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Gang Zhao - One of the best experts on this subject based on the ideXlab platform.
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determination of the volatile and polyphenol constituents and the antimicrobial antioxidant and tyrosinase inhibitory activities of the bioactive compounds from the by product of Rosa Rugosa thunb var plena regal tea
BMC Complementary and Alternative Medicine, 2018Co-Authors: Guixing Ren, Peng Xue, Xiaoyan Sun, Gang ZhaoAbstract:The phytochemical constituents and biological activities of Rosa Rugosa Thunb. var. plena Regal flower cell sap (RFCS) were investigated. Volatile constituent, such as linalool, phenylethyl alcohol, citronellol, α-bisabolol, were identified by GC-MS. The contents of hyperoside, kaempferol-3-O-rutinosid, rutin, and luteolin as well as the total flavonoid content in RFCS were determined by HPLC and HPLC-MS. The total polyphenol content was evaluated by the Folin-Ciocalteu colorimetric method. The antioxidant activities of RFCS and the standards were evaluated by DPPH and ABTS radical scavenging assays. The tyrosinase inhibitory activities of the rose samples and standard substance were determined by a spectrophotometric method. The antimicrobial effects of RFCS were evaluated in terms of minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) or minimum Fungicidal concentrations (MFCs). The rose fraction exhibited a high content of biologically active ingredients. The total content of volatile compounds in RFCS was approximately 48.21 ± 2.76 ng/mL. The total phenolic acid content and total flavonoid content were 0.31 ± 0.01 mg/mL and 0.43 ± 0.01 mg/mL, respectively. Its IC50 value in the DPPH assay was 1120 ± 42 μg/mL, and its IC50 value for ABTS radical scavenging activity was 1430 ± 42 μg/mL.RFCS strongly inhibited L-tyrosine oxidation with an IC50 value of 570 ± 21 μg/mL. Every compound identified in RFCS exhibited broad-spectrum antimicrobial activity. F. nucleatum was most susceptible to RFCS with an MIC of 64 μg/mL and MBC of 250 μg/mL. Due to its rose-like aroma, phenylethyl alcohol may be combined with linalool for use as a natural skin-whitening agent and skin care additive in the and pharmaceutical industries.
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Determination of the volatile and polyphenol constituents and the antimicrobial, antioxidant, and tyrosinase inhibitory activities of the bioactive compounds from the by-product of Rosa Rugosa Thunb. var. plena Regal tea
BMC, 2018Co-Authors: Guixing Ren, Peng Xue, Xiaoyan Sun, Gang ZhaoAbstract:Abstract Background The phytochemical constituents and biological activities of Rosa Rugosa Thunb. var. plena Regal flower cell sap (RFCS) were investigated. Methods Volatile constituent, such as linalool, phenylethyl alcohol, citronellol, α-bisabolol, were identified by GC-MS. The contents of hyperoside, kaempferol-3-O-rutinosid, rutin, and luteolin as well as the total flavonoid content in RFCS were determined by HPLC and HPLC-MS. The total polyphenol content was evaluated by the Folin-Ciocalteu colorimetric method. The antioxidant activities of RFCS and the standards were evaluated by DPPH and ABTS radical scavenging assays. The tyrosinase inhibitory activities of the rose samples and standard substance were determined by a spectrophotometric method. The antimicrobial effects of RFCS were evaluated in terms of minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) or minimum Fungicidal concentrations (MFCs). Results The rose fraction exhibited a high content of biologically active ingredients. The total content of volatile compounds in RFCS was approximately 48.21 ± 2.76 ng/mL. The total phenolic acid content and total flavonoid content were 0.31 ± 0.01 mg/mL and 0.43 ± 0.01 mg/mL, respectively. Its IC50 value in the DPPH assay was 1120 ± 42 μg/mL, and its IC50 value for ABTS radical scavenging activity was 1430 ± 42 μg/mL.RFCS strongly inhibited L-tyrosine oxidation with an IC50 value of 570 ± 21 μg/mL. Every compound identified in RFCS exhibited broad-spectrum antimicrobial activity. F. nucleatum was most susceptible to RFCS with an MIC of 64 μg/mL and MBC of 250 μg/mL. Conclusions Due to its rose-like aroma, phenylethyl alcohol may be combined with linalool for use as a natural skin-whitening agent and skin care additive in the and pharmaceutical industries
Nguyen Phuong Thao - One of the best experts on this subject based on the ideXlab platform.
