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Wolfgang E. Berdel - One of the best experts on this subject based on the ideXlab platform.
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cyclin a1 the alternative a type cyclin contributeS to g1 S Cell cycle progreSSion in Somatic CellS
Oncogene, 2005Co-Authors: Shuchi Agrawal, Sven Diederichs, Carmela Beger, Nicole Bäumer, Wolfgang E. Berdel, Thomas Cauvet, Karl Welte, Annette Becker, Sascha Kowski, Hubert ServeAbstract:Cyclin A1 iS an alternative A-type cyclin that iS eSSential for SpermatogeneSiS, but it iS alSo expreSSed in hematopoietic progenitor CellS and in acute myeloid leukemia. ItS functionS during Cell cycle progreSSion of Somatic CellS are incompletely underStood. Here, we have analySed the Cell cycle functionS of cyclin A1 in tranSformed and nontranSformed CellS. Murine embryonic fibroblaStS derived from cyclin A1-deficient mice were Significantly impaired in their proliferative capacity. In accordance, cyclin A1-/- CellS accumulated in G1 and G2/M phaSe while the percentage of S phaSe CellS decreaSed. AlSo, lectin Stimulated Splenic lymphocyteS from cyclin A1-/- mice proliferated Slower than their wild-type counterpartS. Forced cyclin A1 overexpreSSion in NIH3T3 CellS and in U937 leukemic CellS either by tranSient tranSfection or by retroviral infection enhanced S phaSe entry. ConSequently, SiRNA mediated Silencing of cyclin A1 in highly cyclin A1 expreSSing ML1 leukemic CellS Significantly Slowed S phaSe entry, decreaSed proliferation and inhibited colony formation. Taken together, theSe analySeS demonStrate that cyclin A1 contributeS to G1 to S Cell cycle progreSSion in Somatic CellS. Cyclin A1 overexpreSSion enhanceS S phaSe entry conSiStent with an oncogenic function. Finally, cyclin A1 might be a therapeutic target Since itS Silencing inhibited leukemia Cell growth.
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cyclin a1 the alternative a type cyclin contributeS to g1 S Cell cycle progreSSion in Somatic CellS
Oncogene, 2005Co-Authors: Ping Ji, Sven Diederichs, Carmela Beger, Nicole Bäumer, Thomas Cauvet, Karl Welte, Shuchi Agrawal, Annette Becker, Sascha Kowski, Wolfgang E. BerdelAbstract:Cyclin A1, the alternative A-type cyclin, contributeS to G1/S Cell cycle progreSSion in Somatic CellS
Sheng S Zhang - One of the best experts on this subject based on the ideXlab platform.
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poly acrylic acid gel aS a polySulphide blocking layer for high performance lithium Sulphur battery
Journal of Materials Chemistry, 2014Co-Authors: Sheng S Zhang, Dat T Tran, Zhengcheng ZhangAbstract:The lithium/Sulphur (Li/S) battery iS one of the moSt promiSing electrochemical energy Storage SyStemS after the Li ion battery, due to the high theoretical energy denSity and low coSt of elemental Sulphur. However, itS development haS been hindered by many problemS in relation to the out-diffuSion of diSSolved lithium polySulphide (PS, Li2Sn with 4 ≤ n ≤ 8), the SerieS of Sulphur reduction intermediateS. In thiS paper we demonStrate a proof of concept for blocking the out-diffuSion of the diSSolved PS by employing a dual-layer Structural Sulphur cathode with a porouS poly(acrylic acid) (PAA) membrane coated on the top Surface. Upon activation with the liquid electrolyte, the porouS PAA membrane becomeS a gel and the reSulting gel chemically blockS the out-diffuSion of PS anionS by forming hydrogen bondS between the COOH groupS in the gelled PAA and the negatively charged PS anionS. Verified viSually by a potentioStatic polarization experiment at 1.7 V vS. Li/Li+, the out-diffuSion of PS in an electrolyte-flooded Li/S Cell iS effectively blocked by the dual-layer Structural Sulphur cathode. AS a reSult, the Li/S Cell conSiSting of a dual-layer Structural Sulphur cathode exhibitS much improved capacity retention while Still providing a Similar Specific capacity, aS compared with the Cell uSing the conventional Sulphur cathode.
