The Experts below are selected from a list of 40563 Experts worldwide ranked by ideXlab platform
Masashi Fukayama - One of the best experts on this subject based on the ideXlab platform.
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criteria for the research institute for fragrance materials inc rifm Safety evaluation Process for fragrance ingredients
Food and Chemical Toxicology, 2015Co-Authors: D. Belsito, P. Cadby, Peter Calow, G. Ellis, A D Fryer, Maria Lúcia Zaidan Dagli, Magnus Bruze, Masashi Fukayama, Wolfgang Dekant, P GriemAbstract:The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of Safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing Safety has evolved as the tools for risk Assessment evolved. This publication is designed to update the RIFM Safety Assessment Process, which follows a series of decision trees, reflecting advances in approaches in risk Assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of Toxicological Concern (TTC), 3) the Quantitative Risk Assessment (QRA) for dermal contact sensitization, 4) the respiratory route of exposure, 5) aggregate exposure Assessment methodology, 6) the latest methodology and approaches to risk Assessments, 7) the latest alternatives to animal testing methodology and 8) environmental risk Assessment. The Assessment begins with a thorough analysis of existing data followed by in silico analysis, identification of 'read across' analogs, generation of additional data through in vitro testing as well as consideration of the TTC approach. If necessary, risk management may be considered. (Less)
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Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) Safety evaluation Process for fragrance ingredients
Food and Chemical Toxicology, 2015Co-Authors: Anne Marie Api, P. Cadby, Peter Calow, D. Belsito, G. Ellis, A D Fryer, Maria Lúcia Zaidan Dagli, Magnus Bruze, Wolfgang Dekant, Masashi FukayamaAbstract:The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of Safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing Safety has evolved as the tools for risk Assessment evolved. This publication is designed to update the RIFM Safety Assessment Process, which follows a series of decision trees, reflecting advances in approaches in risk Assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of Toxicological Concern (TTC), 3) the Quantitative Risk Assessment (QRA) for dermal sensitization, 4) the respiratory route of exposure, 5) aggregate exposure Assessment methodology, 6) the latest methodology and approaches to risk Assessments, 7) the latest alternatives to animal testing methodology and 8) environmental risk Assessment. The Assessment begins with a thorough analysis of existing data followed by in silico analysis, identification of 'read across' analogs, generation of additional data through in vitro testing as well as consideration of the TTC approach. If necessary, risk management may be considered.
D. Belsito - One of the best experts on this subject based on the ideXlab platform.
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criteria for the research institute for fragrance materials inc rifm Safety evaluation Process for fragrance ingredients
Food and Chemical Toxicology, 2015Co-Authors: D. Belsito, P. Cadby, Peter Calow, G. Ellis, A D Fryer, Maria Lúcia Zaidan Dagli, Magnus Bruze, Masashi Fukayama, Wolfgang Dekant, P GriemAbstract:The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of Safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing Safety has evolved as the tools for risk Assessment evolved. This publication is designed to update the RIFM Safety Assessment Process, which follows a series of decision trees, reflecting advances in approaches in risk Assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of Toxicological Concern (TTC), 3) the Quantitative Risk Assessment (QRA) for dermal contact sensitization, 4) the respiratory route of exposure, 5) aggregate exposure Assessment methodology, 6) the latest methodology and approaches to risk Assessments, 7) the latest alternatives to animal testing methodology and 8) environmental risk Assessment. The Assessment begins with a thorough analysis of existing data followed by in silico analysis, identification of 'read across' analogs, generation of additional data through in vitro testing as well as consideration of the TTC approach. If necessary, risk management may be considered. (Less)
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Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) Safety evaluation Process for fragrance ingredients
Food and Chemical Toxicology, 2015Co-Authors: Anne Marie Api, P. Cadby, Peter Calow, D. Belsito, G. Ellis, A D Fryer, Maria Lúcia Zaidan Dagli, Magnus Bruze, Wolfgang Dekant, Masashi FukayamaAbstract:The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of Safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing Safety has evolved as the tools for risk Assessment evolved. This publication is designed to update the RIFM Safety Assessment Process, which follows a series of decision trees, reflecting advances in approaches in risk Assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of Toxicological Concern (TTC), 3) the Quantitative Risk Assessment (QRA) for dermal sensitization, 4) the respiratory route of exposure, 5) aggregate exposure Assessment methodology, 6) the latest methodology and approaches to risk Assessments, 7) the latest alternatives to animal testing methodology and 8) environmental risk Assessment. The Assessment begins with a thorough analysis of existing data followed by in silico analysis, identification of 'read across' analogs, generation of additional data through in vitro testing as well as consideration of the TTC approach. If necessary, risk management may be considered.
P Griem - One of the best experts on this subject based on the ideXlab platform.
