The Experts below are selected from a list of 1329 Experts worldwide ranked by ideXlab platform
R Hiremath - One of the best experts on this subject based on the ideXlab platform.
-
formulation and evaluation of controlled release transdermal patches of theophylline Salbutamol Sulfate
Drug Development and Industrial Pharmacy, 2001Co-Authors: Narasimha S Murthy, Shobha Rani, R HiremathAbstract:Transdermal formulations containing theophylline and Salbutamol Sulfate (SS) were formulated using hydroxypropylmethylcellulose. Theophylline was loaded by adsorption with the aid of the coadsorbate sodium chloride. The formulations were subjected to in vitro release studies, and the dose of Salbutamol and theophylline was optimized to yield the desired flux. The films were uniform and 93 ± 5.4 μm thick. The in vitro fluxes of theophylline and Salbutamol Sulfate from the formulation were 1.22 ± 0.4 mg/h/cm2 and 13.36 ± 1.02 μg/h/cm2, respectively. The formulation was subjected to pharmacodynamic studies in guinea pigs. The preconvulsive time (PCT) of guinea pigs increased significantly after 4 h, and the same was observed even after 24 h. Pharmacokinetic studies were carried out in healthy human volunteers. Theophylline was analyzed in saliva, and Salbutamol was analyzed in the blood plasma. The Tmax of the drugs was 3 h, and appreciable concentrations of the drugs above their MEC could be analyzed even a...
-
Formulation and Evaluation of Controlled-Release Transdermal Patches of Theophylline–Salbutamol Sulfate
Drug development and industrial pharmacy, 2001Co-Authors: S. Narasimha Murthy, Shobha Rani, R HiremathAbstract:Transdermal formulations containing theophylline and Salbutamol Sulfate (SS) were formulated using hydroxypropylmethylcellulose. Theophylline was loaded by adsorption with the aid of the coadsorbate sodium chloride. The formulations were subjected to in vitro release studies, and the dose of Salbutamol and theophylline was optimized to yield the desired flux. The films were uniform and 93 +/- 5.4 microm thick. The in vitro fluxes of theophylline and Salbutamol Sulfate from the formulation were 1.22 +/- 0.4 mg/h/cm2 and 13.36 +/- 1.02 microg/h/cm2, respectively. The formulation was subjected to pharmacodynamic studies in guinea pigs. The preconvulsive time (PCT) of guinea pigs increased significantly after 4 h, and the same was observed even after 24 h Pharmacokinetic studies were carried out in healthy human volunteers. Theophylline was analyzed in saliva, and Salbutamol was analyzed in the blood plasma. The Tmax of the drugs was 3 h, and appreciable concentrations of the drugs above their MEC could be analyzed even after 12 h. The elimination half-life of the drugs was significantly prolonged compared to that for tablets. There were no signs of erythema or edema in the volunteers during observation for a period of 7 days.
Amit Kumar Nayak - One of the best experts on this subject based on the ideXlab platform.
-
in situ cross linked matrix tablets for sustained Salbutamol Sulfate release formulation development by statistical optimization
Polimery w medycynie, 2014Co-Authors: Jadupati Malakar, Krishnagopal Das, Amit Kumar NayakAbstract:Background. The use of natural polymers in designing of matrix tablets for sustained-release drug delivery systems has received much attention. Objectives. The study involves the development and optimization of in situ cross-linked matrix tablets for sustained Salbutamol Sulfate release. Material and Methods. In situ cross-linked matrix tablets of Salbutamol Sulfate were prepared by direct compression and optimized by response surface methodology based on 3 2 factorial design. The influence on sodium alginate and a calcium salt (calcium carbonate) amounts in Salbutamol Sulfate matrix tablets on the properties like drug release and hardness of Salbutamol Sulfate sustained release matrix tablets were analyzed by response surface plots and corresponding contour plots. Drug contents, weight variations, hardness, and in vitro drug release with release kinetic analysis of these newly developed matrix tablets were also investigated. Results. All these in situ cross-linked Salbutamol Sulfate matrix tablets showed satisfactory drug contents, weight variations, hardness and prolonged sustained release of Salbutamol Sulfate over 6 h. Conclusions. The developed Salbutamol Sulfate matrix tablets might be beneficial over the conventional tablets to decrease the dosing frequency and enhanced patient compliance (Polim. Med. 2014, 44, 4, 221–230).
