The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Michael A Quinn - One of the best experts on this subject based on the ideXlab platform.
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challenging salpingectomy as a Risk Reducing Measure for ovarian cancer histopathological analysis of the tubo ovarian interface in women undergoing Risk Reducing salpingo oophorectomy
International Journal of Gynecological Cancer, 2017Co-Authors: Chloe Ayres, Gayanie Ratnayake, Orla Mcnally, Michael A QuinnAbstract:Objective Opportunistic bilateral salpingectomy is now promoted for women at the time of hysterectomy for a benign disease, consequent to the fimbrial end of the fallopian tube emerging as the primary site for carcinogenesis in high-grade serous carcinomas. In high-Risk women with an identified germ line mutation, bilateral salpingo-oophorectomy offers the greatest Risk reduction for ovarian cancer. Currently, no prospective evidence exists with respect to the effectiveness of opportunistic salpingectomy alone in preventing ovarian cancer. Although it is thought that there is no direct connection between the ovary and its adjacent fallopian tube, we often find remnants of the fimbria adherent to the ovary at the time of surgery. If this tubo-ovarian interface is not separate, then practices such as salpingectomy and radical fimbriectomy may be incomplete, and the effectiveness of this technique as a prophylactic strategy may need reconsideration. We aimed to establish whether there might exist a direct attachment of the fimbria to the ovary by examining this interface in surgically removed specimens. Methods The tubes and ovaries of 20 women undergoing Risk-Reducing salpingo-oophorectomy were examined using the Sectioning and Extensively Examining the Fimbriated End of the Tubes protocol and p53 immunohistochemistry for lesions suspicious of serous intraepithelial tubal carcinoma. Results Three specimens showed fimbria adherent to the ovary at the histopathological analysis. One p53 signature was identified, but there were no occult cancers or serous intraepithelial tubal carcinomas. Conclusions Although only a small study, the findings show that microscopic fimbriae are adherent to the ovary. This relationship challenges the recommendation for bilateral salpingectomy alone for Risk-Reducing surgery because the primary site of carcinogenesis may be left on the ovary to later develop into a high-grade serous carcinoma. A larger study is needed to assess our findings related to the tubo-ovarian interface and its implications for long-term ovarian cancer development. Until then, caution on using this technique alone in the high-Risk patient should be adopted.
Chloe Ayres - One of the best experts on this subject based on the ideXlab platform.
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challenging salpingectomy as a Risk Reducing Measure for ovarian cancer histopathological analysis of the tubo ovarian interface in women undergoing Risk Reducing salpingo oophorectomy
International Journal of Gynecological Cancer, 2017Co-Authors: Chloe Ayres, Gayanie Ratnayake, Orla Mcnally, Michael A QuinnAbstract:Objective Opportunistic bilateral salpingectomy is now promoted for women at the time of hysterectomy for a benign disease, consequent to the fimbrial end of the fallopian tube emerging as the primary site for carcinogenesis in high-grade serous carcinomas. In high-Risk women with an identified germ line mutation, bilateral salpingo-oophorectomy offers the greatest Risk reduction for ovarian cancer. Currently, no prospective evidence exists with respect to the effectiveness of opportunistic salpingectomy alone in preventing ovarian cancer. Although it is thought that there is no direct connection between the ovary and its adjacent fallopian tube, we often find remnants of the fimbria adherent to the ovary at the time of surgery. If this tubo-ovarian interface is not separate, then practices such as salpingectomy and radical fimbriectomy may be incomplete, and the effectiveness of this technique as a prophylactic strategy may need reconsideration. We aimed to establish whether there might exist a direct attachment of the fimbria to the ovary by examining this interface in surgically removed specimens. Methods The tubes and ovaries of 20 women undergoing Risk-Reducing salpingo-oophorectomy were examined using the Sectioning and Extensively Examining the Fimbriated End of the Tubes protocol and p53 immunohistochemistry for lesions suspicious of serous intraepithelial tubal carcinoma. Results Three specimens showed fimbria adherent to the ovary at the histopathological analysis. One p53 signature was identified, but there were no occult cancers or serous intraepithelial tubal carcinomas. Conclusions Although only a small study, the findings show that microscopic fimbriae are adherent to the ovary. This relationship challenges the recommendation for bilateral salpingectomy alone for Risk-Reducing surgery because the primary site of carcinogenesis may be left on the ovary to later develop into a high-grade serous carcinoma. A larger study is needed to assess our findings related to the tubo-ovarian interface and its implications for long-term ovarian cancer development. Until then, caution on using this technique alone in the high-Risk patient should be adopted.
Gayanie Ratnayake - One of the best experts on this subject based on the ideXlab platform.
