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Ivan Kreft - One of the best experts on this subject based on the ideXlab platform.
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The temperature threshold for the transformation of Rutin to quercetin in Tartary buckwheat dough
Food Chemistry, 2019Co-Authors: Mateja Germ, Aleksandra Golob, Zlata Luthar, Alena Vollmannova, Tomas Toth, Július Árvay, Ivan KreftAbstract:Abstract The aim was to determine conditions under which Rutin can be retained during production of Tartary buckwheat (Fagopyrum tataricum) dough. Tartary buckwheat flour was hydrothermally treated by mixing with water at 25, 40, 60, 80 and 95 °C, with unprocessed Tartary buckwheat flour as control. With hydrothermal treatments at 25, 40 and 60 °C, most of the Rutin was transformed to quercetin. However, for hydrothermal treatments at 80 and 95 °C, Rutin was retained due to denaturation of the Rutin-degrading enzymes during hydrothermal treatment. This is the first report to describe a temperature threshold for denaturation of Rutin-degrading enzymes in any buckwheat material. Tartary buckwheat dough produced at 95 °C contained 12 mg Rutin/g dry matter. Based on these characteristics, dough from hydrothermally treated Tartary buckwheat is a promising, Rutin-rich functional food material.
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Rutin content in buckwheat fagopyrum esculentum moench food materials and products
Food Chemistry, 2006Co-Authors: Ivan Kreft, N Fabjan, K YasumotoAbstract:Abstract The Rutin content of buckwheat products was compared to the Rutin content in their raw materials, in order to evaluate their value for producing functional foods. There is much less Rutin in noodles (78 mg/kg, d.w.b. – dry weight basis), than in the dark buckwheat flour (218 mg/kg, d.w.b.) from which they are produced. One of the possible explanations is the presence of the Rutin degrading enzyme. In raw (uncooked) groats there is 230 mg/kg (d.w.b.) of Rutin and in precooked groats, 88 mg/kg (d.w.b.). In buckwheat beer and vinegar there is a negligible content of Rutin. Buckwheat leaf flour contains about 2700 mg/kg (d.w.b.) Rutin, and is thus a suitable material for enriching functional foods, giving it the potential for preventive nutrition.
Yuji Mukasa - One of the best experts on this subject based on the ideXlab platform.
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effects of uv b radiation cold and desiccation stress on Rutin concentration and Rutin glucosidase activity in tartary buckwheat fagopyrum tataricum leaves
Plant Science, 2005Co-Authors: Tatsuro Suzuki, Yutaka Honda, Yuji MukasaAbstract:Abstract To study the physiological role of flavonoids in tartary buckwheat (Fagopyrum tataricum) leaf, we focused on Rutin and Rutin glucosidase activity. First, we investigated the Rutin concentration and Rutin glucosidase activity in leaves from different positions of tartary buckwheat. The Rutin concentration by dry weight was high in young leaves (more than 20% in unexpanded young leaves) and decreased along with the decrease of leaf position. Rutin glucosidase activity by dry weight was also high in young leaves and decreased along with the decrease of leaf position. Most Rutin and Rutin glucosidase activities were distributed in the epidermis. To obtain further information about the physiological role of Rutin, tartary buckwheat leaf was treated with stress using UV-B radiation, cold and desiccation. The Rutin concentration was increased 122% by UV-B radiation and 129% by desiccation treatment. On the other hand, Rutin glucosidase activity was increased 363% by UV-B radiation, 190% by cold treatment and 158% by desiccation treatment over the control. From these results, we propose that Rutin and Rutin glucosidase activity may be related to enhancement of the defense system against stress conditions in tartary buckwheat leaf.
Cornelia M Keck - One of the best experts on this subject based on the ideXlab platform.
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Kinetic solubility and dissolution velocity of Rutin nanocrystals.
