Risk Evaluation

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Jodi De Greef - One of the best experts on this subject based on the ideXlab platform.

  • ecotoxicological Risk Evaluation of the cationic fabric softener dtdmac ii exposure modelling
    Chemosphere, 1992
    Co-Authors: To De Nijs, Jodi De Greef
    Abstract:

    Abstract For the Risk assessment of substances the dilution of effluent from the majority of waste water treatment plants in The Netherlands has been estimated. The results of this study have been applied in the Risk Evaluation of ditallow dimethyl ammonium chloride (DTDMAC) to estimate exposure concentrations in the surface waters. The information from a national database has been combined with a dilution model to estimate dilution factors at these waste facilities. The surface water system in The Netherlands is for an extensive part made up by polders. The results of the model show that the median dilution factor in The Netherlands is about 30. However, the distribution of the dilution factor varies from 1 for polder waters up to 100,000 in the River Rhine. In 20 percent of the cases the dilution factor is less than 5, mostly in the narrow polder waters and small tributaries. Application of the dilution factors in the case of DTDMAC results in a medium exposure concentration of 3 μg/l but it ranges from 0.01 up to 250 μg/l, showing the importance to consider the large variation of the dilution factor. Risk assessment of substances applying medium or average values will result in an under-estimation in about 50 percent of the cases of the concentration in the aquatic environment.

  • ecotoxicological Risk Evaluation of the cationic fabric softener dtdmac iii Risk assessment
    Chemosphere, 1992
    Co-Authors: Kees Van Leeuwe, To De Nijs, Carla Roghai, Jodi De Greef
    Abstract:

    Abstract The use of cationic surfactants in the Netherlands (about 2500 tonnes as active ingredient on an annual basis) poses a serious Risk to a wide variety of aquatic ecosystems. On the basis of ecotoxicological studies with ditallow-dimethyl-ammoniumchloride (DTDMAC), the most important fabric softener, a maximum permissible Risk level of 50 μg/l and a negligible Risk level of 0.5 μg/l have been derived. In 1990, concentrations of 6 – 25 μg/l were measured in the rivers Rhine, Meuse and Scheldt. Model predictions, confirmed by measurements in Germany and The Netherlands, show that in approximately 30 to 40% of the surface waters considerably higher DTDMAC are expected to occur. On the basis of this Risk Evaluation, which was discussed in the Dutch Parliament in spring 1990, the Netherlands Association of Detergent Industries agreed to replace DTDMAC by chemicals of lower environmental concern within a period of two years. Already by the end of 1990 almost all DTDMAC had been replaced by readily biodegradable substitutes. However, in June 1991, DTDMAC was detected in the rivers Rhine, Meuse and Scheldt at concentrations between 12 and 34 μg/l, which indicates that other than only national measures are required to reduce the large-scale pollution of surface waters with DTDMAC.

S L Kane - One of the best experts on this subject based on the ideXlab platform.

To De Nijs - One of the best experts on this subject based on the ideXlab platform.

  • ecotoxicological Risk Evaluation of the cationic fabric softener dtdmac ii exposure modelling
    Chemosphere, 1992
    Co-Authors: To De Nijs, Jodi De Greef
    Abstract:

    Abstract For the Risk assessment of substances the dilution of effluent from the majority of waste water treatment plants in The Netherlands has been estimated. The results of this study have been applied in the Risk Evaluation of ditallow dimethyl ammonium chloride (DTDMAC) to estimate exposure concentrations in the surface waters. The information from a national database has been combined with a dilution model to estimate dilution factors at these waste facilities. The surface water system in The Netherlands is for an extensive part made up by polders. The results of the model show that the median dilution factor in The Netherlands is about 30. However, the distribution of the dilution factor varies from 1 for polder waters up to 100,000 in the River Rhine. In 20 percent of the cases the dilution factor is less than 5, mostly in the narrow polder waters and small tributaries. Application of the dilution factors in the case of DTDMAC results in a medium exposure concentration of 3 μg/l but it ranges from 0.01 up to 250 μg/l, showing the importance to consider the large variation of the dilution factor. Risk assessment of substances applying medium or average values will result in an under-estimation in about 50 percent of the cases of the concentration in the aquatic environment.