-
floating capsules containing alginate based beads of Salbutamol Sulfate in vitro in vivo evaluations
International Journal of Biological Macromolecules, 2014Co-Authors: Jadupati Malakar, Prabir Kumar Datta, Saikat Das Purakayastha, Satyahari Dey, Amit Kumar NayakAbstract:Abstract The present study deals with the development and evaluations of stomach-specific floating capsules containing Salbutamol Sulfate-loaded oil-entrapped alginate-based beads. Salbutamol Sulfate-loaded oil-entrapped beads were prepared and capsulated within hard gelatin capsules (size 1). The effects of HPMC K4M and potato starch weight masses on drug encapsulation efficiency (DEE) of beads and cumulative drug release at 10 h ( R 10 h ) from capsules was analyzed by 3 2 factorial design. The optimization results indicate increasing of DEE in the oil-entrapped beads and decreasing R 10 h from capsules with increment of HPMC K4M and potato starch weight masses. The optimized formulation showed DEE of 70.02 ± 3.16% and R 10 h of 56.96 ± 2.92%. These capsules showed floatation over 6 h and sustained drug release over 10 h in gastric pH (1.2). In vivo X-ray imaging study of optimized floating capsules in rabbits showed stomach-specific gastroretention over a prolonged period.
-
In situ cross-linked matrix tablets for sustained Salbutamol Sulfate release - formulation development by statistical optimization.
Polimery w medycynie, 2014Co-Authors: Jadupati Malakar, Krishnagopal Das, Amit Kumar NayakAbstract:The use of natural polymers in designing of matrix tablets for sustained-release drug delivery systems has received much attention. The study involves the development and optimization of in situ cross-linked matrix tablets for sustained Salbutamol Sulfate release. In situ cross-linked matrix tablets of Salbutamol Sulfate were prepared by direct compression and optimized by response surface methodology based on 32 factorial design. The influence on sodium alginate and a calcium salt (calcium carbonate) amounts in Salbutamol Sulfate matrix tablets on the properties like drug release and hardness of Salbutamol Sulfate sustained release matrix tablets were analyzed by response surface plots and corresponding contour plots. Drug contents, weight variations, hardness, and in vitro drug release with release kinetic analysis of these newly developed matrix tablets were also investigated. All these in situ cross-linked Salbutamol Sulfate matrix tablets showed satisfactory drug contents, weight variations, hardness and prolonged sustained release of Salbutamol Sulfate over 6 h. The developed Salbutamol Sulfate matrix tablets might be beneficial over the conventional tablets to decrease the dosing frequency and enhanced patient compliance.
-
Floating capsules containing alginate-based beads of Salbutamol Sulfate: In vitro–in vivo evaluations
International journal of biological macromolecules, 2013Co-Authors: Jadupati Malakar, Prabir Kumar Datta, Saikat Das Purakayastha, Satyahari Dey, Amit Kumar NayakAbstract:The present study deals with the development and evaluations of stomach-specific floating capsules containing Salbutamol Sulfate-loaded oil-entrapped alginate-based beads. Salbutamol Sulfate-loaded oil-entrapped beads were prepared and capsulated within hard gelatin capsules (size 1). The effects of HPMC K4M and potato starch weight masses on drug encapsulation efficiency (DEE) of beads and cumulative drug release at 10h (R10 h) from capsules was analyzed by 3(2) factorial design. The optimization results indicate increasing of DEE in the oil-entrapped beads and decreasing R10 h from capsules with increment of HPMC K4M and potato starch weight masses. The optimized formulation showed DEE of 70.02 ± 3.16% and R10 h of 56.96 ± 2.92%. These capsules showed floatation over 6h and sustained drug release over 10h in gastric pH (1.2). In vivo X-ray imaging study of optimized floating capsules in rabbits showed stomach-specific gastroretention over a prolonged period.
Zhu Ya-ling - One of the best experts on this subject based on the ideXlab platform.
