The Experts below are selected from a list of 42 Experts worldwide ranked by ideXlab platform
J. S. Yadav - One of the best experts on this subject based on the ideXlab platform.
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Stereoselective Synthesis of 2-(2-Hydroxyalkyl)piperidine Alkaloids Through Prins–Ritter Reaction
Synthetic Communications, 2014Co-Authors: B. V. Subba Reddy, Supriya Ghanty, N. Siva Senkar Reddy, Y. Jayasudhan Reddy, J. S. YadavAbstract:Abstract A stereoselective total synthesis of the 2-(2-hydroxyalkyl)piperidine alkaloids has been accomplished by a Prins–Ritter Amidation sequence. Other steps involved in this synthesis are Jacobsen's hydrolytic kinetic resolution (HRK) and ring-closing metathesis (RCM).
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The stereoselective total synthesis of (+)-8-ethylnorlobelol from anti-1,3-aminoalcohols
Tetrahedron Letters, 2013Co-Authors: B. V. Subba Reddy, Y. Jayasudhan Reddy, B. Phaneendra Reddy, P. Sivaramakrishna Reddy, J. S. YadavAbstract:Abstract A novel and efficient approach has been developed for the total synthesis of (+)-8-ethylnorlobelol ( 1 ) in a highly stereoselective manner. The key anti -1,3-aminoalcohol core is constructed through the reductive opening of 2-iodomethyl-4-amidotetrahydropyranyl ether which is prepared by a Prins/Ritter Amidation sequence.
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HBF4·OEt2 as a mild and versatile reagent for the Ritter Amidation of olefins: a facile synthesis of secondary amides
Tetrahedron Letters, 2010Co-Authors: B. V. Subba Reddy, N. Sivasankar Reddy, Ch. Madan, J. S. YadavAbstract:Abstract A variety of alkenes undergo smooth Amidation with nitriles in the presence of HBF4·OEt2 at room temperature under mild conditions to afford the corresponding secondary amides in good to excellent yields. This is a highly efficient method for the preparation of α-aryl ethyl amides especially from vinyl arenes without any side reactions such as olefin polymerization. The use of readily available and easy to handle reagent HBF4·OEt2 makes this method simple, convenient, and practical.
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hbf4 oet2 as a mild and versatile reagent for the Ritter Amidation of olefins a facile synthesis of secondary amides
Tetrahedron Letters, 2010Co-Authors: B Subba V Reddy, Ch. Madan, Sivasankar N Reddy, J. S. YadavAbstract:Abstract A variety of alkenes undergo smooth Amidation with nitriles in the presence of HBF4·OEt2 at room temperature under mild conditions to afford the corresponding secondary amides in good to excellent yields. This is a highly efficient method for the preparation of α-aryl ethyl amides especially from vinyl arenes without any side reactions such as olefin polymerization. The use of readily available and easy to handle reagent HBF4·OEt2 makes this method simple, convenient, and practical.
B Narsaiah - One of the best experts on this subject based on the ideXlab platform.
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synthesis of novel amide functionalized 2h chromene derivatives by Ritter Amidation of primary alcohol using hbf4 oet2 as a mild and versatile reagent and evaluation of their antimicrobial and anti biofilm activities
ChemInform, 2015Co-Authors: Ratnakar K Reddy, Y Poornachandra, Jitender G Dev, G Mallareddy, Jagadeesh Babu Nanubolu, Ganesh C Kumar, B NarsaiahAbstract:Among all the tested compounds (IV), derivative (IVe) appears to be the most potent sample with respect to antimicrobial, MBC and anti bio-film activities.
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Synthesis of Novel Amide Functionalized 2H-Chromene Derivatives by Ritter Amidation of Primary Alcohol Using HBF4·OEt2 as a Mild and Versatile Reagent and Evaluation of Their Antimicrobial and anti-Biofilm Activities.
ChemInform, 2015Co-Authors: K. Ratnakar Reddy, Y Poornachandra, G Mallareddy, Jagadeesh Babu Nanubolu, G. Jitender Dev, C. Ganesh Kumar, B NarsaiahAbstract:Among all the tested compounds (IV), derivative (IVe) appears to be the most potent sample with respect to antimicrobial, MBC and anti bio-film activities.