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liquid electrolyte lithium Sulfur battery fundamental chemiStry problemS and SolutionS
Journal of Power Sources, 2013Co-Authors: Sheng S ZhangAbstract:AbStract Lithium/Sulfur (Li/S) battery haS a 3–5 fold higher theoretical energy denSity than State-of-art lithium-ion batterieS, and reSearch haS been ongoing for more than three decadeS. However, the commercialization of Li/S battery Still cannot be realized due to many problematic iSSueS, including Short cycle life, low cycling efficiency, poor Safety and a high Self-diScharge rate. All theSe iSSueS are related to the diSSolution of lithium polySulfide (PS), the SerieS of Sulfur reduction intermediateS, in liquid electrolyte and to reSulting paraSitic reactionS with the lithium anode and electrolyte componentS. On the other hand, the diSSolution of PS iS eSSential for the performance of a Li/S Cell. Without diSSolution of PS, the Li/S Cell cannot operate progreSSively due to the non-conductive nature of elemental Sulfur and itS reduction productS. In thiS review article, we Start with the fundamental chemiStry of elemental Sulfur in order to diScuSS the problemS and SolutionS of liquid electrolyte Li/S battery.
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improved cyclability of liquid electrolyte lithium Sulfur batterieS by optimizing electrolyte Sulfur ratio
Energies, 2012Co-Authors: Sheng S ZhangAbstract:AbStract: A liquid electrolyte lithium/Sulfur (Li/S) Cell iS a liquid electrochemical SyStem. In diScharge, Sulfur iS firSt reduced to highly Soluble Li 2 S 8 , which diSSolveS into the organic electrolyte and ServeS aS the liquid cathode. In Solution, lithium polySulfide (PS) undergoeS a SerieS of complicated diSproportionationS, whoSe chemical equilibriumS vary with the PS concentration and affect the Cell’S performance. Since the PS concentration relateS to a certain electrolyte/Sulfur (E/S) ratio, there iS an optimized E/S ratio for the cyclability of each Li/S Cell SyStem. In thiS work, we Study the optimized E/S ratio by meaSuring the cycling performance of Li/S CellS, and propoSe an empirical method for determination of the optimized E/S ratio. By employing an electrolyte of 0.25 m LiSO 3 CF 3 -0.25 m LiNO 3 diSSolved in a 1:1 (wt:wt) mixture of dimethyl ether (DME) and 1,3-dioxolane (DOL) in an optimized E/S ratio, we Show that the Li/S Cell with a cathode containing 72% Sulfur and 2 mg cm
Elton J Cairns - One of the best experts on this subject based on the ideXlab platform.
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effectS of photochemical oxidation of the carbonaceouS additiveS on li S Cell performance
ACS Applied Materials & Interfaces, 2021Co-Authors: Jungjin Park, Joonhee Moon, Kookhan Kim, Sangheon Lee, Byung Hee Hong, Yungeun Sung, Chunjoong Kim, Elton J CairnsAbstract:We introduce a Simple and eaSy way to functionalize the Surface of variouS carbonaceouS materialS through the ultraviolet light/ozone (UV/O3) plaSma where we utilize the zero-, one-, and two-dimenSional carbon frameworkS. In a general manner, the lampS of a UV/O3 generator create two different wavelengthS (λ = 185 and 254 nm); the Shorter wavelength (λ = 185 nm) diSSociateS the oxygen (O2) in air and the longer wavelength (λ = 254 nm) diSSociateS the O3 and createS the reactive and monoatomic oxygen radical, which tendS to incorporate onto the defectS of the carbonS. By tailoring the aSSociation and diSSociation of the oxygen with variouS formS, carbon black, carbon nanofiberS, and graphite flakeS, choSen aS repreSentative modelS for the zero-, one-, and two-dimenSional carbon frameworkS, their Structure can be oxidized, reSpectively, which iS known aS photochemical oxidation. VariouS carbonS have their own diStinctive morphology and electron tranSport propertieS, which are applicable for the lithium-Sulfur (Li-S) Cell. We, here, report on the improvement of electrochemical performance of the lithium/Sulfur Cell through Such an efficient functionalization approach.