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Triterpenoid saponins from the roots of Rosa Rugosa Thunb. as rat intestinal sucrase inhibitors
Archives of Pharmacal Research, 2014Co-Authors: Nguyen Phuong Thao, Bui Thi Thuy Luyen, Nguyen Xuan Cuong, Nguyen Hoai Nam, Young In Kwon, Tran Manh Hung, Chau Van Minh, Young Ho KimAbstract:Medicinal plants constitute an important source of potential therapeutic agents for diabetes. The purpose of present study is to investigate the effect of root extract of Rosa Rugosa Thunb. on inhibition of sucrase related to diabetes mellitus (DM). Bioassay-guided fractionation of the methanol extract led to the identification of 13 triterpenoid saponins ( 1 – 13 ). Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D, 2D NMR, and MS. The n -butanol fraction showed potent rat intestinal sucrase inhibitory activity with value of 87.62 ± 5.84 % inhibition compared to the positive control acarbose (50.96 ± 2.97 % inhibition at 0.02 mM). Subsequently, compounds 11 – 13 (1.0 mM) exhibited significant sucrase inhibitory activity, with inhibition percentage values of 41.17 ± 3.52, 46.80 ± 4.00, and 39.39 ± 4.19 %, respectively. Whereas, compounds 2 – 6 , 8 , and 10 showed moderate sucrase inhibitory activity (ranging from 13.26 ± 7.00 to 32.08 ± 6.04 % inhibition) at a same concentration. The data provide a starting point for creating new sucrase inhibitors, which may be useful for the development of effective therapies for the treatment of DM.
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rat intestinal sucrase inhibition of constituents from the roots of Rosa Rugosa thunb
Bioorganic & Medicinal Chemistry Letters, 2014Co-Authors: Nguyen Phuong Thao, Bui Thi Thuy Luyen, Bui Huu Tai, Seo Young Yang, Nguyen Xuan Cuong, Nguyen Hoai Nam, Young In Kwon, Chau Van MinhAbstract:A new octanordammarane triterpene, 3β,15α-dihydroxymansumbinol (1) and a novel A-ring contracted oleanane triterpenoid, 2-formyl-(A)1-19α-hydroxy-1-norolean-2,12-dien-28-oic acid (2) were isolated from the roots extract of Rosa Rugosa along with fifteen known compounds (3-17). Their structures were elucidated by extensive spectroscopic analysis, including 1D and 2D NMR, and FTICRMS. The MeOH extract, as well as CH2Cl2 and EtOAc fractions at a concentration of 0.5mg/mL showed potent sucrase inhibitory activity, with inhibition percentage values of 84.67±5.37%, 87.50±2.78%, and 81.91±2.90%, respectively. In addition, compounds 7-13 (1.0 mM) showed potent sucrase inhibitory activity (61.88±3.19% to 84.70±3.07% inhibition), which was comparable to that of the positive control, acarbose, with an inhibition percentage value of 50.96±2.97%. Compounds 1, 2, 4, and 14-17 showed moderate and/or weak inhibitory activities at the same concentration. The α-glucosidase inhibitory activities of the extracts and purified compounds may provide a novel opportunity to develop a new class of antidiabetic agents.
Hans Henrik Bruun - One of the best experts on this subject based on the ideXlab platform.