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synthesis of novel amide functionalized 2h chromene derivatives by Ritter Amidation of primary alcohol using hbf4 oet2 as a mild and versatile reagent and evaluation of their antimicrobial and anti biofilm activities
Bioorganic & Medicinal Chemistry Letters, 2015Co-Authors: Ratnakar K Reddy, Y Poornachandra, Jitender G Dev, G Mallareddy, Jagadeesh Babu Nanubolu, Ganesh C Kumar, B NarsaiahAbstract:A series of novel amide functionalized 2H-chromene derivatives 3 were prepared starting from ethyl-2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate 1 via sodium borohydride reduction followed by Ritter Amidation using HBF4·OEt2 as a mild and versatile reagent. All the products 3 were screened for antimicrobial activity against various Gram-positive, Gram-negative bacteria and fungal strain. The promising derivatives such as 3f, 3g, 3k, 3l, 3m, 3n and 3o were further screened for minimum bactericidal concentration and bio-film inhibition activity and identified the potential ones. Among all the promising, compound 3g was more potent for antimicrobial, MBC and anti bio-film activities. The structure verses activity relationship of 3g revealed that the presence of two bromine atoms at sixth and R position promotes high activity.
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Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter Amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities.
Bioorganic & medicinal chemistry letters, 2015Co-Authors: K. Ratnakar Reddy, Y Poornachandra, G Mallareddy, Jagadeesh Babu Nanubolu, G. Jitender Dev, C. Ganesh Kumar, B NarsaiahAbstract:A series of novel amide functionalized 2H-chromene derivatives 3 were prepared starting from ethyl-2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate 1 via sodium borohydride reduction followed by Ritter Amidation using HBF4·OEt2 as a mild and versatile reagent. All the products 3 were screened for antimicrobial activity against various Gram-positive, Gram-negative bacteria and fungal strain. The promising derivatives such as 3f, 3g, 3k, 3l, 3m, 3n and 3o were further screened for minimum bactericidal concentration and bio-film inhibition activity and identified the potential ones. Among all the promising, compound 3g was more potent for antimicrobial, MBC and anti bio-film activities. The structure verses activity relationship of 3g revealed that the presence of two bromine atoms at sixth and R position promotes high activity.
B. V. Subba Reddy - One of the best experts on this subject based on the ideXlab platform.
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o-Benzenedisulfonimide as a Recyclable Homogeneous Organocatalyst for an Efficient and Facile Synthesis of 4-Amidotetrahydropyran Derivatives Through Prins–Ritter Reaction
Synthetic Communications, 2014Co-Authors: B. V. Subba Reddy, Supriya GhantyAbstract:Abstract A highly diastereoselective synthesis of 4-amidotetrahydropyran derivatives has been achieved using a catalytic amount of o-benzenedisulfonimide under mild conditions involving sequential allylation and Prins–Ritter Amidation. The oxo-carbenium ion formed in Prins cyclization could be successfully trapped with nitriles through Ritter Amidation. The catalyst is highly efficient in promoting both allylation and Prins cyclization with a net addition of nitrile. The catalyst can be easily recovered and reused in subsequent reactions.
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Stereoselective Synthesis of 2-(2-Hydroxyalkyl)piperidine Alkaloids Through Prins–Ritter Reaction
Synthetic Communications, 2014Co-Authors: B. V. Subba Reddy, Supriya Ghanty, N. Siva Senkar Reddy, Y. Jayasudhan Reddy, J. S. YadavAbstract:Abstract A stereoselective total synthesis of the 2-(2-hydroxyalkyl)piperidine alkaloids has been accomplished by a Prins–Ritter Amidation sequence. Other steps involved in this synthesis are Jacobsen's hydrolytic kinetic resolution (HRK) and ring-closing metathesis (RCM).