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direct viSualization of lithium polySulfideS and their SuppreSSion in liquid electrolyte
Nano Letters, 2020Co-Authors: Hyeon Kook Seo, Elton J Cairns, Yoon Hwa, Joon Ha Chang, Jae Yeol Park, Jae Sang Lee, Jungjae Park, Jong Min YukAbstract:UnderStanding of lithium polySulfide (Li-PS) formation and the Shuttle phenomenon iS eSSential for practical application of the lithium/Sulfur (Li/S) Cell, which haS Superior theoretical Specific e...
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n methyl n butyl pyrrolidinium biS trifluoromethaneSulfonyl imide litfSi poly ethylene glycol dimethyl ether mixture aS a li S Cell electrolyte
Journal of Power Sources, 2008Co-Authors: Joonho Shin, Elton J CairnsAbstract:AbStract We have characterized a ternary mixture of N-methyl-(n-butyl)pyrrolidinium biS(trifluoromethaneSulfonyl)imide (PYR14TFSI) + 0.5 M LiTFSI + y poly(ethylene glycol) dimethyl ether (PEGDME) (y = kg PEGDME/kg PYR14TFSI) aS an electrolyte in Li metal/S CellS. The preSence of PYR14TFSI in the mixture reSulted in a Significant improvement of the thermal Stability and the ionic conductivity (σ) of the mixture with increaSing PEGDME contentS (for example, σ = 4.2 × 10−3 S cm−1 at 29 °C for y = 2.0). TheSe improvementS are moSt Significant at low temperatureS, which iS probably due to a lowering of the viScoSity of the mixture with higher amountS of PEGDME. It iS found that the mixture haS good compatibility with reSpect to Li metal aS demonStrated by time-dependent interfacial impedance and galvanoStatic Li Stripping/depoSition meaSurementS. We found that a Li/S Cell with PYR14TFSI + 0.5 M LiTFSI + y PEGDME (y = 2.0) can deliver about 1300 mAh g−1-Sulfur at 0.054 mA cm−2 at ambient temperature at the firSt cycle. A better charge/diScharge cyclability of the Li/S Cell in PYR14TFSI + 0.5 M LiTFSI + y PEGDME waS found at higher PEGDME contentS, and a Li/S Cell with the mixture having y = 2.0 exhibited a capacity fading rate of 0.42% per cycle over 100 cycleS at 0.054 mA cm−2 at 40 °C. ConSequently the PYR14TFSI + LiTFSI + PEGDME mixture iS a promiSing electrolyte for Li/S CellS.
Shuchi Agrawal - One of the best experts on this subject based on the ideXlab platform.
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cyclin a1 the alternative a type cyclin contributeS to g1 S Cell cycle progreSSion in Somatic CellS
Oncogene, 2005Co-Authors: Shuchi Agrawal, Sven Diederichs, Carmela Beger, Nicole Bäumer, Wolfgang E. Berdel, Thomas Cauvet, Karl Welte, Annette Becker, Sascha Kowski, Hubert ServeAbstract:Cyclin A1 iS an alternative A-type cyclin that iS eSSential for SpermatogeneSiS, but it iS alSo expreSSed in hematopoietic progenitor CellS and in acute myeloid leukemia. ItS functionS during Cell cycle progreSSion of Somatic CellS are incompletely underStood. Here, we have analySed the Cell cycle functionS of cyclin A1 in tranSformed and nontranSformed CellS. Murine embryonic fibroblaStS derived from cyclin A1-deficient mice were Significantly impaired in their proliferative capacity. In accordance, cyclin A1-/- CellS accumulated in G1 and G2/M phaSe while the percentage of S phaSe CellS decreaSed. AlSo, lectin Stimulated Splenic lymphocyteS from cyclin A1-/- mice proliferated Slower than their wild-type counterpartS. Forced cyclin A1 overexpreSSion in NIH3T3 CellS and in U937 leukemic CellS either by tranSient tranSfection or by retroviral infection enhanced S phaSe entry. ConSequently, SiRNA mediated Silencing of cyclin A1 in highly cyclin A1 expreSSing ML1 leukemic CellS Significantly Slowed S phaSe entry, decreaSed proliferation and inhibited colony formation. Taken together, theSe analySeS demonStrate that cyclin A1 contributeS to G1 to S Cell cycle progreSSion in Somatic CellS. Cyclin A1 overexpreSSion enhanceS S phaSe entry conSiStent with an oncogenic function. Finally, cyclin A1 might be a therapeutic target Since itS Silencing inhibited leukemia Cell growth.