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multiple introductions and no loss of genetic diversity invasion history of japanese rose Rosa Rugosa in europe
Biological Invasions, 2013Co-Authors: Andreas Kelager, Jes S Pedersen, Hans Henrik BruunAbstract:The shrub Rosa Rugosa (Japanese Rose), native to East Asia, is considered one of the most troublesome invasive plant species in natural or semi- natural habitats of northern Europe and has proven very difficult to control. We aimed at disentangling the species' invasion history in Europe, including deter- mining the number of introductions and their geo- graphic origin, and at investigating whether populations in the introduced and native ranges differ in genetic diversity, structure and degree of differentiation. We found that introduced (n = 16) and native (n = 16) populations had similar levels of genetic diversity at seven nuclear SSR (micRosatellite) loci. European populations lack isolation by distance and are less genetically differentiated than are populations in East Asia. Multiple and at least three independent coloniza- tion events, one of which was particularly successful, gave rise to current R. Rugosa populations in Europe. The geographic distribution patterns of these three genetic clusters could not be explained by natural dispersal alone, indicating that human mediated sec- ondary dispersal is driving the expansion in Europe. One cluster representing three of the European popu- lations was most likely derived from NW Japan, whereas the origin of the remaining thirteen populations could not clearly be resolved. The introduction and expansion in Europe occurred with no significant loss of genetic diversity. We conclude that high propagule pressure at the primary establishment phase is the most parsimonious explanation for this pattern. A potential for long distance seed dispersal, coastal habitat con- nectivity and an outcrossing breeding system are factors likely to have enabled populations of R. Rugosa to avoid detrimental effects of genetic bottlenecks and will further increase the species' range size and abundance in Europe. We recommend that human-mediated dis- persal should be prevented in order to halt the continued expansion.
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limiting factors for seedling emergence and establishment of the invasive non native Rosa Rugosa in a coastal dune system
Biological Invasions, 2006Co-Authors: Johannes Kollmann, Lise Frederiksen, Peter Vestergaard, Hans Henrik BruunAbstract:The relative importance of seed, habitat and microhabitat limitation has rarely been investigated for invasive non-native species, although this is critical for their effective management and for predicting future range expansion. Rosa Rugosa is an abundant non-native shrub in coastal habitats of NW Europe; it is common along the Baltic coast but more scarce in exposed dunes of the North Sea. To investigate whether invasion of exposed dunes is limited by seed, habitat and microhabitat limitation, seedling emergence and establishment were examined in a factorial sowing, transplant and disturbance experiment. Twenty plots were randomly placed in each of five dune habitats (white dune, Empetrum dune, grey dune, outer dune heath, inner dune heath), and studied over 2 years. Seedling emergence in control subplots was zero in all habitats, whereas 96% and 98% of the undisturbed and disturbed seeded subplots produced seedlings. Disturbance had a positive effect on emergence and subsequent survival in white dune, outer and inner dune heath. Seedling survival and growth, and growth of transplanted seedlings, were markedly lower in grey dune. These findings indicate that establishment of R. Rugosa is seed-limited in coastal dune habitats, and that the species is able to establish in both active and fixed dunes once seeds have arrived. Although differential seedling emergence and growth indicate that habitats differ in their degree of invasion susceptibility by R. Rugosa, the positive influence of small-scale disturbance suggests microhabitat limitation in some dune habitats as well. Dune management should aim to reduce seed production and dispersal of R. Rugosa in near-natural sites, and anthropogenic changes of habitat dynamics should be prevented.
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Prospects for Biocontrol of Invasive Rosa Rugosa
BioControl, 2006Co-Authors: Hans Henrik BruunAbstract:The biota of herbivorous arthropods and pathogenic microorganisms associated with Rosa Rugosa in its native and exotic ranges is reviewed. This is done as an initial step towards the identification of potential agents for biological control of this plant species invasive in Europe and North America. It is shown that more insect (but apparently not fungal) species attack R. Rugosa in its native range than in its exotic range, and that most of the specialized insect and fungal enemies are confined to its native range. Among the close relatives of R. Rugosa in its exotic ranges are many native species, as well as economically important crop plants. Few organisms appear to be narrowly specialized to R. Rugosa , but true host specificity can only be identified through experimental testing. Based on the literature, the most promising candidates for biocontrol seem to be the aphids Myzus japonensis and Amphorophora amurensis , the leaf hopper Empoasca ussurica , the tortricid moth Notocelia longispina , the cynipid gall-wasp Diplolepis fukudae , and the rust fungi Phragmidium Rosae-Rugosae and P. yezoense . A screening programme is suggested, investigating the impact of these organisms on R. Rugosa performance, their host specificity and the risk of undesired indirect effects in the ecosystem where agents are released. In addition, demographic studies of the target plant should be integrated to provide guidance for the stage in the life cycle most sensitive to control and, thus, enable selection of the most efficient and safe biocontrol agents.