European Journal of Pharmaceutical Sciences, 2008Co-Authors: Rachmat Mauludin, Rainer H Müller, Cornelia M KeckAbstract:Lyophilized Rutin nanocrystals were intensively evaluated regarding their physicochemical properties with respect to particle size analyses, crystallinity, kinetic solubility and dissolution behavior. The particle size was determined by photon correlation spectroscopy (PCS) and laser diffraction (LD). DSC and X-ray diffraction were used to study the crystalline state of Rutin nanocrystals. In a period of 1 week, the kinetic solubility was determined using a shaker at 25 °C. DSC and X-ray diffraction analyses showed that lyophilized Rutin nanocrystals prepared by high pressure homogenization remained in crystalline state. Lyophilized Rutin nanocrystals could be re-dispersed completely in water and the kinetic solubility in water increased to 133 μg/ml.. Lyophilized Rutin nanocrystals were almost completely dissolved within 15 min in water, buffer of pH 1.2 and buffer of pH 6.8. In contrast, only 70% of Rutin raw material (Rutin microcrystals) was dissolved within 15 min. The superior physicochemical properties of Rutin nanocrystals should overcome the absorption problem in the gastrointestinal tract and increase the bioavailability.
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Kinetic solubility and dissolution velocity of Rutin nanocrystals.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2008Co-Authors: Rachmat Mauludin, Rainer H Müller, Cornelia M KeckAbstract:Lyophilized Rutin nanocrystals were intensively evaluated regarding their physicochemical properties with respect to particle size analyses, crystallinity, kinetic solubility and dissolution behavior. The particle size was determined by photon correlation spectroscopy (PCS) and laser diffraction (LD). DSC and X-ray diffraction were used to study the crystalline state of Rutin nanocrystals. In a period of 1 week, the kinetic solubility was determined using a shaker at 25 degrees C. DSC and X-ray diffraction analyses showed that lyophilized Rutin nanocrystals prepared by high pressure homogenization remained in crystalline state. Lyophilized Rutin nanocrystals could be re-dispersed completely in water and the kinetic solubility in water increased to 133 microg/ml.. Lyophilized Rutin nanocrystals were almost completely dissolved within 15 min in water, buffer of pH 1.2 and buffer of pH 6.8. In contrast, only 70% of Rutin raw material (Rutin microcrystals) was dissolved within 15 min. The superior physicochemical properties of Rutin nanocrystals should overcome the absorption problem in the gastrointestinal tract and increase the bioavailability.
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Development of an oral Rutin nanocrystal formulation.
International journal of pharmaceutics, 2008Co-Authors: Rachmat Mauludin, Rainer H Müller, Cornelia M KeckAbstract:Dried Rutin nanocrystals have been prepared by lyophilization and investigated regarding their physicochemical properties with respect to re-dispersability, particle size, morphology and dissolution behavior. Photon correlation spectroscopy (PCS) and laser diffractometry (LD) were employed to determine the particle size. Morphology of the particles was analyzed by light microscopy. Lyophilized Rutin nanocrystals were incorporated into tablets and the dissolution behavior of the tablets was evaluated. Very fine particles of lyophilized Rutin could be completely re-dispersed in the water. The PCS size average and polydispersity index (PI) of lyophilized Rutin were of 721nm and of 0.288 after re-dispersion. The Rutin nanocrystal-loaded tablets were produced using direct compression. The dissolution velocity of the Rutin nanocrystal-loaded tablet was superior compared to Rutin microcrystal-loaded and a marketed tablet. After 30min Rutin was released and dissolved completely from the nanocrystal tablets in water. In contrast, only 71% and 55% of the total amount of Rutin were dissolved from the microcrystal tablets and the marketed tablet, respectively. The improving dissolution behavior of the Rutin nanocrystal-loaded tablet should lead to a better bioavailability of the poorly soluble Rutin in the body.
Tatsuro Suzuki - One of the best experts on this subject based on the ideXlab platform.
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effects of uv b radiation cold and desiccation stress on Rutin concentration and Rutin glucosidase activity in tartary buckwheat fagopyrum tataricum leaves
Plant Science, 2005Co-Authors: Tatsuro Suzuki, Yutaka Honda, Yuji MukasaAbstract:Abstract To study the physiological role of flavonoids in tartary buckwheat (Fagopyrum tataricum) leaf, we focused on Rutin and Rutin glucosidase activity. First, we investigated the Rutin concentration and Rutin glucosidase activity in leaves from different positions of tartary buckwheat. The Rutin concentration by dry weight was high in young leaves (more than 20% in unexpanded young leaves) and decreased along with the decrease of leaf position. Rutin glucosidase activity by dry weight was also high in young leaves and decreased along with the decrease of leaf position. Most Rutin and Rutin glucosidase activities were distributed in the epidermis. To obtain further information about the physiological role of Rutin, tartary buckwheat leaf was treated with stress using UV-B radiation, cold and desiccation. The Rutin concentration was increased 122% by UV-B radiation and 129% by desiccation treatment. On the other hand, Rutin glucosidase activity was increased 363% by UV-B radiation, 190% by cold treatment and 158% by desiccation treatment over the control. From these results, we propose that Rutin and Rutin glucosidase activity may be related to enhancement of the defense system against stress conditions in tartary buckwheat leaf.
