The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform
Fone Kevin - One of the best experts on this subject based on the ideXlab platform.
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Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro04-6790
2018Co-Authors: Woolley Marie, Marsden Charles, Sleight Andrew, Fone KevinAbstract:Rationale: Accumulating evidence suggests a potential role for the 5-HT6 receptor in cognitive function and the potential use of 5-HT6 receptor antagonists in the treatment of learning and memory disorders. Objectives: The aim of the current study was to investigate the effect of the selective 5-HT6 receptor antagonist, Ro04-6790, on both the performance of normal adult rats and restoration of a pharmacological disruption of memory function produced by the non-selective muscarinic receptor antagonist, scopolamine, or the dopamine D2 receptor antagonist, raclopride, in a rodent model of recognition memory. Methods: Passive, perceptually based, recognition memory was assessed using a novel object discrimination task. Following habituation to an arena, rats were presented with two identical objects during trial 1 (T1) and a novel and familiar object during trial 2 (T2). The time spent exploring the two objects in each trial was measured and novel object discrimination assessed in T2. Results: In the absence of drug all rats spent an equal time exploring the two identical objects in T1 but more time exploring the novel object in T2. Scopolamine (but not N-methylscopolamine) and raclopride both produced a dose-dependent reduction in novel object discrimination whilst the 5-HT6 receptor antagonist, Ro04-6790, had no effect on discrimination when given alone but completely reversed the scopolamine- but not the raclopride-induced deficit. Conclusion: This study demonstrates that acute administration of Ro04-6790 reverses a cholinergic but not a dopaminergic deficit in a rodent model of recognition memory and provides further support for a role of the 5-HT6 receptor in the regulation of cognitive functio
Woolley Marie - One of the best experts on this subject based on the ideXlab platform.
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Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro04-6790
2018Co-Authors: Woolley Marie, Marsden Charles, Sleight Andrew, Fone KevinAbstract:Rationale: Accumulating evidence suggests a potential role for the 5-HT6 receptor in cognitive function and the potential use of 5-HT6 receptor antagonists in the treatment of learning and memory disorders. Objectives: The aim of the current study was to investigate the effect of the selective 5-HT6 receptor antagonist, Ro04-6790, on both the performance of normal adult rats and restoration of a pharmacological disruption of memory function produced by the non-selective muscarinic receptor antagonist, scopolamine, or the dopamine D2 receptor antagonist, raclopride, in a rodent model of recognition memory. Methods: Passive, perceptually based, recognition memory was assessed using a novel object discrimination task. Following habituation to an arena, rats were presented with two identical objects during trial 1 (T1) and a novel and familiar object during trial 2 (T2). The time spent exploring the two objects in each trial was measured and novel object discrimination assessed in T2. Results: In the absence of drug all rats spent an equal time exploring the two identical objects in T1 but more time exploring the novel object in T2. Scopolamine (but not N-methylscopolamine) and raclopride both produced a dose-dependent reduction in novel object discrimination whilst the 5-HT6 receptor antagonist, Ro04-6790, had no effect on discrimination when given alone but completely reversed the scopolamine- but not the raclopride-induced deficit. Conclusion: This study demonstrates that acute administration of Ro04-6790 reverses a cholinergic but not a dopaminergic deficit in a rodent model of recognition memory and provides further support for a role of the 5-HT6 receptor in the regulation of cognitive functio
Marsden Charles - One of the best experts on this subject based on the ideXlab platform.
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Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro04-6790
2018Co-Authors: Woolley Marie, Marsden Charles, Sleight Andrew, Fone KevinAbstract:Rationale: Accumulating evidence suggests a potential role for the 5-HT6 receptor in cognitive function and the potential use of 5-HT6 receptor antagonists in the treatment of learning and memory disorders. Objectives: The aim of the current study was to investigate the effect of the selective 5-HT6 receptor antagonist, Ro04-6790, on both the performance of normal adult rats and restoration of a pharmacological disruption of memory function produced by the non-selective muscarinic receptor antagonist, scopolamine, or the dopamine D2 receptor antagonist, raclopride, in a rodent model of recognition memory. Methods: Passive, perceptually based, recognition memory was assessed using a novel object discrimination task. Following habituation to an arena, rats were presented with two identical objects during trial 1 (T1) and a novel and familiar object during trial 2 (T2). The time spent exploring the two objects in each trial was measured and novel object discrimination assessed in T2. Results: In the absence of drug all rats spent an equal time exploring the two identical objects in T1 but more time exploring the novel object in T2. Scopolamine (but not N-methylscopolamine) and raclopride both produced a dose-dependent reduction in novel object discrimination whilst the 5-HT6 receptor antagonist, Ro04-6790, had no effect on discrimination when given alone but completely reversed the scopolamine- but not the raclopride-induced deficit. Conclusion: This study demonstrates that acute administration of Ro04-6790 reverses a cholinergic but not a dopaminergic deficit in a rodent model of recognition memory and provides further support for a role of the 5-HT6 receptor in the regulation of cognitive functio
Sleight Andrew - One of the best experts on this subject based on the ideXlab platform.
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Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro04-6790
2018Co-Authors: Woolley Marie, Marsden Charles, Sleight Andrew, Fone KevinAbstract:Rationale: Accumulating evidence suggests a potential role for the 5-HT6 receptor in cognitive function and the potential use of 5-HT6 receptor antagonists in the treatment of learning and memory disorders. Objectives: The aim of the current study was to investigate the effect of the selective 5-HT6 receptor antagonist, Ro04-6790, on both the performance of normal adult rats and restoration of a pharmacological disruption of memory function produced by the non-selective muscarinic receptor antagonist, scopolamine, or the dopamine D2 receptor antagonist, raclopride, in a rodent model of recognition memory. Methods: Passive, perceptually based, recognition memory was assessed using a novel object discrimination task. Following habituation to an arena, rats were presented with two identical objects during trial 1 (T1) and a novel and familiar object during trial 2 (T2). The time spent exploring the two objects in each trial was measured and novel object discrimination assessed in T2. Results: In the absence of drug all rats spent an equal time exploring the two identical objects in T1 but more time exploring the novel object in T2. Scopolamine (but not N-methylscopolamine) and raclopride both produced a dose-dependent reduction in novel object discrimination whilst the 5-HT6 receptor antagonist, Ro04-6790, had no effect on discrimination when given alone but completely reversed the scopolamine- but not the raclopride-induced deficit. Conclusion: This study demonstrates that acute administration of Ro04-6790 reverses a cholinergic but not a dopaminergic deficit in a rodent model of recognition memory and provides further support for a role of the 5-HT6 receptor in the regulation of cognitive functio