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Rosa Rugosa thunb ex murray
Journal of Ecology, 2005Co-Authors: Hans Henrik BruunAbstract:Rosaceae, Rosoideae, Rosa L.; subgenus EuRosa Focke; section Cinnamomeae (DC.) Rehder. Japanese Rose. Rhizomatous multi-stemmed erect deciduous shrub, strongly suckering, mature clones forming impenetrable thickets. Rhizomes woody, with orange-brown cortex and triangulate scale leaves. Rhizome branches and suckers emerge from axillary buds subtended by scale leaves. In addition, suckers may arise from buds on the roots. Stems erect, sometimes arching, to 1.5( − 2) m, often much branched, tomentose when young, densely prickly. Cortex light yellowish brown. Prickles subulate, slender and straight, of all sizes down to acicles. Larger prickles tomentose, at least near the base, and usually glabrous in the apical part. Leaves alternate with (5–)7–9 leaflets contiguous on the rachis. Leaflets nearly equally sized, 2–5 × 1.5–3 cm, leathery and robust, widely elliptical, acute, with broadly cuneate or rounded base. Adaxial side dark green, conspicuously bullate or rugose, rather shiny. Abaxial side green-grey, tomentose to pubescent, with sessile pale glands, and with reticulate nervation. Leaf margin bluntly and simply crenate-serrate, involute, edge of teeth often deflexed. Petiole and rachis densely pubescent, and with many unequal subulate prickles. Stipules pale green, densely pubescent, 2.5 × 1–1.5 cm, divergent, the free part broadly ovate or deltoid. Flowers usually solitary or few together, 6–9 cm across, fragrant, nectarless. Sepals 2–3 cm, entire, with a broad, expanded tip, appressedly pubescent, aciculate and glandular (sometimes with stipitate glands), erect on the hip, persistent. Petals five, bright purplish-pink, sometimes white ( R. Rugosa f. alba (Ware) Rehder). Stamens 200– 250 per flower, and styles often more than hundred. Styles pilose; stigmas in a large, domed head, sunk in the narrow, concave disc; disc 2.5–4 mm across; orifice large, at least half the diameter of the disc. A hypanthium (hip) encloses the achenes. It is depressed globose, 1.5–2 cm long and 2–2.5 cm wide, with a distinct neck below the sepals, dull green to orange when unripe, becoming glossy and brilliant red when ripe, most often smooth. Pedicel of the same length as the hip, tomentose, often with gland-tipped acicles, erect in flower, curved in fruit so that the hip points downwards. Achenes with a woody-bony pericarp enclosing the seed. Achenes broadly ovoid, obtusely angular, 4.0–6.0 mm long and 2.0–2.6 mm wide and 1.8–2.2 mm thick, with a distinct suture on both ventral and dorsal sides, hilum basal. Achene surface more or less lustrous, orange-brown. Mean seed (achene) mass is 6.6 mg. The albumen is oily. No subspecies of R. Rugosa have been recognized in the British Isles. Despite the many cultivated varieties of the species, mainly forms close to the wild type are seen naturalized. However, naturalized clones may be confused with R. × hollandica (syn. R. × kamtchatica ). This taxon differs morphologically from R. Rugosa by having soft-textured, dull leaflets, without prominent veins, less prickly stems, conspicuously glandular sepals, and smaller flowers and hips (Rutherford 1990). Taxonomic position: Rosa L., subgenus EuRosa Focke (syn. subgen. Rosa ), section Cinnamomeae (DC) Rehder (syn. sect. Rosa ; sect. Cassiorhodon Dumort.). Section Cinnamomeae is central in the subgenus EuRosa , which contains all but four of the approximately 150 Rosa species in the world. The diploid species of this section, including R. Rugosa , are probably basal in the reticulate evolutionary series from diploid species to irregular polyploid species within this genus (Erlanson 1938; Grossi et al . 1998). Originally introduced as a garden and landscape ornamental, and widely used as rootstock for other cultivated roses, R. Rugosa can be found in many different cultivated settings. Now a well-established naturalized alien occurring scattered throughout Britain and invasive in fixed dunes and other coastal habitats.