Rachmat Mauludin - One of the best experts on this subject based on the ideXlab platform.
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Kinetic solubility and dissolution velocity of Rutin nanocrystals.
European Journal of Pharmaceutical Sciences, 2008Co-Authors: Rachmat Mauludin, Rainer H Müller, Cornelia M KeckAbstract:Lyophilized Rutin nanocrystals were intensively evaluated regarding their physicochemical properties with respect to particle size analyses, crystallinity, kinetic solubility and dissolution behavior. The particle size was determined by photon correlation spectroscopy (PCS) and laser diffraction (LD). DSC and X-ray diffraction were used to study the crystalline state of Rutin nanocrystals. In a period of 1 week, the kinetic solubility was determined using a shaker at 25 °C. DSC and X-ray diffraction analyses showed that lyophilized Rutin nanocrystals prepared by high pressure homogenization remained in crystalline state. Lyophilized Rutin nanocrystals could be re-dispersed completely in water and the kinetic solubility in water increased to 133 μg/ml.. Lyophilized Rutin nanocrystals were almost completely dissolved within 15 min in water, buffer of pH 1.2 and buffer of pH 6.8. In contrast, only 70% of Rutin raw material (Rutin microcrystals) was dissolved within 15 min. The superior physicochemical properties of Rutin nanocrystals should overcome the absorption problem in the gastrointestinal tract and increase the bioavailability.
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Kinetic solubility and dissolution velocity of Rutin nanocrystals.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2008Co-Authors: Rachmat Mauludin, Rainer H Müller, Cornelia M KeckAbstract:Lyophilized Rutin nanocrystals were intensively evaluated regarding their physicochemical properties with respect to particle size analyses, crystallinity, kinetic solubility and dissolution behavior. The particle size was determined by photon correlation spectroscopy (PCS) and laser diffraction (LD). DSC and X-ray diffraction were used to study the crystalline state of Rutin nanocrystals. In a period of 1 week, the kinetic solubility was determined using a shaker at 25 degrees C. DSC and X-ray diffraction analyses showed that lyophilized Rutin nanocrystals prepared by high pressure homogenization remained in crystalline state. Lyophilized Rutin nanocrystals could be re-dispersed completely in water and the kinetic solubility in water increased to 133 microg/ml.. Lyophilized Rutin nanocrystals were almost completely dissolved within 15 min in water, buffer of pH 1.2 and buffer of pH 6.8. In contrast, only 70% of Rutin raw material (Rutin microcrystals) was dissolved within 15 min. The superior physicochemical properties of Rutin nanocrystals should overcome the absorption problem in the gastrointestinal tract and increase the bioavailability.
-
Development of an oral Rutin nanocrystal formulation.
International journal of pharmaceutics, 2008Co-Authors: Rachmat Mauludin, Rainer H Müller, Cornelia M KeckAbstract:Dried Rutin nanocrystals have been prepared by lyophilization and investigated regarding their physicochemical properties with respect to re-dispersability, particle size, morphology and dissolution behavior. Photon correlation spectroscopy (PCS) and laser diffractometry (LD) were employed to determine the particle size. Morphology of the particles was analyzed by light microscopy. Lyophilized Rutin nanocrystals were incorporated into tablets and the dissolution behavior of the tablets was evaluated. Very fine particles of lyophilized Rutin could be completely re-dispersed in the water. The PCS size average and polydispersity index (PI) of lyophilized Rutin were of 721nm and of 0.288 after re-dispersion. The Rutin nanocrystal-loaded tablets were produced using direct compression. The dissolution velocity of the Rutin nanocrystal-loaded tablet was superior compared to Rutin microcrystal-loaded and a marketed tablet. After 30min Rutin was released and dissolved completely from the nanocrystal tablets in water. In contrast, only 71% and 55% of the total amount of Rutin were dissolved from the microcrystal tablets and the marketed tablet, respectively. The improving dissolution behavior of the Rutin nanocrystal-loaded tablet should lead to a better bioavailability of the poorly soluble Rutin in the body.
