Root Sheath

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Denis Salomon - One of the best experts on this subject based on the ideXlab platform.

  • an autologous epidermal equivalent tissue engineered from follicular outer Root Sheath keratinocytes is as effective as split thickness skin autograft in recalcitrant vascular leg ulcers
    Wound Repair and Regeneration, 2003
    Co-Authors: Anne-kathrin Tausche, Mouna Skaria, Lorenz M Böhlen, Kristin Liebold, Jürg Hafner, Helmut Friedlein, Michael Meurer, Rene J. Goedkoop, Uwe Wollina, Denis Salomon
    Abstract:

    The outer Root Sheath of hair follicles plays an important role in epidermal regeneration in vivo. Keratinocytes isolated by explantation of outer Root Sheath tissue have extensive proliferative capacity irrespective of donor age, which probably depends on pluripotent epithelial stem cells residing in the outer Root Sheath. These keratinocytes can be organotypically grown to epidermal equivalents in vitro. We report here that in a multicenter, randomized phase II study, EpiDex trade mark, a tissue-engineered, fully differentiated autologous epidermal equivalent derived from keratinocytes of the outer Root Sheath of plucked anagen hair follicles, is as effective as split-thickness skin autografting in the promotion of healing and complete closure of recalcitrant vascular leg ulcers.

  • An autologous epidermal equivalent tissue-engineered from follicular outer Root Sheath keratinocytes is as effective as split-thickness skin autograft in recalcitrant vascular leg ulcers
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2003
    Co-Authors: Anne-kathrin Tausche, Mouna Skaria, Lorenz M Böhlen, Kristin Liebold, Jürg Hafner, Helmut Friedlein, Michael Meurer, Rene J. Goedkoop, Uwe Wollina, Denis Salomon
    Abstract:

    The outer Root Sheath of hair follicles plays an important role in epidermal regeneration in vivo. Keratinocytes isolated by explantation of outer Root Sheath tissue have extensive proliferative capacity irrespective of donor age, which probably depends on pluripotent epithelial stem cells residing in the outer Root Sheath. These keratinocytes can be organotypically grown to epidermal equivalents in vitro. We report here that in a multicenter, randomized phase II study, EpiDex� , a tissue-engineered, fully differentiated autologous epidermal equivalent derived from keratinocytes of the outer Root Sheath of plucked anagen hair follicles, is as effective as split-thickness skin autografting in the promotion of healing and complete closure of recalcitrant vascular leg ulcers. (WOUND REP REG 2003;11:248–252) Chronic ulceration of the legs is a significant and costly problem in modern health care. 1 A history of leg ulceration occurs in approximately 1% of the adult population and the prevalence of venous leg ulcers ranges from 0.1 to 2%. 1

Anne-kathrin Tausche - One of the best experts on this subject based on the ideXlab platform.

  • an autologous epidermal equivalent tissue engineered from follicular outer Root Sheath keratinocytes is as effective as split thickness skin autograft in recalcitrant vascular leg ulcers
    Wound Repair and Regeneration, 2003
    Co-Authors: Anne-kathrin Tausche, Mouna Skaria, Lorenz M Böhlen, Kristin Liebold, Jürg Hafner, Helmut Friedlein, Michael Meurer, Rene J. Goedkoop, Uwe Wollina, Denis Salomon
    Abstract:

    The outer Root Sheath of hair follicles plays an important role in epidermal regeneration in vivo. Keratinocytes isolated by explantation of outer Root Sheath tissue have extensive proliferative capacity irrespective of donor age, which probably depends on pluripotent epithelial stem cells residing in the outer Root Sheath. These keratinocytes can be organotypically grown to epidermal equivalents in vitro. We report here that in a multicenter, randomized phase II study, EpiDex trade mark, a tissue-engineered, fully differentiated autologous epidermal equivalent derived from keratinocytes of the outer Root Sheath of plucked anagen hair follicles, is as effective as split-thickness skin autografting in the promotion of healing and complete closure of recalcitrant vascular leg ulcers.