Guixing Ren - One of the best experts on this subject based on the ideXlab platform.
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determination of the volatile and polyphenol constituents and the antimicrobial antioxidant and tyrosinase inhibitory activities of the bioactive compounds from the by product of Rosa Rugosa thunb var plena regal tea
BMC Complementary and Alternative Medicine, 2018Co-Authors: Guixing Ren, Peng Xue, Xiaoyan Sun, Gang ZhaoAbstract:The phytochemical constituents and biological activities of Rosa Rugosa Thunb. var. plena Regal flower cell sap (RFCS) were investigated. Volatile constituent, such as linalool, phenylethyl alcohol, citronellol, α-bisabolol, were identified by GC-MS. The contents of hyperoside, kaempferol-3-O-rutinosid, rutin, and luteolin as well as the total flavonoid content in RFCS were determined by HPLC and HPLC-MS. The total polyphenol content was evaluated by the Folin-Ciocalteu colorimetric method. The antioxidant activities of RFCS and the standards were evaluated by DPPH and ABTS radical scavenging assays. The tyrosinase inhibitory activities of the rose samples and standard substance were determined by a spectrophotometric method. The antimicrobial effects of RFCS were evaluated in terms of minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) or minimum Fungicidal concentrations (MFCs). The rose fraction exhibited a high content of biologically active ingredients. The total content of volatile compounds in RFCS was approximately 48.21 ± 2.76 ng/mL. The total phenolic acid content and total flavonoid content were 0.31 ± 0.01 mg/mL and 0.43 ± 0.01 mg/mL, respectively. Its IC50 value in the DPPH assay was 1120 ± 42 μg/mL, and its IC50 value for ABTS radical scavenging activity was 1430 ± 42 μg/mL.RFCS strongly inhibited L-tyrosine oxidation with an IC50 value of 570 ± 21 μg/mL. Every compound identified in RFCS exhibited broad-spectrum antimicrobial activity. F. nucleatum was most susceptible to RFCS with an MIC of 64 μg/mL and MBC of 250 μg/mL. Due to its rose-like aroma, phenylethyl alcohol may be combined with linalool for use as a natural skin-whitening agent and skin care additive in the and pharmaceutical industries.