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The stereoselective total synthesis of (+)-8-ethylnorlobelol from anti-1,3-aminoalcohols
Tetrahedron Letters, 2013Co-Authors: B. V. Subba Reddy, Y. Jayasudhan Reddy, B. Phaneendra Reddy, P. Sivaramakrishna Reddy, J. S. YadavAbstract:Abstract A novel and efficient approach has been developed for the total synthesis of (+)-8-ethylnorlobelol ( 1 ) in a highly stereoselective manner. The key anti -1,3-aminoalcohol core is constructed through the reductive opening of 2-iodomethyl-4-amidotetrahydropyranyl ether which is prepared by a Prins/Ritter Amidation sequence.
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HBF4·OEt2 as a mild and versatile reagent for the Ritter Amidation of olefins: a facile synthesis of secondary amides
Tetrahedron Letters, 2010Co-Authors: B. V. Subba Reddy, N. Sivasankar Reddy, Ch. Madan, J. S. YadavAbstract:Abstract A variety of alkenes undergo smooth Amidation with nitriles in the presence of HBF4·OEt2 at room temperature under mild conditions to afford the corresponding secondary amides in good to excellent yields. This is a highly efficient method for the preparation of α-aryl ethyl amides especially from vinyl arenes without any side reactions such as olefin polymerization. The use of readily available and easy to handle reagent HBF4·OEt2 makes this method simple, convenient, and practical.
Y Poornachandra - One of the best experts on this subject based on the ideXlab platform.
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synthesis of novel amide functionalized 2h chromene derivatives by Ritter Amidation of primary alcohol using hbf4 oet2 as a mild and versatile reagent and evaluation of their antimicrobial and anti biofilm activities
ChemInform, 2015Co-Authors: Ratnakar K Reddy, Y Poornachandra, Jitender G Dev, G Mallareddy, Jagadeesh Babu Nanubolu, Ganesh C Kumar, B NarsaiahAbstract:Among all the tested compounds (IV), derivative (IVe) appears to be the most potent sample with respect to antimicrobial, MBC and anti bio-film activities.
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Synthesis of Novel Amide Functionalized 2H-Chromene Derivatives by Ritter Amidation of Primary Alcohol Using HBF4·OEt2 as a Mild and Versatile Reagent and Evaluation of Their Antimicrobial and anti-Biofilm Activities.
ChemInform, 2015Co-Authors: K. Ratnakar Reddy, Y Poornachandra, G Mallareddy, Jagadeesh Babu Nanubolu, G. Jitender Dev, C. Ganesh Kumar, B NarsaiahAbstract:Among all the tested compounds (IV), derivative (IVe) appears to be the most potent sample with respect to antimicrobial, MBC and anti bio-film activities.
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synthesis of novel amide functionalized 2h chromene derivatives by Ritter Amidation of primary alcohol using hbf4 oet2 as a mild and versatile reagent and evaluation of their antimicrobial and anti biofilm activities
Bioorganic & Medicinal Chemistry Letters, 2015Co-Authors: Ratnakar K Reddy, Y Poornachandra, Jitender G Dev, G Mallareddy, Jagadeesh Babu Nanubolu, Ganesh C Kumar, B NarsaiahAbstract:A series of novel amide functionalized 2H-chromene derivatives 3 were prepared starting from ethyl-2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate 1 via sodium borohydride reduction followed by Ritter Amidation using HBF4·OEt2 as a mild and versatile reagent. All the products 3 were screened for antimicrobial activity against various Gram-positive, Gram-negative bacteria and fungal strain. The promising derivatives such as 3f, 3g, 3k, 3l, 3m, 3n and 3o were further screened for minimum bactericidal concentration and bio-film inhibition activity and identified the potential ones. Among all the promising, compound 3g was more potent for antimicrobial, MBC and anti bio-film activities. The structure verses activity relationship of 3g revealed that the presence of two bromine atoms at sixth and R position promotes high activity.
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Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter Amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities.
Bioorganic & medicinal chemistry letters, 2015Co-Authors: K. Ratnakar Reddy, Y Poornachandra, G Mallareddy, Jagadeesh Babu Nanubolu, G. Jitender Dev, C. Ganesh Kumar, B NarsaiahAbstract:A series of novel amide functionalized 2H-chromene derivatives 3 were prepared starting from ethyl-2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate 1 via sodium borohydride reduction followed by Ritter Amidation using HBF4·OEt2 as a mild and versatile reagent. All the products 3 were screened for antimicrobial activity against various Gram-positive, Gram-negative bacteria and fungal strain. The promising derivatives such as 3f, 3g, 3k, 3l, 3m, 3n and 3o were further screened for minimum bactericidal concentration and bio-film inhibition activity and identified the potential ones. Among all the promising, compound 3g was more potent for antimicrobial, MBC and anti bio-film activities. The structure verses activity relationship of 3g revealed that the presence of two bromine atoms at sixth and R position promotes high activity.
