The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Pullaiah Kattanguru - One of the best experts on this subject based on the ideXlab platform.
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Total synthesis of (8S,11R,12R)- and (8R,11R,12R)-topsentolide B2 diastereomers and assignment of the absolute configuration
Tetrahedron-asymmetry, 2011Co-Authors: Rodney A. Fernandes, Pullaiah KattanguruAbstract:Abstract An improved total synthesis of (8 S ,11 R ,12 R )- and (8 R ,11 R ,12 R )-topsentolide B 2 diastereomers has been completed in eight steps with overall yields of 10.2% and 10.4%, respectively. The key steps involve a regioselective asymmetric dihydroxylation, diastereoselective Roush Allylation, and ring closing metathesis. The stereochemistry of natural topsentolide B 2 has been determined to be (8 S ,11 R ,12 R ) by comparison of the specific rotation.
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Total synthesis of topsentolide B2
Tetrahedron Letters, 2011Co-Authors: Rodney A. Fernandes, Pullaiah KattanguruAbstract:Abstract A stereoselective total synthesis of topsentolide B2, a selective cytotoxic oxylipin against SK-OV-3 and SK-MEL-2 cancer cell lines has been achieved based on asymmetric dihydroxylation, Roush Allylation, and ring closing metathesis (RCM) reactions. The synthesis is completed in 11 steps and 2.1% overall yield.
Rodney A. Fernandes - One of the best experts on this subject based on the ideXlab platform.
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Total synthesis of (8S,11R,12R)- and (8R,11R,12R)-topsentolide B2 diastereomers and assignment of the absolute configuration
Tetrahedron-asymmetry, 2011Co-Authors: Rodney A. Fernandes, Pullaiah KattanguruAbstract:Abstract An improved total synthesis of (8 S ,11 R ,12 R )- and (8 R ,11 R ,12 R )-topsentolide B 2 diastereomers has been completed in eight steps with overall yields of 10.2% and 10.4%, respectively. The key steps involve a regioselective asymmetric dihydroxylation, diastereoselective Roush Allylation, and ring closing metathesis. The stereochemistry of natural topsentolide B 2 has been determined to be (8 S ,11 R ,12 R ) by comparison of the specific rotation.
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Total synthesis of topsentolide B2
Tetrahedron Letters, 2011Co-Authors: Rodney A. Fernandes, Pullaiah KattanguruAbstract:Abstract A stereoselective total synthesis of topsentolide B2, a selective cytotoxic oxylipin against SK-OV-3 and SK-MEL-2 cancer cell lines has been achieved based on asymmetric dihydroxylation, Roush Allylation, and ring closing metathesis (RCM) reactions. The synthesis is completed in 11 steps and 2.1% overall yield.
Kattanguru P - One of the best experts on this subject based on the ideXlab platform.
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Total synthesis of topsentolide B(2)
'Elsevier BV', 2011Co-Authors: Ra Fernandes, Kattanguru PAbstract:A stereoselective total synthesis of topsentolide B(2), a selective cytotoxic oxylipin against SK-OV-3 and SK-MEL-2 cancer cell lines has been achieved based on asymmetric dihydroxylation, Roush Allylation, and ring closing metathesis (RCM) reactions. The synthesis is completed in 11 steps and 2.1% overall yield. (C) 2011 Elsevier Ltd. All rights reserved
Ra Fernandes - One of the best experts on this subject based on the ideXlab platform.
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Total synthesis of topsentolide B(2)
'Elsevier BV', 2011Co-Authors: Ra Fernandes, Kattanguru PAbstract:A stereoselective total synthesis of topsentolide B(2), a selective cytotoxic oxylipin against SK-OV-3 and SK-MEL-2 cancer cell lines has been achieved based on asymmetric dihydroxylation, Roush Allylation, and ring closing metathesis (RCM) reactions. The synthesis is completed in 11 steps and 2.1% overall yield. (C) 2011 Elsevier Ltd. All rights reserved