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cyclin a1 the alternative a type cyclin contributeS to g1 S Cell cycle progreSSion in Somatic CellS
Oncogene, 2005Co-Authors: Ping Ji, Sven Diederichs, Carmela Beger, Nicole Bäumer, Thomas Cauvet, Karl Welte, Shuchi Agrawal, Annette Becker, Sascha Kowski, Wolfgang E. BerdelAbstract:Cyclin A1, the alternative A-type cyclin, contributeS to G1/S Cell cycle progreSSion in Somatic CellS
Carmela Beger - One of the best experts on this subject based on the ideXlab platform.
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cyclin a1 the alternative a type cyclin contributeS to g1 S Cell cycle progreSSion in Somatic CellS
Oncogene, 2005Co-Authors: Shuchi Agrawal, Sven Diederichs, Carmela Beger, Nicole Bäumer, Wolfgang E. Berdel, Thomas Cauvet, Karl Welte, Annette Becker, Sascha Kowski, Hubert ServeAbstract:Cyclin A1 iS an alternative A-type cyclin that iS eSSential for SpermatogeneSiS, but it iS alSo expreSSed in hematopoietic progenitor CellS and in acute myeloid leukemia. ItS functionS during Cell cycle progreSSion of Somatic CellS are incompletely underStood. Here, we have analySed the Cell cycle functionS of cyclin A1 in tranSformed and nontranSformed CellS. Murine embryonic fibroblaStS derived from cyclin A1-deficient mice were Significantly impaired in their proliferative capacity. In accordance, cyclin A1-/- CellS accumulated in G1 and G2/M phaSe while the percentage of S phaSe CellS decreaSed. AlSo, lectin Stimulated Splenic lymphocyteS from cyclin A1-/- mice proliferated Slower than their wild-type counterpartS. Forced cyclin A1 overexpreSSion in NIH3T3 CellS and in U937 leukemic CellS either by tranSient tranSfection or by retroviral infection enhanced S phaSe entry. ConSequently, SiRNA mediated Silencing of cyclin A1 in highly cyclin A1 expreSSing ML1 leukemic CellS Significantly Slowed S phaSe entry, decreaSed proliferation and inhibited colony formation. Taken together, theSe analySeS demonStrate that cyclin A1 contributeS to G1 to S Cell cycle progreSSion in Somatic CellS. Cyclin A1 overexpreSSion enhanceS S phaSe entry conSiStent with an oncogenic function. Finally, cyclin A1 might be a therapeutic target Since itS Silencing inhibited leukemia Cell growth.
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cyclin a1 the alternative a type cyclin contributeS to g1 S Cell cycle progreSSion in Somatic CellS
Oncogene, 2005Co-Authors: Ping Ji, Sven Diederichs, Carmela Beger, Nicole Bäumer, Thomas Cauvet, Karl Welte, Shuchi Agrawal, Annette Becker, Sascha Kowski, Wolfgang E. BerdelAbstract:Cyclin A1, the alternative A-type cyclin, contributeS to G1/S Cell cycle progreSSion in Somatic CellS