  • An autologous epidermal equivalent tissue-engineered from follicular outer Root Sheath keratinocytes is as effective as split-thickness skin autograft in recalcitrant vascular leg ulcers
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2003
    Co-Authors: Anne-kathrin Tausche, Mouna Skaria, Lorenz M Böhlen, Kristin Liebold, Jürg Hafner, Helmut Friedlein, Michael Meurer, Rene J. Goedkoop, Uwe Wollina, Denis Salomon
    Abstract:

    The outer Root Sheath of hair follicles plays an important role in epidermal regeneration in vivo. Keratinocytes isolated by explantation of outer Root Sheath tissue have extensive proliferative capacity irrespective of donor age, which probably depends on pluripotent epithelial stem cells residing in the outer Root Sheath. These keratinocytes can be organotypically grown to epidermal equivalents in vitro. We report here that in a multicenter, randomized phase II study, EpiDex� , a tissue-engineered, fully differentiated autologous epidermal equivalent derived from keratinocytes of the outer Root Sheath of plucked anagen hair follicles, is as effective as split-thickness skin autografting in the promotion of healing and complete closure of recalcitrant vascular leg ulcers. (WOUND REP REG 2003;11:248–252) Chronic ulceration of the legs is a significant and costly problem in modern health care. 1 A history of leg ulceration occurs in approximately 1% of the adult population and the prevalence of venous leg ulcers ranges from 0.1 to 2%. 1

Jürg Hafner - One of the best experts on this subject based on the ideXlab platform.

  • an autologous epidermal equivalent tissue engineered from follicular outer Root Sheath keratinocytes is as effective as split thickness skin autograft in recalcitrant vascular leg ulcers
    Wound Repair and Regeneration, 2003
    Co-Authors: Anne-kathrin Tausche, Mouna Skaria, Lorenz M Böhlen, Kristin Liebold, Jürg Hafner, Helmut Friedlein, Michael Meurer, Rene J. Goedkoop, Uwe Wollina, Denis Salomon
    Abstract:

    The outer Root Sheath of hair follicles plays an important role in epidermal regeneration in vivo. Keratinocytes isolated by explantation of outer Root Sheath tissue have extensive proliferative capacity irrespective of donor age, which probably depends on pluripotent epithelial stem cells residing in the outer Root Sheath. These keratinocytes can be organotypically grown to epidermal equivalents in vitro. We report here that in a multicenter, randomized phase II study, EpiDex trade mark, a tissue-engineered, fully differentiated autologous epidermal equivalent derived from keratinocytes of the outer Root Sheath of plucked anagen hair follicles, is as effective as split-thickness skin autografting in the promotion of healing and complete closure of recalcitrant vascular leg ulcers.

  • An autologous epidermal equivalent tissue-engineered from follicular outer Root Sheath keratinocytes is as effective as split-thickness skin autograft in recalcitrant vascular leg ulcers
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2003
    Co-Authors: Anne-kathrin Tausche, Mouna Skaria, Lorenz M Böhlen, Kristin Liebold, Jürg Hafner, Helmut Friedlein, Michael Meurer, Rene J. Goedkoop, Uwe Wollina, Denis Salomon
    Abstract:

    The outer Root Sheath of hair follicles plays an important role in epidermal regeneration in vivo. Keratinocytes isolated by explantation of outer Root Sheath tissue have extensive proliferative capacity irrespective of donor age, which probably depends on pluripotent epithelial stem cells residing in the outer Root Sheath. These keratinocytes can be organotypically grown to epidermal equivalents in vitro. We report here that in a multicenter, randomized phase II study, EpiDex� , a tissue-engineered, fully differentiated autologous epidermal equivalent derived from keratinocytes of the outer Root Sheath of plucked anagen hair follicles, is as effective as split-thickness skin autografting in the promotion of healing and complete closure of recalcitrant vascular leg ulcers. (WOUND REP REG 2003;11:248–252) Chronic ulceration of the legs is a significant and costly problem in modern health care. 1 A history of leg ulceration occurs in approximately 1% of the adult population and the prevalence of venous leg ulcers ranges from 0.1 to 2%. 1

Kristin Liebold - One of the best experts on this subject based on the ideXlab platform.

  • an autologous epidermal equivalent tissue engineered from follicular outer Root Sheath keratinocytes is as effective as split thickness skin autograft in recalcitrant vascular leg ulcers
    Wound Repair and Regeneration, 2003
    Co-Authors: Anne-kathrin Tausche, Mouna Skaria, Lorenz M Böhlen, Kristin Liebold, Jürg Hafner, Helmut Friedlein, Michael Meurer, Rene J. Goedkoop, Uwe Wollina, Denis Salomon
    Abstract:

    The outer Root Sheath of hair follicles plays an important role in epidermal regeneration in vivo. Keratinocytes isolated by explantation of outer Root Sheath tissue have extensive proliferative capacity irrespective of donor age, which probably depends on pluripotent epithelial stem cells residing in the outer Root Sheath. These keratinocytes can be organotypically grown to epidermal equivalents in vitro. We report here that in a multicenter, randomized phase II study, EpiDex trade mark, a tissue-engineered, fully differentiated autologous epidermal equivalent derived from keratinocytes of the outer Root Sheath of plucked anagen hair follicles, is as effective as split-thickness skin autografting in the promotion of healing and complete closure of recalcitrant vascular leg ulcers.