G Mallareddy - One of the best experts on this subject based on the ideXlab platform.
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synthesis of novel amide functionalized 2h chromene derivatives by Ritter Amidation of primary alcohol using hbf4 oet2 as a mild and versatile reagent and evaluation of their antimicrobial and anti biofilm activities
ChemInform, 2015Co-Authors: Ratnakar K Reddy, Y Poornachandra, Jitender G Dev, G Mallareddy, Jagadeesh Babu Nanubolu, Ganesh C Kumar, B NarsaiahAbstract:Among all the tested compounds (IV), derivative (IVe) appears to be the most potent sample with respect to antimicrobial, MBC and anti bio-film activities.
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Synthesis of Novel Amide Functionalized 2H-Chromene Derivatives by Ritter Amidation of Primary Alcohol Using HBF4·OEt2 as a Mild and Versatile Reagent and Evaluation of Their Antimicrobial and anti-Biofilm Activities.
ChemInform, 2015Co-Authors: K. Ratnakar Reddy, Y Poornachandra, G Mallareddy, Jagadeesh Babu Nanubolu, G. Jitender Dev, C. Ganesh Kumar, B NarsaiahAbstract:Among all the tested compounds (IV), derivative (IVe) appears to be the most potent sample with respect to antimicrobial, MBC and anti bio-film activities.
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synthesis of novel amide functionalized 2h chromene derivatives by Ritter Amidation of primary alcohol using hbf4 oet2 as a mild and versatile reagent and evaluation of their antimicrobial and anti biofilm activities
Bioorganic & Medicinal Chemistry Letters, 2015Co-Authors: Ratnakar K Reddy, Y Poornachandra, Jitender G Dev, G Mallareddy, Jagadeesh Babu Nanubolu, Ganesh C Kumar, B NarsaiahAbstract:A series of novel amide functionalized 2H-chromene derivatives 3 were prepared starting from ethyl-2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate 1 via sodium borohydride reduction followed by Ritter Amidation using HBF4·OEt2 as a mild and versatile reagent. All the products 3 were screened for antimicrobial activity against various Gram-positive, Gram-negative bacteria and fungal strain. The promising derivatives such as 3f, 3g, 3k, 3l, 3m, 3n and 3o were further screened for minimum bactericidal concentration and bio-film inhibition activity and identified the potential ones. Among all the promising, compound 3g was more potent for antimicrobial, MBC and anti bio-film activities. The structure verses activity relationship of 3g revealed that the presence of two bromine atoms at sixth and R position promotes high activity.
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Synthesis of novel amide functionalized 2H-chromene derivatives by Ritter Amidation of primary alcohol using HBF4·OEt2 as a mild and versatile reagent and evaluation of their antimicrobial and anti-biofilm activities.
Bioorganic & medicinal chemistry letters, 2015Co-Authors: K. Ratnakar Reddy, Y Poornachandra, G Mallareddy, Jagadeesh Babu Nanubolu, G. Jitender Dev, C. Ganesh Kumar, B NarsaiahAbstract:A series of novel amide functionalized 2H-chromene derivatives 3 were prepared starting from ethyl-2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate 1 via sodium borohydride reduction followed by Ritter Amidation using HBF4·OEt2 as a mild and versatile reagent. All the products 3 were screened for antimicrobial activity against various Gram-positive, Gram-negative bacteria and fungal strain. The promising derivatives such as 3f, 3g, 3k, 3l, 3m, 3n and 3o were further screened for minimum bactericidal concentration and bio-film inhibition activity and identified the potential ones. Among all the promising, compound 3g was more potent for antimicrobial, MBC and anti bio-film activities. The structure verses activity relationship of 3g revealed that the presence of two bromine atoms at sixth and R position promotes high activity.