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challenging salpingectomy as a Risk Reducing Measure for ovarian cancer histopathological analysis of the tubo ovarian interface in women undergoing Risk Reducing salpingo oophorectomy
International Journal of Gynecological Cancer, 2017Co-Authors: Chloe Ayres, Gayanie Ratnayake, Orla Mcnally, Michael A QuinnAbstract:Objective Opportunistic bilateral salpingectomy is now promoted for women at the time of hysterectomy for a benign disease, consequent to the fimbrial end of the fallopian tube emerging as the primary site for carcinogenesis in high-grade serous carcinomas. In high-Risk women with an identified germ line mutation, bilateral salpingo-oophorectomy offers the greatest Risk reduction for ovarian cancer. Currently, no prospective evidence exists with respect to the effectiveness of opportunistic salpingectomy alone in preventing ovarian cancer. Although it is thought that there is no direct connection between the ovary and its adjacent fallopian tube, we often find remnants of the fimbria adherent to the ovary at the time of surgery. If this tubo-ovarian interface is not separate, then practices such as salpingectomy and radical fimbriectomy may be incomplete, and the effectiveness of this technique as a prophylactic strategy may need reconsideration. We aimed to establish whether there might exist a direct attachment of the fimbria to the ovary by examining this interface in surgically removed specimens. Methods The tubes and ovaries of 20 women undergoing Risk-Reducing salpingo-oophorectomy were examined using the Sectioning and Extensively Examining the Fimbriated End of the Tubes protocol and p53 immunohistochemistry for lesions suspicious of serous intraepithelial tubal carcinoma. Results Three specimens showed fimbria adherent to the ovary at the histopathological analysis. One p53 signature was identified, but there were no occult cancers or serous intraepithelial tubal carcinomas. Conclusions Although only a small study, the findings show that microscopic fimbriae are adherent to the ovary. This relationship challenges the recommendation for bilateral salpingectomy alone for Risk-Reducing surgery because the primary site of carcinogenesis may be left on the ovary to later develop into a high-grade serous carcinoma. A larger study is needed to assess our findings related to the tubo-ovarian interface and its implications for long-term ovarian cancer development. Until then, caution on using this technique alone in the high-Risk patient should be adopted.
Orla Mcnally - One of the best experts on this subject based on the ideXlab platform.
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challenging salpingectomy as a Risk Reducing Measure for ovarian cancer histopathological analysis of the tubo ovarian interface in women undergoing Risk Reducing salpingo oophorectomy
International Journal of Gynecological Cancer, 2017Co-Authors: Chloe Ayres, Gayanie Ratnayake, Orla Mcnally, Michael A QuinnAbstract:Objective Opportunistic bilateral salpingectomy is now promoted for women at the time of hysterectomy for a benign disease, consequent to the fimbrial end of the fallopian tube emerging as the primary site for carcinogenesis in high-grade serous carcinomas. In high-Risk women with an identified germ line mutation, bilateral salpingo-oophorectomy offers the greatest Risk reduction for ovarian cancer. Currently, no prospective evidence exists with respect to the effectiveness of opportunistic salpingectomy alone in preventing ovarian cancer. Although it is thought that there is no direct connection between the ovary and its adjacent fallopian tube, we often find remnants of the fimbria adherent to the ovary at the time of surgery. If this tubo-ovarian interface is not separate, then practices such as salpingectomy and radical fimbriectomy may be incomplete, and the effectiveness of this technique as a prophylactic strategy may need reconsideration. We aimed to establish whether there might exist a direct attachment of the fimbria to the ovary by examining this interface in surgically removed specimens. Methods The tubes and ovaries of 20 women undergoing Risk-Reducing salpingo-oophorectomy were examined using the Sectioning and Extensively Examining the Fimbriated End of the Tubes protocol and p53 immunohistochemistry for lesions suspicious of serous intraepithelial tubal carcinoma. Results Three specimens showed fimbria adherent to the ovary at the histopathological analysis. One p53 signature was identified, but there were no occult cancers or serous intraepithelial tubal carcinomas. Conclusions Although only a small study, the findings show that microscopic fimbriae are adherent to the ovary. This relationship challenges the recommendation for bilateral salpingectomy alone for Risk-Reducing surgery because the primary site of carcinogenesis may be left on the ovary to later develop into a high-grade serous carcinoma. A larger study is needed to assess our findings related to the tubo-ovarian interface and its implications for long-term ovarian cancer development. Until then, caution on using this technique alone in the high-Risk patient should be adopted.
Claudia Spahn - One of the best experts on this subject based on the ideXlab platform.
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co2 Measurements in instrumental and vocal closed room settings as a Risk Reducing Measure for a coronavirus infection
medRxiv, 2020Co-Authors: Manfred Nusseck, Bernhard Richter, Ludwig Holtmeier, Dominik Skala, Claudia SpahnAbstract:ABSTRACT Contaminated aerosols in room air are one of the transmission routes of the coronavirus. The amount of contaminated aerosols in the room seems to play an important role for the infection Risk. In rooms without technical air refreshing systems, the aerosol concentration can be reduced with simple natural ventilation activity. Instrumental and vocal lessons and rehearsals take place in closed indoor rooms. Therefore it is important to optimize the necessary ventilation activity in order to keep the infection Risk for musicians low. Therefore, knowledge about the maximum duration of the lesson or rehearsal for ventilation intervals are necessary. In this study, carbon dioxide concentration (CO2) as an indicator of the indoor air quality (IAQ) was Measured during 47 music lessons and rehearsals at a university of music including 141 persons. From these Measurements, the air exchange rates of the rooms and the CO2 emission rates per person were extracted. The results show that the CO2 emission in musical activities can be assigned to light and moderate activities between 28 l/h and 39 l/h. Wind instruments had the highest CO2 emissions. Singers showed low CO2 emission rates comparable to the control group which only spoke and listened. Recommendations for the frequency of ventilation breaks were derived from empirical data and allow for an individual Risk assessment of instrumental and vocal lessons and rehearsals depending on room size and number of musicians.