-
Clinical efficacy of Salbutamol Sulfate sustained-release capsules in the treatment of bronchial asthma in adults
The Chinese Journal of Clinical Pharmacology, 2004Co-Authors: Zhu Ya-lingAbstract:Objective To compare the clinical efficacy and safety of Salbutamol Sulfatesustained-release capsules and bambuterol hydrochloride tablets in the treatmentof bronchial asthma in adults. Methods A multicenter randomized controlled clinicaltrial was conducted.Ninety four patients with mild-to-moderate bronchial asthmawere enrolled in the study, of which 50 patients in the test group (SalbutamolSulfate sustained-release capsules group), 44 patients in the control group(bambuterol hydrochloride tablets group). The test group was treated withSalbutamol Sulfate sustained-release capsules 4mg twice daily for 1 week, followedby Salbutamol Sulfate sustained-release capsules 8mg twice daily for another 1 week.The control group was treated with bambuterol hydrochloride tablets 10mg oncedaily for 1 week, followed by bambuterol hydrochloride tablets 8mg once daily foranother 1 week. Results The lung function and clinical manifestation weresignificantly improved in both groups after treatment, the clinical manifestationgained further improvement with larger dosage in two groups. The clinical efficacyrates after 1-week treatment and 2-week treatment were 32.0% and 64.0% in testgroup, respectively. In the control group, there were 31.8% and 61.4%, respectively.After 2-week treatment, the clinical control rate of the test group(56%) was betterthan that of the control group(32%). After 1-week treatment, average inhalation timesof β2 -agonist in the test group were decreased compared with pretreatment, whilethere was no statistical deference in the control group. The incidences of adversereaction were 15.7% and 19.1%, respectively in the test group and control group.Conclusion Salbutamol Sulfate sustained-release capsules is a safe and effectivedrug in the treatment of bronchial asthma in adults.
Shobha Rani - One of the best experts on this subject based on the ideXlab platform.
-
formulation and evaluation of controlled release transdermal patches of theophylline Salbutamol Sulfate
Drug Development and Industrial Pharmacy, 2001Co-Authors: Narasimha S Murthy, Shobha Rani, R HiremathAbstract:Transdermal formulations containing theophylline and Salbutamol Sulfate (SS) were formulated using hydroxypropylmethylcellulose. Theophylline was loaded by adsorption with the aid of the coadsorbate sodium chloride. The formulations were subjected to in vitro release studies, and the dose of Salbutamol and theophylline was optimized to yield the desired flux. The films were uniform and 93 ± 5.4 μm thick. The in vitro fluxes of theophylline and Salbutamol Sulfate from the formulation were 1.22 ± 0.4 mg/h/cm2 and 13.36 ± 1.02 μg/h/cm2, respectively. The formulation was subjected to pharmacodynamic studies in guinea pigs. The preconvulsive time (PCT) of guinea pigs increased significantly after 4 h, and the same was observed even after 24 h. Pharmacokinetic studies were carried out in healthy human volunteers. Theophylline was analyzed in saliva, and Salbutamol was analyzed in the blood plasma. The Tmax of the drugs was 3 h, and appreciable concentrations of the drugs above their MEC could be analyzed even a...
-
Formulation and Evaluation of Controlled-Release Transdermal Patches of Theophylline–Salbutamol Sulfate
Drug development and industrial pharmacy, 2001Co-Authors: S. Narasimha Murthy, Shobha Rani, R HiremathAbstract:Transdermal formulations containing theophylline and Salbutamol Sulfate (SS) were formulated using hydroxypropylmethylcellulose. Theophylline was loaded by adsorption with the aid of the coadsorbate sodium chloride. The formulations were subjected to in vitro release studies, and the dose of Salbutamol and theophylline was optimized to yield the desired flux. The films were uniform and 93 +/- 5.4 microm thick. The in vitro fluxes of theophylline and Salbutamol Sulfate from the formulation were 1.22 +/- 0.4 mg/h/cm2 and 13.36 +/- 1.02 microg/h/cm2, respectively. The formulation was subjected to pharmacodynamic studies in guinea pigs. The preconvulsive time (PCT) of guinea pigs increased significantly after 4 h, and the same was observed even after 24 h Pharmacokinetic studies were carried out in healthy human volunteers. Theophylline was analyzed in saliva, and Salbutamol was analyzed in the blood plasma. The Tmax of the drugs was 3 h, and appreciable concentrations of the drugs above their MEC could be analyzed even after 12 h. The elimination half-life of the drugs was significantly prolonged compared to that for tablets. There were no signs of erythema or edema in the volunteers during observation for a period of 7 days.
Jadupati Malakar - One of the best experts on this subject based on the ideXlab platform.