  • ecotoxicological Risk Evaluation of the cationic fabric softener dtdmac iii Risk assessment
    Chemosphere, 1992
    Co-Authors: Kees Van Leeuwe, To De Nijs, Carla Roghai, Jodi De Greef
    Abstract:

    Abstract The use of cationic surfactants in the Netherlands (about 2500 tonnes as active ingredient on an annual basis) poses a serious Risk to a wide variety of aquatic ecosystems. On the basis of ecotoxicological studies with ditallow-dimethyl-ammoniumchloride (DTDMAC), the most important fabric softener, a maximum permissible Risk level of 50 μg/l and a negligible Risk level of 0.5 μg/l have been derived. In 1990, concentrations of 6 – 25 μg/l were measured in the rivers Rhine, Meuse and Scheldt. Model predictions, confirmed by measurements in Germany and The Netherlands, show that in approximately 30 to 40% of the surface waters considerably higher DTDMAC are expected to occur. On the basis of this Risk Evaluation, which was discussed in the Dutch Parliament in spring 1990, the Netherlands Association of Detergent Industries agreed to replace DTDMAC by chemicals of lower environmental concern within a period of two years. Already by the end of 1990 almost all DTDMAC had been replaced by readily biodegradable substitutes. However, in June 1991, DTDMAC was detected in the rivers Rhine, Meuse and Scheldt at concentrations between 12 and 34 μg/l, which indicates that other than only national measures are required to reduce the large-scale pollution of surface waters with DTDMAC.

Ngaire Kerse - One of the best experts on this subject based on the ideXlab platform.

Thomas A Orszulak - One of the best experts on this subject based on the ideXlab platform.

  • is the european system for cardiac operative Risk Evaluation model valid for estimating the operative Risk of patients considered for percutaneous aortic valve replacement
    The Journal of Thoracic and Cardiovascular Surgery, 2008
    Co-Authors: Morgan L Brown, Hartzell V Schaff, Maurice E Sarano, Thoralf M Sundt, Joseph A Dearani, Charles J Mullany, Thomas A Orszulak
    Abstract:

    Objective The European System for Cardiac Operative Risk Evaluation has been used to define a particularly high-Risk group of patients for aortic valve replacement in whom alternative procedures, such as stent-mounted percutaneous valve procedures, may be appropriate. Our objective was to assess the validity of this Risk assessment at a large-volume, tertiary cardiac surgical center. Methods From January 1, 2000, to December 30, 2006, a total of 1177 patients underwent isolated aortic valve replacement at the Mayo Clinic. Patient and operative demographics were recorded in a prospective database. Early mortality (≤30 days) was obtained. Additive and logistic European System for Cardiac Operative Risk Evaluations were calculated for each patient. Results The mean patient age was 68.0 years (±14.7 years) at the time of surgery, and 36.8% were female. Variables used in the calculation of the European System for Cardiac Operative Risk Evaluation included chronic lung disease (15% of our cohort), extracardiac arteriopathy (13.8%), neurologic dysfunction (0.2%), previous cardiac surgery (23.2%), renal failure (6.5%), active endocarditis (3.1%), recent myocardial infarction (1.1%), unstable angina (0.1%), and severe pulmonary hypertension (6.5%). The ejection fraction was severely reduced (≤30%) in 4.9% of patients and moderately reduced (≤50%) in 12.7% of patients. One percent of patients were in a critical state, and operation was performed urgently in 3.4% of patients. Although mean mortality estimates were 6.9% ± 3.4% (additive European System for Cardiac Operative Risk Evaluation) and 10.9% ± 12.7% (logistic European System for Cardiac Operative Risk Evaluation), actual overall operative mortality in our patients was 2.5%. Additive and logistic European System for Cardiac Operative Risk Evaluations overestimated operative mortality in low, intermediate, and high-Risk subgroups by up to 17.8%. Conclusions The European System for Cardiac Operative Risk Evaluation should not be used to determine the operability of patients for isolated aortic valve replacement. Elevated European System for Cardiac Operative Risk Evaluations alone do not appropriately define a population for use of a percutaneous aortic valve.