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criteria for the research institute for fragrance materials inc rifm Safety evaluation Process for fragrance ingredients
Food and Chemical Toxicology, 2015Co-Authors: D. Belsito, P. Cadby, Peter Calow, G. Ellis, A D Fryer, Maria Lúcia Zaidan Dagli, Magnus Bruze, Masashi Fukayama, Wolfgang Dekant, P GriemAbstract:The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of Safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing Safety has evolved as the tools for risk Assessment evolved. This publication is designed to update the RIFM Safety Assessment Process, which follows a series of decision trees, reflecting advances in approaches in risk Assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of Toxicological Concern (TTC), 3) the Quantitative Risk Assessment (QRA) for dermal contact sensitization, 4) the respiratory route of exposure, 5) aggregate exposure Assessment methodology, 6) the latest methodology and approaches to risk Assessments, 7) the latest alternatives to animal testing methodology and 8) environmental risk Assessment. The Assessment begins with a thorough analysis of existing data followed by in silico analysis, identification of 'read across' analogs, generation of additional data through in vitro testing as well as consideration of the TTC approach. If necessary, risk management may be considered. (Less)
G. Ellis - One of the best experts on this subject based on the ideXlab platform.
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criteria for the research institute for fragrance materials inc rifm Safety evaluation Process for fragrance ingredients
Food and Chemical Toxicology, 2015Co-Authors: D. Belsito, P. Cadby, Peter Calow, G. Ellis, A D Fryer, Maria Lúcia Zaidan Dagli, Magnus Bruze, Masashi Fukayama, Wolfgang Dekant, P GriemAbstract:The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of Safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing Safety has evolved as the tools for risk Assessment evolved. This publication is designed to update the RIFM Safety Assessment Process, which follows a series of decision trees, reflecting advances in approaches in risk Assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of Toxicological Concern (TTC), 3) the Quantitative Risk Assessment (QRA) for dermal contact sensitization, 4) the respiratory route of exposure, 5) aggregate exposure Assessment methodology, 6) the latest methodology and approaches to risk Assessments, 7) the latest alternatives to animal testing methodology and 8) environmental risk Assessment. The Assessment begins with a thorough analysis of existing data followed by in silico analysis, identification of 'read across' analogs, generation of additional data through in vitro testing as well as consideration of the TTC approach. If necessary, risk management may be considered. (Less)
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Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) Safety evaluation Process for fragrance ingredients
Food and Chemical Toxicology, 2015Co-Authors: Anne Marie Api, P. Cadby, Peter Calow, D. Belsito, G. Ellis, A D Fryer, Maria Lúcia Zaidan Dagli, Magnus Bruze, Wolfgang Dekant, Masashi FukayamaAbstract:The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of Safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing Safety has evolved as the tools for risk Assessment evolved. This publication is designed to update the RIFM Safety Assessment Process, which follows a series of decision trees, reflecting advances in approaches in risk Assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of Toxicological Concern (TTC), 3) the Quantitative Risk Assessment (QRA) for dermal sensitization, 4) the respiratory route of exposure, 5) aggregate exposure Assessment methodology, 6) the latest methodology and approaches to risk Assessments, 7) the latest alternatives to animal testing methodology and 8) environmental risk Assessment. The Assessment begins with a thorough analysis of existing data followed by in silico analysis, identification of 'read across' analogs, generation of additional data through in vitro testing as well as consideration of the TTC approach. If necessary, risk management may be considered.
Magnus Bruze - One of the best experts on this subject based on the ideXlab platform.
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criteria for the research institute for fragrance materials inc rifm Safety evaluation Process for fragrance ingredients
Food and Chemical Toxicology, 2015Co-Authors: D. Belsito, P. Cadby, Peter Calow, G. Ellis, A D Fryer, Maria Lúcia Zaidan Dagli, Magnus Bruze, Masashi Fukayama, Wolfgang Dekant, P GriemAbstract:The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of Safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing Safety has evolved as the tools for risk Assessment evolved. This publication is designed to update the RIFM Safety Assessment Process, which follows a series of decision trees, reflecting advances in approaches in risk Assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of Toxicological Concern (TTC), 3) the Quantitative Risk Assessment (QRA) for dermal contact sensitization, 4) the respiratory route of exposure, 5) aggregate exposure Assessment methodology, 6) the latest methodology and approaches to risk Assessments, 7) the latest alternatives to animal testing methodology and 8) environmental risk Assessment. The Assessment begins with a thorough analysis of existing data followed by in silico analysis, identification of 'read across' analogs, generation of additional data through in vitro testing as well as consideration of the TTC approach. If necessary, risk management may be considered. (Less)
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Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) Safety evaluation Process for fragrance ingredients
Food and Chemical Toxicology, 2015Co-Authors: Anne Marie Api, P. Cadby, Peter Calow, D. Belsito, G. Ellis, A D Fryer, Maria Lúcia Zaidan Dagli, Magnus Bruze, Wolfgang Dekant, Masashi FukayamaAbstract:The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of Safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing Safety has evolved as the tools for risk Assessment evolved. This publication is designed to update the RIFM Safety Assessment Process, which follows a series of decision trees, reflecting advances in approaches in risk Assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of Toxicological Concern (TTC), 3) the Quantitative Risk Assessment (QRA) for dermal sensitization, 4) the respiratory route of exposure, 5) aggregate exposure Assessment methodology, 6) the latest methodology and approaches to risk Assessments, 7) the latest alternatives to animal testing methodology and 8) environmental risk Assessment. The Assessment begins with a thorough analysis of existing data followed by in silico analysis, identification of 'read across' analogs, generation of additional data through in vitro testing as well as consideration of the TTC approach. If necessary, risk management may be considered.