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Determination of the volatile and polyphenol constituents and the antimicrobial, antioxidant, and tyrosinase inhibitory activities of the bioactive compounds from the by-product of Rosa Rugosa Thunb. var. plena Regal tea
BMC, 2018Co-Authors: Guixing Ren, Peng Xue, Xiaoyan Sun, Gang ZhaoAbstract:Abstract Background The phytochemical constituents and biological activities of Rosa Rugosa Thunb. var. plena Regal flower cell sap (RFCS) were investigated. Methods Volatile constituent, such as linalool, phenylethyl alcohol, citronellol, α-bisabolol, were identified by GC-MS. The contents of hyperoside, kaempferol-3-O-rutinosid, rutin, and luteolin as well as the total flavonoid content in RFCS were determined by HPLC and HPLC-MS. The total polyphenol content was evaluated by the Folin-Ciocalteu colorimetric method. The antioxidant activities of RFCS and the standards were evaluated by DPPH and ABTS radical scavenging assays. The tyrosinase inhibitory activities of the rose samples and standard substance were determined by a spectrophotometric method. The antimicrobial effects of RFCS were evaluated in terms of minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) or minimum Fungicidal concentrations (MFCs). Results The rose fraction exhibited a high content of biologically active ingredients. The total content of volatile compounds in RFCS was approximately 48.21 ± 2.76 ng/mL. The total phenolic acid content and total flavonoid content were 0.31 ± 0.01 mg/mL and 0.43 ± 0.01 mg/mL, respectively. Its IC50 value in the DPPH assay was 1120 ± 42 μg/mL, and its IC50 value for ABTS radical scavenging activity was 1430 ± 42 μg/mL.RFCS strongly inhibited L-tyrosine oxidation with an IC50 value of 570 ± 21 μg/mL. Every compound identified in RFCS exhibited broad-spectrum antimicrobial activity. F. nucleatum was most susceptible to RFCS with an MIC of 64 μg/mL and MBC of 250 μg/mL. Conclusions Due to its rose-like aroma, phenylethyl alcohol may be combined with linalool for use as a natural skin-whitening agent and skin care additive in the and pharmaceutical industries
Wenqing Zhang - One of the best experts on this subject based on the ideXlab platform.
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structure characteristics hypoglycemic and immunomodulatory activities of pectic polysaccharides from Rosa setate x Rosa Rugosa waste
Carbohydrate Polymers, 2021Co-Authors: Yilin Zhang, Lei Shi, Wei Xia, Wenqing ZhangAbstract:In this study, two polysaccharide components named WSRP-2a and WSRP-2b, were purified from Rosa setate x Rosa Rugosa waste via anion exchange and gel filtration chromatography. Monosaccharide composition, Congo red assay, FT-IR and NMR spectra analysis confirmed that both of these fractions were mainly composed of galacturonic acid, arabinose, galactose and rhamnose, which were pectin-type polysaccharides with non-triple-helix structure. WSRP-2a and WSRP-2b, however, differed in molecular weight of 56.8 kD and 23.9 kD. The followed bioassay presented their impressive hypoglycemic and immunomodulatory activities. WSRP-2a promoted more proliferation, NO release, and the secretion of cytokines in RAW264.7 macrophages, while WSRP-2b presented higher α-amylase and α-glucosidase inhibitory activities. Collectively, these results suggested that the Rosa Setate x Rosa Rugosa waste biomass could be used as a promising source of bioactive pectic polysaccharides.
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structural elucidation and immunomodulatory activity of a neutral polysaccharide from the kushui rose Rosa setate x Rosa Rugosa waste
Carbohydrate Polymers, 2020Co-Authors: Huafeng Feng, Wei Xia, Jinxing Song, Linxiao Chen, Wenqing ZhangAbstract:Abstract In this present study, the structure and immunomodulatory activity of a novel polysaccharide (WSRP-1b) from Kushui rose (Rosa setate x Rosa Rugosa) waste were investigated. Structure characterization demonstrated that WSRP-1b had a weight-average molecular weight of 1.11 × 104 Da and consisted of glucose (42.6 %), mannose (21.4 %), arabinose (9.9 %), xylose (2.2 %), and galactose (23.9 %). Its backbone was composed of 1, 4-linked α-Glcp, 1, 4-linked β-Glcp, and 1, 4-linked β-Manp, with branches of 1, 4-linked α-Glcp and 1, 4-linked β-Manp substituted at C-6 by 1, 6-linked β-Galp. The branches mainly contained 1, 5-linked Araf, terminal arabinose and terminal glucose. Bioactivity assays showed that WSRP-1b had immunomodulatory activity by enhancing phagocytosis of macrophages, increasing production of ROS, NO, cytokines (IL-6, TNF-α), and activating NF-κB signaling pathway. These results suggested that it could be developed as a potential and safe immunomodulatory agent in fields of pharmacological or functional foods.