-
in situ cross linked matrix tablets for sustained Salbutamol Sulfate release formulation development by statistical optimization
Polimery w medycynie, 2014Co-Authors: Jadupati Malakar, Krishnagopal Das, Amit Kumar NayakAbstract:Background. The use of natural polymers in designing of matrix tablets for sustained-release drug delivery systems has received much attention. Objectives. The study involves the development and optimization of in situ cross-linked matrix tablets for sustained Salbutamol Sulfate release. Material and Methods. In situ cross-linked matrix tablets of Salbutamol Sulfate were prepared by direct compression and optimized by response surface methodology based on 3 2 factorial design. The influence on sodium alginate and a calcium salt (calcium carbonate) amounts in Salbutamol Sulfate matrix tablets on the properties like drug release and hardness of Salbutamol Sulfate sustained release matrix tablets were analyzed by response surface plots and corresponding contour plots. Drug contents, weight variations, hardness, and in vitro drug release with release kinetic analysis of these newly developed matrix tablets were also investigated. Results. All these in situ cross-linked Salbutamol Sulfate matrix tablets showed satisfactory drug contents, weight variations, hardness and prolonged sustained release of Salbutamol Sulfate over 6 h. Conclusions. The developed Salbutamol Sulfate matrix tablets might be beneficial over the conventional tablets to decrease the dosing frequency and enhanced patient compliance (Polim. Med. 2014, 44, 4, 221–230).
-
floating capsules containing alginate based beads of Salbutamol Sulfate in vitro in vivo evaluations
International Journal of Biological Macromolecules, 2014Co-Authors: Jadupati Malakar, Prabir Kumar Datta, Saikat Das Purakayastha, Satyahari Dey, Amit Kumar NayakAbstract:Abstract The present study deals with the development and evaluations of stomach-specific floating capsules containing Salbutamol Sulfate-loaded oil-entrapped alginate-based beads. Salbutamol Sulfate-loaded oil-entrapped beads were prepared and capsulated within hard gelatin capsules (size 1). The effects of HPMC K4M and potato starch weight masses on drug encapsulation efficiency (DEE) of beads and cumulative drug release at 10 h ( R 10 h ) from capsules was analyzed by 3 2 factorial design. The optimization results indicate increasing of DEE in the oil-entrapped beads and decreasing R 10 h from capsules with increment of HPMC K4M and potato starch weight masses. The optimized formulation showed DEE of 70.02 ± 3.16% and R 10 h of 56.96 ± 2.92%. These capsules showed floatation over 6 h and sustained drug release over 10 h in gastric pH (1.2). In vivo X-ray imaging study of optimized floating capsules in rabbits showed stomach-specific gastroretention over a prolonged period.
-
In situ cross-linked matrix tablets for sustained Salbutamol Sulfate release - formulation development by statistical optimization.
Polimery w medycynie, 2014Co-Authors: Jadupati Malakar, Krishnagopal Das, Amit Kumar NayakAbstract:The use of natural polymers in designing of matrix tablets for sustained-release drug delivery systems has received much attention. The study involves the development and optimization of in situ cross-linked matrix tablets for sustained Salbutamol Sulfate release. In situ cross-linked matrix tablets of Salbutamol Sulfate were prepared by direct compression and optimized by response surface methodology based on 32 factorial design. The influence on sodium alginate and a calcium salt (calcium carbonate) amounts in Salbutamol Sulfate matrix tablets on the properties like drug release and hardness of Salbutamol Sulfate sustained release matrix tablets were analyzed by response surface plots and corresponding contour plots. Drug contents, weight variations, hardness, and in vitro drug release with release kinetic analysis of these newly developed matrix tablets were also investigated. All these in situ cross-linked Salbutamol Sulfate matrix tablets showed satisfactory drug contents, weight variations, hardness and prolonged sustained release of Salbutamol Sulfate over 6 h. The developed Salbutamol Sulfate matrix tablets might be beneficial over the conventional tablets to decrease the dosing frequency and enhanced patient compliance.
-
Floating capsules containing alginate-based beads of Salbutamol Sulfate: In vitro–in vivo evaluations
International journal of biological macromolecules, 2013Co-Authors: Jadupati Malakar, Prabir Kumar Datta, Saikat Das Purakayastha, Satyahari Dey, Amit Kumar NayakAbstract:The present study deals with the development and evaluations of stomach-specific floating capsules containing Salbutamol Sulfate-loaded oil-entrapped alginate-based beads. Salbutamol Sulfate-loaded oil-entrapped beads were prepared and capsulated within hard gelatin capsules (size 1). The effects of HPMC K4M and potato starch weight masses on drug encapsulation efficiency (DEE) of beads and cumulative drug release at 10h (R10 h) from capsules was analyzed by 3(2) factorial design. The optimization results indicate increasing of DEE in the oil-entrapped beads and decreasing R10 h from capsules with increment of HPMC K4M and potato starch weight masses. The optimized formulation showed DEE of 70.02 ± 3.16% and R10 h of 56.96 ± 2.92%. These capsules showed floatation over 6h and sustained drug release over 10h in gastric pH (1.2). In vivo X-ray imaging study of optimized floating capsules in rabbits showed stomach-specific gastroretention over a prolonged period.
