefrontal cortex and prelimbic/infralimbic cortex. Because significant baseline BOLD declines were only observed in target regions of the Right dorsal Hippocampus, it might reflect functional connectivity between these regions. In all observed regions the decline in baseline BOLD signals was significantly delayed and less pronounced in Trpm4−/− knockout rats when compared to wild type rats. Thus, either Trpm4 channels are involved in mediating these baseline BOLD shifts or functional connectivity of the Hippocampus is impaired in Trpm4−/− knockout rats.
Rogier B Mars - One of the best experts on this subject based on the ideXlab platform.
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the Right Hippocampus participates in short term memory maintenance of object location associations
NeuroImage, 2006Co-Authors: Carinne Piekema, Rogier B Mars, Roy P. C. Kessels, Guillén Fernández, Karl Magnus PeterssonAbstract:Doubts have been cast on the strict dissociation between short- and long-term memory systems. Specifically, several neuroimaging studies have shown that the medial temporal lobe, a region almost invariably associated with long-term memory, is involved in active short-term memory maintenance. Furthermore, a recent study in hippocampally lesioned patients has shown that the Hippocampus is critically involved in associating objects and their locations, even when the delay period lasts only 8 s. However, the critical feature that causes the medial temporal lobe, and in particular the Hippocampus, to participate in active maintenance is still unknown. This study was designed in order to explore hippocampal involvement in active maintenance of spatial and non-spatial associations. Eighteen participants performed a delayed-match-to-sample task in which they had to maintain either object–location associations, color–number association, single colors, or single locations. Whole-brain activity was measured using event-related functional magnetic resonance imaging and analyzed using a random effects model. Right lateralized hippocampal activity was evident when participants had to maintain object–location associations, but not when they had to maintain object–color associations or single items. The present results suggest a hippocampal involvement in active maintenance when feature combinations that include spatial information have to be maintained online.
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The Right Hippocampus participates in short-term memory maintenance of object–location associations
NeuroImage, 2006Co-Authors: Carinne Piekema, Rogier B Mars, Roy P. C. Kessels, Karl Magnus Petersson, Guillén FernándezAbstract:Doubts have been cast on the strict dissociation between short- and long-term memory systems. Specifically, several neuroimaging studies have shown that the medial temporal lobe, a region almost invariably associated with long-term memory, is involved in active short-term memory maintenance. Furthermore, a recent study in hippocampally lesioned patients has shown that the Hippocampus is critically involved in associating objects and their locations, even when the delay period lasts only 8 s. However, the critical feature that causes the medial temporal lobe, and in particular the Hippocampus, to participate in active maintenance is still unknown. This study was designed in order to explore hippocampal involvement in active maintenance of spatial and non-spatial associations. Eighteen participants performed a delayed-match-to-sample task in which they had to maintain either object–location associations, color–number association, single colors, or single locations. Whole-brain activity was measured using event-related functional magnetic resonance imaging and analyzed using a random effects model. Right lateralized hippocampal activity was evident when participants had to maintain object–location associations, but not when they had to maintain object–color associations or single items. The present results suggest a hippocampal involvement in active maintenance when feature combinations that include spatial information have to be maintained online.
Roy P. C. Kessels - One of the best experts on this subject based on the ideXlab platform.
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the Right Hippocampus participates in short term memory maintenance of object location associations
NeuroImage, 2006Co-Authors: Carinne Piekema, Rogier B Mars, Roy P. C. Kessels, Guillén Fernández, Karl Magnus PeterssonAbstract:Doubts have been cast on the strict dissociation between short- and long-term memory systems. Specifically, several neuroimaging studies have shown that the medial temporal lobe, a region almost invariably associated with long-term memory, is involved in active short-term memory maintenance. Furthermore, a recent study in hippocampally lesioned patients has shown that the Hippocampus is critically involved in associating objects and their locations, even when the delay period lasts only 8 s. However, the critical feature that causes the medial temporal lobe, and in particular the Hippocampus, to participate in active maintenance is still unknown. This study was designed in order to explore hippocampal involvement in active maintenance of spatial and non-spatial associations. Eighteen participants performed a delayed-match-to-sample task in which they had to maintain either object–location associations, color–number association, single colors, or single locations. Whole-brain activity was measured using event-related functional magnetic resonance imaging and analyzed using a random effects model. Right lateralized hippocampal activity was evident when participants had to maintain object–location associations, but not when they had to maintain object–color associations or single items. The present results suggest a hippocampal involvement in active maintenance when feature combinations that include spatial information have to be maintained online.
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The Right Hippocampus participates in short-term memory maintenance of object–location associations
NeuroImage, 2006Co-Authors: Carinne Piekema, Rogier B Mars, Roy P. C. Kessels, Karl Magnus Petersson, Guillén FernándezAbstract:Doubts have been cast on the strict dissociation between short- and long-term memory systems. Specifically, several neuroimaging studies have shown that the medial temporal lobe, a region almost invariably associated with long-term memory, is involved in active short-term memory maintenance. Furthermore, a recent study in hippocampally lesioned patients has shown that the Hippocampus is critically involved in associating objects and their locations, even when the delay period lasts only 8 s. However, the critical feature that causes the medial temporal lobe, and in particular the Hippocampus, to participate in active maintenance is still unknown. This study was designed in order to explore hippocampal involvement in active maintenance of spatial and non-spatial associations. Eighteen participants performed a delayed-match-to-sample task in which they had to maintain either object–location associations, color–number association, single colors, or single locations. Whole-brain activity was measured using event-related functional magnetic resonance imaging and analyzed using a random effects model. Right lateralized hippocampal activity was evident when participants had to maintain object–location associations, but not when they had to maintain object–color associations or single items. The present results suggest a hippocampal involvement in active maintenance when feature combinations that include spatial information have to be maintained online.