  • An autologous epidermal equivalent tissue-engineered from follicular outer Root Sheath keratinocytes is as effective as split-thickness skin autograft in recalcitrant vascular leg ulcers
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2003
    Co-Authors: Anne-kathrin Tausche, Mouna Skaria, Lorenz M Böhlen, Kristin Liebold, Jürg Hafner, Helmut Friedlein, Michael Meurer, Rene J. Goedkoop, Uwe Wollina, Denis Salomon
    Abstract:

    The outer Root Sheath of hair follicles plays an important role in epidermal regeneration in vivo. Keratinocytes isolated by explantation of outer Root Sheath tissue have extensive proliferative capacity irrespective of donor age, which probably depends on pluripotent epithelial stem cells residing in the outer Root Sheath. These keratinocytes can be organotypically grown to epidermal equivalents in vitro. We report here that in a multicenter, randomized phase II study, EpiDex� , a tissue-engineered, fully differentiated autologous epidermal equivalent derived from keratinocytes of the outer Root Sheath of plucked anagen hair follicles, is as effective as split-thickness skin autografting in the promotion of healing and complete closure of recalcitrant vascular leg ulcers. (WOUND REP REG 2003;11:248–252) Chronic ulceration of the legs is a significant and costly problem in modern health care. 1 A history of leg ulceration occurs in approximately 1% of the adult population and the prevalence of venous leg ulcers ranges from 0.1 to 2%. 1

Mouna Skaria - One of the best experts on this subject based on the ideXlab platform.

  • an autologous epidermal equivalent tissue engineered from follicular outer Root Sheath keratinocytes is as effective as split thickness skin autograft in recalcitrant vascular leg ulcers
    Wound Repair and Regeneration, 2003
    Co-Authors: Anne-kathrin Tausche, Mouna Skaria, Lorenz M Böhlen, Kristin Liebold, Jürg Hafner, Helmut Friedlein, Michael Meurer, Rene J. Goedkoop, Uwe Wollina, Denis Salomon
    Abstract:

    The outer Root Sheath of hair follicles plays an important role in epidermal regeneration in vivo. Keratinocytes isolated by explantation of outer Root Sheath tissue have extensive proliferative capacity irrespective of donor age, which probably depends on pluripotent epithelial stem cells residing in the outer Root Sheath. These keratinocytes can be organotypically grown to epidermal equivalents in vitro. We report here that in a multicenter, randomized phase II study, EpiDex trade mark, a tissue-engineered, fully differentiated autologous epidermal equivalent derived from keratinocytes of the outer Root Sheath of plucked anagen hair follicles, is as effective as split-thickness skin autografting in the promotion of healing and complete closure of recalcitrant vascular leg ulcers.

  • An autologous epidermal equivalent tissue-engineered from follicular outer Root Sheath keratinocytes is as effective as split-thickness skin autograft in recalcitrant vascular leg ulcers
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2003
    Co-Authors: Anne-kathrin Tausche, Mouna Skaria, Lorenz M Böhlen, Kristin Liebold, Jürg Hafner, Helmut Friedlein, Michael Meurer, Rene J. Goedkoop, Uwe Wollina, Denis Salomon
    Abstract:

    The outer Root Sheath of hair follicles plays an important role in epidermal regeneration in vivo. Keratinocytes isolated by explantation of outer Root Sheath tissue have extensive proliferative capacity irrespective of donor age, which probably depends on pluripotent epithelial stem cells residing in the outer Root Sheath. These keratinocytes can be organotypically grown to epidermal equivalents in vitro. We report here that in a multicenter, randomized phase II study, EpiDex� , a tissue-engineered, fully differentiated autologous epidermal equivalent derived from keratinocytes of the outer Root Sheath of plucked anagen hair follicles, is as effective as split-thickness skin autografting in the promotion of healing and complete closure of recalcitrant vascular leg ulcers. (WOUND REP REG 2003;11:248–252) Chronic ulceration of the legs is a significant and costly problem in modern health care. 1 A history of leg ulceration occurs in approximately 1% of the adult population and the prevalence of venous leg ulcers ranges from 0.1 to 2%. 1